Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway.

Abstract:

:LIGHT was recently described as a member of the tumor necrosis factor (TNF) 'superfamily'. We have isolated a mouse homolog of human LIGHT and investigated its immunoregulatory functions in vitro and in vivo. LIGHT has potent, CD28-independent co-stimulatory activity leading to T-cell growth and secretion of gamma interferon and granulocyte-macrophage colony-stimulating factor. Gene transfer of LIGHT induced an antigen-specific cytolytic T-cell response and therapeutic immunity against established mouse P815 tumor. In contrast, blockade of LIGHT by administration of soluble receptor or antibody led to decreased cell-mediated immunity and ameliorated graft-versus-host disease. Our studies identify a previously unknown T-cell co-stimulatory pathway as a potential therapeutic target.

journal_name

Nat Med

journal_title

Nature medicine

authors

Tamada K,Shimozaki K,Chapoval AI,Zhu G,Sica G,Flies D,Boone T,Hsu H,Fu YX,Nagata S,Ni J,Chen L

doi

10.1038/73136

keywords:

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

283-9

issue

3

eissn

1078-8956

issn

1546-170X

journal_volume

6

pub_type

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