Abstract:
:Recent studies suggest that statins can function to protect the vasculature in a manner that is independent of their lipid-lowering activity. We show here that statins rapidly activate the protein kinase Akt/PKB in endothelial cells. Accordingly, simvastatin enhanced phosphorylation of the endogenous Akt substrate endothelial nitric oxide synthase (eNOS), inhibited apoptosis and accelerated vascular structure formation in vitro in an Akt-dependent manner. Similar to vascular endothelial growth factor (VEGF) treatment, both simvastatin administration and enhanced Akt signaling in the endothelium promoted angiogenesis in ischemic limbs of normocholesterolemic rabbits. Therefore, activation of Akt represents a mechanism that can account for some of the beneficial side effects of statins, including the promotion of new blood vessel growth.
journal_name
Nat Medjournal_title
Nature medicineauthors
Kureishi Y,Luo Z,Shiojima I,Bialik A,Fulton D,Lefer DJ,Sessa WC,Walsh Kdoi
10.1038/79510keywords:
subject
Has Abstractpub_date
2000-09-01 00:00:00pages
1004-10issue
9eissn
1078-8956issn
1546-170Xjournal_volume
6pub_type
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