Abstract:
:We studied the effects of Lyn ablation on the survival of drug-resistant chronic myelogenous leukemia (CML) blast crisis cells using siRNA. Lyn siRNA reduced Lyn protein in both normal hematopoietic cells and BCR-ABL1-expressing (BCR-ABL1(+)) blasts by 80-95%. Within 48 h, siRNA-treated BCR-ABL1(+) blasts underwent apoptosis, whereas normal cells remained viable. This increased dependence on Lyn signaling for BCR-ABL1(+) blast survival provides the basis for rational treatment of drug-resistant CML blast crisis, particularly when lymphoid in nature.
journal_name
Nat Medjournal_title
Nature medicineauthors
Ptasznik A,Nakata Y,Kalota A,Emerson SG,Gewirtz AMdoi
10.1038/nm1127keywords:
subject
Has Abstractpub_date
2004-11-01 00:00:00pages
1187-9issue
11eissn
1078-8956issn
1546-170Xpii
nm1127journal_volume
10pub_type
杂志文章相关文献
NATURE MEDICINE文献大全abstract::Transforming growth factor beta 1 (TGF-beta 1) is a platelet-derived cytokine involved in both normal wound healing and scarring. We show that human platelets contain two pools of latent TGF-beta 1, which constitute more than 95% of the total TGF-beta assayed in whole platelets. During clotting, one pool, the large la...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0995-932
更新日期:1995-09-01 00:00:00
abstract::Genetic alterations in malignant tissues are potential targets for gene-based cancer therapies. Alternatively, aberrant expression of certain specific genes associated with malignant transformation may be envisioned to enhance the expression of chemosensitizing drugs. Epstein-Barr virus (EBV)-related B-cell lymphomas ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1296-1379
更新日期:1996-12-01 00:00:00
abstract::In the version of this article originally published, an author was missing from the author list. Alexander J. Lazar should have been included between Jorge M. Blando and James P. Allison. The author has been added to the list, and the author contributions section has been updated to include Alexander J. Lazar's contri...
journal_title:Nature medicine
pub_type: 已发布勘误
doi:10.1038/s41591-018-0305-2
更新日期:2019-01-01 00:00:00
abstract::The use of genetically manipulated mouse models, gene and protein discovery and the cataloguing of genetic mutations have each allowed us to obtain new insights into skeletal morphogenesis and remodeling. These techniques have made it possible to identify molecules that are obligatory for specific cellular functions, ...
journal_title:Nature medicine
pub_type: 杂志文章,评审
doi:10.1038/nm1593
更新日期:2007-07-01 00:00:00
abstract::In the version of this article originally published, there was an error in Fig. 2b. RECIST ORR and pCR were both listed as 25%. RECIST ORR was actually 73%, and pCR was 45%. Also, an author's name was incorrect in the author list. Danny K. Wells should have been listed as Daniel K. Wells. The errors have been correcte...
journal_title:Nature medicine
pub_type: 已发布勘误
doi:10.1038/s41591-018-0251-z
更新日期:2018-12-01 00:00:00
abstract::Defects in major histocompatibility complex (MHC) class I-restricted antigen presentation are frequently observed in human cancers and result in escape of tumors from cytotoxic T lymphocyte (CTL) immune surveillance in mice. Here, we show the existence of a unique category of CTLs that can prevent this escape. The CTL...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1381
更新日期:2006-04-01 00:00:00
abstract::The ability to patent human genes has been costly to researchers and patients, and has restricted competition in the biotech marketplace. The recent US Supreme Court decision making isolated human genes unpatentable will bring freedom of choice to the patient, and level the playing field for research and development. ...
journal_title:Nature medicine
pub_type: 社论
doi:10.1038/nm.3279
更新日期:2013-07-01 00:00:00
abstract::Infections are thought to be important in the pathogenesis of many heart diseases. Coxsackievirus B3 (CVB3) has been linked to chronic dilated cardiomyopathy, a common cause of progressive heart disease, heart failure and sudden death. We show here that the sarcoma (Src) family kinase Lck (p56lck) is required for effi...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/74689
更新日期:2000-04-01 00:00:00
abstract:: ...
journal_title:Nature medicine
pub_type: 评论,杂志文章
doi:10.1038/s41591-018-0286-1
更新日期:2018-12-01 00:00:00
abstract::Although prognostic gene expression signatures for survival in early-stage lung cancer have been proposed, for clinical application, it is critical to establish their performance across different subject populations and in different laboratories. Here we report a large, training-testing, multi-site, blinded validation...
journal_title:Nature medicine
pub_type: 杂志文章,多中心研究
doi:10.1038/nm.1790
更新日期:2008-08-01 00:00:00
abstract::CD4(+) T cells that express the forkhead box P3 (FOXP3) transcription factor function as regulatory T (Treg) cells and hinder effective immune responses against cancer cells. Abundant Treg cell infiltration into tumors is associated with poor clinical outcomes in various types of cancers. However, the role of Treg cel...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.4086
更新日期:2016-06-01 00:00:00
abstract::Metastasis of breast cancer occurs primarily through the lymphatic system, and the extent of lymph node involvement is a key prognostic factor for the disease. Whereas the significance of angiogenesis for tumor progression has been well documented, the ability of tumor cells to induce the growth of lymphatic vessels (...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/84643
更新日期:2001-02-01 00:00:00
abstract::Hepatic injury is associated with a defective intestinal barrier and increased hepatic exposure to bacterial products. Here we report that the intestinal bacterial microflora and a functional Toll-like receptor 4 (TLR4), but not TLR2, are required for hepatic fibrogenesis. Using Tlr4-chimeric mice and in vivo lipopoly...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1663
更新日期:2007-11-01 00:00:00
abstract::Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutrition...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.4280
更新日期:2017-03-01 00:00:00
abstract::Mice carrying mutations in both the dystrophin and utrophin genes die prematurely as a consequence of severe muscular dystrophy. Here, we show that intravascular administration of recombinant adeno-associated viral (rAAV) vectors carrying a microdystrophin gene restores expression of dystrophin in the respiratory, car...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1439
更新日期:2006-07-01 00:00:00
abstract::Osteopontin (Opn) is important for T helper type 1 (T(H)1) immunity and autoimmunity. However, the role of this cytokine in T(H)2-mediated allergic disease as well as its effects on primary versus secondary antigenic encounters remain unclear. Here we demonstrate that OPN is expressed in the lungs of asthmatic individ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1580
更新日期:2007-05-01 00:00:00
abstract::Inflammation may underlie the metabolic disorders of insulin resistance and type 2 diabetes. IkappaB kinase beta (IKK-beta, encoded by Ikbkb) is a central coordinator of inflammatory responses through activation of NF-kappaB. To understand the role of IKK-beta in insulin resistance, we used mice lacking this enzyme in...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1185
更新日期:2005-02-01 00:00:00
abstract::Unlike normal melanocytes, primary and metastatic human melanomas express high levels of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) messenger RNA, and expression of these genes is essential in sustaining the proliferation of malignant melanomas in vitro. To determine whether...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0897-887
更新日期:1997-08-01 00:00:00
abstract::Most of what we know about adaptive immunity has come from inbred mouse studies, using methods that are often difficult or impossible to confirm in humans. In addition, vaccine responses in mice are often poorly predictive of responses to those same vaccines in humans. Here we use human tonsils, readily available lymp...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-01145-0
更新日期:2021-01-01 00:00:00
abstract::Increased production of very low-density lipoprotein (VLDL) is a critical feature of the metabolic syndrome. Here we report that a selective increase in brain glucose lowered circulating triglycerides (TG) through the inhibition of TG-VLDL secretion by the liver. We found that the effect of glucose required its conver...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1540
更新日期:2007-02-01 00:00:00
abstract::Brown adipose tissue (BAT) promotes a lean and healthy phenotype and improves insulin sensitivity. In response to cold or exercise, brown fat cells also emerge in the white adipose tissue (WAT; also known as beige cells), a process known as browning. Here we show that the development of functional beige fat in the ing...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.3994
更新日期:2015-12-01 00:00:00
abstract::A high-fat diet increases the risk of colon, breast and prostate cancer. The molecular mechanism by which dietary lipids promote tumorigenesis is unknown. Their effects may be mediated at least in part by the peroxisome proliferator-activated receptors (PPARs). These ligand-activated nuclear receptors modulate gene ex...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/2042
更新日期:1998-09-01 00:00:00
abstract::Chondrocyte hypertrophy followed by cartilage matrix degradation and vascular invasion, characterized by expression of type X collagen (COL10A1), matrix metalloproteinase-13 (MMP-13) and vascular endothelial growth factor (VEGF), respectively, are central steps of endochondral ossification during normal skeletal growt...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.2146
更新日期:2010-06-01 00:00:00
abstract::Much has been written about the advantages and disadvantages of various oncology model systems, with the overall finding that these models lack the predictive power required to translate preclinical efficacy into clinical activity. Despite assertions that some preclinical model systems are superior to others, no singl...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.3853
更新日期:2015-05-01 00:00:00
abstract::Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) that compromise its chloride channel activity. The most common mutation, p.Phe508del, results in the production of a misfolded CFTR protein, which has residual channel activity but is prematu...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.4305
更新日期:2017-05-01 00:00:00
abstract::Whereas uncoupling protein 1 (UCP-1) is clearly involved in thermogenesis, the role of UCP-2 is less clear. Using hybridization, cloning techniques and cDNA array analysis to identify inducible neuroprotective genes, we found that neuronal survival correlates with increased expression of Ucp2. In mice overexpressing h...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm903
更新日期:2003-08-01 00:00:00
abstract::Restriction factors are host cell proteins that inhibit retroviral infection. A new study using mutants of human HIV-1 restriction factor SAMHD1 suggests that it inhibits infection through degradation of viral RNA rather than through its dNTPase activity as previously suggested. ...
journal_title:Nature medicine
pub_type: 评论,杂志文章
doi:10.1038/nm.3657
更新日期:2014-08-01 00:00:00
abstract::We have studied the effects of amyloid beta-peptide analogues on the activity of tissue-type plasminogen activator (t-PA) in vitro. We have found that these peptides have a marked stimulatory effect upon plasminogen activation by t-PA, comparable to that of known stimulators of t-PA. This stimulatory activity appears ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0295-138
更新日期:1995-02-01 00:00:00
abstract::Movement towards or away from a given stimulus guides the directional migration of prokaryotes, simple eukaryotes and neurons. As bi-directional cues may influence entry and exit of immune effector cells from tissue sites, we evaluated the migratory responses of T-cell subsets to varying concentrations of the chemokin...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/75022
更新日期:2000-05-01 00:00:00
abstract::Huntington's disease is caused by an expanded polyglutamine repeat in the huntingtin protein (HTT), but the pathophysiological sequence of events that trigger synaptic failure and neuronal loss are not fully understood. Alterations in N-methyl-D-aspartate (NMDA)-type glutamate receptors (NMDARs) have been implicated. ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.3246
更新日期:2013-08-01 00:00:00