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HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy.

Abstract：

:Despite years of fully suppressive antiretroviral therapy (ART), HIV persists in its hosts and is never eradicated. One major barrier to eradication is that the virus infects multiple cell types that may individually contribute to HIV persistence. Tissue macrophages are critical contributors to HIV pathogenesis; however, their specific role in HIV persistence during long-term suppressive ART has not been established. Using humanized myeloid-only mice (MoM), we demonstrate that HIV infection of tissue macrophages is rapidly suppressed by ART, as reflected by a rapid drop in plasma viral load and a dramatic decrease in the levels of cell-associated viral RNA and DNA. No viral rebound was observed in the plasma of 67% of the ART-treated animals at 7 weeks after ART interruption, and no replication-competent virus was rescued from the tissue macrophages obtained from these animals. In contrast, in a subset of animals (∼33%), a delayed viral rebound was observed that is consistent with the establishment of persistent infection in tissue macrophages. These observations represent the first direct evidence, to our knowledge, of HIV persistence in tissue macrophages in vivo.

journal_name

Nat Med

journal_title

Nature medicine

authors

Honeycutt JB,Thayer WO,Baker CE,Ribeiro RM,Lada SM,Cao Y,Cleary RA,Hudgens MG,Richman DD,Garcia JV

doi

10.1038/nm.4319

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

638-643

issue

5

eissn

1078-8956

issn

1546-170X

pii

nm.4319

journal_volume

23

pub_type

杂志文章

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