Abstract：
:Epstein-Barr virus is ubiquitous and is causally implicated in lymphoid and epithelial malignancies. Virus invades oropharyngeal mucosa and establishes latency in B lymphocytes. Reactivating lymphocytes shed virus into saliva for spread to new hosts. A complex of three virus glycoproteins, gH, gL and gp42, is essential for entry. B-cell entry requires binding of gp42 to human leukocyte antigen (HLA) class II whereas entry into epithelial cells lacking HLA class II requires complexes without gp42. To accommodate infection of each, the virus carries both three-part and two-part complexes. We show here that HLA class II in the virus-producing cell alters the ratio of three-part to two-part complexes. As a consequence, virus originating in epithelial cells efficiently infects B cells whereas B-cell derived virus better infects epithelial cells. This molecular switch is a novel strategy that could alter tropism of virus from epithelium to B cells and then back to epithelium in a new host.
journal_name
Nat Medjournal_title
Nature medicineauthors
Borza CM,Hutt-Fletcher LMdoi
10.1038/nm0602-594keywords:
subject
Has Abstractpub_date
2002-06-01 00:00:00pages
594-9issue
6eissn
1078-8956issn
1546-170Xpii
nm0602-594journal_volume
8pub_type
杂志文章相关文献
NATURE MEDICINE文献大全abstract：:Natural inhibitors of angiogenesis are able to block pathological neovascularization without harming the preexisting vasculature. Here we show that two such inhibitors, thrombospondin-1 and pigment epithelium-derived factor, derive specificity for remodeling vessels from their dependence on Fas/Fas ligand (FasL)-media...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm0402-349
更新日期：2002-04-01 00:00:00
abstract：:Although Nogo-A has been identified in the central nervous system as an inhibitor of axonal regeneration, the peripheral roles of Nogo isoforms remain virtually unknown. Here, using a proteomic analysis to identify proteins enriched in caveolae and/or lipid rafts (CEM/LR), we show that Nogo-B is highly expressed in cu...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm1020
更新日期：2004-04-01 00:00:00
abstract：:The identification of the genes associated with chromosomal translocation breakpoints has fundamentally changed understanding of the molecular basis of hematological malignancies. By contrast, the study of chromosomal deletions has been hampered by the large number of genes deleted and the complexity of their analysis...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.2063
更新日期：2010-01-01 00:00:00
abstract：:Spinal sensorimotor networks that are functionally disconnected from the brain because of spinal cord injury (SCI) can be facilitated via epidural electrical stimulation (EES) to restore robust, coordinated motor activity in humans with paralysis1-3. Previously, we reported a clinical case of complete sensorimotor par...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/s41591-018-0175-7
更新日期：2018-11-01 00:00:00
abstract：:Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutrition...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.4280
更新日期：2017-03-01 00:00:00
abstract：:Neurovascular dysfunction substantially contributes to Alzheimer disease. Here, we show that transcriptional profiling of human brain endothelial cells (BECs) defines a subset of genes whose expression is age-independent but is considerably altered in Alzheimer disease, including the homeobox gene MEOX2 (also known as...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm1287
更新日期：2005-09-01 00:00:00
abstract：:Despite years of fully suppressive antiretroviral therapy (ART), HIV persists in its hosts and is never eradicated. One major barrier to eradication is that the virus infects multiple cell types that may individually contribute to HIV persistence. Tissue macrophages are critical contributors to HIV pathogenesis; howev...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.4319
更新日期：2017-05-01 00:00:00
abstract：:The pathogenic bacterium Neisseria meningitidis is an important cause of septicemia and meningitis, especially in childhood. The establishment and maintenance of bacteremic infection is a pre-requisite for all the pathological sequelae of meningococcal infection. To further understand the genetic basis of this essenti...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/81380
更新日期：2000-11-01 00:00:00
abstract：:In most cases of sporadic colorectal cancers, tumorigenesis is a multistep process, involving genomic alterations in parallel with morphologic changes. In addition, accumulating evidence suggests that the human gut microbiome is linked to the development of colorectal cancer. Here we performed fecal metagenomic and me...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/s41591-019-0458-7
更新日期：2019-06-01 00:00:00
abstract：:There has been a rise in the prevalence of nonalcoholic fatty liver disease (NAFLD), paralleling a worldwide increase in diabetes and metabolic syndrome. NAFLD, a continuum of liver abnormalities from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), has a variable course but can lead to cirrhosi...
journal_title：Nature medicine
pub_type： 杂志文章,评审
doi：10.1038/s41591-018-0104-9
更新日期：2018-07-01 00:00:00
abstract：:In the version of this article originally published, Dimitry G. Sayenko's affiliations were not correct. The following affiliation for this author was missing: Department of Neurosurgery, Center for Neuroregeneration, Houston Methodist Research Institute, Houston, TX, USA. This affiliation has been added for the autho...
journal_title：Nature medicine
pub_type： 已发布勘误
doi：10.1038/s41591-018-0248-7
更新日期：2018-12-01 00:00:00
abstract：:How well antibodies can protect against disease due to HIV-1 infection remains a pivotal but unresolved issue with important implications for vaccine design and the use of prophylactic antibody to prevent infection after accidental exposure to the virus and to interrupt transmission of virus from mother to child. Stro...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm1297-1389
更新日期：1997-12-01 00:00:00
abstract：:Intraoperative diagnosis is essential for providing safe and effective care during cancer surgery1. The existing workflow for intraoperative diagnosis based on hematoxylin and eosin staining of processed tissue is time, resource and labor intensive2,3. Moreover, interpretation of intraoperative histologic images is de...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/s41591-019-0715-9
更新日期：2020-01-01 00:00:00
abstract：:Massive release of tumor necrosis factor is responsible for the potentially fatal larisch-Herxheimer reaction that follows antibiotic treatment of relapsing fever due to Borrelia recurrentis. We have undertaken the quantitative purification of the components of B. recurrentis that stimulate human monocytes to produce ...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/4007
更新日期：1998-12-01 00:00:00
abstract：:Hepatic insulin resistance is a driving force in the pathogenesis of type 2 diabetes mellitus (T2DM) and is tightly coupled with excessive storage of fat and the ensuing inflammation within the liver. There is compelling evidence that activation of the transcription factor nuclear factor-κB (NF-κB) and downstream infl...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.3084
更新日期：2013-03-01 00:00:00
abstract：:Alternative splicing ensures the expression of functionally diverse proteins from individual genes; however, aberrant mRNA splicing is associated with various conditions, including heart disease. A recent study provides new mechanistic insights into heart failure by showing that a human cardiomyopathy-linked mutation ...
journal_title：Nature medicine
pub_type： 评论,杂志文章
doi：10.1038/nm.2762
更新日期：2012-05-04 00:00:00
abstract：:Breast cancers are either primarily resistant to chemotherapy (intrinsic resistance), or respond to chemotherapy but later recur with a multidrug-resistant phenotype because of overexpression of the multidrug transporter P-glycoprotein. The MDR1 gene encoding P-glycoprotein may be transcriptionally regulated by a Y-bo...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm0497-447
更新日期：1997-04-01 00:00:00
abstract：:Huntington's disease is caused by an expanded polyglutamine repeat in the huntingtin protein (HTT), but the pathophysiological sequence of events that trigger synaptic failure and neuronal loss are not fully understood. Alterations in N-methyl-D-aspartate (NMDA)-type glutamate receptors (NMDARs) have been implicated. ...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.3246
更新日期：2013-08-01 00:00:00
abstract：:The neural tube defects (NTDs) spina bifida and anencephaly are widely prevalent severe birth defects. The mouse mutant curly tail (ct/ct) has served as a model of NTDs for 50 years, even though the responsible genetic defect remained unrecognized. Here we show by gene targeting, mapping and genetic complementation st...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm961
更新日期：2003-12-01 00:00:00
abstract：:The optimism of the early period of antimicrobial discovery has been tempered by the emergence of bacterial strains with resistance to these therapeutics. Today, clinically important bacteria are characterized not only by single drug resistance but also by multiple antibiotic resistance--the legacy of past decades of ...
journal_title：Nature medicine
pub_type： 杂志文章,评审
doi：10.1038/nm1145
更新日期：2004-12-01 00:00:00
abstract：:Disruption of systemic homeostasis by either chronic or acute stressors, such as obesity1 or surgery2, alters cancer pathogenesis. Patients with cancer, particularly those with breast cancer, can be at increased risk of cardiovascular disease due to treatment toxicity and changes in lifestyle behaviors3-5. While eleva...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/s41591-020-0964-7
更新日期：2020-09-01 00:00:00
abstract：:In many areas of oncology, we lack sensitive tools to track low-burden disease. Although cell-free DNA (cfDNA) shows promise in detecting cancer mutations, we found that the combination of low tumor fraction (TF) and limited number of DNA fragments restricts low-disease-burden monitoring through the prevailing deep ta...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/s41591-020-0915-3
更新日期：2020-07-01 00:00:00
abstract：:The adoptive transfer of T cells engineered with a chimeric antigen receptor (CAR) (hereafter referred to as CAR-T cells) specific for the B lymphocyte antigen CD19 has shown impressive clinical responses in patients with refractory B cell malignancies. However, the therapeutic effects of CAR-T cells that target other...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.4478
更新日期：2018-03-01 00:00:00
abstract：:After transplantation of primarily vascularized xenografts (Xgs), T-independent mechanisms may lead to Xg rejection before T-cell activation even takes place. The possibility of achieving T-independent xenotolerance was evaluated in nude rats that normally reject hamster cardiac Xgs within 4 days by non-T cell-mediate...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm0298-173
更新日期：1998-02-01 00:00:00
abstract：:Angiogenesis, the formation of new blood vessels, is a requirement for malignant tumor growth and metastasis. In the absence of angiogenesis, local tumor expansion is suppressed at a few millimeters and cells lack routes for distant hematogenous spread. Clinical studies have demonstrated that the degree of angiogenesi...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm0598-623
更新日期：1998-05-01 00:00:00
abstract：:Delayed T cell recovery and restricted T cell receptor (TCR) diversity after allogeneic hematopoietic stem cell transplantation (allo-HSCT) are associated with increased risks of infection and cancer relapse. Technical challenges have limited faithful measurement of TCR diversity after allo-HSCT. Here we combined 5' r...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.3100
更新日期：2013-03-01 00:00:00
abstract：:How should clinical trials be improved? Ken Getz, a senior fellow at the Tufts Center for the Study of Drug Development, has been thinking up answers to this question for two decades. In 2003, Getz took on a new challenge when he launched the Center for Information & Study on Clinical Research, a nonprofit focused on ...
journal_title：Nature medicine
pub_type： 面试
doi：10.1038/nm0210-154
更新日期：2010-02-01 00:00:00
abstract：:Idiopathic voiding disorders affect up to 10-15% of men and women. We describe bladder abnormalities in mice with targeted deletion of the gene for neuronal nitric oxide synthase which model the clinical disorders. The mice possess hypertrophic dilated bladders and dysfunctional urinary outlets which do not relax in r...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm0597-571
更新日期：1997-05-01 00:00:00
abstract：:The Zero Childhood Cancer Program is a precision medicine program to benefit children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline whole genome sequencing (WGS) and RNA sequencing (RNAseq) across 252 tumors from high-risk pediatric patients with cancer, we identified 968 reportable ...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/s41591-020-1072-4
更新日期：2020-11-01 00:00:00
abstract：:Because of their abundance, resistance to proteolysis, rapid aggregation and neurotoxicity, N-terminally truncated and, in particular, pyroglutamate (pE)-modified Abeta peptides have been suggested as being important in the initiation of pathological cascades resulting in the development of Alzheimer's disease. We fou...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.1872
更新日期：2008-10-01 00:00:00
