Abstract:
:Alternative splicing ensures the expression of functionally diverse proteins from individual genes; however, aberrant mRNA splicing is associated with various conditions, including heart disease. A recent study provides new mechanistic insights into heart failure by showing that a human cardiomyopathy-linked mutation in a cardiac splice factor affects post-transcriptional regulation, causing the expression of anomalous isoforms of a whole network of cardiac proteins (pages 766-773).
journal_name
Nat Medjournal_title
Nature medicineauthors
Linke WA,Bücker Sdoi
10.1038/nm.2762subject
Has Abstractpub_date
2012-05-04 00:00:00pages
660-1issue
5eissn
1078-8956issn
1546-170Xpii
nm.2762journal_volume
18pub_type
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