Aura of mystery.

Abstract:

:It begins as a slowly expanding spot of light or similar visual disturbance, often accompanied by phantom noises and other sensory distortions. People who experience such 'auras' know all too well that these early warning signs will culminate in a head-splitting migraine, yet scientists have little idea what causes the debilitating deluge of symptoms. Elie Dolgin talks to neurologists hoping to change that - by triggering auras in the laboratory in order to study them.

journal_name

Nat Med

journal_title

Nature medicine

authors

Dolgin E

doi

10.1038/nm0913-1083

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

1083-5

issue

9

eissn

1078-8956

issn

1546-170X

pii

nm0913-1083

journal_volume

19

pub_type

新闻
  • The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption.

    abstract::Period (Per) genes are involved in regulation of the circadian clock and are thought to modulate several brain functions. We demonstrate that Per2(Brdm1) mutant mice, which have a deletion in the PAS domain of the Per2 protein, show alterations in the glutamatergic system. Lowered expression of the glutamate transport...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm1163

    authors: Spanagel R,Pendyala G,Abarca C,Zghoul T,Sanchis-Segura C,Magnone MC,Lascorz J,Depner M,Holzberg D,Soyka M,Schreiber S,Matsuda F,Lathrop M,Schumann G,Albrecht U

    更新日期:2005-01-01 00:00:00

  • Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions.

    abstract::Colon cancer is a clinically diverse disease. This heterogeneity makes it difficult to determine which patients will benefit most from adjuvant therapy and impedes the development of new targeted agents. More insight into the biological diversity of colon cancers, especially in relation to clinical features, is theref...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm.3174

    authors: De Sousa E Melo F,Wang X,Jansen M,Fessler E,Trinh A,de Rooij LP,de Jong JH,de Boer OJ,van Leersum R,Bijlsma MF,Rodermond H,van der Heijden M,van Noesel CJ,Tuynman JB,Dekker E,Markowetz F,Medema JP,Vermeulen L

    更新日期:2013-05-01 00:00:00

  • Transplantation of male germ line stem cells restores fertility in infertile mice.

    abstract::Azoospermia or oligozoospermia due to disruption of spermatogenesis are common causes of human male infertility. We used the technique of spermatogonial transplantation in two infertile mouse strains, Steel (Sl) and dominant white spotting (W), to determine if stem cells from an infertile male were capable of generati...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/71496

    authors: Ogawa T,Dobrinski I,Avarbock MR,Brinster RL

    更新日期:2000-01-01 00:00:00

  • Author Correction: China's response to a novel coronavirus stands in stark contrast to the 2002 SARS outbreak response.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature medicine

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/s41591-020-0816-5

    authors: Nkengasong J

    更新日期:2020-03-01 00:00:00

  • Anti-cancer activity of targeted pro-apoptotic peptides.

    abstract::We have designed short peptides composed of two functional domains, one a tumor blood vessel 'homing' motif and the other a programmed cell death-inducing sequence, and synthesized them by simple peptide chemistry. The 'homing' domain was designed to guide the peptide to targeted cells and allow its internalization. T...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/12469

    authors: Ellerby HM,Arap W,Ellerby LM,Kain R,Andrusiak R,Rio GD,Krajewski S,Lombardo CR,Rao R,Ruoslahti E,Bredesen DE,Pasqualini R

    更新日期:1999-09-01 00:00:00

  • In situ genetic analysis of cellular chimerism.

    abstract::Copy number variants are a recently discovered source of large-scale genomic diversity present in all individuals. We capitalize on these inherent genomic differences, focusing on deletion polymorphisms, to develop informative fluorescence in situ hybridization probes with the ability to unequivocally distinguish betw...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm.1862

    authors: Wu D,Vu Q,Nguyen A,Stone JR,Stubbs H,Kuhlmann G,Sholl LM,Iafrate AJ

    更新日期:2009-02-01 00:00:00

  • Durvalumab compared to maintenance chemotherapy in metastatic breast cancer: the randomized phase II SAFIR02-BREAST IMMUNO trial.

    abstract::The impact of single-agent antibodies against programmed death-ligand 1 (PD-L1) as maintenance therapy is unknown in patients with metastatic breast cancer. The SAFIR02-BREAST IMMUNO substudy included patients with human epidermal growth factor receptor type 2 (Her2)-negative metastatic breast cancer whose disease did...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-020-01189-2

    authors: Bachelot T,Filleron T,Bieche I,Arnedos M,Campone M,Dalenc F,Coussy F,Sablin MP,Debled M,Lefeuvre-Plesse C,Goncalves A,Reynier MM,Jacot W,You B,Barthelemy P,Verret B,Isambert N,Tchiknavorian X,Levy C,Thery JC,L'Har

    更新日期:2021-01-18 00:00:00

  • Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis.

    abstract::Given the associations between chronic inflammation and epithelial cancer, we studied susceptibility to skin carcinogenesis in mice deficient for the pro-inflammatory cytokine TNF-alpha (refs. 5,6). TNF-alpha(-/-) mice were resistant to development of benign and malignant skin tumors, whether induced by initiation wit...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/10552

    authors: Moore RJ,Owens DM,Stamp G,Arnott C,Burke F,East N,Holdsworth H,Turner L,Rollins B,Pasparakis M,Kollias G,Balkwill F

    更新日期:1999-07-01 00:00:00

  • SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses.

    abstract::Members of the suppressor of cytokine signaling (SOCS) family are involved in the pathogenesis of many inflammatory diseases. SOCS-3 is predominantly expressed in T-helper type 2 (T(H)2) cells, but its role in T(H)2-related allergic diseases remains to be investigated. In this study we provide a strong correlation bet...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm896

    authors: Seki Y,Inoue H,Nagata N,Hayashi K,Fukuyama S,Matsumoto K,Komine O,Hamano S,Himeno K,Inagaki-Ohara K,Cacalano N,O'Garra A,Oshida T,Saito H,Johnston JA,Yoshimura A,Kubo M

    更新日期:2003-08-01 00:00:00

  • Production of atypical measles in rhesus macaques: evidence for disease mediated by immune complex formation and eosinophils in the presence of fusion-inhibiting antibody.

    abstract::The severe disease atypical measles occurred when individuals immunized with a poorly protective inactivated vaccine contracted measles, and was postulated to be due to a lack of fusion-inhibiting antibodies. Here, rhesus macaques immunized with formalin-inactivated measles vaccine developed transient neutralizing and...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/9473

    authors: Polack FP,Auwaerter PG,Lee SH,Nousari HC,Valsamakis A,Leiferman KM,Diwan A,Adams RJ,Griffin DE

    更新日期:1999-06-01 00:00:00

  • HIV-specific mucosal and cellular immunity in HIV-seronegative partners of HIV-seropositive individuals.

    abstract::HIV-specific mucosal and cellular immunity was analyzed in heterosexual couples discordant for HIV status in serum and in HIV-unexposed controls. HIV-specific IgA but not IgG was present in urine and vaginal wash samples from HIV-exposed seronegative individuals (ESN), whereas both IgA and IgG were observed in their H...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm1197-1250

    authors: Mazzoli S,Trabattoni D,Lo Caputo S,Piconi S,Blé C,Meacci F,Ruzzante S,Salvi A,Semplici F,Longhi R,Fusi ML,Tofani N,Biasin M,Villa ML,Mazzotta F,Clerici M

    更新日期:1997-11-01 00:00:00

  • Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins.

    abstract::Mutations in genes encoding splicing factors (which we refer to as spliceosomal genes) are commonly found in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). These mutations recurrently affect specific amino acid residues, leading to perturbed normal splice site and exon recognition. Spl...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm.4097

    authors: Lee SC,Dvinge H,Kim E,Cho H,Micol JB,Chung YR,Durham BH,Yoshimi A,Kim YJ,Thomas M,Lobry C,Chen CW,Pastore A,Taylor J,Wang X,Krivtsov A,Armstrong SA,Palacino J,Buonamici S,Smith PG,Bradley RK,Abdel-Wahab O

    更新日期:2016-06-01 00:00:00

  • Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity.

    abstract::Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapy for hematological malignancies. However, graft-versus-host disease (GVHD) and relapse after allo-HSCT remain major impediments to the success of allo-HSCT. Chimeric antigen receptors (CARs) direct tumor cell recognition of...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm.4258

    authors: Ghosh A,Smith M,James SE,Davila ML,Velardi E,Argyropoulos KV,Gunset G,Perna F,Kreines FM,Levy ER,Lieberman S,Jay HV,Tuckett AZ,Zakrzewski JL,Tan L,Young LF,Takvorian K,Dudakov JA,Jenq RR,Hanash AM,Motta AC,Murph

    更新日期:2017-02-01 00:00:00

  • Failure of T-cell homeostasis preceding AIDS in HIV-1 infection. The Multicenter AIDS Cohort Study.

    abstract::We and others have postulated that a constant number of T lymphocytes is normally maintained without regard to CD4+ or CD8+ phenotype ('blind' T-cell homeostasis). Here we confirm essentially constant T-cell levels (despite marked decline in CD4+ T cells and increase in CD8+ T cells) in homosexual men with incident hu...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm0795-674

    authors: Margolick JB,Muñoz A,Donnenberg AD,Park LP,Galai N,Giorgi JV,O'Gorman MR,Ferbas J

    更新日期:1995-07-01 00:00:00

  • Direct-to-stomach delivery.

    abstract:: ...

    journal_title:Nature medicine

    pub_type: 评论,杂志文章

    doi:10.1038/s41591-019-0397-3

    authors: Stower H

    更新日期:2019-03-01 00:00:00

  • Identification of an endogenous inhibitor of prostatic carcinoma cell growth.

    abstract::The rate of expansion of primary prostatic carcinoma is comparatively slow, with tumours frequently taking years or decades to reach clinically relevant size. We now report the presence of an endogenous inhibitor, derived from aqueous extracts of human prostate tissue, which blocks prostatic carcinoma cell proliferati...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm1095-1040

    authors: Smith RC,Litwin MS,Lu Y,Zetter BR

    更新日期:1995-10-01 00:00:00

  • Reduction of serum cholesterol in Watanabe rabbits by xenogeneic hepatocellular transplantation.

    abstract::Transplantation of xenogeneic hepatocytes would provide a novel therapy for liver disease and would help to solve the problem of an insufficient supply of donor organs. We have tested whether xenogeneic cells infused into the liver could correct the metabolic defect in the Watanable heritable hyperlipidemic (WHHL) rab...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm0197-48

    authors: Gunsalus JR,Brady DA,Coulter SM,Gray BM,Edge AS

    更新日期:1997-01-01 00:00:00

  • GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes.

    abstract::GLUT4, the insulin-responsive glucose transporter, plays an important role in postprandial glucose disposal. Altered GLUT4 activity is suggested to be one of the factors responsible for decreased glucose uptake in muscle and adipose tissue in obesity and diabetes. To assess the effect of GLUT4 expression on whole-body...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm1097-1096

    authors: Stenbit AE,Tsao TS,Li J,Burcelin R,Geenen DL,Factor SM,Houseknecht K,Katz EB,Charron MJ

    更新日期:1997-10-01 00:00:00

  • Deacetylase inhibition promotes the generation and function of regulatory T cells.

    abstract::Histone/protein deacetylases (HDACs) regulate chromatin remodeling and gene expression as well as the functions of more than 50 transcription factors and nonhistone proteins. We found that administration of an HDAC inhibitor (HDACi) in vivo increased Foxp3 gene expression, as well as the production and suppressive fun...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm1652

    authors: Tao R,de Zoeten EF,Ozkaynak E,Chen C,Wang L,Porrett PM,Li B,Turka LA,Olson EN,Greene MI,Wells AD,Hancock WW

    更新日期:2007-11-01 00:00:00

  • A novel chimeric antigen receptor containing a JAK-STAT signaling domain mediates superior antitumor effects.

    abstract::The adoptive transfer of T cells engineered with a chimeric antigen receptor (CAR) (hereafter referred to as CAR-T cells) specific for the B lymphocyte antigen CD19 has shown impressive clinical responses in patients with refractory B cell malignancies. However, the therapeutic effects of CAR-T cells that target other...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm.4478

    authors: Kagoya Y,Tanaka S,Guo T,Anczurowski M,Wang CH,Saso K,Butler MO,Minden MD,Hirano N

    更新日期:2018-03-01 00:00:00

  • A cannabinoid mechanism in relapse to cocaine seeking.

    abstract::Treatment of cocaine addiction is hampered by high rates of relapse even after prolonged drug abstinence. This relapse to compulsive cocaine use can be triggered by re-exposure to cocaine, by re-exposure to stimuli previously associated with cocaine or by exposure to stress. In laboratory rats, similar events reinstat...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm1001-1151

    authors: De Vries TJ,Shaham Y,Homberg JR,Crombag H,Schuurman K,Dieben J,Vanderschuren LJ,Schoffelmeer AN

    更新日期:2001-10-01 00:00:00

  • King of hearts: a splicing factor rules cardiac proteins.

    abstract::Alternative splicing ensures the expression of functionally diverse proteins from individual genes; however, aberrant mRNA splicing is associated with various conditions, including heart disease. A recent study provides new mechanistic insights into heart failure by showing that a human cardiomyopathy-linked mutation ...

    journal_title:Nature medicine

    pub_type: 评论,杂志文章

    doi:10.1038/nm.2762

    authors: Linke WA,Bücker S

    更新日期:2012-05-04 00:00:00

  • Fighting tobacco dependence in Europe.

    abstract::The World Health Organization estimates that tobacco will become the largest single health problem by 2020, causing an estimated 8.4 million deaths annually. But the smoking burden will not be distributed evenly across the globe; deaths in developed nations are set to rise 50% to 2.4 million while those in Asia will s...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/83281

    authors: Raw M

    更新日期:2001-01-01 00:00:00

  • Non-invasive in vivo monitoring of trackable viruses expressing soluble marker peptides.

    abstract::Noninvasive methods are needed to study the kinetic properties of viruses in living organisms. Oncolytic viruses are used increasingly for cancer therapy but there is currently no satisfactory way to measure efficiency of tumor transduction, changing levels of viral gene expression or the timing of virus elimination. ...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm0502-527

    authors: Peng KW,Facteau S,Wegman T,O'Kane D,Russell SJ

    更新日期:2002-05-01 00:00:00

  • Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment.

    abstract::The mechanism by which angiogenic factors recruit bone marrow (BM)-derived quiescent endothelial and hematopoietic stem cells (HSCs) is not known. Here, we report that functional vascular endothelial growth factor receptor-1 (VEGFR1) is expressed on human CD34(+) and mouse Lin(-)Sca-1(+)c-Kit(+) BM-repopulating stem c...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm740

    authors: Hattori K,Heissig B,Wu Y,Dias S,Tejada R,Ferris B,Hicklin DJ,Zhu Z,Bohlen P,Witte L,Hendrikx J,Hackett NR,Crystal RG,Moore MA,Werb Z,Lyden D,Rafii S

    更新日期:2002-08-01 00:00:00

  • Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy.

    abstract::Peripheral nerve injuries represent a significant problem in public health, constituting 2-5% of all trauma cases1. For severe nerve injuries, even advanced forms of clinical intervention often lead to incomplete and unsatisfactory motor and/or sensory function2. Numerous studies report the potential of pharmacologica...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-018-0196-2

    authors: Koo J,MacEwan MR,Kang SK,Won SM,Stephen M,Gamble P,Xie Z,Yan Y,Chen YY,Shin J,Birenbaum N,Chung S,Kim SB,Khalifeh J,Harburg DV,Bean K,Paskett M,Kim J,Zohny ZS,Lee SM,Zhang R,Luo K,Ji B,Banks A,Lee HM,Hua

    更新日期:2018-12-01 00:00:00

  • Author Correction: Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma.

    abstract::In the version of this article originally published, there was an error in Fig. 2b. RECIST ORR and pCR were both listed as 25%. RECIST ORR was actually 73%, and pCR was 45%. Also, an author's name was incorrect in the author list. Danny K. Wells should have been listed as Daniel K. Wells. The errors have been correcte...

    journal_title:Nature medicine

    pub_type: 已发布勘误

    doi:10.1038/s41591-018-0251-z

    authors: Amaria RN,Reddy SM,Tawbi HA,Davies MA,Ross MI,Glitza IC,Cormier JN,Lewis C,Hwu WJ,Hanna E,Diab A,Wong MK,Royal R,Gross N,Weber R,Lai SY,Ehlers R,Blando J,Milton DR,Woodman S,Kageyama R,Wells DK,Hwu P,Patel S

    更新日期:2018-12-01 00:00:00

  • Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor.

    abstract::The androgen receptor (AR) is involved in the development, growth and progression of prostate cancer (CaP). CaP often progresses from an androgen-dependent to an androgen-independent tumor, making androgen ablation therapy ineffective. However, the mechanisms for the development of androgen-independent CaP are unclear...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/76287

    authors: Zhao XY,Malloy PJ,Krishnan AV,Swami S,Navone NM,Peehl DM,Feldman D

    更新日期:2000-06-01 00:00:00

  • Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria.

    abstract::The role of nitric oxide (NO) in the genesis of cerebral malaria is controversial. Most investigators propose that the unfortunate consequence of the high concentrations of NO produced to kill the parasite is the development of cerebral malaria. Here we have tested this high NO bioavailability hypothesis in the settin...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm1499

    authors: Gramaglia I,Sobolewski P,Meays D,Contreras R,Nolan JP,Frangos JA,Intaglietta M,van der Heyde HC

    更新日期:2006-12-01 00:00:00

  • Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension.

    abstract::Pulmonary hypertension (PH) is characterized by increased proliferation and apoptosis resistance of pulmonary artery smooth muscle cells (PASMCs). Forkhead box O (FoxO) transcription factors are key regulators of cellular proliferation. Here we show that in pulmonary vessels and PASMCs of human and experimental PH lun...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm.3695

    authors: Savai R,Al-Tamari HM,Sedding D,Kojonazarov B,Muecke C,Teske R,Capecchi MR,Weissmann N,Grimminger F,Seeger W,Schermuly RT,Pullamsetti SS

    更新日期:2014-11-01 00:00:00