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Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons.

Abstract：

:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces clinical, biochemical and neuropathologic changes reminiscent of those which occur in idiopathic Parkinson's disease. 7-Nitroindazole (7-NI) is a relatively selective inhibitor of the neuronal isoform of nitric oxide synthase (NOS) that blocks MPTP neurotoxicity in mice. We now show that 7-NI protects against profound striatal dopamine depletions and loss of tyrosine hydroxylase-positive neurons in the substantia nigra in MPTP-treated baboons. Furthermore, 7-NI protected against MPTP-induced motor and frontal-type cognitive deficits. These results strongly implicate a role of nitric oxide in MPTP neurotoxicity and suggest that inhibitors of neuronal NOS might be useful in treating Parkinson's disease.

journal_name

Nat Med

journal_title

Nature medicine

authors

Hantraye P,Brouillet E,Ferrante R,Palfi S,Dolan R,Matthews RT,Beal MF

doi

10.1038/nm0996-1017

subject

Has Abstract

pub_date

1996-09-01 00:00:00

pages

1017-21

issue

9

eissn

1078-8956

issn

1546-170X

journal_volume

2

pub_type

杂志文章

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