Abstract:
:Chlamydia trachomatis is the leading cause worldwide of preventable infectious blindness (trachoma) and sexually transmitted disease, including nongonoccocal urethritis and pelvic inflammatory disease. To date, no effective vaccine against C. trachomatis infection has been identified. A monoclonal anti-idiotypic antibody (anti-Id) to the chlamydial exoglycolipid antigen (GLXA) was tested in a murine model of ocular chlamydial infection for its ability to induce systemic immunity, which reduces microbiologic and clinical disease. The anti-Id to GLXA, delivered either systemically in soluble form or orally after encapsulation in poly(lactide) microspheres, induced significant protective immunity against ocular challenge of mice with a human biovar of C. trachomatis. Protection was associated with induction of anti-GLXA antibody and anti-chlamydial neutralizing antibody.
journal_name
Nat Medjournal_title
Nature medicineauthors
Whittum-Hudson JA,An LL,Saltzman WM,Prendergast RA,MacDonald ABdoi
10.1038/nm1096-1116subject
Has Abstractpub_date
1996-10-01 00:00:00pages
1116-21issue
10eissn
1078-8956issn
1546-170Xjournal_volume
2pub_type
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