当前位置： SCI文献检索 > NATURE MEDICINE期刊下所有文献 > Decreased expression of AMPA receptor messenger RNA and protein in AIDS: a model for HIV-associated neurotoxicity.

Decreased expression of AMPA receptor messenger RNA and protein in AIDS: a model for HIV-associated neurotoxicity.

Abstract：

:HIV infection can cause extensive neuronal loss and clinically a severe dementia. The cause of the neurotoxicity remains unclear as neurons are not infected, but disturbance of glutamate-linked calcium entry has been implicated. In this study, we have shown a decrease in HIV-infected brain of the expression of mRNA and protein of the GluR-A flop subtype of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) glutamate receptor in cerebellar Purkinje cells. Although Purkinje cells are relatively resistant to loss, the observed disturbance of AMPA receptors may contribute to the neurotoxic process in other vulnerable brain regions and clinically to the development of dementia.

journal_name

Nat Med

journal_title

Nature medicine

authors

Everall IP,Hudson L,al-Sarraj S,Honavar M,Lantos P,Kerwin R

doi

10.1038/nm1195-1174

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

1174-8

issue

11

eissn

1078-8956

issn

1546-170X

journal_volume

1

pub_type

杂志文章

相关文献

NATURE MEDICINE文献大全
  • Under pressure: the search for the essential mechanisms of hypertension.

    abstract：:High blood pressure, or hypertension, is a very common disorder with a substantial impact on public health because of its associated complications. Despite the high prevalence of essential hypertension and years of research, the basic causes remain obscure. Here I review recent advances in understanding the pathophysi...

    journal_title：Nature medicine

    pub_type： 杂志文章,评审

    doi：10.1038/nm.2541

    authors： Coffman TM

    更新日期：2011-11-07 00:00:00

  • Marked amelioration of established collagen-induced arthritis by treatment with antibodies to CD23 in vivo.

    abstract：:CD23 is a low-affinity receptor for immunoglobulin E (IgE) expressed by a variety of haematopoietic cells. Proteolytic cleavage of the transmembrane receptor generates soluble forms, which can be detected in biological fluids. CD23 regulates many functional aspects of immune cells, both in its cell-associated and solu...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0895-781

    authors： Plater-Zyberk C,Bonnefoy JY

    更新日期：1995-08-01 00:00:00

  • A novel chimeric antigen receptor containing a JAK-STAT signaling domain mediates superior antitumor effects.

    abstract：:The adoptive transfer of T cells engineered with a chimeric antigen receptor (CAR) (hereafter referred to as CAR-T cells) specific for the B lymphocyte antigen CD19 has shown impressive clinical responses in patients with refractory B cell malignancies. However, the therapeutic effects of CAR-T cells that target other...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.4478

    authors： Kagoya Y,Tanaka S,Guo T,Anczurowski M,Wang CH,Saso K,Butler MO,Minden MD,Hirano N

    更新日期：2018-03-01 00:00:00

  • Oral immunization with an anti-idiotypic antibody to the exoglycolipid antigen protects against experimental Chlamydia trachomatis infection.

    abstract：:Chlamydia trachomatis is the leading cause worldwide of preventable infectious blindness (trachoma) and sexually transmitted disease, including nongonoccocal urethritis and pelvic inflammatory disease. To date, no effective vaccine against C. trachomatis infection has been identified. A monoclonal anti-idiotypic antib...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1096-1116

    authors： Whittum-Hudson JA,An LL,Saltzman WM,Prendergast RA,MacDonald AB

    更新日期：1996-10-01 00:00:00

  • Age and generational patterns of overdose death risk from opioids and other drugs.

    abstract：:The ongoing substance misuse epidemic in the United States is complex and dynamic and should be approached as such in the development and evaluation of policy1. Drug overdose deaths (largely attributable to opioid misuse) in the United States have grown exponentially for almost four decades, but the mechanisms of this...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/s41591-020-0855-y

    authors： Jalal H,Buchanich JM,Sinclair DR,Roberts MS,Burke DS

    更新日期：2020-05-01 00:00:00

  • Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma.

    abstract：:Targeting EGFR is a validated approach in the treatment of squamous-cell cancers (SCCs), although there are no established biomarkers for predicting response. We have identified a synonymous mutation in EGFR, c.2361G>A (encoding p.Gln787Gln), in two patients with head and neck SCC (HNSCC) who were exceptional responde...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.4401

    authors： Tan DSW,Chong FT,Leong HS,Toh SY,Lau DP,Kwang XL,Zhang X,Sundaram GM,Tan GS,Chang MM,Chua BT,Lim WT,Tan EH,Ang MK,Lim TKH,Sampath P,Chowbay B,Skanderup AJ,DasGupta R,Iyer NG

    更新日期：2017-10-01 00:00:00

  • Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial.

    abstract：:Preoperative immunotherapy with anti-PD1 plus anti-CTLA4 antibodies has shown remarkable pathological responses in melanoma1 and colorectal cancer2. In NABUCCO (ClinicalTrials.gov: NCT03387761 ), a single-arm feasibility trial, 24 patients with stage III urothelial cancer (UC) received two doses of ipilimumab and two ...

    journal_title：Nature medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1038/s41591-020-1085-z

    authors： van Dijk N,Gil-Jimenez A,Silina K,Hendricksen K,Smit LA,de Feijter JM,van Montfoort ML,van Rooijen C,Peters D,Broeks A,van der Poel HG,Bruining A,Lubeck Y,Sikorska K,Boellaard TN,Kvistborg P,Vis DJ,Hooijberg E,Schumac

    更新日期：2020-12-01 00:00:00

  • Reversion of CTL escape-variant immunodeficiency viruses in vivo.

    abstract：:Engendering cytotoxic T-lymphocyte (CTL) responses is likely to be an important goal of HIV vaccines. However, CTLs select for viral variants that escape immune detection. Maintenance of such escape variants in human populations could pose an obstacle to HIV vaccine development. We first observed that escape mutations...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm998

    authors： Friedrich TC,Dodds EJ,Yant LJ,Vojnov L,Rudersdorf R,Cullen C,Evans DT,Desrosiers RC,Mothé BR,Sidney J,Sette A,Kunstman K,Wolinsky S,Piatak M,Lifson J,Hughes AL,Wilson N,O'Connor DH,Watkins DI

    更新日期：2004-03-01 00:00:00

  • G-CSF induces E-selectin ligand expression on human myeloid cells.

    abstract：:Clinical use of G-CSF can result in vascular and inflammatory complications. To investigate the molecular basis of these effects, we analyzed the adherence of G-CSF-mobilized human peripheral blood leukocytes (ML) to inflamed (TNF-alpha-stimulated) vascular endothelium. Studies using parallel plate assays under physio...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1470

    authors： Dagia NM,Gadhoum SZ,Knoblauch CA,Spencer JA,Zamiri P,Lin CP,Sackstein R

    更新日期：2006-10-01 00:00:00

  • Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity.

    abstract：:A variable region gene of the T-cell receptor, V beta 8.2, is rearranged, and its product is expressed on pathogenic T cells that induce experimental autoimmune encephalomyelitis (EAE) in H-2u mice after immunization with myelin basic protein (MBP). Vaccination of these mice with naked DNA encoding V beta 8.2 protecte...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0896-899

    authors： Waisman A,Ruiz PJ,Hirschberg DL,Gelman A,Oksenberg JR,Brocke S,Mor F,Cohen IR,Steinman L

    更新日期：1996-08-01 00:00:00

  • Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus.

    abstract：:Hepatic insulin resistance is a driving force in the pathogenesis of type 2 diabetes mellitus (T2DM) and is tightly coupled with excessive storage of fat and the ensuing inflammation within the liver. There is compelling evidence that activation of the transcription factor nuclear factor-κB (NF-κB) and downstream infl...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.3084

    authors： Kiechl S,Wittmann J,Giaccari A,Knoflach M,Willeit P,Bozec A,Moschen AR,Muscogiuri G,Sorice GP,Kireva T,Summerer M,Wirtz S,Luther J,Mielenz D,Billmeier U,Egger G,Mayr A,Oberhollenzer F,Kronenberg F,Orthofer M,Penni

    更新日期：2013-03-01 00:00:00

  • Author Correction: Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis.

    abstract：:In the version of this article originally published, an author was missing from the author list. Alexander J. Lazar should have been included between Jorge M. Blando and James P. Allison. The author has been added to the list, and the author contributions section has been updated to include Alexander J. Lazar's contri...

    journal_title：Nature medicine

    pub_type： 已发布勘误

    doi：10.1038/s41591-018-0305-2

    authors： Wang Y,Wiesnoski DH,Helmink BA,Gopalakrishnan V,Choi K,DuPont HL,Jiang ZD,Abu-Sbeih H,Sanchez CA,Chang CC,Parra ER,Francisco-Cruz A,Raju GS,Stroehlein JR,Campbell MT,Gao J,Subudhi SK,Maru DM,Blando JM,Lazar AJ,All

    更新日期：2019-01-01 00:00:00

  • Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance.

    abstract：:Oral administration of protein can induce antigen-specific immune hyporesponsiveness. However, the utility of oral tolerance to autoantigens in the treatment of autoimmune diseases may be limited when candidate autoantigens cannot be produced by conventional systems in quantities sufficient for clinical studies. Plant...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0797-793

    authors： Ma SW,Zhao DL,Yin ZQ,Mukherjee R,Singh B,Qin HY,Stiller CR,Jevnikar AM

    更新日期：1997-07-01 00:00:00

  • Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity.

    abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapy for hematological malignancies. However, graft-versus-host disease (GVHD) and relapse after allo-HSCT remain major impediments to the success of allo-HSCT. Chimeric antigen receptors (CARs) direct tumor cell recognition of...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.4258

    authors： Ghosh A,Smith M,James SE,Davila ML,Velardi E,Argyropoulos KV,Gunset G,Perna F,Kreines FM,Levy ER,Lieberman S,Jay HV,Tuckett AZ,Zakrzewski JL,Tan L,Young LF,Takvorian K,Dudakov JA,Jenq RR,Hanash AM,Motta AC,Murph

    更新日期：2017-02-01 00:00:00

  • Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension.

    abstract：:Pulmonary hypertension (PH) is characterized by increased proliferation and apoptosis resistance of pulmonary artery smooth muscle cells (PASMCs). Forkhead box O (FoxO) transcription factors are key regulators of cellular proliferation. Here we show that in pulmonary vessels and PASMCs of human and experimental PH lun...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.3695

    authors： Savai R,Al-Tamari HM,Sedding D,Kojonazarov B,Muecke C,Teske R,Capecchi MR,Weissmann N,Grimminger F,Seeger W,Schermuly RT,Pullamsetti SS

    更新日期：2014-11-01 00:00:00

  • Requirement for CD154 in the progression of atherosclerosis.

    abstract：:Atherosclerosis is a systemic disease of the large arteries, and activation of inflammatory pathways is important in its pathogenesis. Increasing evidence supports the importance of CD40-CD154 interactions in atherosclerosis, interactions originally known to be essential in major immune reactions and autoimmune diseas...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/15271

    authors： Lutgens E,Gorelik L,Daemen MJ,de Muinck ED,Grewal IS,Koteliansky VE,Flavell RA

    更新日期：1999-11-01 00:00:00

  • Functional genomics of Neisseria meningitidis pathogenesis.

    abstract：:The pathogenic bacterium Neisseria meningitidis is an important cause of septicemia and meningitis, especially in childhood. The establishment and maintenance of bacteremic infection is a pre-requisite for all the pathological sequelae of meningococcal infection. To further understand the genetic basis of this essenti...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/81380

    authors： Sun YH,Bakshi S,Chalmers R,Tang CM

    更新日期：2000-11-01 00:00:00

  • gammadelta T cells provide a breath of fresh air for asthma research.

    abstract：:gammadelta T cells downregulate airways responsiveness to allergen challenge, possibly by controlling the 'repair' response of the airway epithelium to alphabeta T cell-mediated damage (pages 1150-1156). ...

    journal_title：Nature medicine

    pub_type： 评论,新闻

    doi：10.1038/13447

    authors： Holt PG,Sly PD

    更新日期：1999-10-01 00:00:00

  • Author Correction: China's response to a novel coronavirus stands in stark contrast to the 2002 SARS outbreak response.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature medicine

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41591-020-0816-5

    authors： Nkengasong J

    更新日期：2020-03-01 00:00:00

  • Thymosin beta 15: a novel regulator of tumor cell motility upregulated in metastatic prostate cancer.

    abstract：:The Dunning rat prostatic carcinoma is a model system where cell motility closely correlates with the metastatic phenotype. We have identified a novel gene, upregulated in the highly motile and metastatic Dunning cancer cell lines, that represents a new member of the thymosin-beta family, thymosin beta 15. Transfectio...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1296-1322

    authors： Bao L,Loda M,Janmey PA,Stewart R,Anand-Apte B,Zetter BR

    更新日期：1996-12-01 00:00:00

  • Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection.

    abstract：:Understanding the pathophysiology of SARS-CoV-2 infection is critical for therapeutic and public health strategies. Viral-host interactions can guide discovery of disease regulators, and protein structure function analysis points to several immune pathways, including complement and coagulation, as targets of coronavir...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/s41591-020-1021-2

    authors： Ramlall V,Thangaraj PM,Meydan C,Foox J,Butler D,Kim J,May B,De Freitas JK,Glicksberg BS,Mason CE,Tatonetti NP,Shapira SD

    更新日期：2020-10-01 00:00:00

  • Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity.

    abstract：:Proper function of the endoplasmic reticulum (ER) and mitochondria is crucial for cellular homeostasis, and dysfunction at either site has been linked to pathophysiological states, including metabolic diseases. Although the ER and mitochondria play distinct cellular roles, these organelles also form physical interacti...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.3735

    authors： Arruda AP,Pers BM,Parlakgül G,Güney E,Inouye K,Hotamisligil GS

    更新日期：2014-12-01 00:00:00

  • Direct-to-stomach delivery.

    abstract：: ...

    journal_title：Nature medicine

    pub_type： 评论,杂志文章

    doi：10.1038/s41591-019-0397-3

    authors： Stower H

    更新日期：2019-03-01 00:00:00

  • Near real-time intraoperative brain tumor diagnosis using stimulated Raman histology and deep neural networks.

    abstract：:Intraoperative diagnosis is essential for providing safe and effective care during cancer surgery1. The existing workflow for intraoperative diagnosis based on hematoxylin and eosin staining of processed tissue is time, resource and labor intensive2,3. Moreover, interpretation of intraoperative histologic images is de...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/s41591-019-0715-9

    authors： Hollon TC,Pandian B,Adapa AR,Urias E,Save AV,Khalsa SSS,Eichberg DG,D'Amico RS,Farooq ZU,Lewis S,Petridis PD,Marie T,Shah AH,Garton HJL,Maher CO,Heth JA,McKean EL,Sullivan SE,Hervey-Jumper SL,Patil PG,Thompson BG

    更新日期：2020-01-01 00:00:00

  • Inhibition of telomerase limits the growth of human cancer cells.

    abstract：:Telomerase is a ribonucleoprotein enzyme that maintains the protective structures at the ends of eukaryotic chromosomes, called telomeres. In most human somatic cells, telomerase expression is repressed, and telomeres shorten progressively with each cell division. In contrast, most human tumors express telomerase, res...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/13495

    authors： Hahn WC,Stewart SA,Brooks MW,York SG,Eaton E,Kurachi A,Beijersbergen RL,Knoll JH,Meyerson M,Weinberg RA

    更新日期：1999-10-01 00:00:00

  • Graft-versus-host disease: suppression by statins.

    abstract：:Two big challenges of transplantation biology are controlling the reaction of the graft to the host after hematopoietic stem cell transplantation and preventing rejection of donor organs by the host. Raewyn Broady and Megan K. Levings discuss the first challenge, examining studies suggesting that statins might be help...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1108-1155

    authors： Broady R,Levings MK

    更新日期：2008-11-01 00:00:00

  • Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.

    abstract：:With the goal of modeling human disease of the large intestine, we sought to develop an effective protocol for deriving colonic organoids (COs) from differentiated human embryonic stem cells (hESCs) or induced pluripotent stem cells (iPSCs). Extensive gene and immunohistochemical profiling confirmed that the derived C...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.4355

    authors： Crespo M,Vilar E,Tsai SY,Chang K,Amin S,Srinivasan T,Zhang T,Pipalia NH,Chen HJ,Witherspoon M,Gordillo M,Xiang JZ,Maxfield FR,Lipkin S,Evans T,Chen S

    更新日期：2017-07-01 00:00:00

  • Brown adipose tissue is associated with cardiometabolic health.

    abstract：:White fat stores excess energy, whereas brown and beige fat are thermogenic and dissipate energy as heat. Thermogenic adipose tissues markedly improve glucose and lipid homeostasis in mouse models, although the extent to which brown adipose tissue (BAT) influences metabolic and cardiovascular disease in humans is uncl...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/s41591-020-1126-7

    authors： Becher T,Palanisamy S,Kramer DJ,Eljalby M,Marx SJ,Wibmer AG,Butler SD,Jiang CS,Vaughan R,Schöder H,Mark A,Cohen P

    更新日期：2021-01-01 00:00:00

  • The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity.

    abstract：:The TAM receptors Tyro3, Axl and Mertk are receptor tyrosine kinases that dampen host innate immune responses following engagement with their ligands Gas6 and Protein S, which recognize phosphatidylserine on apoptotic cells. In a form of apoptotic mimicry, many enveloped viruses display phosphatidylserine on the outer...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.3974

    authors： Miner JJ,Daniels BP,Shrestha B,Proenca-Modena JL,Lew ED,Lazear HM,Gorman MJ,Lemke G,Klein RS,Diamond MS

    更新日期：2015-12-01 00:00:00

  • Production of atypical measles in rhesus macaques: evidence for disease mediated by immune complex formation and eosinophils in the presence of fusion-inhibiting antibody.

    abstract：:The severe disease atypical measles occurred when individuals immunized with a poorly protective inactivated vaccine contracted measles, and was postulated to be due to a lack of fusion-inhibiting antibodies. Here, rhesus macaques immunized with formalin-inactivated measles vaccine developed transient neutralizing and...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/9473

    authors： Polack FP,Auwaerter PG,Lee SH,Nousari HC,Valsamakis A,Leiferman KM,Diwan A,Adams RJ,Griffin DE

    更新日期：1999-06-01 00:00:00