当前位置： SCI文献检索 > NATURE MEDICINE期刊下所有文献 > Wearable sensor data and self-reported symptoms for COVID-19 detection.

Wearable sensor data and self-reported symptoms for COVID-19 detection.

Abstract：

:Traditional screening for COVID-19 typically includes survey questions about symptoms and travel history, as well as temperature measurements. Here, we explore whether personal sensor data collected over time may help identify subtle changes indicating an infection, such as in patients with COVID-19. We have developed a smartphone app that collects smartwatch and activity tracker data, as well as self-reported symptoms and diagnostic testing results, from individuals in the United States, and have assessed whether symptom and sensor data can differentiate COVID-19 positive versus negative cases in symptomatic individuals. We enrolled 30,529 participants between 25 March and 7 June 2020, of whom 3,811 reported symptoms. Of these symptomatic individuals, 54 reported testing positive and 279 negative for COVID-19. We found that a combination of symptom and sensor data resulted in an area under the curve (AUC) of 0.80 (interquartile range (IQR): 0.73-0.86) for discriminating between symptomatic individuals who were positive or negative for COVID-19, a performance that is significantly better (P < 0.01) than a model1 that considers symptoms alone (AUC = 0.71; IQR: 0.63-0.79). Such continuous, passively captured data may be complementary to virus testing, which is generally a one-off or infrequent sampling assay.

journal_name

Nat Med

journal_title

Nature medicine

authors

Quer G,Radin JM,Gadaleta M,Baca-Motes K,Ariniello L,Ramos E,Kheterpal V,Topol EJ,Steinhubl SR

doi

10.1038/s41591-020-1123-x

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

73-77

issue

1

eissn

1078-8956

issn

1546-170X

pii

10.1038/s41591-020-1123-x

journal_volume

27

pub_type

杂志文章

相关文献

NATURE MEDICINE文献大全
  • Polygenic architecture informs potential vulnerability to drug-induced liver injury.

    abstract：:Drug-induced liver injury (DILI) is a leading cause of termination in drug development programs and removal of drugs from the market; this is partially due to the inability to identify patients who are at risk1. In this study, we developed a polygenic risk score (PRS) for DILI by aggregating effects of numerous genome...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/s41591-020-1023-0

    authors： Koido M,Kawakami E,Fukumura J,Noguchi Y,Ohori M,Nio Y,Nicoletti P,Aithal GP,Daly AK,Watkins PB,Anayama H,Dragan Y,Shinozawa T,Takebe T

    更新日期：2020-10-01 00:00:00

  • Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus.

    abstract：:The HIV-1-specific cytotoxic T lymphocyte (CTL) response is temporally associated with the decline in viremia during primary HIV-1 infection, but definitive evidence that it is of importance in virus containment has been lacking. Here we show that in a patient whose early CTL response was focused on a highly immunodom...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0297-205

    authors： Borrow P,Lewicki H,Wei X,Horwitz MS,Peffer N,Meyers H,Nelson JA,Gairin JE,Hahn BH,Oldstone MB,Shaw GM

    更新日期：1997-02-01 00:00:00

  • Antibacterial resistance worldwide: causes, challenges and responses.

    abstract：:The optimism of the early period of antimicrobial discovery has been tempered by the emergence of bacterial strains with resistance to these therapeutics. Today, clinically important bacteria are characterized not only by single drug resistance but also by multiple antibiotic resistance--the legacy of past decades of ...

    journal_title：Nature medicine

    pub_type： 杂志文章,评审

    doi：10.1038/nm1145

    authors： Levy SB,Marshall B

    更新日期：2004-12-01 00:00:00

  • Chip-NMR biosensor for detection and molecular analysis of cells.

    abstract：:Rapid and accurate measurement of biomarkers in tissue and fluid samples is a major challenge in medicine. Here we report the development of a new, miniaturized diagnostic magnetic resonance (DMR) system for multiplexed, quantitative and rapid analysis. By using magnetic particles as a proximity sensor to amplify mole...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.1711

    authors： Lee H,Sun E,Ham D,Weissleder R

    更新日期：2008-08-01 00:00:00

  • Inhibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivo.

    abstract：:Proliferation of smooth muscle cells of the arterial wall in response to local injury is an important aetiologic factor of vascular proliferative disorders such as atherosclerosis and restenosis after angioplasty. Ras proteins are key transducers of mitogenic signals from membrane to nucleus in many cell types. We inv...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0695-541

    authors： Indolfi C,Avvedimento EV,Rapacciuolo A,Di Lorenzo E,Esposito G,Stabile E,Feliciello A,Mele E,Giuliano P,Condorelli G

    更新日期：1995-06-01 00:00:00

  • Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays.

    abstract：:Naturally occurring mutations in HIV-1-infected patients have important implications for therapy and the outcome of clinical studies. However, little is known about the prevalence of mutations that confer resistance to HIV-1 protease inhibitors in isolates derived from patients naive for such inhibitors. In the first ...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0796-753

    authors： Kozal MJ,Shah N,Shen N,Yang R,Fucini R,Merigan TC,Richman DD,Morris D,Hubbell E,Chee M,Gingeras TR

    更新日期：1996-07-01 00:00:00

  • Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury.

    abstract：:Traumatic spinal cord injury often results in complete loss of voluntary motor and sensory function below the site of injury. The long-term neurological deficits after spinal cord trauma may be due in part to widespread apoptosis of neurons and oligodendroglia in regions distant from and relatively unaffected by the i...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/11387

    authors： Springer JE,Azbill RD,Knapp PE

    更新日期：1999-08-01 00:00:00

  • In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency.

    abstract：:Although it is presumed that the integration of HIV-1 into the genome of infected CD4+ T lymphocytes allows viral persistence, there has been little direct evidence that CD4+ T cells with integrated provirus function as a latent reservoir for HIV-1 in infected individuals. Using resting CD4+ T-cell populations of extr...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1295-1284

    authors： Chun TW,Finzi D,Margolick J,Chadwick K,Schwartz D,Siliciano RF

    更新日期：1995-12-01 00:00:00

  • Vaccines: past, present and future.

    abstract：:The vaccines developed over the first two hundred years since Jenner's lifetime have accomplished striking reductions of infection and disease wherever applied. Pasteur's early approaches to vaccine development, attenuation and inactivation, are even now the two poles of vaccine technology. Today, purification of micr...

    journal_title：Nature medicine

    pub_type： 历史文章,杂志文章

    doi：10.1038/nm1209

    authors： Plotkin SA

    更新日期：2005-04-01 00:00:00

  • Bovine beta-lactoglobulin modified by 3-hydroxyphthalic anhydride blocks the CD4 cell receptor for HIV.

    abstract：:Sexual transmission is the most frequent (86%) route of adult HIV-1 transmission worldwide. In the absence of a prophylactic anti-HIV vaccine, other methods of preventing infection should be implemented. Virucidal spermicides have been considered for this purpose, but their application is contraindicated by adverse ef...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0296-230

    authors： Neurath AR,Jiang S,Strick N,Lin K,Li YY,Debnath AK

    更新日期：1996-02-01 00:00:00

  • Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.

    abstract：:Because of their abundance, resistance to proteolysis, rapid aggregation and neurotoxicity, N-terminally truncated and, in particular, pyroglutamate (pE)-modified Abeta peptides have been suggested as being important in the initiation of pathological cascades resulting in the development of Alzheimer's disease. We fou...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.1872

    authors： Schilling S,Zeitschel U,Hoffmann T,Heiser U,Francke M,Kehlen A,Holzer M,Hutter-Paier B,Prokesch M,Windisch M,Jagla W,Schlenzig D,Lindner C,Rudolph T,Reuter G,Cynis H,Montag D,Demuth HU,Rossner S

    更新日期：2008-10-01 00:00:00

  • Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer.

    abstract：:Expression of the oncogenic transcription factor MYC is disproportionately elevated in triple-negative breast cancer (TNBC), as compared to estrogen receptor-, progesterone receptor- or human epidermal growth factor 2 receptor-positive (RP) breast cancer. We and others have shown that MYC alters metabolism during tumo...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.4055

    authors： Camarda R,Zhou AY,Kohnz RA,Balakrishnan S,Mahieu C,Anderton B,Eyob H,Kajimura S,Tward A,Krings G,Nomura DK,Goga A

    更新日期：2016-04-01 00:00:00

  • Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1.

    abstract：:Focal segmental glomerulosclerosis (FSGS) is a frequent and severe glomerular disease characterized by destabilization of podocyte foot processes. We report that transgenic expression of the microRNA miR-193a in mice rapidly induces FSGS with extensive podocyte foot process effacement. Mechanistically, miR-193a inhibi...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.3142

    authors： Gebeshuber CA,Kornauth C,Dong L,Sierig R,Seibler J,Reiss M,Tauber S,Bilban M,Wang S,Kain R,Böhmig GA,Moeller MJ,Gröne HJ,Englert C,Martinez J,Kerjaschki D

    更新日期：2013-04-01 00:00:00

  • Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy.

    abstract：:Despite the central role of the liver in the regulation of glucose and lipid metabolism, there are currently no methods to directly assess hepatic oxidative metabolism in humans in vivo. By using a new (13)C-labeling strategy in combination with (13)C magnetic resonance spectroscopy, we show that rates of mitochondria...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.3415

    authors： Befroy DE,Perry RJ,Jain N,Dufour S,Cline GW,Trimmer JK,Brosnan J,Rothman DL,Petersen KF,Shulman GI

    更新日期：2014-01-01 00:00:00

  • Anti-cancer activity of targeted pro-apoptotic peptides.

    abstract：:We have designed short peptides composed of two functional domains, one a tumor blood vessel 'homing' motif and the other a programmed cell death-inducing sequence, and synthesized them by simple peptide chemistry. The 'homing' domain was designed to guide the peptide to targeted cells and allow its internalization. T...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/12469

    authors： Ellerby HM,Arap W,Ellerby LM,Kain R,Andrusiak R,Rio GD,Krajewski S,Lombardo CR,Rao R,Ruoslahti E,Bredesen DE,Pasqualini R

    更新日期：1999-09-01 00:00:00

  • Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice.

    abstract：:Pten is an important phosphatase, suppressing the phosphatidylinositol-3 kinase/Akt pathway. Here, we generated adipose-specific Pten-deficient (AdipoPten-KO) mice, using newly generated Acdc promoter-driven Cre transgenic mice. AdipoPten-KO mice showed lower body and adipose tissue weights despite hyperphagia and enh...

    journal_title：Nature medicine

    pub_type： 杂志文章,收录出版

    doi：10.1038/nm1117

    authors： Komazawa N,Matsuda M,Kondoh G,Mizunoya W,Iwaki M,Takagi T,Sumikawa Y,Inoue K,Suzuki A,Mak TW,Nakano T,Fushiki T,Takeda J,Shimomura I

    更新日期：2004-11-01 00:00:00

  • PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide.

    abstract：:Platelet-activating factor (PAF) induces pulmonary edema and has a key role in acute lung injury (ALI). Here we show that PAF induces pulmonary edema through two mechanisms: acid sphingomyelinase (ASM)-dependent production of ceramide, and activation of the cyclooxygenase pathway. Agents that interfere with PAF-induce...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm977

    authors： Göggel R,Winoto-Morbach S,Vielhaber G,Imai Y,Lindner K,Brade L,Brade H,Ehlers S,Slutsky AS,Schütze S,Gulbins E,Uhlig S

    更新日期：2004-02-01 00:00:00

  • Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy.

    abstract：:The microbiome of the female reproductive tract has implications for women's reproductive health. We examined the vaginal microbiome in two cohorts of women who experienced normal term births: a cross-sectionally sampled cohort of 613 pregnant and 1,969 non-pregnant women, focusing on 300 pregnant and 300 non-pregnant...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/s41591-019-0465-8

    authors： Serrano MG,Parikh HI,Brooks JP,Edwards DJ,Arodz TJ,Edupuganti L,Huang B,Girerd PH,Bokhari YA,Bradley SP,Brooks JL,Dickinson MR,Drake JI,Duckworth RA 3rd,Fong SS,Glascock AL,Jean S,Jimenez NR,Khoury J,Koparde VN,La

    更新日期：2019-06-01 00:00:00

  • Non-invasive in vivo monitoring of trackable viruses expressing soluble marker peptides.

    abstract：:Noninvasive methods are needed to study the kinetic properties of viruses in living organisms. Oncolytic viruses are used increasingly for cancer therapy but there is currently no satisfactory way to measure efficiency of tumor transduction, changing levels of viral gene expression or the timing of virus elimination. ...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0502-527

    authors： Peng KW,Facteau S,Wegman T,O'Kane D,Russell SJ

    更新日期：2002-05-01 00:00:00

  • Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins.

    abstract：:Increased production of very low-density lipoprotein (VLDL) is a critical feature of the metabolic syndrome. Here we report that a selective increase in brain glucose lowered circulating triglycerides (TG) through the inhibition of TG-VLDL secretion by the liver. We found that the effect of glucose required its conver...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1540

    authors： Lam TK,Gutierrez-Juarez R,Pocai A,Bhanot S,Tso P,Schwartz GJ,Rossetti L

    更新日期：2007-02-01 00:00:00

  • Patient-derived induced pluripotent stem cells in cancer research and precision oncology.

    abstract：:Together with recent advances in the processing and culture of human tissue, bioengineering, xenotransplantation and genome editing, Induced pluripotent stem cells (iPSCs) present a range of new opportunities for the study of human cancer. Here we discuss the main advantages and limitations of iPSC modeling, and how t...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.4238

    authors： Papapetrou EP

    更新日期：2016-12-06 00:00:00

  • Quantification of antibody responses against multiple antigens of the two infectious forms of Vaccinia virus provides a benchmark for smallpox vaccination.

    abstract：:Smallpox was eradicated without an adequate understanding of how vaccination induced protection. In response to possible bioterrorism with smallpox, the UK government vaccinated approximately 300 health care workers with vaccinia virus (VACV) strain Lister. Antibody responses were analyzed using ELISA for multiple sur...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1457

    authors： Pütz MM,Midgley CM,Law M,Smith GL

    更新日期：2006-11-01 00:00:00

  • Publisher Correction: Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature medicine

    pub_type： 已发布勘误

    doi：10.1038/s41591-019-0562-8

    authors： Qi X,Yun C,Sun L,Xia J,Wu Q,Wang Y,Wang L,Zhang Y,Liang X,Wang L,Gonzalez FJ,Patterson AD,Liu H,Mu L,Zhou Z,Zhao Y,Li R,Liu P,Zhong C,Pang Y,Jiang C,Qiao J

    更新日期：2019-09-01 00:00:00

  • Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring.

    abstract：:In many areas of oncology, we lack sensitive tools to track low-burden disease. Although cell-free DNA (cfDNA) shows promise in detecting cancer mutations, we found that the combination of low tumor fraction (TF) and limited number of DNA fragments restricts low-disease-burden monitoring through the prevailing deep ta...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/s41591-020-0915-3

    authors： Zviran A,Schulman RC,Shah M,Hill STK,Deochand S,Khamnei CC,Maloney D,Patel K,Liao W,Widman AJ,Wong P,Callahan MK,Ha G,Reed S,Rotem D,Frederick D,Sharova T,Miao B,Kim T,Gydush G,Rhoades J,Huang KY,Omans ND,Bo

    更新日期：2020-07-01 00:00:00

  • Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.

    abstract：:Human liver cancer research currently lacks in vitro models that can faithfully recapitulate the pathophysiology of the original tumor. We recently described a novel, near-physiological organoid culture system, wherein primary human healthy liver cells form long-term expanding organoids that retain liver tissue functi...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.4438

    authors： Broutier L,Mastrogiovanni G,Verstegen MM,Francies HE,Gavarró LM,Bradshaw CR,Allen GE,Arnes-Benito R,Sidorova O,Gaspersz MP,Georgakopoulos N,Koo BK,Dietmann S,Davies SE,Praseedom RK,Lieshout R,IJzermans JNM,Wigmore SJ,

    更新日期：2017-12-01 00:00:00

  • Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis.

    abstract：:Accumulation of fibrils composed of amyloid A in tissues resulting in displacement of normal structures and cellular dysfunction is the characteristic feature of systemic amyloidoses. Here we show that RAGE, a multiligand immunoglobulin superfamily cell surface molecule, is a receptor for the amyloidogenic form of ser...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/76216

    authors： Yan SD,Zhu H,Zhu A,Golabek A,Du H,Roher A,Yu J,Soto C,Schmidt AM,Stern D,Kindy M

    更新日期：2000-06-01 00:00:00

  • Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation.

    abstract：:Surgery or radiation therapy of metastatic cancer often damages lymph nodes, leading to secondary lymphedema. Here we show, using a newly established mouse model, that collecting lymphatic vessels can be regenerated and fused to lymph node transplants after lymph node removal. Treatment of lymph node-excised mice with...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1689

    authors： Tammela T,Saaristo A,Holopainen T,Lyytikkä J,Kotronen A,Pitkonen M,Abo-Ramadan U,Ylä-Herttuala S,Petrova TV,Alitalo K

    更新日期：2007-12-01 00:00:00

  • Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma.

    abstract：:We describe results from IMmotion150, a randomized phase 2 study of atezolizumab (anti-PD-L1) alone or combined with bevacizumab (anti-VEGF) versus sunitinib in 305 patients with treatment-naive metastatic renal cell carcinoma. Co-primary endpoints were progression-free survival (PFS) in intent-to-treat and PD-L1+ pop...

    journal_title：Nature medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1038/s41591-018-0053-3

    authors： McDermott DF,Huseni MA,Atkins MB,Motzer RJ,Rini BI,Escudier B,Fong L,Joseph RW,Pal SK,Reeves JA,Sznol M,Hainsworth J,Rathmell WK,Stadler WM,Hutson T,Gore ME,Ravaud A,Bracarda S,Suárez C,Danielli R,Gruenwald V,Ch

    更新日期：2018-06-01 00:00:00

  • Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation.

    abstract：:Our understanding of Alzheimer's disease (AD) pathophysiology remains incomplete. Here we used quantitative mass spectrometry and coexpression network analysis to conduct the largest proteomic study thus far on AD. A protein network module linked to sugar metabolism emerged as one of the modules most significantly ass...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/s41591-020-0815-6

    authors： Johnson ECB,Dammer EB,Duong DM,Ping L,Zhou M,Yin L,Higginbotham LA,Guajardo A,White B,Troncoso JC,Thambisetty M,Montine TJ,Lee EB,Trojanowski JQ,Beach TG,Reiman EM,Haroutunian V,Wang M,Schadt E,Zhang B,Dickson DW

    更新日期：2020-05-01 00:00:00

  • A novel chimeric antigen receptor containing a JAK-STAT signaling domain mediates superior antitumor effects.

    abstract：:The adoptive transfer of T cells engineered with a chimeric antigen receptor (CAR) (hereafter referred to as CAR-T cells) specific for the B lymphocyte antigen CD19 has shown impressive clinical responses in patients with refractory B cell malignancies. However, the therapeutic effects of CAR-T cells that target other...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.4478

    authors： Kagoya Y,Tanaka S,Guo T,Anczurowski M,Wang CH,Saso K,Butler MO,Minden MD,Hirano N

    更新日期：2018-03-01 00:00:00