CD8+ T cell efficacy in vaccination and disease.

abstract：:Technologies are needed to map and image biological barriers in vivo that limit solid tumor delivery and, ultimately, the effectiveness of imaging and therapeutic agents. Here we integrate proteomic and imaging analyses of caveolae at the blood-tumor interface to discover an active transendothelial portal to infiltrat...

journal_title：Nature medicine

authors： Oh P,Testa JE,Borgstrom P,Witkiewicz H,Li Y,Schnitzer JE

更新日期：2014-09-01 00:00:00

abstract：:Phase 3 trials are the mainstay of drug development across medicine but have often not met expectations set by preceding phase 2 studies. A systematic meta-analysis evaluated all randomized controlled, double-blind trials investigating targeted disease-modifying anti-rheumatic drugs in rheumatoid and psoriatic arthrit...

journal_title：Nature medicine

authors： Kerschbaumer A,Smolen JS,Herkner H,Stefanova T,Chwala E,Aletaha D

更新日期：2020-06-01 00:00:00

abstract：:The principles that govern the evolution of tumors exposed to targeted therapy are poorly understood. Here we modeled the selection and propagation of an amplification in the BRAF oncogene (BRAFamp) in patient-derived tumor xenografts (PDXs) that were treated with a direct inhibitor of the kinase ERK, either alone or ...

journal_title：Nature medicine

authors： Xue Y,Martelotto L,Baslan T,Vides A,Solomon M,Mai TT,Chaudhary N,Riely GJ,Li BT,Scott K,Cechhi F,Stierner U,Chadalavada K,de Stanchina E,Schwartz S,Hembrough T,Nanjangud G,Berger MF,Nilsson J,Lowe SW,Reis-Filho JS

更新日期：2017-08-01 00:00:00

abstract：:The skin-associated chemokine CCL27 (also called CTACK, ALP and ESkine) and its receptor CCR10 (GPR-2) mediate chemotactic responses of skin-homing T cells in vitro. Here we report that most skin-infiltrating lymphocytes in patients suffering from psoriasis, atopic or allergic-contact dermatitis express CCR10. Epiderm...

journal_title：Nature medicine

authors： Homey B,Alenius H,Müller A,Soto H,Bowman EP,Yuan W,McEvoy L,Lauerma AI,Assmann T,Bünemann E,Lehto M,Wolff H,Yen D,Marxhausen H,To W,Sedgwick J,Ruzicka T,Lehmann P,Zlotnik A

更新日期：2002-02-01 00:00:00

abstract：:The acceleration of atherosclerosis by polygenic (essential) hypertension is well-characterized in humans; however, the lack of an animal model that simulates human disease hinders the elucidation of pathogenic mechanisms. We report here a transgenic atherosclerosis-polygenic hypertension model in Dahl salt-sensitive ...

journal_title：Nature medicine

authors： Herrera VL,Makrides SC,Xie HX,Adari H,Krauss RM,Ryan US,Ruiz-Opazo N

更新日期：1999-12-01 00:00:00

abstract：:Retinal neovascularization is a major cause of blindness in such disorders as retinopathy of prematurity, proliferative diabetic retinopathy and senile macular degeneration. Because ligation of vitronectin receptor-type integrins appears to be required for the survival and maturation of newly formed but not quiescent ...

journal_title：Nature medicine

authors： Hammes HP,Brownlee M,Jonczyk A,Sutter A,Preissner KT

更新日期：1996-05-01 00:00:00

abstract：:Lung cancer is the leading cause of death from cancer in the US and the world. The high mortality rate (80-85% within 5 years) results, in part, from a lack of effective tools to diagnose the disease at an early stage. Given that cigarette smoke creates a field of injury throughout the airway, we sought to determine i...

journal_title：Nature medicine

authors： Spira A,Beane JE,Shah V,Steiling K,Liu G,Schembri F,Gilman S,Dumas YM,Calner P,Sebastiani P,Sridhar S,Beamis J,Lamb C,Anderson T,Gerry N,Keane J,Lenburg ME,Brody JS

更新日期：2007-03-01 00:00:00

abstract：:Use of wearable devices that monitor physical activity is projected to increase more than fivefold per half-decade1. We investigated how device-based physical activity energy expenditure (PAEE) and different intensity profiles were associated with all-cause mortality. We used a network harmonization approach to map do...

journal_title：Nature medicine

authors： Strain T,Wijndaele K,Dempsey PC,Sharp SJ,Pearce M,Jeon J,Lindsay T,Wareham N,Brage S

更新日期：2020-09-01 00:00:00

abstract：:Understanding the pathophysiology of SARS-CoV-2 infection is critical for therapeutic and public health strategies. Viral-host interactions can guide discovery of disease regulators, and protein structure function analysis points to several immune pathways, including complement and coagulation, as targets of coronavir...

journal_title：Nature medicine

authors： Ramlall V,Thangaraj PM,Meydan C,Foox J,Butler D,Kim J,May B,De Freitas JK,Glicksberg BS,Mason CE,Tatonetti NP,Shapira SD

更新日期：2020-10-01 00:00:00

abstract：:The cycle of gallbladder filling and emptying controls the flow of bile into the intestine for digestion. Here we show that fibroblast growth factor-15, a hormone made by the distal small intestine in response to bile acids, is required for gallbladder filling. These studies demonstrate that gallbladder filling is act...

journal_title：Nature medicine

authors： Choi M,Moschetta A,Bookout AL,Peng L,Umetani M,Holmstrom SR,Suino-Powell K,Xu HE,Richardson JA,Gerard RD,Mangelsdorf DJ,Kliewer SA

更新日期：2006-11-01 00:00:00

abstract：:We report the involvement of an evolutionarily conserved set of mycobacterial genes, the esx-3 region, in evasion of bacterial killing by innate immunity. Whereas high-dose intravenous infections of mice with the rapidly growing mycobacterial species Mycobacterium smegmatis bearing an intact esx-3 locus were rapidly l...

journal_title：Nature medicine

authors： Sweeney KA,Dao DN,Goldberg MF,Hsu T,Venkataswamy MM,Henao-Tamayo M,Ordway D,Sellers RS,Jain P,Chen B,Chen M,Kim J,Lukose R,Chan J,Orme IM,Porcelli SA,Jacobs WR Jr

更新日期：2011-09-04 00:00:00

abstract：:One hallmark of Alzheimer disease is the accumulation of amyloid beta-peptide in the brain and its deposition as plaques. Mice transgenic for an amyloid beta precursor protein (APP) mini-gene driven by a platelet-derived (PD) growth factor promoter (PDAPP mice), which overexpress one of the disease-linked mutant forms...

journal_title：Nature medicine

authors： Bard F,Cannon C,Barbour R,Burke RL,Games D,Grajeda H,Guido T,Hu K,Huang J,Johnson-Wood K,Khan K,Kholodenko D,Lee M,Lieberburg I,Motter R,Nguyen M,Soriano F,Vasquez N,Weiss K,Welch B,Seubert P,Schenk D,Yednock

更新日期：2000-08-01 00:00:00

abstract：:Evolutionary patterns of virus replication and distribution in lymphoid tissue during the early phases of HIV infection have not been delineated. Lymph node (LN) biopsies were excised from patients at different times after the estimated time of primary infection. Within 3 months of the acute viral syndrome, HIV was mo...

journal_title：Nature medicine

authors： Pantaleo G,Cohen OJ,Schacker T,Vaccarezza M,Graziosi C,Rizzardi GP,Kahn J,Fox CH,Schnittman SM,Schwartz DH,Corey L,Fauci AS

更新日期：1998-03-01 00:00:00

abstract：:Noninvasive methods are needed to study the kinetic properties of viruses in living organisms. Oncolytic viruses are used increasingly for cancer therapy but there is currently no satisfactory way to measure efficiency of tumor transduction, changing levels of viral gene expression or the timing of virus elimination. ...

journal_title：Nature medicine

authors： Peng KW,Facteau S,Wegman T,O'Kane D,Russell SJ

更新日期：2002-05-01 00:00:00

abstract：:The mechanisms that regulate hematopoietic stem cell (HSC) regeneration after myelosuppressive injury are not well understood. We identified epidermal growth factor (EGF) to be highly enriched in the bone marrow serum of mice bearing deletion of Bak and Bax in TIE2-expressing cells in Tie2Cre; Bak1(-/-); Bax(flox/-) m...

journal_title：Nature medicine

authors： Doan PL,Himburg HA,Helms K,Russell JL,Fixsen E,Quarmyne M,Harris JR,Deoliviera D,Sullivan JM,Chao NJ,Kirsch DG,Chute JP

更新日期：2013-03-01 00:00:00

abstract：:Molecular targeted therapy has the potential to dramatically improve survival in patients with cancer. However, complete and durable responses to targeted therapy are rare in individuals with advanced-stage solid cancers. Even the most effective targeted therapies generally do not induce a complete tumor response, res...

journal_title：Nature medicine

authors： Bivona TG,Doebele RC

更新日期：2016-05-05 00:00:00

abstract：:Efforts to identify and annotate cancer driver genetic lesions have been focused primarily on the analysis of protein-coding genes; however, most genetic abnormalities found in human cancer are located in intergenic regions. Here we identify a new long range-acting MYC enhancer controlled by NOTCH1 that is targeted by...

journal_title：Nature medicine

authors： Herranz D,Ambesi-Impiombato A,Palomero T,Schnell SA,Belver L,Wendorff AA,Xu L,Castillo-Martin M,Llobet-Navás D,Cordon-Cardo C,Clappier E,Soulier J,Ferrando AA

更新日期：2014-10-01 00:00:00

abstract：:Members of the suppressor of cytokine signaling (SOCS) family are involved in the pathogenesis of many inflammatory diseases. SOCS-3 is predominantly expressed in T-helper type 2 (T(H)2) cells, but its role in T(H)2-related allergic diseases remains to be investigated. In this study we provide a strong correlation bet...

journal_title：Nature medicine

authors： Seki Y,Inoue H,Nagata N,Hayashi K,Fukuyama S,Matsumoto K,Komine O,Hamano S,Himeno K,Inagaki-Ohara K,Cacalano N,O'Garra A,Oshida T,Saito H,Johnston JA,Yoshimura A,Kubo M

更新日期：2003-08-01 00:00:00

abstract：:Surgery or radiation therapy of metastatic cancer often damages lymph nodes, leading to secondary lymphedema. Here we show, using a newly established mouse model, that collecting lymphatic vessels can be regenerated and fused to lymph node transplants after lymph node removal. Treatment of lymph node-excised mice with...

journal_title：Nature medicine

authors： Tammela T,Saaristo A,Holopainen T,Lyytikkä J,Kotronen A,Pitkonen M,Abo-Ramadan U,Ylä-Herttuala S,Petrova TV,Alitalo K

更新日期：2007-12-01 00:00:00

abstract：:Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutrition...

journal_title：Nature medicine

authors： Zee T,Bose N,Zee J,Beck JN,Yang S,Parihar J,Yang M,Damodar S,Hall D,O'Leary MN,Ramanathan A,Gerona RR,Killilea DW,Chi T,Tischfield J,Sahota A,Kahn A,Stoller ML,Kapahi P

更新日期：2017-03-01 00:00:00

abstract：:Dendritic cells, the most potent antigen-presenting cells, need to be activated before they can function to initiate an immune response. We report here that, in the absence of any foreign substances, dendritic cells can be activated by endogenous signals received from cells that are stressed, virally infected or kille...

journal_title：Nature medicine

authors： Gallucci S,Lolkema M,Matzinger P

更新日期：1999-11-01 00:00:00

abstract：:We show that the fraction of proliferating CD4+ lymphocytes is similar in HIV-infected subjects in the early stage of disease and in HIV-negative subjects, whereas the fraction of proliferating CD8+ lymphocytes is increased 6.8-fold in HIV-infected subjects. After initiation of antiviral therapy, there is a late incre...

journal_title：Nature medicine

authors： Fleury S,de Boer RJ,Rizzardi GP,Wolthers KC,Otto SA,Welbon CC,Graziosi C,Knabenhans C,Soudeyns H,Bart PA,Gallant S,Corpataux JM,Gillet M,Meylan P,Schnyder P,Meuwly JY,Spreen W,Glauser MP,Miedema F,Pantaleo G

更新日期：1998-07-01 00:00:00

abstract：:We previously demonstrated that low biosynthesis of ω-3 fatty acid-derived proresolution mediators, termed protectins, is associated with an impaired global resolution capacity, inflammation and insulin resistance in obese high-fat diet-fed mice. These findings prompted a more direct study of the therapeutic potential...

journal_title：Nature medicine

authors： White PJ,St-Pierre P,Charbonneau A,Mitchell PL,St-Amand E,Marcotte B,Marette A

更新日期：2014-06-01 00:00:00

abstract：:Metastasis of breast cancer occurs primarily through the lymphatic system, and the extent of lymph node involvement is a key prognostic factor for the disease. Whereas the significance of angiogenesis for tumor progression has been well documented, the ability of tumor cells to induce the growth of lymphatic vessels (...

journal_title：Nature medicine

authors： Skobe M,Hawighorst T,Jackson DG,Prevo R,Janes L,Velasco P,Riccardi L,Alitalo K,Claffey K,Detmar M

更新日期：2001-02-01 00:00:00

abstract：:How should clinical trials be improved? Ken Getz, a senior fellow at the Tufts Center for the Study of Drug Development, has been thinking up answers to this question for two decades. In 2003, Getz took on a new challenge when he launched the Center for Information & Study on Clinical Research, a nonprofit focused on ...

journal_title：Nature medicine

authors： Getz K

更新日期：2010-02-01 00:00:00

abstract：:The mechanism underlying the autoimmune polyglandular syndrome type-1 (APS1) has been attributed to defective T-cell negative selection resulting from reduced expression and presentation of autoantigens in thymic medullary epithelial cells (MECs). It has also been postulated that Aire is involved in development of reg...

journal_title：Nature medicine

authors： Mi QS,Deng ZB,Joshi SK,Wang ZZ,Zhou L,Eckenrode S,Joshi R,Ly D,Yi B,Delovitch TL,She JX

更新日期：2006-06-01 00:00:00

abstract：:Adequate lipid secretion by mammary glands during lactation is essential for the survival of mammalian offspring. However, the mechanism governing this process is poorly understood. Here we show that Cidea is expressed at high levels in lactating mammary glands and its deficiency leads to premature pup death as a resu...

journal_title：Nature medicine

authors： Wang W,Lv N,Zhang S,Shui G,Qian H,Zhang J,Chen Y,Ye J,Xie Y,Shen Y,Wenk MR,Li P

更新日期：2012-01-15 00:00:00

abstract：:Neutrophil extracellular traps (NETs) are released as neutrophils die in vitro in a process requiring hours, leaving a temporal gap that invasive microbes may exploit. Neutrophils capable of migration and phagocytosis while undergoing NETosis have not been documented. During Gram-positive skin infections, we directly ...

journal_title：Nature medicine

authors： Yipp BG,Petri B,Salina D,Jenne CN,Scott BN,Zbytnuik LD,Pittman K,Asaduzzaman M,Wu K,Meijndert HC,Malawista SE,de Boisfleury Chevance A,Zhang K,Conly J,Kubes P

更新日期：2012-09-01 00:00:00

abstract：:Activation of the zinc-finger transcription factor early growth response (Egr)-1, initially linked to developmental processes, is shown here to function as a master switch activated by ischemia to trigger expression of pivotal regulators of inflammation, coagulation and vascular hyperpermeability. Chemokine, adhesion ...

journal_title：Nature medicine

authors： Yan SF,Fujita T,Lu J,Okada K,Shan Zou Y,Mackman N,Pinsky DJ,Stern DM

更新日期：2000-12-01 00:00:00

abstract：:Chlamydia trachomatis is the leading cause worldwide of preventable infectious blindness (trachoma) and sexually transmitted disease, including nongonoccocal urethritis and pelvic inflammatory disease. To date, no effective vaccine against C. trachomatis infection has been identified. A monoclonal anti-idiotypic antib...

journal_title：Nature medicine

authors： Whittum-Hudson JA,An LL,Saltzman WM,Prendergast RA,MacDonald AB

更新日期：1996-10-01 00:00:00