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Nociceptor sensitization in pain pathogenesis.

Abstract：

:The incidence of chronic pain is estimated to be 20-25% worldwide. Few patients with chronic pain obtain complete relief from the drugs that are currently available, and more than half report inadequate relief. Underlying the challenge of developing better drugs to manage chronic pain is incomplete understanding of the heterogeneity of mechanisms that contribute to the transition from acute tissue insult to chronic pain and to pain conditions for which the underlying pathology is not apparent. An intact central nervous system (CNS) is required for the conscious perception of pain, and changes in the CNS are clearly evident in chronic pain states. However, the blockage of nociceptive input into the CNS can effectively relieve or markedly attenuate discomfort and pain, revealing the importance of ongoing peripheral input to the maintenance of chronic pain. Accordingly, we focus here on nociceptors: their excitability, their heterogeneity and their role in initiating and maintaining pain.

journal_name

Nat Med

journal_title

Nature medicine

authors

Gold MS,Gebhart GF

doi

10.1038/nm.2235

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

1248-57

issue

11

eissn

1078-8956

issn

1546-170X

pii

nm.2235

journal_volume

16

pub_type

杂志文章

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