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A new role for Nogo as a regulator of vascular remodeling.

Abstract：

:Although Nogo-A has been identified in the central nervous system as an inhibitor of axonal regeneration, the peripheral roles of Nogo isoforms remain virtually unknown. Here, using a proteomic analysis to identify proteins enriched in caveolae and/or lipid rafts (CEM/LR), we show that Nogo-B is highly expressed in cultured endothelial and smooth muscle cells, as well as in intact blood vessels. The N terminus of Nogo-B promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle (VSM) cells, processes necessary for vascular remodeling. Vascular injury in Nogo-A/B-deficient mice promotes exaggerated neointimal proliferation, and adenoviral-mediated gene transfer of Nogo-B rescues the abnormal vascular expansion in those knockout mice. Our discovery that Nogo-B is a regulator of vascular homeostasis and remodeling broadens the functional scope of this family of proteins.

journal_name

Nat Med

journal_title

Nature medicine

authors

Acevedo L,Yu J,Erdjument-Bromage H,Miao RQ,Kim JE,Fulton D,Tempst P,Strittmatter SM,Sessa WC

doi

10.1038/nm1020

keywords:

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

382-8

issue

4

eissn

1078-8956

issn

1546-170X

pii

nm1020

journal_volume

10

pub_type

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