Abstract：
:Dendritic cells, the most potent antigen-presenting cells, need to be activated before they can function to initiate an immune response. We report here that, in the absence of any foreign substances, dendritic cells can be activated by endogenous signals received from cells that are stressed, virally infected or killed necrotically, but not by healthy cells or those dying apoptotically. Injected in vivo with an antigen, the endogenous activating substances can function as natural adjuvants to stimulate a primary immune response, and they may represent the natural initiators of transplant rejection, spontaneous tumor rejection, and some forms of autoimmunity.
journal_name
Nat Medjournal_title
Nature medicineauthors
Gallucci S,Lolkema M,Matzinger Pdoi
10.1038/15200keywords:
subject
Has Abstractpub_date
1999-11-01 00:00:00pages
1249-55issue
11eissn
1078-8956issn
1546-170Xjournal_volume
5pub_type
杂志文章相关文献
NATURE MEDICINE文献大全abstract：:The skin protects mammals from insults, infection and dehydration and enables thermoregulation and sensory perception. Various skin-resident cells carry out these diverse functions. Constant turnover of cells and healing upon injury necessitate multiple reservoirs of stem cells. Thus, the skin provides a model for stu...
journal_title：Nature medicine
pub_type： 杂志文章,评审
doi：10.1038/nm.3643
更新日期：2014-08-01 00:00:00
abstract：:Although it is presumed that the integration of HIV-1 into the genome of infected CD4+ T lymphocytes allows viral persistence, there has been little direct evidence that CD4+ T cells with integrated provirus function as a latent reservoir for HIV-1 in infected individuals. Using resting CD4+ T-cell populations of extr...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm1295-1284
更新日期：1995-12-01 00:00:00
abstract：:Parkinson's disease symptoms can be improved by transplanting fetal dopamine cells into the putamen of parkinsonian patients. Because the supply of human donor tissue is limited and variable, an alternative and genetically modifiable non-human source of tissue would be valuable. We have generated cloned transgenic bov...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm0598-569
更新日期：1998-05-01 00:00:00
abstract：:Neutrophils have key roles in modulating the immune response. We present a robust methodology for rapidly isolating neutrophils directly from whole blood with 'on-chip' processing for mRNA and protein isolation for genomics and proteomics. We validate this device with an ex vivo stimulation experiment and by compariso...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.2205
更新日期：2010-09-01 00:00:00
abstract：:Adequate lipid secretion by mammary glands during lactation is essential for the survival of mammalian offspring. However, the mechanism governing this process is poorly understood. Here we show that Cidea is expressed at high levels in lactating mammary glands and its deficiency leads to premature pup death as a resu...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.2614
更新日期：2012-01-15 00:00:00
abstract：:Immune sensing of a microbe occurs via multiple receptors. How signals from different receptors are coordinated to yield a specific immune response is poorly understood. We show that two pathogen recognition receptors, Toll-like receptor 2 (TLR2) and dectin-1, recognizing the same microbial stimulus, stimulate distinc...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.1925
更新日期：2009-04-01 00:00:00
abstract：:Retinal ischemia can cause vision-threatening pathological neovascularization. The mechanisms of retinal ischemia are not fully understood, however. Here we have shown that leukocytes prune the retinal vasculature during normal development and obliterate it in disease. Beginning at postnatal day 5 (P5) in the normal r...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm877
更新日期：2003-06-01 00:00:00
abstract：:Surgery or radiation therapy of metastatic cancer often damages lymph nodes, leading to secondary lymphedema. Here we show, using a newly established mouse model, that collecting lymphatic vessels can be regenerated and fused to lymph node transplants after lymph node removal. Treatment of lymph node-excised mice with...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm1689
更新日期：2007-12-01 00:00:00
abstract：:Mobilization of hematopoietic stem and progenitor cells (HSPCs) from bone marrow into peripheral blood by the cytokine granulocyte colony-stimulating factor (G-CSF) has become the preferred source of HSPCs for stem cell transplants. However, G-CSF fails to mobilize sufficient numbers of stem cells in up to 10% of dono...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.2217
更新日期：2010-10-01 00:00:00
abstract：:The concentration of human immunodeficiency virus type 1 (HIV-1) particles in blood plasma is very predictive of the subsequent disease course in an infected individual; its measurement has become one of the most important parameters for monitoring clinical status. Steady-state virus levels in plasma reflect a balance...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/5576
更新日期：1999-02-01 00:00:00
abstract：:Endogenous mechanisms leading to host protection and resolution of infections without immunosuppression are of wide interest. Here we elucidate the structures of four new host-protective molecules produced in neutrophil-endothelial cocultures and present in human and mouse tissues after sterile inflammation or infecti...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.3911
更新日期：2015-09-01 00:00:00
abstract：:The Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) is expressed in all KSHV-associated tumors, including Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). We found that beta-catenin is overexpressed in both PEL cells and KS tissue. Introduction of anti-LANA small inte...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm829
更新日期：2003-03-01 00:00:00
abstract：:Neurovascular dysfunction substantially contributes to Alzheimer disease. Here, we show that transcriptional profiling of human brain endothelial cells (BECs) defines a subset of genes whose expression is age-independent but is considerably altered in Alzheimer disease, including the homeobox gene MEOX2 (also known as...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm1287
更新日期：2005-09-01 00:00:00
abstract：:Advances in imaging are transforming our understanding of angiogenesis and the evaluation of drugs that stimulate or inhibit angiogenesis in preclinical models and human disease. Vascular imaging makes it possible to quantify the number and spacing of blood vessels, measure blood flow and vascular permeability, and an...
journal_title：Nature medicine
pub_type： 杂志文章,评审
doi：10.1038/nm0603-713
更新日期：2003-06-01 00:00:00
abstract：:Single-cell genomics is essential to chart tumor ecosystems. Although single-cell RNA-Seq (scRNA-Seq) profiles RNA from cells dissociated from fresh tumors, single-nucleus RNA-Seq (snRNA-Seq) is needed to profile frozen or hard-to-dissociate tumors. Each requires customization to different tissue and tumor types, posi...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/s41591-020-0844-1
更新日期：2020-05-01 00:00:00
abstract：:Major depressive disorder is a devastating psychiatric disease that afflicts up to 17% of the world's population. Postmortem brain analyses and imaging studies of patients with depression have implicated basal lateral amygdala (BLA) dysfunction in the pathophysiology of depression. However, the circuit and molecular m...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/s41591-018-0299-9
更新日期：2019-02-01 00:00:00
abstract：:LIGHT was recently described as a member of the tumor necrosis factor (TNF) 'superfamily'. We have isolated a mouse homolog of human LIGHT and investigated its immunoregulatory functions in vitro and in vivo. LIGHT has potent, CD28-independent co-stimulatory activity leading to T-cell growth and secretion of gamma int...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/73136
更新日期：2000-03-01 00:00:00
abstract：:Copy number variants are a recently discovered source of large-scale genomic diversity present in all individuals. We capitalize on these inherent genomic differences, focusing on deletion polymorphisms, to develop informative fluorescence in situ hybridization probes with the ability to unequivocally distinguish betw...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.1862
更新日期：2009-02-01 00:00:00
abstract：:The World Health Organization estimates that tobacco will become the largest single health problem by 2020, causing an estimated 8.4 million deaths annually. But the smoking burden will not be distributed evenly across the globe; deaths in developed nations are set to rise 50% to 2.4 million while those in Asia will s...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/83281
更新日期：2001-01-01 00:00:00
abstract：:Post-ischemic inflammation is an essential step in the progression of brain ischemia-reperfusion injury. However, the mechanism that activates infiltrating macrophages in the ischemic brain remains to be clarified. Here we demonstrate that peroxiredoxin (Prx) family proteins released extracellularly from necrotic brai...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.2749
更新日期：2012-06-01 00:00:00
abstract：:Kidney transplantation has been one of the major medical advances of the past 30 years. However, tissue availability remains a major obstacle. This can potentially be overcome by the use of undifferentiated or partially developed kidney precursor cells derived from early embryos and fetal tissue. Here, transplantation...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm812
更新日期：2003-01-01 00:00:00
abstract：:Understanding the pathophysiology of SARS-CoV-2 infection is critical for therapeutic and public health strategies. Viral-host interactions can guide discovery of disease regulators, and protein structure function analysis points to several immune pathways, including complement and coagulation, as targets of coronavir...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/s41591-020-1021-2
更新日期：2020-10-01 00:00:00
abstract：:Increased production of very low-density lipoprotein (VLDL) is a critical feature of the metabolic syndrome. Here we report that a selective increase in brain glucose lowered circulating triglycerides (TG) through the inhibition of TG-VLDL secretion by the liver. We found that the effect of glucose required its conver...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm1540
更新日期：2007-02-01 00:00:00
abstract：: ...
journal_title：Nature medicine
pub_type： 评论,杂志文章
doi：10.1038/s41591-018-0286-1
更新日期：2018-12-01 00:00:00
abstract：:Sepsis remains a global clinical problem. By using the mouse cecal ligation and puncture model of sepsis, here we identify an important aspect of mast cell (MC)-dependent, innate immune defenses against Gram-negative bacteria by demonstrating that MC protease activity is regulated by interleukin-15 (IL-15). Mouse MCs ...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm1615
更新日期：2007-08-01 00:00:00
abstract：:Treatment with glatiramer acetate (GA, copolymer-1, Copaxone), a drug approved for multiple sclerosis (MS), in a mouse model promoted development of anti-inflammatory type II monocytes, characterized by increased secretion of interleukin (IL)-10 and transforming growth factor (TGF)-beta, and decreased production of IL...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm1620
更新日期：2007-08-01 00:00:00
abstract：:The ongoing substance misuse epidemic in the United States is complex and dynamic and should be approached as such in the development and evaluation of policy1. Drug overdose deaths (largely attributable to opioid misuse) in the United States have grown exponentially for almost four decades, but the mechanisms of this...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/s41591-020-0855-y
更新日期：2020-05-01 00:00:00
abstract：:Treating KRAS-mutant lung adenocarcinoma (LUAD) remains a major challenge in cancer treatment given the difficulties associated with directly inhibiting the KRAS oncoprotein. One approach to addressing this challenge is to define mutations that frequently co-occur with those in KRAS, which themselves may lead to thera...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.4407
更新日期：2017-11-01 00:00:00
abstract：:Obesity and metabolic syndrome are increasingly recognized as major risk factors for cardiovascular disease. Herein we show that Krüppel-like transcription factor 5 (KLF5) is a crucial regulator of energy metabolism. Klf5(+/-) mice were resistant to high fat-induced obesity, hypercholesterolemia and glucose intoleranc...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm1756
更新日期：2008-06-01 00:00:00
abstract：:Excitotoxic neuronal damage caused by overactivation of N-methyl-D-aspartate glutamate receptors (NMDARs) is thought to be a principal cause of neuronal loss after stroke and brain trauma. Here we report that activation of sterol regulatory element binding protein-1 (SREBP-1) transcription factor in affected neurons i...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.2064
更新日期：2009-12-01 00:00:00
