当前位置： SCI文献检索 > NATURE MEDICINE期刊下所有文献 > Cancer genes and the pathways they control.

Cancer genes and the pathways they control.

Abstract：

:The revolution in cancer research can be summed up in a single sentence: cancer is, in essence, a genetic disease. In the last decade, many important genes responsible for the genesis of various cancers have been discovered, their mutations precisely identified, and the pathways through which they act characterized. The purposes of this review are to highlight examples of progress in these areas, indicate where knowledge is scarce and point out fertile grounds for future investigation.

journal_name

Nat Med

journal_title

Nature medicine

authors

Vogelstein B,Kinzler KW

doi

10.1038/nm1087

keywords:

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

789-99

issue

8

eissn

1078-8956

issn

1546-170X

pii

nm1087

journal_volume

10

pub_type

杂志文章,评审

相关文献

NATURE MEDICINE文献大全
  • Angiopoietin-related growth factor antagonizes obesity and insulin resistance.

    abstract：:Angiopoietin-related growth factor (AGF), a member of the angiopoietin-like protein (Angptl) family, is secreted predominantly from the liver into the systemic circulation. Here, we show that most (>80%) of the AGF-deficient mice die at about embryonic day 13, whereas the surviving AGF-deficient mice develop marked ob...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1214

    authors： Oike Y,Akao M,Yasunaga K,Yamauchi T,Morisada T,Ito Y,Urano T,Kimura Y,Kubota Y,Maekawa H,Miyamoto T,Miyata K,Matsumoto S,Sakai J,Nakagata N,Takeya M,Koseki H,Ogawa Y,Kadowaki T,Suda T

    更新日期：2005-04-01 00:00:00

  • Transplantation of male germ line stem cells restores fertility in infertile mice.

    abstract：:Azoospermia or oligozoospermia due to disruption of spermatogenesis are common causes of human male infertility. We used the technique of spermatogonial transplantation in two infertile mouse strains, Steel (Sl) and dominant white spotting (W), to determine if stem cells from an infertile male were capable of generati...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/71496

    authors： Ogawa T,Dobrinski I,Avarbock MR,Brinster RL

    更新日期：2000-01-01 00:00:00

  • Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway.

    abstract：:LIGHT was recently described as a member of the tumor necrosis factor (TNF) 'superfamily'. We have isolated a mouse homolog of human LIGHT and investigated its immunoregulatory functions in vitro and in vivo. LIGHT has potent, CD28-independent co-stimulatory activity leading to T-cell growth and secretion of gamma int...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/73136

    authors： Tamada K,Shimozaki K,Chapoval AI,Zhu G,Sica G,Flies D,Boone T,Hsu H,Fu YX,Nagata S,Ni J,Chen L

    更新日期：2000-03-01 00:00:00

  • Combined treatment with oral metronidazole and N-acetylcysteine is effective in ethylmalonic encephalopathy.

    abstract：:Ethylmalonic encephalopathy is caused by mutations in ETHE1, a mitochondrial matrix sulfur dioxygenase, leading to failure to detoxify sulfide, a product of intestinal anaerobes and, in trace amounts, tissues. Metronidazole, a bactericide, or N-acetylcysteine, a precursor of sulfide-buffering glutathione, substantiall...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.2188

    authors： Viscomi C,Burlina AB,Dweikat I,Savoiardo M,Lamperti C,Hildebrandt T,Tiranti V,Zeviani M

    更新日期：2010-08-01 00:00:00

  • Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.

    abstract：:Hedgehog signaling drives oncogenesis in several cancers, and strategies targeting this pathway have been developed, most notably through inhibition of Smoothened (SMO). However, resistance to Smoothened inhibitors occurs by genetic changes of Smoothened or other downstream Hedgehog components. Here we overcome these ...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.3613

    authors： Tang Y,Gholamin S,Schubert S,Willardson MI,Lee A,Bandopadhayay P,Bergthold G,Masoud S,Nguyen B,Vue N,Balansay B,Yu F,Oh S,Woo P,Chen S,Ponnuswami A,Monje M,Atwood SX,Whitson RJ,Mitra S,Cheshier SH,Qi J,Beroukh

    更新日期：2014-07-01 00:00:00

  • HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures.

    abstract：:Approximately 1-5% of breast cancers are attributed to inherited mutations in BRCA1 or BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In other cancer types, germline and/or somatic mutations in BRCA1 and/or BRCA2 (BRCA1/BRCA2) also confer selective sensitivity to PARP inhibitors....

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.4292

    authors： Davies H,Glodzik D,Morganella S,Yates LR,Staaf J,Zou X,Ramakrishna M,Martin S,Boyault S,Sieuwerts AM,Simpson PT,King TA,Raine K,Eyfjord JE,Kong G,Borg Å,Birney E,Stunnenberg HG,van de Vijver MJ,Børresen-Dale AL,Ma

    更新日期：2017-04-01 00:00:00

  • TLR4 enhances TGF-beta signaling and hepatic fibrosis.

    abstract：:Hepatic injury is associated with a defective intestinal barrier and increased hepatic exposure to bacterial products. Here we report that the intestinal bacterial microflora and a functional Toll-like receptor 4 (TLR4), but not TLR2, are required for hepatic fibrogenesis. Using Tlr4-chimeric mice and in vivo lipopoly...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1663

    authors： Seki E,De Minicis S,Osterreicher CH,Kluwe J,Osawa Y,Brenner DA,Schwabe RF

    更新日期：2007-11-01 00:00:00

  • Isolated small intestinal segments support auxiliary livers with maintenance of hepatic functions.

    abstract：:We determine here the functional integrity of auxiliary livers in containers fashioned from the small intestine. Liver microfragments from dipeptidyl peptidase 4 (DPP4)-deficient rats were transplanted into syngeneic normal animals with isolated intestinal segments characterized by mucosal denudation but intact vascul...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1057

    authors： Joseph B,Berishvili E,Benten D,Kumaran V,Liponava E,Bhargava K,Palestro C,Kakabadze Z,Gupta S

    更新日期：2004-07-01 00:00:00

  • Oral immunization with an anti-idiotypic antibody to the exoglycolipid antigen protects against experimental Chlamydia trachomatis infection.

    abstract：:Chlamydia trachomatis is the leading cause worldwide of preventable infectious blindness (trachoma) and sexually transmitted disease, including nongonoccocal urethritis and pelvic inflammatory disease. To date, no effective vaccine against C. trachomatis infection has been identified. A monoclonal anti-idiotypic antib...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1096-1116

    authors： Whittum-Hudson JA,An LL,Saltzman WM,Prendergast RA,MacDonald AB

    更新日期：1996-10-01 00:00:00

  • Inflammasome-derived IL-1β production induces nitric oxide-mediated resistance to Leishmania.

    abstract：:Parasites of the Leishmania genus are the causative agents of leishmaniasis in humans, a disease that affects more than 12 million people worldwide. These parasites replicate intracellularly in macrophages, and the primary mechanisms underlying host resistance involve the production of nitric oxide (NO). In this study...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.3221

    authors： Lima-Junior DS,Costa DL,Carregaro V,Cunha LD,Silva AL,Mineo TW,Gutierrez FR,Bellio M,Bortoluci KR,Flavell RA,Bozza MT,Silva JS,Zamboni DS

    更新日期：2013-07-01 00:00:00

  • CD8+ T cell efficacy in vaccination and disease.

    abstract：:Much effort has been devoted to the design of vaccines that induce adaptive cellular immunity, in particular CD8+ T cells, which have a central role in the host response to viral infections and cancers. To date, however, the development of effective T cell vaccines remains elusive. This is due, in part, to the lack of...

    journal_title：Nature medicine

    pub_type： 杂志文章,评审

    doi：10.1038/nm.f.1774

    authors： Appay V,Douek DC,Price DA

    更新日期：2008-06-01 00:00:00

  • A molecularly engineered split reporter for imaging protein-protein interactions with positron emission tomography.

    abstract：:Improved techniques to noninvasively image protein-protein interactions (PPIs) are essential. We molecularly engineered a positron emission tomography (PET)-based split reporter (herpes simplex virus type 1 thymidine kinase), cleaved between Thr265 and Ala266, and used this in a protein-fragment complementation assay ...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.2185

    authors： Massoud TF,Paulmurugan R,Gambhir SS

    更新日期：2010-08-01 00:00:00

  • A framework for understanding and targeting residual disease in oncogene-driven solid cancers.

    abstract：:Molecular targeted therapy has the potential to dramatically improve survival in patients with cancer. However, complete and durable responses to targeted therapy are rare in individuals with advanced-stage solid cancers. Even the most effective targeted therapies generally do not induce a complete tumor response, res...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.4091

    authors： Bivona TG,Doebele RC

    更新日期：2016-05-05 00:00:00

  • An approach to suppress the evolution of resistance in BRAFV600E-mutant cancer.

    abstract：:The principles that govern the evolution of tumors exposed to targeted therapy are poorly understood. Here we modeled the selection and propagation of an amplification in the BRAF oncogene (BRAFamp) in patient-derived tumor xenografts (PDXs) that were treated with a direct inhibitor of the kinase ERK, either alone or ...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.4369

    authors： Xue Y,Martelotto L,Baslan T,Vides A,Solomon M,Mai TT,Chaudhary N,Riely GJ,Li BT,Scott K,Cechhi F,Stierner U,Chadalavada K,de Stanchina E,Schwartz S,Hembrough T,Nanjangud G,Berger MF,Nilsson J,Lowe SW,Reis-Filho JS

    更新日期：2017-08-01 00:00:00

  • ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents.

    abstract：:The 55-kilodalton (kDa) protein from the E1B-region of adenovirus binds to and inactivates the p53 gene, which is mutated in half of human cancers. We have previously shown that the replication and cytopathogenicity of an E1B, 55-kDa gene-attenuated adenovirus, ONYX-015, is blocked by functional p53 in RKO and U20S ca...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0697-639

    authors： Heise C,Sampson-Johannes A,Williams A,McCormick F,Von Hoff DD,Kirn DH

    更新日期：1997-06-01 00:00:00

  • Interstitial cells of Cajal generate a rhythmic pacemaker current.

    abstract：:Networks of interstitial cells of Cajal embedded in the musculature of the gastrointestinal tract are involved in the generation of electrical pacemaker activity for gastrointestinal motility. This pacemaker activity manifests itself as rhythmic slow waves in membrane potential, and controls the frequency and propagat...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0798-848

    authors： Thomsen L,Robinson TL,Lee JC,Farraway LA,Hughes MJ,Andrews DW,Huizinga JD

    更新日期：1998-07-01 00:00:00

  • A novel chimeric antigen receptor containing a JAK-STAT signaling domain mediates superior antitumor effects.

    abstract：:The adoptive transfer of T cells engineered with a chimeric antigen receptor (CAR) (hereafter referred to as CAR-T cells) specific for the B lymphocyte antigen CD19 has shown impressive clinical responses in patients with refractory B cell malignancies. However, the therapeutic effects of CAR-T cells that target other...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.4478

    authors： Kagoya Y,Tanaka S,Guo T,Anczurowski M,Wang CH,Saso K,Butler MO,Minden MD,Hirano N

    更新日期：2018-03-01 00:00:00

  • NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages.

    abstract：:Altered metabolism has been implicated in the pathogenesis of inflammatory diseases. NADPH oxidase 4 (NOX4), a source of cellular superoxide anions, has multiple biological functions that may be of importance in inflammation and in the pathogenesis of human metabolic diseases, including diabetes. However, the mechanis...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.4153

    authors： Moon JS,Nakahira K,Chung KP,DeNicola GM,Koo MJ,Pabón MA,Rooney KT,Yoon JH,Ryter SW,Stout-Delgado H,Choi AM

    更新日期：2016-09-01 00:00:00

  • Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis.

    abstract：:Metastasis of breast cancer occurs primarily through the lymphatic system, and the extent of lymph node involvement is a key prognostic factor for the disease. Whereas the significance of angiogenesis for tumor progression has been well documented, the ability of tumor cells to induce the growth of lymphatic vessels (...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/84643

    authors： Skobe M,Hawighorst T,Jackson DG,Prevo R,Janes L,Velasco P,Riccardi L,Alitalo K,Claffey K,Detmar M

    更新日期：2001-02-01 00:00:00

  • Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy.

    abstract：:The cardiac response to increased work includes a reactivation of fetal genes. The response to a decrease in cardiac work is not known. Such information is of clinical interest, because mechanical unloading can improve the functional capacity of the failing heart. We compared here the patterns of gene expression in un...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/3253

    authors： Depre C,Shipley GL,Chen W,Han Q,Doenst T,Moore ML,Stepkowski S,Davies PJ,Taegtmeyer H

    更新日期：1998-11-01 00:00:00

  • Epigenetic modulation of the renal β-adrenergic-WNK4 pathway in salt-sensitive hypertension.

    abstract：:How high salt intake increases blood pressure is a key question in the study of hypertension. Salt intake induces increased renal sympathetic activity resulting in sodium retention. However, the mechanisms underlying the sympathetic control of renal sodium excretion remain unclear. In this study, we found that β(2)-ad...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.2337

    authors： Mu S,Shimosawa T,Ogura S,Wang H,Uetake Y,Kawakami-Mori F,Marumo T,Yatomi Y,Geller DS,Tanaka H,Fujita T

    更新日期：2011-05-01 00:00:00

  • Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells.

    abstract：:We studied the effects of Lyn ablation on the survival of drug-resistant chronic myelogenous leukemia (CML) blast crisis cells using siRNA. Lyn siRNA reduced Lyn protein in both normal hematopoietic cells and BCR-ABL1-expressing (BCR-ABL1(+)) blasts by 80-95%. Within 48 h, siRNA-treated BCR-ABL1(+) blasts underwent ap...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1127

    authors： Ptasznik A,Nakata Y,Kalota A,Emerson SG,Gewirtz AM

    更新日期：2004-11-01 00:00:00

  • The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress.

    abstract：:Autophagy, an evolutionarily conserved process for the bulk degradation of cytoplasmic components, serves as a cell survival mechanism in starving cells. Although altered autophagy has been observed in various heart diseases, including cardiac hypertrophy and heart failure, it remains unclear whether autophagy plays a...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1574

    authors： Nakai A,Yamaguchi O,Takeda T,Higuchi Y,Hikoso S,Taniike M,Omiya S,Mizote I,Matsumura Y,Asahi M,Nishida K,Hori M,Mizushima N,Otsu K

    更新日期：2007-05-01 00:00:00

  • Imaging 26S proteasome activity and inhibition in living mice.

    abstract：:The ubiquitin-proteasome pathway is the central mediator of regulated proteolysis in cells, and defects in this pathway are associated with cancer and neurodegenerative diseases. To assess 26S proteasome function in living animals, we developed a ubiquitin-luciferase reporter for bioluminescence imaging. The reporter ...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm894

    authors： Luker GD,Pica CM,Song J,Luker KE,Piwnica-Worms D

    更新日期：2003-07-01 00:00:00

  • Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure.

    abstract：:Some individuals remain uninfected with human immunodeficiency virus type-1 (HIV-1) despite multiple high-risk sexual exposures. We studied a cohort of 25 subjects with histories of multiple high-risk sexual exposures to HIV-1 and found that their CD8+ lymphocytes had greater anti-HIV-1 activity than did CD8+ lymphocy...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0496-412

    authors： Paxton WA,Martin SR,Tse D,O'Brien TR,Skurnick J,VanDevanter NL,Padian N,Braun JF,Kotler DP,Wolinsky SM,Koup RA

    更新日期：1996-04-01 00:00:00

  • On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver.

    abstract：:Iron is an essential component of the erythrocyte protein hemoglobin and is crucial to oxygen transport in vertebrates. In the steady state, erythrocyte production is in equilibrium with erythrocyte removal. In various pathophysiological conditions, however, erythrocyte life span is compromised severely, which threate...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.4146

    authors： Theurl I,Hilgendorf I,Nairz M,Tymoszuk P,Haschka D,Asshoff M,He S,Gerhardt LM,Holderried TA,Seifert M,Sopper S,Fenn AM,Anzai A,Rattik S,McAlpine C,Theurl M,Wieghofer P,Iwamoto Y,Weber GF,Harder NK,Chousterman BG,

    更新日期：2016-08-01 00:00:00

  • Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo.

    abstract：:Modest clinical outcomes of dendritic-cell (DC) vaccine trials call for the refinement of DC vaccine design. Although many potential antigens have been identified, development of methods to enhance antigen presentation by DCs has lagged. We have engineered a potent, drug-inducible CD40 (iCD40) receptor that permits te...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1183

    authors： Hanks BA,Jiang J,Singh RA,Song W,Barry M,Huls MH,Slawin KM,Spencer DM

    更新日期：2005-02-01 00:00:00

  • A chimeric human-cat fusion protein blocks cat-induced allergy.

    abstract：:Animal allergens are an important cause of asthma and allergic rhinitis. We designed and tested a chimeric human-cat fusion protein composed of a truncated human IgG Fcgamma1 and the major cat allergen Fel d1, as a proof of concept for a new approach to allergy immunotherapy. This Fcgamma-Fel d1 protein induced dose-d...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1219

    authors： Zhu D,Kepley CL,Zhang K,Terada T,Yamada T,Saxon A

    更新日期：2005-04-01 00:00:00

  • AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis.

    abstract：:An effective acquired immune response to infectious agents mediated by HLA-restricted T-cell recognition can target different stages of disease pathogenesis. We show here that three distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct intervals after HIV-1 infection. The discret...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1333

    authors： Gao X,Bashirova A,Iversen AK,Phair J,Goedert JJ,Buchbinder S,Hoots K,Vlahov D,Altfeld M,O'Brien SJ,Carrington M

    更新日期：2005-12-01 00:00:00

  • A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency.

    abstract：:The Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) is expressed in all KSHV-associated tumors, including Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). We found that beta-catenin is overexpressed in both PEL cells and KS tissue. Introduction of anti-LANA small inte...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm829

    authors： Fujimuro M,Wu FY,ApRhys C,Kajumbula H,Young DB,Hayward GS,Hayward SD

    更新日期：2003-03-01 00:00:00