A novel influenza A virus mitochondrial protein that induces cell death.

abstract：:The neural tube defects (NTDs) spina bifida and anencephaly are widely prevalent severe birth defects. The mouse mutant curly tail (ct/ct) has served as a model of NTDs for 50 years, even though the responsible genetic defect remained unrecognized. Here we show by gene targeting, mapping and genetic complementation st...

journal_title：Nature medicine

authors： Ting SB,Wilanowski T,Auden A,Hall M,Voss AK,Thomas T,Parekh V,Cunningham JM,Jane SM

更新日期：2003-12-01 00:00:00

abstract：:Cancer-specific cell-surface antigens are ideal targets for monoclonal antibody (mAb)-based immunotherapy but are likely to have previously been identified in transcriptome or proteome analyses. Here, we show that the active conformer of an integrin can serve as a specific therapeutic target for multiple myeloma (MM)....

journal_title：Nature medicine

authors： Hosen N,Matsunaga Y,Hasegawa K,Matsuno H,Nakamura Y,Makita M,Watanabe K,Yoshida M,Satoh K,Morimoto S,Fujiki F,Nakajima H,Nakata J,Nishida S,Tsuboi A,Oka Y,Manabe M,Ichihara H,Aoyama Y,Mugitani A,Nakao T,Hino M,

更新日期：2017-12-01 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is accompanied by an abnormal location of granule cells in the dentate gyrus. Using a rat model of complex febrile seizures, which are thought to be a precipitating insult of TLE later in life, we report that aberrant migration of neonatal-generated granule cells results in granule cell ec...

journal_title：Nature medicine

authors： Koyama R,Tao K,Sasaki T,Ichikawa J,Miyamoto D,Muramatsu R,Matsuki N,Ikegaya Y

更新日期：2012-08-01 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL), unlike other ALL types, is only infrequently associated with chromosomal aberrations, but it was recently shown that most individuals with T-ALL carry activating mutations in the NOTCH1 gene. However, the signaling pathways and target genes responsible for Notch1-induced ne...

journal_title：Nature medicine

authors： Vilimas T,Mascarenhas J,Palomero T,Mandal M,Buonamici S,Meng F,Thompson B,Spaulding C,Macaroun S,Alegre ML,Kee BL,Ferrando A,Miele L,Aifantis I

更新日期：2007-01-01 00:00:00

abstract：:CD23 is a low-affinity receptor for immunoglobulin E (IgE) expressed by a variety of haematopoietic cells. Proteolytic cleavage of the transmembrane receptor generates soluble forms, which can be detected in biological fluids. CD23 regulates many functional aspects of immune cells, both in its cell-associated and solu...

journal_title：Nature medicine

authors： Plater-Zyberk C,Bonnefoy JY

更新日期：1995-08-01 00:00:00

abstract：:Here we show that ischemia induces sustained contraction of pericytes on microvessels in the intact mouse brain. Pericytes remain contracted despite successful reopening of the middle cerebral artery after 2 h of ischemia. Pericyte contraction causes capillary constriction and obstructs erythrocyte flow. Suppression o...

journal_title：Nature medicine

authors： Yemisci M,Gursoy-Ozdemir Y,Vural A,Can A,Topalkara K,Dalkara T

更新日期：2009-09-01 00:00:00

abstract：:We show that the fraction of proliferating CD4+ lymphocytes is similar in HIV-infected subjects in the early stage of disease and in HIV-negative subjects, whereas the fraction of proliferating CD8+ lymphocytes is increased 6.8-fold in HIV-infected subjects. After initiation of antiviral therapy, there is a late incre...

journal_title：Nature medicine

authors： Fleury S,de Boer RJ,Rizzardi GP,Wolthers KC,Otto SA,Welbon CC,Graziosi C,Knabenhans C,Soudeyns H,Bart PA,Gallant S,Corpataux JM,Gillet M,Meylan P,Schnyder P,Meuwly JY,Spreen W,Glauser MP,Miedema F,Pantaleo G

更新日期：1998-07-01 00:00:00

abstract：:From 28 young children in the Netherlands, we isolated a paramyxovirus that was identified as a tentative new member of the Metapneumovirus genus based on virological data, sequence homology and gene constellation. Previously, avian pneumovirus was the sole member of this recently assigned genus, hence the provisional...

journal_title：Nature medicine

authors： van den Hoogen BG,de Jong JC,Groen J,Kuiken T,de Groot R,Fouchier RA,Osterhaus AD

更新日期：2001-06-01 00:00:00

abstract：:Checkpoint inhibitors produce durable responses in numerous metastatic cancers, but immune-related adverse events (irAEs) complicate and limit their benefit. IrAEs can affect organ systems idiosyncratically; presentations range from mild and self-limited to fulminant and fatal. The molecular mechanisms underlying irAE...

journal_title：Nature medicine

authors： Johnson DB,McDonnell WJ,Gonzalez-Ericsson PI,Al-Rohil RN,Mobley BC,Salem JE,Wang DY,Sanchez V,Wang Y,Chastain CA,Barker K,Liang Y,Warren S,Beechem JM,Menzies AM,Tio M,Long GV,Cohen JV,Guidon AC,O'Hare M,Chandra S

更新日期：2019-08-01 00:00:00

abstract：:We report the development of a new combinatorial approach that allows for peptide-mediated selective tissue targeting of nuclear hormone pharmacology while eliminating adverse effects in other tissues. Specifically, we report the development of a glucagon-like peptide-1 (GLP-1)-estrogen conjugate that has superior sex...

journal_title：Nature medicine

authors： Finan B,Yang B,Ottaway N,Stemmer K,Müller TD,Yi CX,Habegger K,Schriever SC,García-Cáceres C,Kabra DG,Hembree J,Holland J,Raver C,Seeley RJ,Hans W,Irmler M,Beckers J,de Angelis MH,Tiano JP,Mauvais-Jarvis F,Perez-Ti

更新日期：2012-12-01 00:00:00

abstract：:The gene encoding the lysine-specific histone methyltransferase KMT2D has emerged as one of the most frequently mutated genes in follicular lymphoma and diffuse large B cell lymphoma; however, the biological consequences of KMT2D mutations on lymphoma development are not known. Here we show that KMT2D functions as a b...

journal_title：Nature medicine

authors： Ortega-Molina A,Boss IW,Canela A,Pan H,Jiang Y,Zhao C,Jiang M,Hu D,Agirre X,Niesvizky I,Lee JE,Chen HT,Ennishi D,Scott DW,Mottok A,Hother C,Liu S,Cao XJ,Tam W,Shaknovich R,Garcia BA,Gascoyne RD,Ge K,Shilatif

更新日期：2015-10-01 00:00:00

abstract：:Transcription factor FoxO1 promotes hepatic glucose production. Genetic inhibition of FoxO1 function prevents diabetes in experimental animal models, providing impetus to identify pharmacological approaches to modulate this function. Altered Notch signaling is evident in tumorigenesis, and Notch antagonists are in cli...

journal_title：Nature medicine

authors： Pajvani UB,Shawber CJ,Samuel VT,Birkenfeld AL,Shulman GI,Kitajewski J,Accili D

更新日期：2011-07-31 00:00:00

abstract：:Beta-adrenergic receptor (betaAR) blockade is a standard therapy for cardiac failure and ischemia. G protein-coupled receptor kinases (GRKs) desensitize betaARs, suggesting that genetic GRK variants might modify outcomes in these syndromes. Re-sequencing of GRK2 and GRK5 revealed a nonsynonymous polymorphism of GRK5, ...

journal_title：Nature medicine

authors： Liggett SB,Cresci S,Kelly RJ,Syed FM,Matkovich SJ,Hahn HS,Diwan A,Martini JS,Sparks L,Parekh RR,Spertus JA,Koch WJ,Kardia SL,Dorn GW 2nd

更新日期：2008-05-01 00:00:00

abstract：:Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 °C) increased peripheral insulin sensitivity by ∼43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, wit...

journal_title：Nature medicine

authors： Hanssen MJ,Hoeks J,Brans B,van der Lans AA,Schaart G,van den Driessche JJ,Jörgensen JA,Boekschoten MV,Hesselink MK,Havekes B,Kersten S,Mottaghy FM,van Marken Lichtenbelt WD,Schrauwen P

更新日期：2015-08-01 00:00:00

abstract：:Direct evidence in humans for the impact of the microbiome on nutrient absorption is lacking. We conducted an extended inpatient study using two interventions that we hypothesized would alter the gut microbiome and nutrient absorption. In each, stool calorie loss, a direct proxy of nutrient absorption, was measured. T...

journal_title：Nature medicine

authors： Basolo A,Hohenadel M,Ang QY,Piaggi P,Heinitz S,Walter M,Walter P,Parrington S,Trinidad DD,von Schwartzenberg RJ,Turnbaugh PJ,Krakoff J

更新日期：2020-04-01 00:00:00

abstract：:The human CD4 molecule (hCD4) is expressed on T lymphocytes and macrophages and acts as a key component of the cellular receptor for HIV. At baseline, hCD4 transgenic mice expressed hCD4 on microglia, the resident mononuclear phagocytes of the brain, and showed no neuronal damage. Activation of brain microglia by peri...

journal_title：Nature medicine

authors： Buttini M,Westland CE,Masliah E,Yafeh AM,Wyss-Coray T,Mucke L

更新日期：1998-04-01 00:00:00

abstract：:Hemophilia B is a severe X-linked bleeding diathesis caused by the absence of functional blood coagulation factor IX, and is an excellent candidate for treatment of a genetic disease by gene therapy. Using an adeno-associated viral vector, we demonstrate sustained expression (>17 months) of factor IX in a large-animal...

journal_title：Nature medicine

authors： Herzog RW,Yang EY,Couto LB,Hagstrom JN,Elwell D,Fields PA,Burton M,Bellinger DA,Read MS,Brinkhous KM,Podsakoff GM,Nichols TC,Kurtzman GJ,High KA

更新日期：1999-01-01 00:00:00

abstract：:Movement towards or away from a given stimulus guides the directional migration of prokaryotes, simple eukaryotes and neurons. As bi-directional cues may influence entry and exit of immune effector cells from tissue sites, we evaluated the migratory responses of T-cell subsets to varying concentrations of the chemokin...

journal_title：Nature medicine

authors： Poznansky MC,Olszak IT,Foxall R,Evans RH,Luster AD,Scadden DT

更新日期：2000-05-01 00:00:00

abstract：:Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that exhibits specific tumoricidal activity against a variety of tumors. It is expressed on different cells of the immune system and plays a role in natural killer cell-mediated tumor surveillance. In allogeneic he...

journal_title：Nature medicine

authors： Schmaltz C,Alpdogan O,Kappel BJ,Muriglan SJ,Rotolo JA,Ongchin J,Willis LM,Greenberg AS,Eng JM,Crawford JM,Murphy GF,Yagita H,Walczak H,Peschon JJ,van den Brink MR

更新日期：2002-12-01 00:00:00

abstract：:Dendritic cells, the most potent antigen-presenting cells, need to be activated before they can function to initiate an immune response. We report here that, in the absence of any foreign substances, dendritic cells can be activated by endogenous signals received from cells that are stressed, virally infected or kille...

journal_title：Nature medicine

authors： Gallucci S,Lolkema M,Matzinger P

更新日期：1999-11-01 00:00:00

abstract：:Conceptual and practical advances in molecular medicine are changing our understanding of cancer pathogenesis. In time this should provide the opportunity to alter the natural history of many cancers. ...

journal_title：Nature medicine

authors： Karp JE,Broder S

更新日期：1995-04-01 00:00:00

abstract：:Mice carrying mutations in both the dystrophin and utrophin genes die prematurely as a consequence of severe muscular dystrophy. Here, we show that intravascular administration of recombinant adeno-associated viral (rAAV) vectors carrying a microdystrophin gene restores expression of dystrophin in the respiratory, car...

journal_title：Nature medicine

authors： Gregorevic P,Allen JM,Minami E,Blankinship MJ,Haraguchi M,Meuse L,Finn E,Adams ME,Froehner SC,Murry CE,Chamberlain JS

更新日期：2006-07-01 00:00:00

abstract：:The intestine is densely populated by anaerobic commensal bacteria. These microorganisms shape immune system development, but understanding of host-commensal interactions is hampered by a lack of tools for studying the anaerobic intestinal environment. We applied metabolic oligosaccharide engineering and bioorthogonal...

journal_title：Nature medicine

authors： Geva-Zatorsky N,Alvarez D,Hudak JE,Reading NC,Erturk-Hasdemir D,Dasgupta S,von Andrian UH,Kasper DL

更新日期：2015-09-01 00:00:00

abstract：:Parasites of the Leishmania genus are the causative agents of leishmaniasis in humans, a disease that affects more than 12 million people worldwide. These parasites replicate intracellularly in macrophages, and the primary mechanisms underlying host resistance involve the production of nitric oxide (NO). In this study...

journal_title：Nature medicine

authors： Lima-Junior DS,Costa DL,Carregaro V,Cunha LD,Silva AL,Mineo TW,Gutierrez FR,Bellio M,Bortoluci KR,Flavell RA,Bozza MT,Silva JS,Zamboni DS

更新日期：2013-07-01 00:00:00

abstract：:The androgen receptor (AR) is involved in the development, growth and progression of prostate cancer (CaP). CaP often progresses from an androgen-dependent to an androgen-independent tumor, making androgen ablation therapy ineffective. However, the mechanisms for the development of androgen-independent CaP are unclear...

journal_title：Nature medicine

authors： Zhao XY,Malloy PJ,Krishnan AV,Swami S,Navone NM,Peehl DM,Feldman D

更新日期：2000-06-01 00:00:00

abstract：:Hypothalamic brain-derived neurotrophic factor (BDNF) is a key element in the regulation of energy balance. Here we investigated the therapeutic efficacy of BDNF by gene transfer in mouse models of obesity and diabetes. Gene transfer of BDNF led to marked weight loss and alleviation of obesity-associated insulin resis...

journal_title：Nature medicine

authors： Cao L,Lin EJ,Cahill MC,Wang C,Liu X,During MJ

更新日期：2009-04-01 00:00:00

abstract：:We investigated whether immunization with recombinant anti-idiotypic antibody fragments mimicking the conformation of the capsular antigen can protect against infection by group B streptococcus, an important neonatal pathogen. Single-chain fragment-variable anti-idiotypes competed with the type III carbohydrate for bi...

journal_title：Nature medicine

authors： Magliani W,Polonelli L,Conti S,Salati A,Rocca PF,Cusumano V,Mancuso G,Teti G

更新日期：1998-06-01 00:00:00

abstract：:Hutchinson-Gilford progeria syndrome (HGPS) is a rare lethal genetic disorder characterized by symptoms reminiscent of accelerated aging. The major underlying genetic cause is a substitution mutation in the gene coding for lamin A, causing the production of a toxic isoform called progerin. Here we show that reduction ...

journal_title：Nature medicine

authors： Beyret E,Liao HK,Yamamoto M,Hernandez-Benitez R,Fu Y,Erikson G,Reddy P,Izpisua Belmonte JC

更新日期：2019-03-01 00:00:00

abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces clinical, biochemical and neuropathologic changes reminiscent of those which occur in idiopathic Parkinson's disease. 7-Nitroindazole (7-NI) is a relatively selective inhibitor of the neuronal isoform of nitric oxide synthase (NOS) that blocks MPTP neurotoxi...

journal_title：Nature medicine

authors： Hantraye P,Brouillet E,Ferrante R,Palfi S,Dolan R,Matthews RT,Beal MF

更新日期：1996-09-01 00:00:00

abstract：:Late-onset sepsis (LOS) is thought to result from systemic spread of commensal microbes from the intestines of premature infants. Clinical use of probiotics for LOS prophylaxis has varied owing to limited efficacy, reflecting an incomplete understanding of relationships between development of the intestinal microbiome...

journal_title：Nature medicine

authors： Singer JR,Blosser EG,Zindl CL,Silberger DJ,Conlan S,Laufer VA,DiToro D,Deming C,Kumar R,Morrow CD,Segre JA,Gray MJ,Randolph DA,Weaver CT

更新日期：2019-11-01 00:00:00