The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy.

abstract：:Deep brain stimulation (DBS) is a widely used neurosurgical approach to treating tremor and other movement disorders. In addition, the use of DBS in a number of psychiatric diseases, including obsessive-compulsive disorders and depression, is currently being tested. Despite the rapid increase in the number of individu...

journal_title：Nature medicine

authors： Bekar L,Libionka W,Tian GF,Xu Q,Torres A,Wang X,Lovatt D,Williams E,Takano T,Schnermann J,Bakos R,Nedergaard M

更新日期：2008-01-01 00:00:00

abstract：:In the nervous system, NMDA receptors (NMDARs) participate in neurotransmission and modulate the viability of neurons. In contrast, little is known about the role of NMDARs in pancreatic islets and the insulin-secreting beta cells whose functional impairment contributes to diabetes mellitus. Here we found that inhibit...

journal_title：Nature medicine

authors： Marquard J,Otter S,Welters A,Stirban A,Fischer A,Eglinger J,Herebian D,Kletke O,Klemen MS,Stožer A,Wnendt S,Piemonti L,Köhler M,Ferrer J,Thorens B,Schliess F,Rupnik MS,Heise T,Berggren PO,Klöcker N,Meissner T,Ma

更新日期：2015-04-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA) is an important neurotransmitter that, through the subtype A GABA receptor (GABAAR), induces inhibition in the adult brain. Here we show that an excitatory, rather than inhibitory, GABAergic system exists in airway epithelial cells. Both GABAARs and the GABA synthetic enzyme glutamic aci...

journal_title：Nature medicine

authors： Xiang YY,Wang S,Liu M,Hirota JA,Li J,Ju W,Fan Y,Kelly MM,Ye B,Orser B,O'Byrne PM,Inman MD,Yang X,Lu WY

更新日期：2007-07-01 00:00:00

abstract：:Targeting the mammalian target of rapamycin (mTOR) protein is a promising strategy for cancer therapy. The mTOR kinase functions in two complexes, TORC1 (target of rapamycin complex-1) and TORC2 (target of rapamycin complex-2); however, neither of these complexes is fully inhibited by the allosteric inhibitor rapamyci...

journal_title：Nature medicine

authors： Janes MR,Limon JJ,So L,Chen J,Lim RJ,Chavez MA,Vu C,Lilly MB,Mallya S,Ong ST,Konopleva M,Martin MB,Ren P,Liu Y,Rommel C,Fruman DA

更新日期：2010-02-01 00:00:00

abstract：:Amyloid-beta peptide (Abeta) interacts with the vasculature to influence Abeta levels in the brain and cerebral blood flow, providing a means of amplifying the Abeta-induced cellular stress underlying neuronal dysfunction and dementia. Systemic Abeta infusion and studies in genetically manipulated mice show that Abeta...

journal_title：Nature medicine

authors： Deane R,Du Yan S,Submamaryan RK,LaRue B,Jovanovic S,Hogg E,Welch D,Manness L,Lin C,Yu J,Zhu H,Ghiso J,Frangione B,Stern A,Schmidt AM,Armstrong DL,Arnold B,Liliensiek B,Nawroth P,Hofman F,Kindy M,Stern D,Zlokov

更新日期：2003-07-01 00:00:00

abstract：:Both the risk and the rate of development of atherosclerosis are increased in diabetics, but the mechanisms involved are unknown. Here we report a glucose-mediated increase in CD36 mRNA translation efficiency that results in increased expression of the macrophage scavenger receptor CD36. Expression of CD36 was increas...

journal_title：Nature medicine

authors： Griffin E,Re A,Hamel N,Fu C,Bush H,McCaffrey T,Asch AS

更新日期：2001-07-01 00:00:00

abstract：:Tumors have a greater reliance on anaerobic glycolysis for energy production than normal tissues. We developed a noninvasive method for imaging glucose uptake in vivo that is based on magnetic resonance imaging and allows the uptake of unlabeled glucose to be measured through the chemical exchange of protons between h...

journal_title：Nature medicine

authors： Walker-Samuel S,Ramasawmy R,Torrealdea F,Rega M,Rajkumar V,Johnson SP,Richardson S,Gonçalves M,Parkes HG,Arstad E,Thomas DL,Pedley RB,Lythgoe MF,Golay X

更新日期：2013-08-01 00:00:00

abstract：:Evolutionary patterns of virus replication and distribution in lymphoid tissue during the early phases of HIV infection have not been delineated. Lymph node (LN) biopsies were excised from patients at different times after the estimated time of primary infection. Within 3 months of the acute viral syndrome, HIV was mo...

journal_title：Nature medicine

authors： Pantaleo G,Cohen OJ,Schacker T,Vaccarezza M,Graziosi C,Rizzardi GP,Kahn J,Fox CH,Schnittman SM,Schwartz DH,Corey L,Fauci AS

更新日期：1998-03-01 00:00:00

abstract：:Temporal lobe epilepsy is the most prevalent seizure disorder in adults. Compromised inhibitory neurotransmitter function in the hippocampus contributes to the hyperexcitability generating this condition, but the underlying molecular mechanisms are unknown. Combining patch-clamp recording and single-cell mRNA amplific...

journal_title：Nature medicine

authors： Brooks-Kayal AR,Shumate MD,Jin H,Rikhter TY,Coulter DA

更新日期：1998-10-01 00:00:00

abstract：:The gene encoding the lysine-specific histone methyltransferase KMT2D has emerged as one of the most frequently mutated genes in follicular lymphoma and diffuse large B cell lymphoma; however, the biological consequences of KMT2D mutations on lymphoma development are not known. Here we show that KMT2D functions as a b...

journal_title：Nature medicine

authors： Ortega-Molina A,Boss IW,Canela A,Pan H,Jiang Y,Zhao C,Jiang M,Hu D,Agirre X,Niesvizky I,Lee JE,Chen HT,Ennishi D,Scott DW,Mottok A,Hother C,Liu S,Cao XJ,Tam W,Shaknovich R,Garcia BA,Gascoyne RD,Ge K,Shilatif

更新日期：2015-10-01 00:00:00

abstract：:A Correction to this paper has been published: https://doi.org/10.1038/s41591-020-01176-7. ...

journal_title：Nature medicine

authors： Krystal JH

更新日期：2020-12-01 00:00:00

abstract：:Networks of interstitial cells of Cajal embedded in the musculature of the gastrointestinal tract are involved in the generation of electrical pacemaker activity for gastrointestinal motility. This pacemaker activity manifests itself as rhythmic slow waves in membrane potential, and controls the frequency and propagat...

journal_title：Nature medicine

authors： Thomsen L,Robinson TL,Lee JC,Farraway LA,Hughes MJ,Andrews DW,Huizinga JD

更新日期：1998-07-01 00:00:00

abstract：:Dendritic cells, the most potent antigen-presenting cells, need to be activated before they can function to initiate an immune response. We report here that, in the absence of any foreign substances, dendritic cells can be activated by endogenous signals received from cells that are stressed, virally infected or kille...

journal_title：Nature medicine

authors： Gallucci S,Lolkema M,Matzinger P

更新日期：1999-11-01 00:00:00

abstract：:Telomerase is a ribonucleoprotein enzyme that maintains the protective structures at the ends of eukaryotic chromosomes, called telomeres. In most human somatic cells, telomerase expression is repressed, and telomeres shorten progressively with each cell division. In contrast, most human tumors express telomerase, res...

journal_title：Nature medicine

authors： Hahn WC,Stewart SA,Brooks MW,York SG,Eaton E,Kurachi A,Beijersbergen RL,Knoll JH,Meyerson M,Weinberg RA

更新日期：1999-10-01 00:00:00

abstract：:Metabolic reprograming is an emerging hallmark of tumor biology and an actively pursued opportunity in discovery of oncology drugs. Extensive efforts have focused on therapeutic targeting of glycolysis, whereas drugging mitochondrial oxidative phosphorylation (OXPHOS) has remained largely unexplored, partly owing to a...

journal_title：Nature medicine

authors： Molina JR,Sun Y,Protopopova M,Gera S,Bandi M,Bristow C,McAfoos T,Morlacchi P,Ackroyd J,Agip AA,Al-Atrash G,Asara J,Bardenhagen J,Carrillo CC,Carroll C,Chang E,Ciurea S,Cross JB,Czako B,Deem A,Daver N,de Groot JF

更新日期：2018-07-01 00:00:00

abstract：:Iron is an essential component of the erythrocyte protein hemoglobin and is crucial to oxygen transport in vertebrates. In the steady state, erythrocyte production is in equilibrium with erythrocyte removal. In various pathophysiological conditions, however, erythrocyte life span is compromised severely, which threate...

journal_title：Nature medicine

authors： Theurl I,Hilgendorf I,Nairz M,Tymoszuk P,Haschka D,Asshoff M,He S,Gerhardt LM,Holderried TA,Seifert M,Sopper S,Fenn AM,Anzai A,Rattik S,McAlpine C,Theurl M,Wieghofer P,Iwamoto Y,Weber GF,Harder NK,Chousterman BG,

更新日期：2016-08-01 00:00:00

abstract：:High blood pressure, or hypertension, is a very common disorder with a substantial impact on public health because of its associated complications. Despite the high prevalence of essential hypertension and years of research, the basic causes remain obscure. Here I review recent advances in understanding the pathophysi...

journal_title：Nature medicine

authors： Coffman TM

更新日期：2011-11-07 00:00:00

abstract：:The World Health Organization estimates that tobacco will become the largest single health problem by 2020, causing an estimated 8.4 million deaths annually. But the smoking burden will not be distributed evenly across the globe; deaths in developed nations are set to rise 50% to 2.4 million while those in Asia will s...

journal_title：Nature medicine

authors： Raw M

更新日期：2001-01-01 00:00:00

abstract：:Restriction factors are host cell proteins that inhibit retroviral infection. A new study using mutants of human HIV-1 restriction factor SAMHD1 suggests that it inhibits infection through degradation of viral RNA rather than through its dNTPase activity as previously suggested. ...

journal_title：Nature medicine

authors： Yang Z,Greene WC

更新日期：2014-08-01 00:00:00

abstract：:Targeted gene transduction to specific tissues and organs through intravenous injection would be the ultimate preferred method of gene delivery. Here, we report successful targeting in a living animal through intravenous injection of a lentiviral vector pseudotyped with a modified chimeric Sindbis virus envelope (term...

journal_title：Nature medicine

authors： Morizono K,Xie Y,Ringpis GE,Johnson M,Nassanian H,Lee B,Wu L,Chen IS

更新日期：2005-03-01 00:00:00

abstract：:Immune evasion is an emerging hallmark of cancer progression. However, functional studies to understand the role of myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment are limited by the lack of available specific cell surface markers. We adapted a competitive peptide phage display platform to ident...

journal_title：Nature medicine

authors： Qin H,Lerman B,Sakamaki I,Wei G,Cha SC,Rao SS,Qian J,Hailemichael Y,Nurieva R,Dwyer KC,Roth J,Yi Q,Overwijk WW,Kwak LW

更新日期：2014-06-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature medicine

authors： He X,Lau EHY,Wu P,Deng X,Wang J,Hao X,Lau YC,Wong JY,Guan Y,Tan X,Mo X,Chen Y,Liao B,Chen W,Hu F,Zhang Q,Zhong M,Wu Y,Zhao L,Zhang F,Cowling BJ,Li F,Leung GM

更新日期：2020-09-01 00:00:00

abstract：:The human protein apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like-3G (APOBEC3G), also known as CEM-15, mediates a newly described form of innate resistance to retroviral infection by catalyzing the deamination of deoxycytidine to deoxyuridine in viral cDNA replication intermediates. Because DNA deamina...

journal_title：Nature medicine

authors： Sheehy AM,Gaddis NC,Malim MH

更新日期：2003-11-01 00:00:00

abstract：:Sexual transmission is the most frequent (86%) route of adult HIV-1 transmission worldwide. In the absence of a prophylactic anti-HIV vaccine, other methods of preventing infection should be implemented. Virucidal spermicides have been considered for this purpose, but their application is contraindicated by adverse ef...

journal_title：Nature medicine

authors： Neurath AR,Jiang S,Strick N,Lin K,Li YY,Debnath AK

更新日期：1996-02-01 00:00:00

abstract：:Disruption of systemic homeostasis by either chronic or acute stressors, such as obesity1 or surgery2, alters cancer pathogenesis. Patients with cancer, particularly those with breast cancer, can be at increased risk of cardiovascular disease due to treatment toxicity and changes in lifestyle behaviors3-5. While eleva...

journal_title：Nature medicine

authors： Koelwyn GJ,Newman AAC,Afonso MS,van Solingen C,Corr EM,Brown EJ,Albers KB,Yamaguchi N,Narke D,Schlegel M,Sharma M,Shanley LC,Barrett TJ,Rahman K,Mezzano V,Fisher EA,Park DS,Newman JD,Quail DF,Nelson ER,Caan BJ,J

更新日期：2020-09-01 00:00:00

abstract：:Human liver cancer research currently lacks in vitro models that can faithfully recapitulate the pathophysiology of the original tumor. We recently described a novel, near-physiological organoid culture system, wherein primary human healthy liver cells form long-term expanding organoids that retain liver tissue functi...

journal_title：Nature medicine

authors： Broutier L,Mastrogiovanni G,Verstegen MM,Francies HE,Gavarró LM,Bradshaw CR,Allen GE,Arnes-Benito R,Sidorova O,Gaspersz MP,Georgakopoulos N,Koo BK,Dietmann S,Davies SE,Praseedom RK,Lieshout R,IJzermans JNM,Wigmore SJ,

更新日期：2017-12-01 00:00:00

abstract：:Hereditary hemochromatosis and transfusional iron overload are frequent clinical conditions associated with progressive iron accumulation in parenchymal tissues, leading to eventual organ failure. We have discovered a new mechanism to reverse iron overload-pharmacological modulation of the divalent metal transporter-1...

journal_title：Nature medicine

authors： Ludwiczek S,Theurl I,Muckenthaler MU,Jakab M,Mair SM,Theurl M,Kiss J,Paulmichl M,Hentze MW,Ritter M,Weiss G

更新日期：2007-04-01 00:00:00

abstract：:Spinal bulbar muscular atrophy (SBMA) is a motor neuron disease caused by toxic gain of function of the androgen receptor (AR). Previously, we found that co-regulator binding through the activation function-2 (AF2) domain of AR is essential for pathogenesis, suggesting that AF2 may be a potential drug target for selec...

journal_title：Nature medicine

authors： Badders NM,Korff A,Miranda HC,Vuppala PK,Smith RB,Winborn BJ,Quemin ER,Sopher BL,Dearman J,Messing J,Kim NC,Moore J,Freibaum BD,Kanagaraj AP,Fan B,Tillman H,Chen PC,Wang Y,Freeman BB III,Li Y,Kim HJ,La Spada AR

更新日期：2018-05-01 00:00:00

abstract：:Viral replication and microbial translocation from the gut to the blood during HIV infection lead to hyperimmune activation, which contributes to the decline in CD4+ T cell numbers during HIV infection. Programmed death-1 (PD-1) and interleukin-10 (IL-10) are both upregulated during HIV infection. Blocking interaction...

journal_title：Nature medicine

authors： Said EA,Dupuy FP,Trautmann L,Zhang Y,Shi Y,El-Far M,Hill BJ,Noto A,Ancuta P,Peretz Y,Fonseca SG,Van Grevenynghe J,Boulassel MR,Bruneau J,Shoukry NH,Routy JP,Douek DC,Haddad EK,Sekaly RP

更新日期：2010-04-01 00:00:00

abstract：:Reactive oxygen species (ROS) induce chemokines responsible for the recruitment of inflammatory cells to sites of injury or infection. Here we show that the plasma membrane Ca(2+)-permeable channel TRPM2 controls ROS-induced chemokine production in monocytes. In human U937 monocytes, hydrogen peroxide (H(2)O(2)) evoke...

journal_title：Nature medicine

authors： Yamamoto S,Shimizu S,Kiyonaka S,Takahashi N,Wajima T,Hara Y,Negoro T,Hiroi T,Kiuchi Y,Okada T,Kaneko S,Lange I,Fleig A,Penner R,Nishi M,Takeshima H,Mori Y

更新日期：2008-07-01 00:00:00