当前位置： SCI文献检索 > NATURE MEDICINE期刊下所有文献 > In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency.

In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency.

Abstract：

:Although it is presumed that the integration of HIV-1 into the genome of infected CD4+ T lymphocytes allows viral persistence, there has been little direct evidence that CD4+ T cells with integrated provirus function as a latent reservoir for HIV-1 in infected individuals. Using resting CD4+ T-cell populations of extremely high purity and a novel assay that selectively and unambiguously detects integrated HIV-1, we show that resting CD4+ T cells harbouring integrated provirus are present in some infected individuals. However, these cells do not accumulate within the circulating pool of resting CD4+ T cells in the early stages of HIV-1 infection and do not accumulate even after prolonged periods in long-term survivors of HIV-1 infection. These results suggest that because of viral cytopathic effects and/or host effector mechanisms, productively infected CD4+ T cells do not generally survive for long enough to revert to a resting memory state in vivo.

journal_name

Nat Med

journal_title

Nature medicine

authors

Chun TW,Finzi D,Margolick J,Chadwick K,Schwartz D,Siliciano RF

doi

10.1038/nm1295-1284

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

1284-90

issue

12

eissn

1078-8956

issn

1546-170X

journal_volume

1

pub_type

杂志文章

相关文献

NATURE MEDICINE文献大全
  • gammadelta T cells provide a breath of fresh air for asthma research.

    abstract：:gammadelta T cells downregulate airways responsiveness to allergen challenge, possibly by controlling the 'repair' response of the airway epithelium to alphabeta T cell-mediated damage (pages 1150-1156). ...

    journal_title：Nature medicine

    pub_type： 评论,新闻

    doi：10.1038/13447

    authors： Holt PG,Sly PD

    更新日期：1999-10-01 00:00:00

  • Antibacterial resistance worldwide: causes, challenges and responses.

    abstract：:The optimism of the early period of antimicrobial discovery has been tempered by the emergence of bacterial strains with resistance to these therapeutics. Today, clinically important bacteria are characterized not only by single drug resistance but also by multiple antibiotic resistance--the legacy of past decades of ...

    journal_title：Nature medicine

    pub_type： 杂志文章,评审

    doi：10.1038/nm1145

    authors： Levy SB,Marshall B

    更新日期：2004-12-01 00:00:00

  • Production of atypical measles in rhesus macaques: evidence for disease mediated by immune complex formation and eosinophils in the presence of fusion-inhibiting antibody.

    abstract：:The severe disease atypical measles occurred when individuals immunized with a poorly protective inactivated vaccine contracted measles, and was postulated to be due to a lack of fusion-inhibiting antibodies. Here, rhesus macaques immunized with formalin-inactivated measles vaccine developed transient neutralizing and...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/9473

    authors： Polack FP,Auwaerter PG,Lee SH,Nousari HC,Valsamakis A,Leiferman KM,Diwan A,Adams RJ,Griffin DE

    更新日期：1999-06-01 00:00:00

  • Elimination of Ehrlich tumours by ATP-induced growth inhibition, glutathione depletion and X-rays.

    abstract：:ATP-induced tumour growth inhibition is accompanied by a selective decrease in the content of the tripeptide glutathione (GSH) within the cancer cells in vivo. Depletion of cellular GSH sensitizes tumours to chemotherapy and radiation, but the usefulness of this depletion depends on whether the levels of GSH can be re...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0195-84

    authors： Estrela JM,Obrador E,Navarro J,Lasso De la Vega MC,Pellicer JA

    更新日期：1995-01-01 00:00:00

  • Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity.

    abstract：:The ability of the human immune system to respond to vaccination declines with age. We identified an age-associated defect in T cell receptor (TCR)-induced extracellular signal-regulated kinase (ERK) phosphorylation in naive CD4(+) T cells, whereas other signals, such as ζ chain-associated protein kinase 70 (ZAP70) an...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.2963

    authors： Li G,Yu M,Lee WW,Tsang M,Krishnan E,Weyand CM,Goronzy JJ

    更新日期：2012-10-01 00:00:00

  • Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies.

    abstract：:To determine the protective potential of the humoral immune response against HIV-1 in vivo we evaluated the potency of three neutralizing antibodies (2G12, 2F5 and 4E10) in suppressing viral rebound in six acutely and eight chronically HIV-1-infected individuals undergoing interruption of antiretroviral treatment (ART...

    journal_title：Nature medicine

    pub_type： 临床试验,杂志文章

    doi：10.1038/nm1244

    authors： Trkola A,Kuster H,Rusert P,Joos B,Fischer M,Leemann C,Manrique A,Huber M,Rehr M,Oxenius A,Weber R,Stiegler G,Vcelar B,Katinger H,Aceto L,Günthard HF

    更新日期：2005-06-01 00:00:00

  • Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB.

    abstract：:Programmed cell death (apoptosis) seems to be the principal mechanism whereby anti-oncogenic therapies such as chemotherapy and radiation effect their responses. Resistance to apoptosis, therefore, is probably a principal mechanism whereby tumors are able to overcome these cancer therapies. The transcription factor NF...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/7410

    authors： Wang CY,Cusack JC Jr,Liu R,Baldwin AS Jr

    更新日期：1999-04-01 00:00:00

  • Identification of the prion protein allotypes which accumulate in the brain of sporadic and familial Creutzfeldt-Jakob disease patients.

    abstract：:A characteristic feature of Creutzfeldt-Jakob disease (CJD) is the accumulation in the brain of the amyloid protease-resistant protein PrPres. PrPres derives from a host-encoded, protease-sensitive isoform, PrPsen. Mutations of this protein are linked to familial variants of the disease, and the presence of a methioni...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0597-521

    authors： Silvestrini MC,Cardone F,Maras B,Pucci P,Barra D,Brunori M,Pocchiari M

    更新日期：1997-05-01 00:00:00

  • The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif.

    abstract：:The human protein apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like-3G (APOBEC3G), also known as CEM-15, mediates a newly described form of innate resistance to retroviral infection by catalyzing the deamination of deoxycytidine to deoxyuridine in viral cDNA replication intermediates. Because DNA deamina...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm945

    authors： Sheehy AM,Gaddis NC,Malim MH

    更新日期：2003-11-01 00:00:00

  • Epigenetic modulation of the renal β-adrenergic-WNK4 pathway in salt-sensitive hypertension.

    abstract：:How high salt intake increases blood pressure is a key question in the study of hypertension. Salt intake induces increased renal sympathetic activity resulting in sodium retention. However, the mechanisms underlying the sympathetic control of renal sodium excretion remain unclear. In this study, we found that β(2)-ad...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.2337

    authors： Mu S,Shimosawa T,Ogura S,Wang H,Uetake Y,Kawakami-Mori F,Marumo T,Yatomi Y,Geller DS,Tanaka H,Fujita T

    更新日期：2011-05-01 00:00:00

  • A molecularly engineered split reporter for imaging protein-protein interactions with positron emission tomography.

    abstract：:Improved techniques to noninvasively image protein-protein interactions (PPIs) are essential. We molecularly engineered a positron emission tomography (PET)-based split reporter (herpes simplex virus type 1 thymidine kinase), cleaved between Thr265 and Ala266, and used this in a protein-fragment complementation assay ...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.2185

    authors： Massoud TF,Paulmurugan R,Gambhir SS

    更新日期：2010-08-01 00:00:00

  • Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques.

    abstract：:The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) is of global concern: the virus has caused severe respiratory illness, with 111 confirmed cases and 52 deaths at the time of this article's publication. Therapeutic interventions have not been evaluated in vivo; thus, patient management relies ex...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.3362

    authors： Falzarano D,de Wit E,Rasmussen AL,Feldmann F,Okumura A,Scott DP,Brining D,Bushmaker T,Martellaro C,Baseler L,Benecke AG,Katze MG,Munster VJ,Feldmann H

    更新日期：2013-10-01 00:00:00

  • The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

    abstract：:Recent studies suggest that statins can function to protect the vasculature in a manner that is independent of their lipid-lowering activity. We show here that statins rapidly activate the protein kinase Akt/PKB in endothelial cells. Accordingly, simvastatin enhanced phosphorylation of the endogenous Akt substrate end...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/79510

    authors： Kureishi Y,Luo Z,Shiojima I,Bialik A,Fulton D,Lefer DJ,Sessa WC,Walsh K

    更新日期：2000-09-01 00:00:00

  • Reversion of CTL escape-variant immunodeficiency viruses in vivo.

    abstract：:Engendering cytotoxic T-lymphocyte (CTL) responses is likely to be an important goal of HIV vaccines. However, CTLs select for viral variants that escape immune detection. Maintenance of such escape variants in human populations could pose an obstacle to HIV vaccine development. We first observed that escape mutations...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm998

    authors： Friedrich TC,Dodds EJ,Yant LJ,Vojnov L,Rudersdorf R,Cullen C,Evans DT,Desrosiers RC,Mothé BR,Sidney J,Sette A,Kunstman K,Wolinsky S,Piatak M,Lifson J,Hughes AL,Wilson N,O'Connor DH,Watkins DI

    更新日期：2004-03-01 00:00:00

  • Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1.

    abstract：:Focal segmental glomerulosclerosis (FSGS) is a frequent and severe glomerular disease characterized by destabilization of podocyte foot processes. We report that transgenic expression of the microRNA miR-193a in mice rapidly induces FSGS with extensive podocyte foot process effacement. Mechanistically, miR-193a inhibi...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.3142

    authors： Gebeshuber CA,Kornauth C,Dong L,Sierig R,Seibler J,Reiss M,Tauber S,Bilban M,Wang S,Kain R,Böhmig GA,Moeller MJ,Gröne HJ,Englert C,Martinez J,Kerjaschki D

    更新日期：2013-04-01 00:00:00

  • Akt2 relaxes podocytes in chronic kidney disease.

    abstract：:A signaling cascade is activated in podocytes to induce survival and cope with stress during advanced glomerular disease, a new study shows. The findings may also explain why the immunosuppressor sirolimus, an inhibitor of this pathway, can cause proteinuria in a subset of patients with chronic kidney disease (pages 1...

    journal_title：Nature medicine

    pub_type： 评论,新闻

    doi：10.1038/nm.3357

    authors： Reiser J

    更新日期：2013-10-01 00:00:00

  • Novel role of human CD4 molecule identified in neurodegeneration.

    abstract：:The human CD4 molecule (hCD4) is expressed on T lymphocytes and macrophages and acts as a key component of the cellular receptor for HIV. At baseline, hCD4 transgenic mice expressed hCD4 on microglia, the resident mononuclear phagocytes of the brain, and showed no neuronal damage. Activation of brain microglia by peri...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0498-441

    authors： Buttini M,Westland CE,Masliah E,Yafeh AM,Wyss-Coray T,Mucke L

    更新日期：1998-04-01 00:00:00

  • A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency.

    abstract：:The Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) is expressed in all KSHV-associated tumors, including Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). We found that beta-catenin is overexpressed in both PEL cells and KS tissue. Introduction of anti-LANA small inte...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm829

    authors： Fujimuro M,Wu FY,ApRhys C,Kajumbula H,Young DB,Hayward GS,Hayward SD

    更新日期：2003-03-01 00:00:00

  • A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors.

    abstract：:Single-cell genomics is essential to chart tumor ecosystems. Although single-cell RNA-Seq (scRNA-Seq) profiles RNA from cells dissociated from fresh tumors, single-nucleus RNA-Seq (snRNA-Seq) is needed to profile frozen or hard-to-dissociate tumors. Each requires customization to different tissue and tumor types, posi...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/s41591-020-0844-1

    authors： Slyper M,Porter CBM,Ashenberg O,Waldman J,Drokhlyansky E,Wakiro I,Smillie C,Smith-Rosario G,Wu J,Dionne D,Vigneau S,Jané-Valbuena J,Tickle TL,Napolitano S,Su MJ,Patel AG,Karlstrom A,Gritsch S,Nomura M,Waghray A,Go

    更新日期：2020-05-01 00:00:00

  • Marked amelioration of established collagen-induced arthritis by treatment with antibodies to CD23 in vivo.

    abstract：:CD23 is a low-affinity receptor for immunoglobulin E (IgE) expressed by a variety of haematopoietic cells. Proteolytic cleavage of the transmembrane receptor generates soluble forms, which can be detected in biological fluids. CD23 regulates many functional aspects of immune cells, both in its cell-associated and solu...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0895-781

    authors： Plater-Zyberk C,Bonnefoy JY

    更新日期：1995-08-01 00:00:00

  • rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice.

    abstract：:Mice carrying mutations in both the dystrophin and utrophin genes die prematurely as a consequence of severe muscular dystrophy. Here, we show that intravascular administration of recombinant adeno-associated viral (rAAV) vectors carrying a microdystrophin gene restores expression of dystrophin in the respiratory, car...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1439

    authors： Gregorevic P,Allen JM,Minami E,Blankinship MJ,Haraguchi M,Meuse L,Finn E,Adams ME,Froehner SC,Murry CE,Chamberlain JS

    更新日期：2006-07-01 00:00:00

  • Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression.

    abstract：:Breast cancers are either primarily resistant to chemotherapy (intrinsic resistance), or respond to chemotherapy but later recur with a multidrug-resistant phenotype because of overexpression of the multidrug transporter P-glycoprotein. The MDR1 gene encoding P-glycoprotein may be transcriptionally regulated by a Y-bo...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0497-447

    authors： Bargou RC,Jürchott K,Wagener C,Bergmann S,Metzner S,Bommert K,Mapara MY,Winzer KJ,Dietel M,Dörken B,Royer HD

    更新日期：1997-04-01 00:00:00

  • GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes.

    abstract：:GLUT4, the insulin-responsive glucose transporter, plays an important role in postprandial glucose disposal. Altered GLUT4 activity is suggested to be one of the factors responsible for decreased glucose uptake in muscle and adipose tissue in obesity and diabetes. To assess the effect of GLUT4 expression on whole-body...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1097-1096

    authors： Stenbit AE,Tsao TS,Li J,Burcelin R,Geenen DL,Factor SM,Houseknecht K,Katz EB,Charron MJ

    更新日期：1997-10-01 00:00:00

  • Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I.

    abstract：:Oxidative damage from elevated production of reactive oxygen species (ROS) contributes to ischemia-reperfusion injury in myocardial infarction and stroke. The mechanism by which the increase in ROS occurs is not known, and it is unclear how this increase can be prevented. A wide variety of nitric oxide donors and S-ni...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.3212

    authors： Chouchani ET,Methner C,Nadtochiy SM,Logan A,Pell VR,Ding S,James AM,Cochemé HM,Reinhold J,Lilley KS,Partridge L,Fearnley IM,Robinson AJ,Hartley RC,Smith RA,Krieg T,Brookes PS,Murphy MP

    更新日期：2013-06-01 00:00:00

  • Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease.

    abstract：:One hallmark of Alzheimer disease is the accumulation of amyloid beta-peptide in the brain and its deposition as plaques. Mice transgenic for an amyloid beta precursor protein (APP) mini-gene driven by a platelet-derived (PD) growth factor promoter (PDAPP mice), which overexpress one of the disease-linked mutant forms...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/78682

    authors： Bard F,Cannon C,Barbour R,Burke RL,Games D,Grajeda H,Guido T,Hu K,Huang J,Johnson-Wood K,Khan K,Kholodenko D,Lee M,Lieberburg I,Motter R,Nguyen M,Soriano F,Vasquez N,Weiss K,Welch B,Seubert P,Schenk D,Yednock

    更新日期：2000-08-01 00:00:00

  • External stenting reduces long-term medial and neointimal thickening and platelet derived growth factor expression in a pig model of arteriovenous bypass grafting.

    abstract：:Bypass of stenotic coronary arteries with autologous saphenous vein is an established treatment for ischemic heart disease. However, its long-term clinical success is limited. Late vein graft failure is the result of medial and intimal thickening consequent upon medial vascular smooth muscle cell migration, proliferat...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0298-235

    authors： Mehta D,George SJ,Jeremy JY,Izzat MB,Southgate KM,Bryan AJ,Newby AC,Angelini GD

    更新日期：1998-02-01 00:00:00

  • Protective immunity from a germinal center sanctuary.

    abstract：:A new study provides mechanistic insights into how live attenuated simian immunodeficiency virus (SIV) vaccines (LAVs) can protect monkeys from infection with pathogenic SIV. The authors show that replicating LAVs stimulate a protective immune response from a safe haven in the germinal centers of lymph nodes (pages 16...

    journal_title：Nature medicine

    pub_type： 评论,杂志文章

    doi：10.1038/nm.2986

    authors： Robinson HL,Amara RR

    更新日期：2012-11-01 00:00:00

  • Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1.

    abstract：:Recent studies of subjects infected with human immunodeficiency virus (HIV-1) have produced conflicting results about the extent of reconstitution possible in the CD4+ lymphocyte repertoire after highly active antiretroviral therapy (HAART). The effect of HAART on the incidence of opportunistic infections will probabl...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0898-953

    authors： Komanduri KV,Viswanathan MN,Wieder ED,Schmidt DK,Bredt BM,Jacobson MA,McCune JM

    更新日期：1998-08-01 00:00:00

  • Bradykinin-evoked sensitization of airway sensory nerves: a mechanism for ACE-inhibitor cough.

    abstract：:Cough accompanied by an increased sensitivity of the cough reflex is the most common symptom of inflammatory airway disease. This symptom is also frequently reported in patients receiving angiotensin-converting enzyme (ACE) inhibitors as therapy for heart failure or hypertension, although the underlying mechanism is u...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0796-814

    authors： Fox AJ,Lalloo UG,Belvisi MG,Bernareggi M,Chung KF,Barnes PJ

    更新日期：1996-07-01 00:00:00

  • The natural killer T-cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice.

    abstract：:Diabetes in non-obese diabetic (NOD) mice is mediated by pathogenic T-helper type 1 (Th1) cells that arise because of a deficiency in regulatory or suppressor T cells. V alpha 14-J alpha 15 natural killer T (NKT) cells recognize lipid antigens presented by the major histocompatibility complex class I-like protein CD1d...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0901-1052

    authors： Hong S,Wilson MT,Serizawa I,Wu L,Singh N,Naidenko OV,Miura T,Haba T,Scherer DC,Wei J,Kronenberg M,Koezuka Y,Van Kaer L

    更新日期：2001-09-01 00:00:00