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TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity.

Abstract：

:We formulate a two-phase paradigm of autoimmunity associated with systemic lupus erythematosus, the archetypal autoimmune disease. The initial Toll-like receptor (TLR)-independent phase is mediated by dendritic cell uptake of apoptotic cell debris and associated nucleic acids, whereas the subsequent TLR-dependent phase serves an amplification function and is mediated by uptake of TLR ligands derived from self-antigens (principally nucleic acids) complexed with autoantibodies. Both phases depend on elaboration of type I interferons (IFNs), and therapeutic interruption of induction or activity of these cytokines in predisposed individuals might have a substantial mitigating effect in lupus and other autoimmune diseases.

journal_name

Nat Med

journal_title

Nature medicine

authors

Baccala R,Hoebe K,Kono DH,Beutler B,Theofilopoulos AN

doi

10.1038/nm1590

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

543-51

issue

5

eissn

1078-8956

issn

1546-170X

pii

nm1590

journal_volume

13

pub_type

杂志文章,评审

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