Abstract:
:White fat stores excess energy, whereas brown and beige fat are thermogenic and dissipate energy as heat. Thermogenic adipose tissues markedly improve glucose and lipid homeostasis in mouse models, although the extent to which brown adipose tissue (BAT) influences metabolic and cardiovascular disease in humans is unclear1,2. Here we retrospectively categorized 134,529 18F-fluorodeoxyglucose positron emission tomography-computed tomography scans from 52,487 patients, by presence or absence of BAT, and used propensity score matching to assemble a study cohort. Scans in the study population were initially conducted for indications related to cancer diagnosis, treatment or surveillance, without previous stimulation. We report that individuals with BAT had lower prevalences of cardiometabolic diseases, and the presence of BAT was independently correlated with lower odds of type 2 diabetes, dyslipidemia, coronary artery disease, cerebrovascular disease, congestive heart failure and hypertension. These findings were supported by improved blood glucose, triglyceride and high-density lipoprotein values. The beneficial effects of BAT were more pronounced in individuals with overweight or obesity, indicating that BAT might play a role in mitigating the deleterious effects of obesity. Taken together, our findings highlight a potential role for BAT in promoting cardiometabolic health.
journal_name
Nat Medjournal_title
Nature medicineauthors
Becher T,Palanisamy S,Kramer DJ,Eljalby M,Marx SJ,Wibmer AG,Butler SD,Jiang CS,Vaughan R,Schöder H,Mark A,Cohen Pdoi
10.1038/s41591-020-1126-7subject
Has Abstractpub_date
2021-01-01 00:00:00pages
58-65issue
1eissn
1078-8956issn
1546-170Xpii
10.1038/s41591-020-1126-7journal_volume
27pub_type
杂志文章相关文献
NATURE MEDICINE文献大全abstract::Colon cancer is a clinically diverse disease. This heterogeneity makes it difficult to determine which patients will benefit most from adjuvant therapy and impedes the development of new targeted agents. More insight into the biological diversity of colon cancers, especially in relation to clinical features, is theref...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.3174
更新日期:2013-05-01 00:00:00
abstract::Sexual transmission is the most frequent (86%) route of adult HIV-1 transmission worldwide. In the absence of a prophylactic anti-HIV vaccine, other methods of preventing infection should be implemented. Virucidal spermicides have been considered for this purpose, but their application is contraindicated by adverse ef...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0296-230
更新日期:1996-02-01 00:00:00
abstract::Lung cancer is the leading cause of death from cancer in the US and the world. The high mortality rate (80-85% within 5 years) results, in part, from a lack of effective tools to diagnose the disease at an early stage. Given that cigarette smoke creates a field of injury throughout the airway, we sought to determine i...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1556
更新日期:2007-03-01 00:00:00
abstract::The search for immunosuppressant drugs to increase the success of organ transplantation led to the discovery of the immunophilins, proteins that interface with a range of signal transduction systems inside cells, especially in the nervous and immune systems. Here we review how these interesting molecules work and cons...
journal_title:Nature medicine
pub_type: 杂志文章,评审
doi:10.1038/nm0195-32
更新日期:1995-01-01 00:00:00
abstract::Skin is an attractive target for delivery of genetic therapies and vaccines. However, new approaches are needed to access this tissue more effectively. Here, we describe a new delivery technology based on arrays of structurally precise, micron-scale silicon projections, which we term microenhancer arrays (MEAs). In a ...
journal_title:Nature medicine
pub_type: 临床试验,杂志文章
doi:10.1038/nm0402-415
更新日期:2002-04-01 00:00:00
abstract::We describe results from IMmotion150, a randomized phase 2 study of atezolizumab (anti-PD-L1) alone or combined with bevacizumab (anti-VEGF) versus sunitinib in 305 patients with treatment-naive metastatic renal cell carcinoma. Co-primary endpoints were progression-free survival (PFS) in intent-to-treat and PD-L1+ pop...
journal_title:Nature medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/s41591-018-0053-3
更新日期:2018-06-01 00:00:00
abstract::Oral administration of protein can induce antigen-specific immune hyporesponsiveness. However, the utility of oral tolerance to autoantigens in the treatment of autoimmune diseases may be limited when candidate autoantigens cannot be produced by conventional systems in quantities sufficient for clinical studies. Plant...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0797-793
更新日期:1997-07-01 00:00:00
abstract::Angiogenic tumor vessels are promising targets for the activity and the selective delivery of cancer therapeutics. The bone marrow contributes different cell types to the tumor stroma, including hematopoietic cells and, as recently suggested, vascular endothelial cells (ECs). Thus, transplantation of genetically modif...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm871
更新日期:2003-06-01 00:00:00
abstract::A new study provides mechanistic insights into how live attenuated simian immunodeficiency virus (SIV) vaccines (LAVs) can protect monkeys from infection with pathogenic SIV. The authors show that replicating LAVs stimulate a protective immune response from a safe haven in the germinal centers of lymph nodes (pages 16...
journal_title:Nature medicine
pub_type: 评论,杂志文章
doi:10.1038/nm.2986
更新日期:2012-11-01 00:00:00
abstract::Sepsis, a leading cause of death worldwide, involves proinflammatory responses and inefficient bacterial clearance. Phagocytic cells play a crucial part in the prevention of sepsis by clearing bacteria through host innate receptors. Here we show that the FcRgamma adaptor, an immunoreceptor tyrosine-based activation mo...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1665
更新日期:2007-11-01 00:00:00
abstract::Here we show that ischemia induces sustained contraction of pericytes on microvessels in the intact mouse brain. Pericytes remain contracted despite successful reopening of the middle cerebral artery after 2 h of ischemia. Pericyte contraction causes capillary constriction and obstructs erythrocyte flow. Suppression o...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.2022
更新日期:2009-09-01 00:00:00
abstract::Infiltration of human cancers by T cells is generally interpreted as a sign of immune recognition, and there is a growing effort to reactivate dysfunctional T cells at such tumor sites1. However, these efforts only have value if the intratumoral T cell receptor (TCR) repertoire of such cells is intrinsically tumor rea...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0266-5
更新日期:2019-01-01 00:00:00
abstract::Migration inhibitory factor (MIF) is known to exert significant pro-inflammatory effects and has the potential to override the anti-inflammatory action of glucocorticoids. In this study we have identified significant quantities of MIF in the alveolar airspaces of patients with acute respiratory distress syndrome (ARDS...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0397-320
更新日期:1997-03-01 00:00:00
abstract::Parkinson's disease symptoms can be improved by transplanting fetal dopamine cells into the putamen of parkinsonian patients. Because the supply of human donor tissue is limited and variable, an alternative and genetically modifiable non-human source of tissue would be valuable. We have generated cloned transgenic bov...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0598-569
更新日期:1998-05-01 00:00:00
abstract::Cystic fibrosis (CF) is caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR). A single recessive mutation, the deletion of phenylalanine 508 (deltaF508), causes severe CF and resides on 70% of mutant chromosomes. Severe CF is also caused by premature stop mutations, which are foun...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0496-467
更新日期:1996-04-01 00:00:00
abstract::T-cell acute lymphoblastic leukemia (T-ALL), unlike other ALL types, is only infrequently associated with chromosomal aberrations, but it was recently shown that most individuals with T-ALL carry activating mutations in the NOTCH1 gene. However, the signaling pathways and target genes responsible for Notch1-induced ne...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1524
更新日期:2007-01-01 00:00:00
abstract::Obesity and metabolic syndrome are increasingly recognized as major risk factors for cardiovascular disease. Herein we show that Krüppel-like transcription factor 5 (KLF5) is a crucial regulator of energy metabolism. Klf5(+/-) mice were resistant to high fat-induced obesity, hypercholesterolemia and glucose intoleranc...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1756
更新日期:2008-06-01 00:00:00
abstract::Natalizumab (NZM), a humanized monoclonal IgG4 antibody to α4 integrins, is used to treat patients with relapsing-remitting multiple sclerosis (MS)1,2, but in about 6% of the cases persistent neutralizing anti-drug antibodies (ADAs) are induced leading to therapy discontinuation3,4. To understand the basis of the ADA ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0568-2
更新日期:2019-09-01 00:00:00
abstract::The notoriously drug-resistant bug MRSA has made headlines for years, but a whole other class of bacteria may prove even more troublesome. These microbes, Gram-negative bacteria, are increasingly a threat--and yet not a single late-stage drug in development specifically targets them. Christian Torres follows one man's...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0610-628
更新日期:2010-06-01 00:00:00
abstract::The skin-associated chemokine CCL27 (also called CTACK, ALP and ESkine) and its receptor CCR10 (GPR-2) mediate chemotactic responses of skin-homing T cells in vitro. Here we report that most skin-infiltrating lymphocytes in patients suffering from psoriasis, atopic or allergic-contact dermatitis express CCR10. Epiderm...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0202-157
更新日期:2002-02-01 00:00:00
abstract::Reactive oxygen species (ROS) induce chemokines responsible for the recruitment of inflammatory cells to sites of injury or infection. Here we show that the plasma membrane Ca(2+)-permeable channel TRPM2 controls ROS-induced chemokine production in monocytes. In human U937 monocytes, hydrogen peroxide (H(2)O(2)) evoke...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1758
更新日期:2008-07-01 00:00:00
abstract::It is estimated that 350 million individuals worldwide suffer from rare diseases, which are predominantly caused by mutation in a single gene1. The current molecular diagnostic rate is estimated at 50%, with whole-exome sequencing (WES) among the most successful approaches2-5. For patients in whom WES is uninformative...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0457-8
更新日期:2019-06-01 00:00:00
abstract::Members of the suppressor of cytokine signaling (SOCS) family are involved in the pathogenesis of many inflammatory diseases. SOCS-3 is predominantly expressed in T-helper type 2 (T(H)2) cells, but its role in T(H)2-related allergic diseases remains to be investigated. In this study we provide a strong correlation bet...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm896
更新日期:2003-08-01 00:00:00
abstract::Unlike normal melanocytes, primary and metastatic human melanomas express high levels of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) messenger RNA, and expression of these genes is essential in sustaining the proliferation of malignant melanomas in vitro. To determine whether...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0897-887
更新日期:1997-08-01 00:00:00
abstract::It has long been assumed that p53 suppresses tumor development through induction of apoptosis, possibly with contributions by cell cycle arrest and cell senescence1,2. However, combined deficiency in these three processes does not result in spontaneous tumor formation as observed upon loss of p53, suggesting the exist...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0043-5
更新日期:2018-07-01 00:00:00
abstract::Mesenchymal tumor subpopulations secrete pro-tumorigenic cytokines and promote treatment resistance1-4. This phenomenon has been implicated in chemorefractory small cell lung cancer and resistance to targeted therapies5-8, but remains incompletely defined. Here, we identify a subclass of endogenous retroviruses (ERVs)...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0116-5
更新日期:2018-08-01 00:00:00
abstract::The incidence of chronic pain is estimated to be 20-25% worldwide. Few patients with chronic pain obtain complete relief from the drugs that are currently available, and more than half report inadequate relief. Underlying the challenge of developing better drugs to manage chronic pain is incomplete understanding of th...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.2235
更新日期:2010-11-01 00:00:00
abstract::The C2 domain of synaptotagmin I, which binds to anionic phospholipids in cell membranes, was shown to bind to the plasma membrane of apoptotic cells by both flow cytometry and confocal microscopy. Conjugation of the protein to superparamagnetic iron oxide nanoparticles allowed detection of this binding using magnetic...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1101-1241
更新日期:2001-11-01 00:00:00
abstract::The ongoing substance misuse epidemic in the United States is complex and dynamic and should be approached as such in the development and evaluation of policy1. Drug overdose deaths (largely attributable to opioid misuse) in the United States have grown exponentially for almost four decades, but the mechanisms of this...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-0855-y
更新日期:2020-05-01 00:00:00
abstract::Preservation of the chemical architecture of a cell or of an organism under changing and perhaps stressful conditions is termed homeostasis. An integral feature of homeostasis is the rapid expression of genes whose products are specifically dedicated to protect cellular functions against stress. One of the best known ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1097-1150
更新日期:1997-10-01 00:00:00