Author Correction: Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.

abstract：:Some individuals remain uninfected with human immunodeficiency virus type-1 (HIV-1) despite multiple high-risk sexual exposures. We studied a cohort of 25 subjects with histories of multiple high-risk sexual exposures to HIV-1 and found that their CD8+ lymphocytes had greater anti-HIV-1 activity than did CD8+ lymphocy...

journal_title：Nature medicine

authors： Paxton WA,Martin SR,Tse D,O'Brien TR,Skurnick J,VanDevanter NL,Padian N,Braun JF,Kotler DP,Wolinsky SM,Koup RA

更新日期：1996-04-01 00:00:00

abstract：:Hutchinson-Gilford progeria syndrome (HGPS) is a childhood premature aging disease caused by a spontaneous point mutation in lamin A (encoded by LMNA), one of the major architectural elements of the mammalian cell nucleus. The HGPS mutation activates an aberrant cryptic splice site in LMNA pre-mRNA, leading to synthes...

journal_title：Nature medicine

authors： Scaffidi P,Misteli T

更新日期：2005-04-01 00:00:00

abstract：:Physical function declines in old age, portending disability, increased health expenditures, and mortality. Cellular senescence, leading to tissue dysfunction, may contribute to these consequences of aging, but whether senescence can directly drive age-related pathology and be therapeutically targeted is still unclear...

journal_title：Nature medicine

authors： Xu M,Pirtskhalava T,Farr JN,Weigand BM,Palmer AK,Weivoda MM,Inman CL,Ogrodnik MB,Hachfeld CM,Fraser DG,Onken JL,Johnson KO,Verzosa GC,Langhi LGP,Weigl M,Giorgadze N,LeBrasseur NK,Miller JD,Jurk D,Singh RJ,Allison

更新日期：2018-08-01 00:00:00

abstract：:We describe results from IMmotion150, a randomized phase 2 study of atezolizumab (anti-PD-L1) alone or combined with bevacizumab (anti-VEGF) versus sunitinib in 305 patients with treatment-naive metastatic renal cell carcinoma. Co-primary endpoints were progression-free survival (PFS) in intent-to-treat and PD-L1+ pop...

journal_title：Nature medicine

authors： McDermott DF,Huseni MA,Atkins MB,Motzer RJ,Rini BI,Escudier B,Fong L,Joseph RW,Pal SK,Reeves JA,Sznol M,Hainsworth J,Rathmell WK,Stadler WM,Hutson T,Gore ME,Ravaud A,Bracarda S,Suárez C,Danielli R,Gruenwald V,Ch

更新日期：2018-06-01 00:00:00

abstract：:Given the associations between chronic inflammation and epithelial cancer, we studied susceptibility to skin carcinogenesis in mice deficient for the pro-inflammatory cytokine TNF-alpha (refs. 5,6). TNF-alpha(-/-) mice were resistant to development of benign and malignant skin tumors, whether induced by initiation wit...

journal_title：Nature medicine

authors： Moore RJ,Owens DM,Stamp G,Arnott C,Burke F,East N,Holdsworth H,Turner L,Rollins B,Pasparakis M,Kollias G,Balkwill F

更新日期：1999-07-01 00:00:00

abstract：:Cells from the telomerase knockout mouse immortalize with an approximately ten million-fold greater frequency than human cells. In this commentary, Wright and Shay discuss the implications of this difference between mice and men and its relationship to cancer. ...

journal_title：Nature medicine

authors： Wright WE,Shay JW

更新日期：2000-08-01 00:00:00

abstract：:Ethylmalonic encephalopathy is caused by mutations in ETHE1, a mitochondrial matrix sulfur dioxygenase, leading to failure to detoxify sulfide, a product of intestinal anaerobes and, in trace amounts, tissues. Metronidazole, a bactericide, or N-acetylcysteine, a precursor of sulfide-buffering glutathione, substantiall...

journal_title：Nature medicine

authors： Viscomi C,Burlina AB,Dweikat I,Savoiardo M,Lamperti C,Hildebrandt T,Tiranti V,Zeviani M

更新日期：2010-08-01 00:00:00

abstract：:Retinal ischemia can cause vision-threatening pathological neovascularization. The mechanisms of retinal ischemia are not fully understood, however. Here we have shown that leukocytes prune the retinal vasculature during normal development and obliterate it in disease. Beginning at postnatal day 5 (P5) in the normal r...

journal_title：Nature medicine

authors： Ishida S,Yamashiro K,Usui T,Kaji Y,Ogura Y,Hida T,Honda Y,Oguchi Y,Adamis AP

更新日期：2003-06-01 00:00:00

abstract：:Glioblastoma is the most common primary central nervous system malignancy and has a poor prognosis. Standard first-line treatment, which includes surgery followed by adjuvant radio-chemotherapy, produces only modest benefits to survival1,2. Here, to explore the feasibility, safety and immunobiological effects of PD-1 ...

journal_title：Nature medicine

authors： Schalper KA,Rodriguez-Ruiz ME,Diez-Valle R,López-Janeiro A,Porciuncula A,Idoate MA,Inogés S,de Andrea C,López-Diaz de Cerio A,Tejada S,Berraondo P,Villarroel-Espindola F,Choi J,Gúrpide A,Giraldez M,Goicoechea I,Gallego Pe

更新日期：2019-03-01 00:00:00

abstract：:Intraoperative diagnosis is essential for providing safe and effective care during cancer surgery1. The existing workflow for intraoperative diagnosis based on hematoxylin and eosin staining of processed tissue is time, resource and labor intensive2,3. Moreover, interpretation of intraoperative histologic images is de...

journal_title：Nature medicine

authors： Hollon TC,Pandian B,Adapa AR,Urias E,Save AV,Khalsa SSS,Eichberg DG,D'Amico RS,Farooq ZU,Lewis S,Petridis PD,Marie T,Shah AH,Garton HJL,Maher CO,Heth JA,McKean EL,Sullivan SE,Hervey-Jumper SL,Patil PG,Thompson BG

更新日期：2020-01-01 00:00:00

abstract：:Oxidative damage from elevated production of reactive oxygen species (ROS) contributes to ischemia-reperfusion injury in myocardial infarction and stroke. The mechanism by which the increase in ROS occurs is not known, and it is unclear how this increase can be prevented. A wide variety of nitric oxide donors and S-ni...

journal_title：Nature medicine

authors： Chouchani ET,Methner C,Nadtochiy SM,Logan A,Pell VR,Ding S,James AM,Cochemé HM,Reinhold J,Lilley KS,Partridge L,Fearnley IM,Robinson AJ,Hartley RC,Smith RA,Krieg T,Brookes PS,Murphy MP

更新日期：2013-06-01 00:00:00

abstract：:Metastasis of breast cancer occurs primarily through the lymphatic system, and the extent of lymph node involvement is a key prognostic factor for the disease. Whereas the significance of angiogenesis for tumor progression has been well documented, the ability of tumor cells to induce the growth of lymphatic vessels (...

journal_title：Nature medicine

authors： Skobe M,Hawighorst T,Jackson DG,Prevo R,Janes L,Velasco P,Riccardi L,Alitalo K,Claffey K,Detmar M

更新日期：2001-02-01 00:00:00

abstract：:Although prognostic gene expression signatures for survival in early-stage lung cancer have been proposed, for clinical application, it is critical to establish their performance across different subject populations and in different laboratories. Here we report a large, training-testing, multi-site, blinded validation...

journal_title：Nature medicine

authors： Director's Challenge Consortium for the Molecular Classification of Lung Adenocarcinoma.,Shedden K,Taylor JM,Enkemann SA,Tsao MS,Yeatman TJ,Gerald WL,Eschrich S,Jurisica I,Giordano TJ,Misek DE,Chang AC,Zhu CQ,Strumpf D,Hanash

更新日期：2008-08-01 00:00:00

abstract：:The androgen receptor (AR) is involved in the development, growth and progression of prostate cancer (CaP). CaP often progresses from an androgen-dependent to an androgen-independent tumor, making androgen ablation therapy ineffective. However, the mechanisms for the development of androgen-independent CaP are unclear...

journal_title：Nature medicine

authors： Zhao XY,Malloy PJ,Krishnan AV,Swami S,Navone NM,Peehl DM,Feldman D

更新日期：2000-06-01 00:00:00

abstract：:High blood pressure, or hypertension, is a very common disorder with a substantial impact on public health because of its associated complications. Despite the high prevalence of essential hypertension and years of research, the basic causes remain obscure. Here I review recent advances in understanding the pathophysi...

journal_title：Nature medicine

authors： Coffman TM

更新日期：2011-11-07 00:00:00

abstract：:Genetic alterations in malignant tissues are potential targets for gene-based cancer therapies. Alternatively, aberrant expression of certain specific genes associated with malignant transformation may be envisioned to enhance the expression of chemosensitizing drugs. Epstein-Barr virus (EBV)-related B-cell lymphomas ...

journal_title：Nature medicine

authors： Franken M,Estabrooks A,Cavacini L,Sherburne B,Wang F,Scadden DT

更新日期：1996-12-01 00:00:00

abstract：:Two papers suggest that apoptosis of alloreactive T cells is required for induction of peripheral transplantation tolerance. These findings raise new questions about how lymphocytes reach from beyond the grave to influence the immune response (pages 1298-1302 and 1303-1307). ...

journal_title：Nature medicine

authors： Ferguson TA,Green DR

更新日期：1999-11-01 00:00:00

abstract：:Infiltration of human cancers by T cells is generally interpreted as a sign of immune recognition, and there is a growing effort to reactivate dysfunctional T cells at such tumor sites1. However, these efforts only have value if the intratumoral T cell receptor (TCR) repertoire of such cells is intrinsically tumor rea...

journal_title：Nature medicine

authors： Scheper W,Kelderman S,Fanchi LF,Linnemann C,Bendle G,de Rooij MAJ,Hirt C,Mezzadra R,Slagter M,Dijkstra K,Kluin RJC,Snaebjornsson P,Milne K,Nelson BH,Zijlmans H,Kenter G,Voest EE,Haanen JBAG,Schumacher TN

更新日期：2019-01-01 00:00:00

abstract：:Massive release of tumor necrosis factor is responsible for the potentially fatal larisch-Herxheimer reaction that follows antibiotic treatment of relapsing fever due to Borrelia recurrentis. We have undertaken the quantitative purification of the components of B. recurrentis that stimulate human monocytes to produce ...

journal_title：Nature medicine

authors： Vidal V,Scragg IG,Cutler SJ,Rockett KA,Fekade D,Warrell DA,Wright DJ,Kwiatkowski D

更新日期：1998-12-01 00:00:00

abstract：:White fat stores excess energy, whereas brown and beige fat are thermogenic and dissipate energy as heat. Thermogenic adipose tissues markedly improve glucose and lipid homeostasis in mouse models, although the extent to which brown adipose tissue (BAT) influences metabolic and cardiovascular disease in humans is uncl...

journal_title：Nature medicine

authors： Becher T,Palanisamy S,Kramer DJ,Eljalby M,Marx SJ,Wibmer AG,Butler SD,Jiang CS,Vaughan R,Schöder H,Mark A,Cohen P

更新日期：2021-01-01 00:00:00

abstract：:We show that the fraction of proliferating CD4+ lymphocytes is similar in HIV-infected subjects in the early stage of disease and in HIV-negative subjects, whereas the fraction of proliferating CD8+ lymphocytes is increased 6.8-fold in HIV-infected subjects. After initiation of antiviral therapy, there is a late incre...

journal_title：Nature medicine

authors： Fleury S,de Boer RJ,Rizzardi GP,Wolthers KC,Otto SA,Welbon CC,Graziosi C,Knabenhans C,Soudeyns H,Bart PA,Gallant S,Corpataux JM,Gillet M,Meylan P,Schnyder P,Meuwly JY,Spreen W,Glauser MP,Miedema F,Pantaleo G

更新日期：1998-07-01 00:00:00

abstract：:CD23 is a low-affinity receptor for immunoglobulin E (IgE) expressed by a variety of haematopoietic cells. Proteolytic cleavage of the transmembrane receptor generates soluble forms, which can be detected in biological fluids. CD23 regulates many functional aspects of immune cells, both in its cell-associated and solu...

journal_title：Nature medicine

authors： Plater-Zyberk C,Bonnefoy JY

更新日期：1995-08-01 00:00:00

abstract：:Platelet-activating factor (PAF) induces pulmonary edema and has a key role in acute lung injury (ALI). Here we show that PAF induces pulmonary edema through two mechanisms: acid sphingomyelinase (ASM)-dependent production of ceramide, and activation of the cyclooxygenase pathway. Agents that interfere with PAF-induce...

journal_title：Nature medicine

authors： Göggel R,Winoto-Morbach S,Vielhaber G,Imai Y,Lindner K,Brade L,Brade H,Ehlers S,Slutsky AS,Schütze S,Gulbins E,Uhlig S

更新日期：2004-02-01 00:00:00

abstract：:Animal allergens are an important cause of asthma and allergic rhinitis. We designed and tested a chimeric human-cat fusion protein composed of a truncated human IgG Fcgamma1 and the major cat allergen Fel d1, as a proof of concept for a new approach to allergy immunotherapy. This Fcgamma-Fel d1 protein induced dose-d...

journal_title：Nature medicine

authors： Zhu D,Kepley CL,Zhang K,Terada T,Yamada T,Saxon A

更新日期：2005-04-01 00:00:00

abstract：:Angiogenesis, the formation of new blood vessels, is a requirement for malignant tumor growth and metastasis. In the absence of angiogenesis, local tumor expansion is suppressed at a few millimeters and cells lack routes for distant hematogenous spread. Clinical studies have demonstrated that the degree of angiogenesi...

journal_title：Nature medicine

authors： Sipkins DA,Cheresh DA,Kazemi MR,Nevin LM,Bednarski MD,Li KC

更新日期：1998-05-01 00:00:00

abstract：:The skin protects mammals from insults, infection and dehydration and enables thermoregulation and sensory perception. Various skin-resident cells carry out these diverse functions. Constant turnover of cells and healing upon injury necessitate multiple reservoirs of stem cells. Thus, the skin provides a model for stu...

journal_title：Nature medicine

authors： Hsu YC,Li L,Fuchs E

更新日期：2014-08-01 00:00:00

abstract：:Relapse is the leading cause of mortality in children with acute lymphoblastic leukemia (ALL). Among chemotherapeutics, thiopurines are key drugs in ALL combination therapy. Using whole-exome sequencing, we identified relapse-specific mutations in the phosphoribosyl pyrophosphate synthetase 1 gene (PRPS1), which encod...

journal_title：Nature medicine

authors： Li B,Li H,Bai Y,Kirschner-Schwabe R,Yang JJ,Chen Y,Lu G,Tzoneva G,Ma X,Wu T,Li W,Lu H,Ding L,Liang H,Huang X,Yang M,Jin L,Kang H,Chen S,Du A,Shen S,Ding J,Chen H,Chen J,von Stackelberg A,Gu L,Zhang J,

更新日期：2015-06-01 00:00:00

abstract：:Targeted gene transduction to specific tissues and organs through intravenous injection would be the ultimate preferred method of gene delivery. Here, we report successful targeting in a living animal through intravenous injection of a lentiviral vector pseudotyped with a modified chimeric Sindbis virus envelope (term...

journal_title：Nature medicine

authors： Morizono K,Xie Y,Ringpis GE,Johnson M,Nassanian H,Lee B,Wu L,Chen IS

更新日期：2005-03-01 00:00:00

abstract：:Whereas uncoupling protein 1 (UCP-1) is clearly involved in thermogenesis, the role of UCP-2 is less clear. Using hybridization, cloning techniques and cDNA array analysis to identify inducible neuroprotective genes, we found that neuronal survival correlates with increased expression of Ucp2. In mice overexpressing h...

journal_title：Nature medicine

authors： Mattiasson G,Shamloo M,Gido G,Mathi K,Tomasevic G,Yi S,Warden CH,Castilho RF,Melcher T,Gonzalez-Zulueta M,Nikolich K,Wieloch T

更新日期：2003-08-01 00:00:00

abstract：:Increased production of very low-density lipoprotein (VLDL) is a critical feature of the metabolic syndrome. Here we report that a selective increase in brain glucose lowered circulating triglycerides (TG) through the inhibition of TG-VLDL secretion by the liver. We found that the effect of glucose required its conver...

journal_title：Nature medicine

authors： Lam TK,Gutierrez-Juarez R,Pocai A,Bhanot S,Tso P,Schwartz GJ,Rossetti L

更新日期：2007-02-01 00:00:00