Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation.

abstract：:Parasites of the Leishmania genus are the causative agents of leishmaniasis in humans, a disease that affects more than 12 million people worldwide. These parasites replicate intracellularly in macrophages, and the primary mechanisms underlying host resistance involve the production of nitric oxide (NO). In this study...

journal_title：Nature medicine

authors： Lima-Junior DS,Costa DL,Carregaro V,Cunha LD,Silva AL,Mineo TW,Gutierrez FR,Bellio M,Bortoluci KR,Flavell RA,Bozza MT,Silva JS,Zamboni DS

更新日期：2013-07-01 00:00:00

abstract：:Azoospermia or oligozoospermia due to disruption of spermatogenesis are common causes of human male infertility. We used the technique of spermatogonial transplantation in two infertile mouse strains, Steel (Sl) and dominant white spotting (W), to determine if stem cells from an infertile male were capable of generati...

journal_title：Nature medicine

authors： Ogawa T,Dobrinski I,Avarbock MR,Brinster RL

更新日期：2000-01-01 00:00:00

abstract：:Evolutionary patterns of virus replication and distribution in lymphoid tissue during the early phases of HIV infection have not been delineated. Lymph node (LN) biopsies were excised from patients at different times after the estimated time of primary infection. Within 3 months of the acute viral syndrome, HIV was mo...

journal_title：Nature medicine

authors： Pantaleo G,Cohen OJ,Schacker T,Vaccarezza M,Graziosi C,Rizzardi GP,Kahn J,Fox CH,Schnittman SM,Schwartz DH,Corey L,Fauci AS

更新日期：1998-03-01 00:00:00

abstract：:White fat stores excess energy, whereas brown and beige fat are thermogenic and dissipate energy as heat. Thermogenic adipose tissues markedly improve glucose and lipid homeostasis in mouse models, although the extent to which brown adipose tissue (BAT) influences metabolic and cardiovascular disease in humans is uncl...

journal_title：Nature medicine

authors： Becher T,Palanisamy S,Kramer DJ,Eljalby M,Marx SJ,Wibmer AG,Butler SD,Jiang CS,Vaughan R,Schöder H,Mark A,Cohen P

更新日期：2021-01-01 00:00:00

abstract：:Although Nogo-A has been identified in the central nervous system as an inhibitor of axonal regeneration, the peripheral roles of Nogo isoforms remain virtually unknown. Here, using a proteomic analysis to identify proteins enriched in caveolae and/or lipid rafts (CEM/LR), we show that Nogo-B is highly expressed in cu...

journal_title：Nature medicine

authors： Acevedo L,Yu J,Erdjument-Bromage H,Miao RQ,Kim JE,Fulton D,Tempst P,Strittmatter SM,Sessa WC

更新日期：2004-04-01 00:00:00

abstract：:Monogenic deficiency diseases provide unique opportunities to define the contributions of individual molecules to human physiology and to identify pathologies arising from their dysfunction. Here we describe a deficiency disease in two human siblings that presented with severe bleeding, frequent infections and osteope...

journal_title：Nature medicine

authors： Malinin NL,Zhang L,Choi J,Ciocea A,Razorenova O,Ma YQ,Podrez EA,Tosi M,Lennon DP,Caplan AI,Shurin SB,Plow EF,Byzova TV

更新日期：2009-03-01 00:00:00

abstract：:How well antibodies can protect against disease due to HIV-1 infection remains a pivotal but unresolved issue with important implications for vaccine design and the use of prophylactic antibody to prevent infection after accidental exposure to the virus and to interrupt transmission of virus from mother to child. Stro...

journal_title：Nature medicine

authors： Gauduin MC,Parren PW,Weir R,Barbas CF,Burton DR,Koup RA

更新日期：1997-12-01 00:00:00

abstract：:Both the risk and the rate of development of atherosclerosis are increased in diabetics, but the mechanisms involved are unknown. Here we report a glucose-mediated increase in CD36 mRNA translation efficiency that results in increased expression of the macrophage scavenger receptor CD36. Expression of CD36 was increas...

journal_title：Nature medicine

authors： Griffin E,Re A,Hamel N,Fu C,Bush H,McCaffrey T,Asch AS

更新日期：2001-07-01 00:00:00

abstract：:The TAM receptors Tyro3, Axl and Mertk are receptor tyrosine kinases that dampen host innate immune responses following engagement with their ligands Gas6 and Protein S, which recognize phosphatidylserine on apoptotic cells. In a form of apoptotic mimicry, many enveloped viruses display phosphatidylserine on the outer...

journal_title：Nature medicine

authors： Miner JJ,Daniels BP,Shrestha B,Proenca-Modena JL,Lew ED,Lazear HM,Gorman MJ,Lemke G,Klein RS,Diamond MS

更新日期：2015-12-01 00:00:00

abstract：:We investigated whether immunization with recombinant anti-idiotypic antibody fragments mimicking the conformation of the capsular antigen can protect against infection by group B streptococcus, an important neonatal pathogen. Single-chain fragment-variable anti-idiotypes competed with the type III carbohydrate for bi...

journal_title：Nature medicine

authors： Magliani W,Polonelli L,Conti S,Salati A,Rocca PF,Cusumano V,Mancuso G,Teti G

更新日期：1998-06-01 00:00:00

abstract：:Period (Per) genes are involved in regulation of the circadian clock and are thought to modulate several brain functions. We demonstrate that Per2(Brdm1) mutant mice, which have a deletion in the PAS domain of the Per2 protein, show alterations in the glutamatergic system. Lowered expression of the glutamate transport...

journal_title：Nature medicine

authors： Spanagel R,Pendyala G,Abarca C,Zghoul T,Sanchis-Segura C,Magnone MC,Lascorz J,Depner M,Holzberg D,Soyka M,Schreiber S,Matsuda F,Lathrop M,Schumann G,Albrecht U

更新日期：2005-01-01 00:00:00

abstract：:New technology has provided methods for collecting large amounts of data reflecting gene expression, metabolite and protein abundance, and post-translational modification of proteins. Integration of these various data sets enable the genetic mapping of many new phenotypes and facilitates the creation of network models...

journal_title：Nature medicine

authors： Newgard CB,Attie AD

更新日期：2010-04-01 00:00:00

abstract：:From 28 young children in the Netherlands, we isolated a paramyxovirus that was identified as a tentative new member of the Metapneumovirus genus based on virological data, sequence homology and gene constellation. Previously, avian pneumovirus was the sole member of this recently assigned genus, hence the provisional...

journal_title：Nature medicine

authors： van den Hoogen BG,de Jong JC,Groen J,Kuiken T,de Groot R,Fouchier RA,Osterhaus AD

更新日期：2001-06-01 00:00:00

abstract：:Natural killer (NK) cells play an essential role in antiviral immunity, but knowledge of their function in secondary lymphoid organs is incomplete. Lymph node follicles constitute a major viral reservoir during infections with HIV-1 and simian immunodeficiency virus of macaques (SIVmac). In contrast, during nonpathoge...

journal_title：Nature medicine

authors： Huot N,Jacquelin B,Garcia-Tellez T,Rascle P,Ploquin MJ,Madec Y,Reeves RK,Derreudre-Bosquet N,Müller-Trutwin M

更新日期：2017-11-01 00:00:00

abstract：:Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) that compromise its chloride channel activity. The most common mutation, p.Phe508del, results in the production of a misfolded CFTR protein, which has residual channel activity but is prematu...

journal_title：Nature medicine

authors： Romani L,Oikonomou V,Moretti S,Iannitti RG,D'Adamo MC,Villella VR,Pariano M,Sforna L,Borghi M,Bellet MM,Fallarino F,Pallotta MT,Servillo G,Ferrari E,Puccetti P,Kroemer G,Pessia M,Maiuri L,Goldstein AL,Garaci E

更新日期：2017-05-01 00:00:00

abstract：:Oxygen-regulated protein 150 kD (ORP150) is a novel endoplasmic-reticulum-associated chaperone induced by hypoxia/ischemia. Although ORP150 was sparingly upregulated in neurons from human brain undergoing ischemic stress, there was robust induction in astrocytes. Cultured neurons overexpressing ORP150 were resistant t...

journal_title：Nature medicine

authors： Tamatani M,Matsuyama T,Yamaguchi A,Mitsuda N,Tsukamoto Y,Taniguchi M,Che YH,Ozawa K,Hori O,Nishimura H,Yamashita A,Okabe M,Yanagi H,Stern DM,Ogawa S,Tohyama M

更新日期：2001-03-01 00:00:00

abstract：:The cardioprotective effects of estrogen are mediated by receptors expressed in vascular cells. Here we show that 27-hydroxycholesterol (27HC), an abundant cholesterol metabolite that is elevated with hypercholesterolemia and found in atherosclerotic lesions, is a competitive antagonist of estrogen receptor action in ...

journal_title：Nature medicine

authors： Umetani M,Domoto H,Gormley AK,Yuhanna IS,Cummins CL,Javitt NB,Korach KS,Shaul PW,Mangelsdorf DJ

更新日期：2007-10-01 00:00:00

abstract：:Intraoperative diagnosis is essential for providing safe and effective care during cancer surgery1. The existing workflow for intraoperative diagnosis based on hematoxylin and eosin staining of processed tissue is time, resource and labor intensive2,3. Moreover, interpretation of intraoperative histologic images is de...

journal_title：Nature medicine

authors： Hollon TC,Pandian B,Adapa AR,Urias E,Save AV,Khalsa SSS,Eichberg DG,D'Amico RS,Farooq ZU,Lewis S,Petridis PD,Marie T,Shah AH,Garton HJL,Maher CO,Heth JA,McKean EL,Sullivan SE,Hervey-Jumper SL,Patil PG,Thompson BG

更新日期：2020-01-01 00:00:00

abstract：:The ubiquitin-proteasome pathway is the central mediator of regulated proteolysis in cells, and defects in this pathway are associated with cancer and neurodegenerative diseases. To assess 26S proteasome function in living animals, we developed a ubiquitin-luciferase reporter for bioluminescence imaging. The reporter ...

journal_title：Nature medicine

authors： Luker GD,Pica CM,Song J,Luker KE,Piwnica-Worms D

更新日期：2003-07-01 00:00:00

abstract：:Alzheimer's disease is a progressive and incurable disease whose prevalence increases dramatically with age. A biochemical marker for monitoring the onset and progression of the disease would be a valuable tool for disease management. In addition, such a marker might be used as an end point in clinical intervention pr...

journal_title：Nature medicine

authors： Kennard ML,Feldman H,Yamada T,Jefferies WA

更新日期：1996-11-01 00:00:00

abstract：:The revolution in cancer research can be summed up in a single sentence: cancer is, in essence, a genetic disease. In the last decade, many important genes responsible for the genesis of various cancers have been discovered, their mutations precisely identified, and the pathways through which they act characterized. T...

journal_title：Nature medicine

authors： Vogelstein B,Kinzler KW

更新日期：2004-08-01 00:00:00

abstract：:The human protein apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like-3G (APOBEC3G), also known as CEM-15, mediates a newly described form of innate resistance to retroviral infection by catalyzing the deamination of deoxycytidine to deoxyuridine in viral cDNA replication intermediates. Because DNA deamina...

journal_title：Nature medicine

authors： Sheehy AM,Gaddis NC,Malim MH

更新日期：2003-11-01 00:00:00

abstract：:The molecular alterations that occur in cells before cancer is manifest are largely uncharted. Lung carcinoma in situ (CIS) lesions are the pre-invasive precursor to squamous cell carcinoma. Although microscopically identical, their future is in equipoise, with half progressing to invasive cancer and half regressing o...

journal_title：Nature medicine

authors： Teixeira VH,Pipinikas CP,Pennycuick A,Lee-Six H,Chandrasekharan D,Beane J,Morris TJ,Karpathakis A,Feber A,Breeze CE,Ntolios P,Hynds RE,Falzon M,Capitanio A,Carroll B,Durrenberger PF,Hardavella G,Brown JM,Lynch AG,Fa

更新日期：2019-03-01 00:00:00

abstract：:In chronic kidney disease (CKD), loss of functional nephrons results in metabolic and mechanical stress in the remaining ones, resulting in further nephron loss. Here we show that Akt2 activation has an essential role in podocyte protection after nephron reduction. Glomerulosclerosis and albuminuria were substantially...

journal_title：Nature medicine

authors： Canaud G,Bienaimé F,Viau A,Treins C,Baron W,Nguyen C,Burtin M,Berissi S,Giannakakis K,Muda AO,Zschiedrich S,Huber TB,Friedlander G,Legendre C,Pontoglio M,Pende M,Terzi F

更新日期：2013-10-01 00:00:00

abstract：:Oral administration of protein can induce antigen-specific immune hyporesponsiveness. However, the utility of oral tolerance to autoantigens in the treatment of autoimmune diseases may be limited when candidate autoantigens cannot be produced by conventional systems in quantities sufficient for clinical studies. Plant...

journal_title：Nature medicine

authors： Ma SW,Zhao DL,Yin ZQ,Mukherjee R,Singh B,Qin HY,Stiller CR,Jevnikar AM

更新日期：1997-07-01 00:00:00

abstract：:Direct evidence in humans for the impact of the microbiome on nutrient absorption is lacking. We conducted an extended inpatient study using two interventions that we hypothesized would alter the gut microbiome and nutrient absorption. In each, stool calorie loss, a direct proxy of nutrient absorption, was measured. T...

journal_title：Nature medicine

authors： Basolo A,Hohenadel M,Ang QY,Piaggi P,Heinitz S,Walter M,Walter P,Parrington S,Trinidad DD,von Schwartzenberg RJ,Turnbaugh PJ,Krakoff J

更新日期：2020-04-01 00:00:00

abstract：:Deep brain stimulation (DBS) is a widely used neurosurgical approach to treating tremor and other movement disorders. In addition, the use of DBS in a number of psychiatric diseases, including obsessive-compulsive disorders and depression, is currently being tested. Despite the rapid increase in the number of individu...

journal_title：Nature medicine

authors： Bekar L,Libionka W,Tian GF,Xu Q,Torres A,Wang X,Lovatt D,Williams E,Takano T,Schnermann J,Bakos R,Nedergaard M

更新日期：2008-01-01 00:00:00

abstract：:Recent years have seen an explosion in the rate of discovery of genetic defects linked to Parkinson's disease. These breakthroughs have not provided a direct explanation for the disease process. Nevertheless, they have helped transform Parkinson's disease research by providing tangible clues to the neurobiology of the...

journal_title：Nature medicine

authors： Vila M,Przedborski S

更新日期：2004-07-01 00:00:00

abstract：:Epigenetic reprogramming is a critical process of pathological gene induction during cardiac hypertrophy and remodeling, but the underlying regulatory mechanisms remain to be elucidated. Here we identified a heart-enriched long noncoding (lnc)RNA, named cardiac-hypertrophy-associated epigenetic regulator (Chaer), whic...

journal_title：Nature medicine

authors： Wang Z,Zhang XJ,Ji YX,Zhang P,Deng KQ,Gong J,Ren S,Wang X,Chen I,Wang H,Gao C,Yokota T,Ang YS,Li S,Cass A,Vondriska TM,Li G,Deb A,Srivastava D,Yang HT,Xiao X,Li H,Wang Y

更新日期：2016-10-01 00:00:00

abstract：:Angiogenesis, the formation of new blood vessels, is a requirement for malignant tumor growth and metastasis. In the absence of angiogenesis, local tumor expansion is suppressed at a few millimeters and cells lack routes for distant hematogenous spread. Clinical studies have demonstrated that the degree of angiogenesi...

journal_title：Nature medicine

authors： Sipkins DA,Cheresh DA,Kazemi MR,Nevin LM,Bednarski MD,Li KC

更新日期：1998-05-01 00:00:00