Abstract:
:We have studied the effects of amyloid beta-peptide analogues on the activity of tissue-type plasminogen activator (t-PA) in vitro. We have found that these peptides have a marked stimulatory effect upon plasminogen activation by t-PA, comparable to that of known stimulators of t-PA. This stimulatory activity appears to increase when beta-peptides form aggregated fibrillar structures similar to those found in amyloid deposits. This finding is significant in that it may provide insights into the pathogenesis of hereditary cerebral haemorrhage with amyloidosis-Dutch type (HCHWA-D) and cerebral amyloid angiopathy-related cerebral haemorrhage. It may also provide an explanation for the deaths resulting from intracerebral haemorrhage that have occurred in patients undergoing t-PA treatment for acute myocardial infarction.
journal_name
Nat Medjournal_title
Nature medicineauthors
Kingston IB,Castro MJ,Anderson Sdoi
10.1038/nm0295-138subject
Has Abstractpub_date
1995-02-01 00:00:00pages
138-42issue
2eissn
1078-8956issn
1546-170Xjournal_volume
1pub_type
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