当前位置： SCI文献检索 > NATURE MEDICINE期刊下所有文献 > Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB.

Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB.

Abstract：

:Programmed cell death (apoptosis) seems to be the principal mechanism whereby anti-oncogenic therapies such as chemotherapy and radiation effect their responses. Resistance to apoptosis, therefore, is probably a principal mechanism whereby tumors are able to overcome these cancer therapies. The transcription factor NF-kappaB is activated by chemotherapy and by irradiation in some cancer cell lines. Furthermore, inhibition of NF-kappaB in vitro leads to enhanced apoptosis in response to a variety of different stimuli. We show here that inhibition of NF-kappaB through the adenoviral delivery of a modified form of IkappaBalpha, the inhibitor of NF-kappaB, sensitizes chemoresistant tumors to the apoptotic potential of TNFalpha and of the chemotherapeutic compound CPT-11, resulting in tumor regression. These results demonstrate that the activation of NF-kappaB in response to chemotherapy is a principal mechanism of inducible tumor chemoresistance, and establish the inhibition of NF-kappaB as a new approach to adjuvant therapy in cancer treatment.

journal_name

Nat Med

journal_title

Nature medicine

authors

Wang CY,Cusack JC Jr,Liu R,Baldwin AS Jr

doi

10.1038/7410

keywords:

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

412-7

issue

4

eissn

1078-8956

issn

1546-170X

journal_volume

5

pub_type

杂志文章

相关文献

NATURE MEDICINE文献大全
  • Inhibition of telomerase limits the growth of human cancer cells.

    abstract：:Telomerase is a ribonucleoprotein enzyme that maintains the protective structures at the ends of eukaryotic chromosomes, called telomeres. In most human somatic cells, telomerase expression is repressed, and telomeres shorten progressively with each cell division. In contrast, most human tumors express telomerase, res...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/13495

    authors： Hahn WC,Stewart SA,Brooks MW,York SG,Eaton E,Kurachi A,Beijersbergen RL,Knoll JH,Meyerson M,Weinberg RA

    更新日期：1999-10-01 00:00:00

  • Mutations in ACTRT1 and its enhancer RNA elements lead to aberrant activation of Hedgehog signaling in inherited and sporadic basal cell carcinomas.

    abstract：:Basal cell carcinoma (BCC), the most common human cancer, results from aberrant activation of the Hedgehog signaling pathway. Although most cases of BCC are sporadic, some forms are inherited, such as Bazex-Dupré-Christol syndrome (BDCS)-a cancer-prone genodermatosis with an X-linked, dominant inheritance pattern. We ...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.4368

    authors： Bal E,Park HS,Belaid-Choucair Z,Kayserili H,Naville M,Madrange M,Chiticariu E,Hadj-Rabia S,Cagnard N,Kuonen F,Bachmann D,Huber M,Le Gall C,Côté F,Hanein S,Rosti RÖ,Aslanger AD,Waisfisz Q,Bodemer C,Hermine O,Morice

    更新日期：2017-10-01 00:00:00

  • Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity.

    abstract：:The ability of the human immune system to respond to vaccination declines with age. We identified an age-associated defect in T cell receptor (TCR)-induced extracellular signal-regulated kinase (ERK) phosphorylation in naive CD4(+) T cells, whereas other signals, such as ζ chain-associated protein kinase 70 (ZAP70) an...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.2963

    authors： Li G,Yu M,Lee WW,Tsang M,Krishnan E,Weyand CM,Goronzy JJ

    更新日期：2012-10-01 00:00:00

  • The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy.

    abstract：:Epigenetic reprogramming is a critical process of pathological gene induction during cardiac hypertrophy and remodeling, but the underlying regulatory mechanisms remain to be elucidated. Here we identified a heart-enriched long noncoding (lnc)RNA, named cardiac-hypertrophy-associated epigenetic regulator (Chaer), whic...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.4179

    authors： Wang Z,Zhang XJ,Ji YX,Zhang P,Deng KQ,Gong J,Ren S,Wang X,Chen I,Wang H,Gao C,Yokota T,Ang YS,Li S,Cass A,Vondriska TM,Li G,Deb A,Srivastava D,Yang HT,Xiao X,Li H,Wang Y

    更新日期：2016-10-01 00:00:00

  • Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity.

    abstract：:A variable region gene of the T-cell receptor, V beta 8.2, is rearranged, and its product is expressed on pathogenic T cells that induce experimental autoimmune encephalomyelitis (EAE) in H-2u mice after immunization with myelin basic protein (MBP). Vaccination of these mice with naked DNA encoding V beta 8.2 protecte...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0896-899

    authors： Waisman A,Ruiz PJ,Hirschberg DL,Gelman A,Oksenberg JR,Brocke S,Mor F,Cohen IR,Steinman L

    更新日期：1996-08-01 00:00:00

  • Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons.

    abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces clinical, biochemical and neuropathologic changes reminiscent of those which occur in idiopathic Parkinson's disease. 7-Nitroindazole (7-NI) is a relatively selective inhibitor of the neuronal isoform of nitric oxide synthase (NOS) that blocks MPTP neurotoxi...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0996-1017

    authors： Hantraye P,Brouillet E,Ferrante R,Palfi S,Dolan R,Matthews RT,Beal MF

    更新日期：1996-09-01 00:00:00

  • Transplantation of male germ line stem cells restores fertility in infertile mice.

    abstract：:Azoospermia or oligozoospermia due to disruption of spermatogenesis are common causes of human male infertility. We used the technique of spermatogonial transplantation in two infertile mouse strains, Steel (Sl) and dominant white spotting (W), to determine if stem cells from an infertile male were capable of generati...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/71496

    authors： Ogawa T,Dobrinski I,Avarbock MR,Brinster RL

    更新日期：2000-01-01 00:00:00

  • Oral immunization with an anti-idiotypic antibody to the exoglycolipid antigen protects against experimental Chlamydia trachomatis infection.

    abstract：:Chlamydia trachomatis is the leading cause worldwide of preventable infectious blindness (trachoma) and sexually transmitted disease, including nongonoccocal urethritis and pelvic inflammatory disease. To date, no effective vaccine against C. trachomatis infection has been identified. A monoclonal anti-idiotypic antib...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1096-1116

    authors： Whittum-Hudson JA,An LL,Saltzman WM,Prendergast RA,MacDonald AB

    更新日期：1996-10-01 00:00:00

  • Author Correction: Temporal dynamics in viral shedding and transmissibility of COVID-19.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature medicine

    pub_type： 已发布勘误

    doi：10.1038/s41591-020-1016-z

    authors： He X,Lau EHY,Wu P,Deng X,Wang J,Hao X,Lau YC,Wong JY,Guan Y,Tan X,Mo X,Chen Y,Liao B,Chen W,Hu F,Zhang Q,Zhong M,Wu Y,Zhao L,Zhang F,Cowling BJ,Li F,Leung GM

    更新日期：2020-09-01 00:00:00

  • Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance.

    abstract：:Oral administration of protein can induce antigen-specific immune hyporesponsiveness. However, the utility of oral tolerance to autoantigens in the treatment of autoimmune diseases may be limited when candidate autoantigens cannot be produced by conventional systems in quantities sufficient for clinical studies. Plant...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0797-793

    authors： Ma SW,Zhao DL,Yin ZQ,Mukherjee R,Singh B,Qin HY,Stiller CR,Jevnikar AM

    更新日期：1997-07-01 00:00:00

  • Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease.

    abstract：:Retinal ischemia can cause vision-threatening pathological neovascularization. The mechanisms of retinal ischemia are not fully understood, however. Here we have shown that leukocytes prune the retinal vasculature during normal development and obliterate it in disease. Beginning at postnatal day 5 (P5) in the normal r...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm877

    authors： Ishida S,Yamashiro K,Usui T,Kaji Y,Ogura Y,Hida T,Honda Y,Oguchi Y,Adamis AP

    更新日期：2003-06-01 00:00:00

  • Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle.

    abstract：:Exercise has numerous health-promoting effects in humans; however, individual responsiveness to exercise with regard to endurance or metabolic health differs markedly. This 'exercise resistance' is considered to be congenital, with no evident acquired causative factors. Here we show that the anti-oxidative hepatokine ...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.4295

    authors： Misu H,Takayama H,Saito Y,Mita Y,Kikuchi A,Ishii KA,Chikamoto K,Kanamori T,Tajima N,Lan F,Takeshita Y,Honda M,Tanaka M,Kato S,Matsuyama N,Yoshioka Y,Iwayama K,Tokuyama K,Akazawa N,Maeda S,Takekoshi K,Matsugo S,

    更新日期：2017-04-01 00:00:00

  • The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.

    abstract：:The gene encoding the lysine-specific histone methyltransferase KMT2D has emerged as one of the most frequently mutated genes in follicular lymphoma and diffuse large B cell lymphoma; however, the biological consequences of KMT2D mutations on lymphoma development are not known. Here we show that KMT2D functions as a b...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.3943

    authors： Ortega-Molina A,Boss IW,Canela A,Pan H,Jiang Y,Zhao C,Jiang M,Hu D,Agirre X,Niesvizky I,Lee JE,Chen HT,Ennishi D,Scott DW,Mottok A,Hother C,Liu S,Cao XJ,Tam W,Shaknovich R,Garcia BA,Gascoyne RD,Ge K,Shilatif

    更新日期：2015-10-01 00:00:00

  • A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors.

    abstract：:Single-cell genomics is essential to chart tumor ecosystems. Although single-cell RNA-Seq (scRNA-Seq) profiles RNA from cells dissociated from fresh tumors, single-nucleus RNA-Seq (snRNA-Seq) is needed to profile frozen or hard-to-dissociate tumors. Each requires customization to different tissue and tumor types, posi...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/s41591-020-0844-1

    authors： Slyper M,Porter CBM,Ashenberg O,Waldman J,Drokhlyansky E,Wakiro I,Smillie C,Smith-Rosario G,Wu J,Dionne D,Vigneau S,Jané-Valbuena J,Tickle TL,Napolitano S,Su MJ,Patel AG,Karlstrom A,Gritsch S,Nomura M,Waghray A,Go

    更新日期：2020-05-01 00:00:00

  • Serum levels of the iron binding protein p97 are elevated in Alzheimer's disease.

    abstract：:Alzheimer's disease is a progressive and incurable disease whose prevalence increases dramatically with age. A biochemical marker for monitoring the onset and progression of the disease would be a valuable tool for disease management. In addition, such a marker might be used as an end point in clinical intervention pr...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1196-1230

    authors： Kennard ML,Feldman H,Yamada T,Jefferies WA

    更新日期：1996-11-01 00:00:00

  • Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.

    abstract：:Mobilization of hematopoietic stem and progenitor cells (HSPCs) from bone marrow into peripheral blood by the cytokine granulocyte colony-stimulating factor (G-CSF) has become the preferred source of HSPCs for stem cell transplants. However, G-CSF fails to mobilize sufficient numbers of stem cells in up to 10% of dono...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.2217

    authors： Ryan MA,Nattamai KJ,Xing E,Schleimer D,Daria D,Sengupta A,Köhler A,Liu W,Gunzer M,Jansen M,Ratner N,Le Cras TD,Waterstrat A,Van Zant G,Cancelas JA,Zheng Y,Geiger H

    更新日期：2010-10-01 00:00:00

  • Publisher Correction: Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia.

    abstract：:In the version of this article originally published, Dimitry G. Sayenko's affiliations were not correct. The following affiliation for this author was missing: Department of Neurosurgery, Center for Neuroregeneration, Houston Methodist Research Institute, Houston, TX, USA. This affiliation has been added for the autho...

    journal_title：Nature medicine

    pub_type： 已发布勘误

    doi：10.1038/s41591-018-0248-7

    authors： Gill ML,Grahn PJ,Calvert JS,Linde MB,Lavrov IA,Strommen JA,Beck LA,Sayenko DG,Van Straaten MG,Drubach DI,Veith DD,Thoreson AR,Lopez C,Gerasimenko YP,Edgerton VR,Lee KH,Zhao KD

    更新日期：2018-12-01 00:00:00

  • A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitis.

    abstract：:Checkpoint inhibitors produce durable responses in numerous metastatic cancers, but immune-related adverse events (irAEs) complicate and limit their benefit. IrAEs can affect organ systems idiosyncratically; presentations range from mild and self-limited to fulminant and fatal. The molecular mechanisms underlying irAE...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/s41591-019-0523-2

    authors： Johnson DB,McDonnell WJ,Gonzalez-Ericsson PI,Al-Rohil RN,Mobley BC,Salem JE,Wang DY,Sanchez V,Wang Y,Chastain CA,Barker K,Liang Y,Warren S,Beechem JM,Menzies AM,Tio M,Long GV,Cohen JV,Guidon AC,O'Hare M,Chandra S

    更新日期：2019-08-01 00:00:00

  • Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastoma.

    abstract：:Glioblastoma is the most common primary central nervous system malignancy and has a poor prognosis. Standard first-line treatment, which includes surgery followed by adjuvant radio-chemotherapy, produces only modest benefits to survival1,2. Here, to explore the feasibility, safety and immunobiological effects of PD-1 ...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/s41591-018-0339-5

    authors： Schalper KA,Rodriguez-Ruiz ME,Diez-Valle R,López-Janeiro A,Porciuncula A,Idoate MA,Inogés S,de Andrea C,López-Diaz de Cerio A,Tejada S,Berraondo P,Villarroel-Espindola F,Choi J,Gúrpide A,Giraldez M,Goicoechea I,Gallego Pe

    更新日期：2019-03-01 00:00:00

  • Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells.

    abstract：:Beta-catenin is a central molecule in the Wnt pathway. Expression of a stable form of beta-catenin on CD4+CD25+ regulatory T (T(reg)) cells resulted in a marked enhancement of survival of these cells in vitro. Furthermore, stable beta-catenin-expressing CD4+CD25+ T(reg) cells outcompeted control T(reg) cells in vivo, ...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1707

    authors： Ding Y,Shen S,Lino AC,Curotto de Lafaille MA,Lafaille JJ

    更新日期：2008-02-01 00:00:00

  • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand.

    abstract：:Myelin-specific T lymphocytes are considered essential in the pathogenesis of multiple sclerosis. The myelin basic protein peptide (a.a. 83-99) represents one candidate antigen; therefore, it was chosen to design an altered peptide ligand, CGP77116, for specific immunotherapy of multiple sclerosis. A magnetic resonanc...

    journal_title：Nature medicine

    pub_type： 临床试验,杂志文章

    doi：10.1038/80516

    authors： Bielekova B,Goodwin B,Richert N,Cortese I,Kondo T,Afshar G,Gran B,Eaton J,Antel J,Frank JA,McFarland HF,Martin R

    更新日期：2000-10-01 00:00:00

  • Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.

    abstract：:Because of their abundance, resistance to proteolysis, rapid aggregation and neurotoxicity, N-terminally truncated and, in particular, pyroglutamate (pE)-modified Abeta peptides have been suggested as being important in the initiation of pathological cascades resulting in the development of Alzheimer's disease. We fou...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.1872

    authors： Schilling S,Zeitschel U,Hoffmann T,Heiser U,Francke M,Kehlen A,Holzer M,Hutter-Paier B,Prokesch M,Windisch M,Jagla W,Schlenzig D,Lindner C,Rudolph T,Reuter G,Cynis H,Montag D,Demuth HU,Rossner S

    更新日期：2008-10-01 00:00:00

  • A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome.

    abstract：:The identification of the genes associated with chromosomal translocation breakpoints has fundamentally changed understanding of the molecular basis of hematological malignancies. By contrast, the study of chromosomal deletions has been hampered by the large number of genes deleted and the complexity of their analysis...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.2063

    authors： Barlow JL,Drynan LF,Hewett DR,Holmes LR,Lorenzo-Abalde S,Lane AL,Jolin HE,Pannell R,Middleton AJ,Wong SH,Warren AJ,Wainscoat JS,Boultwood J,McKenzie AN

    更新日期：2010-01-01 00:00:00

  • In vivo imaging and tracking of host-microbiota interactions via metabolic labeling of gut anaerobic bacteria.

    abstract：:The intestine is densely populated by anaerobic commensal bacteria. These microorganisms shape immune system development, but understanding of host-commensal interactions is hampered by a lack of tools for studying the anaerobic intestinal environment. We applied metabolic oligosaccharide engineering and bioorthogonal...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.3929

    authors： Geva-Zatorsky N,Alvarez D,Hudak JE,Reading NC,Erturk-Hasdemir D,Dasgupta S,von Andrian UH,Kasper DL

    更新日期：2015-09-01 00:00:00

  • Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial.

    abstract：:Preoperative immunotherapy with anti-PD1 plus anti-CTLA4 antibodies has shown remarkable pathological responses in melanoma1 and colorectal cancer2. In NABUCCO (ClinicalTrials.gov: NCT03387761 ), a single-arm feasibility trial, 24 patients with stage III urothelial cancer (UC) received two doses of ipilimumab and two ...

    journal_title：Nature medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1038/s41591-020-1085-z

    authors： van Dijk N,Gil-Jimenez A,Silina K,Hendricksen K,Smit LA,de Feijter JM,van Montfoort ML,van Rooijen C,Peters D,Broeks A,van der Poel HG,Bruining A,Lubeck Y,Sikorska K,Boellaard TN,Kvistborg P,Vis DJ,Hooijberg E,Schumac

    更新日期：2020-12-01 00:00:00

  • Conversion of vascular endothelial cells into multipotent stem-like cells.

    abstract：:Mesenchymal stem cells can give rise to several cell types, but varying results depending on isolation methods and tissue source have led to controversies about their usefulness in clinical medicine. Here we show that vascular endothelial cells can transform into multipotent stem-like cells by an activin-like kinase-2...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.2252

    authors： Medici D,Shore EM,Lounev VY,Kaplan FS,Kalluri R,Olsen BR

    更新日期：2010-12-01 00:00:00

  • Local immune monitoring.

    abstract：: ...

    journal_title：Nature medicine

    pub_type： 评论,杂志文章

    doi：10.1038/s41591-018-0332-z

    authors： Stower H

    更新日期：2019-01-01 00:00:00

  • gammadelta T cells provide a breath of fresh air for asthma research.

    abstract：:gammadelta T cells downregulate airways responsiveness to allergen challenge, possibly by controlling the 'repair' response of the airway epithelium to alphabeta T cell-mediated damage (pages 1150-1156). ...

    journal_title：Nature medicine

    pub_type： 评论,新闻

    doi：10.1038/13447

    authors： Holt PG,Sly PD

    更新日期：1999-10-01 00:00:00

  • Differential requirement for CD18 in T-helper effector homing.

    abstract：:To understand the integrin requirements of T-helper (T(H)) effector subsets, we investigated the contribution of CD18 (beta(2) integrin) to T(H)1 and T(H)2 function in vitro and in relevant disease models. CD18-deficient (Itgb2(-/-)) T cells showed largely normal in vitro function. Compared with wild-type mice, Itgb2(...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm932

    authors： Lee SH,Prince JE,Rais M,Kheradmand F,Shardonofsky F,Lu H,Beaudet AL,Smith CW,Soong L,Corry DB

    更新日期：2003-10-01 00:00:00

  • Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.

    abstract：:Hedgehog signaling drives oncogenesis in several cancers, and strategies targeting this pathway have been developed, most notably through inhibition of Smoothened (SMO). However, resistance to Smoothened inhibitors occurs by genetic changes of Smoothened or other downstream Hedgehog components. Here we overcome these ...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.3613

    authors： Tang Y,Gholamin S,Schubert S,Willardson MI,Lee A,Bandopadhayay P,Bergthold G,Masoud S,Nguyen B,Vue N,Balansay B,Yu F,Oh S,Woo P,Chen S,Ponnuswami A,Monje M,Atwood SX,Whitson RJ,Mitra S,Cheshier SH,Qi J,Beroukh

    更新日期：2014-07-01 00:00:00