Direct-to-stomach delivery.

Abstract:

:

journal_name

Nat Med

journal_title

Nature medicine

authors

Stower H

doi

10.1038/s41591-019-0397-3

subject

pub_date

2019-03-01 00:00:00

pages

358

issue

3

eissn

1078-8956

issn

1546-170X

pii

10.1038/s41591-019-0397-3

journal_volume

25

pub_type

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    authors: Miyawaki K,Yamada Y,Ban N,Ihara Y,Tsukiyama K,Zhou H,Fujimoto S,Oku A,Tsuda K,Toyokuni S,Hiai H,Mizunoya W,Fushiki T,Holst JJ,Makino M,Tashita A,Kobara Y,Tsubamoto Y,Jinnouchi T,Jomori T,Seino Y

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  • In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency.

    abstract::Although it is presumed that the integration of HIV-1 into the genome of infected CD4+ T lymphocytes allows viral persistence, there has been little direct evidence that CD4+ T cells with integrated provirus function as a latent reservoir for HIV-1 in infected individuals. Using resting CD4+ T-cell populations of extr...

    journal_title:Nature medicine

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    doi:10.1038/nm1295-1284

    authors: Chun TW,Finzi D,Margolick J,Chadwick K,Schwartz D,Siliciano RF

    更新日期:1995-12-01 00:00:00

  • Isolated small intestinal segments support auxiliary livers with maintenance of hepatic functions.

    abstract::We determine here the functional integrity of auxiliary livers in containers fashioned from the small intestine. Liver microfragments from dipeptidyl peptidase 4 (DPP4)-deficient rats were transplanted into syngeneic normal animals with isolated intestinal segments characterized by mucosal denudation but intact vascul...

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    doi:10.1038/nm1057

    authors: Joseph B,Berishvili E,Benten D,Kumaran V,Liponava E,Bhargava K,Palestro C,Kakabadze Z,Gupta S

    更新日期:2004-07-01 00:00:00

  • Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.

    abstract::Neurofibrillary tangles (NFTs), composed of truncated and hyperphosphorylated tau, are a common feature of numerous aging-related neurodegenerative diseases, including Alzheimer's disease (AD). However, the molecular mechanisms mediating tau truncation and aggregation during aging remain elusive. Here we show that asp...

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    doi:10.1038/nm.3700

    authors: Zhang Z,Song M,Liu X,Kang SS,Kwon IS,Duong DM,Seyfried NT,Hu WT,Liu Z,Wang JZ,Cheng L,Sun YE,Yu SP,Levey AI,Ye K

    更新日期:2014-11-01 00:00:00

  • Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector.

    abstract::Hemophilia B is a severe X-linked bleeding diathesis caused by the absence of functional blood coagulation factor IX, and is an excellent candidate for treatment of a genetic disease by gene therapy. Using an adeno-associated viral vector, we demonstrate sustained expression (>17 months) of factor IX in a large-animal...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/4743

    authors: Herzog RW,Yang EY,Couto LB,Hagstrom JN,Elwell D,Fields PA,Burton M,Bellinger DA,Read MS,Brinkhous KM,Podsakoff GM,Nichols TC,Kurtzman GJ,High KA

    更新日期:1999-01-01 00:00:00

  • Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner.

    abstract::Transcription factor FoxO1 promotes hepatic glucose production. Genetic inhibition of FoxO1 function prevents diabetes in experimental animal models, providing impetus to identify pharmacological approaches to modulate this function. Altered Notch signaling is evident in tumorigenesis, and Notch antagonists are in cli...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm.2378

    authors: Pajvani UB,Shawber CJ,Samuel VT,Birkenfeld AL,Shulman GI,Kitajewski J,Accili D

    更新日期:2011-07-31 00:00:00

  • A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice.

    abstract::The balance between detrimental, pro-aging, often stochastic processes and counteracting homeostatic mechanisms largely determines the progression of aging. There is substantial evidence suggesting that the endocannabinoid system (ECS) is part of the latter system because it modulates the physiological processes under...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm.4311

    authors: Bilkei-Gorzo A,Albayram O,Draffehn A,Michel K,Piyanova A,Oppenheimer H,Dvir-Ginzberg M,Rácz I,Ulas T,Imbeault S,Bab I,Schultze JL,Zimmer A

    更新日期:2017-06-01 00:00:00