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Mechanisms of NAFLD development and therapeutic strategies.

Abstract：

:There has been a rise in the prevalence of nonalcoholic fatty liver disease (NAFLD), paralleling a worldwide increase in diabetes and metabolic syndrome. NAFLD, a continuum of liver abnormalities from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), has a variable course but can lead to cirrhosis and liver cancer. Here we review the pathogenic and clinical features of NAFLD, its major comorbidities, clinical progression and risk of complications and in vitro and animal models of NAFLD enabling refinement of therapeutic targets that can accelerate drug development. We also discuss evolving principles of clinical trial design to evaluate drug efficacy and the emerging targets for drug development that involve either single agents or combination therapies intended to arrest or reverse disease progression.

journal_name

Nat Med

journal_title

Nature medicine

authors

Friedman SL,Neuschwander-Tetri BA,Rinella M,Sanyal AJ

doi

10.1038/s41591-018-0104-9

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

908-922

issue

7

eissn

1078-8956

issn

1546-170X

pii

10.1038/s41591-018-0104-9

journal_volume

24

pub_type

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