GABAergic excitation after febrile seizures induces ectopic granule cells and adult epilepsy.

abstract：:Beta-adrenergic receptor (betaAR) blockade is a standard therapy for cardiac failure and ischemia. G protein-coupled receptor kinases (GRKs) desensitize betaARs, suggesting that genetic GRK variants might modify outcomes in these syndromes. Re-sequencing of GRK2 and GRK5 revealed a nonsynonymous polymorphism of GRK5, ...

journal_title：Nature medicine

authors： Liggett SB,Cresci S,Kelly RJ,Syed FM,Matkovich SJ,Hahn HS,Diwan A,Martini JS,Sparks L,Parekh RR,Spertus JA,Koch WJ,Kardia SL,Dorn GW 2nd

更新日期：2008-05-01 00:00:00

abstract：:Checkpoint inhibitors produce durable responses in numerous metastatic cancers, but immune-related adverse events (irAEs) complicate and limit their benefit. IrAEs can affect organ systems idiosyncratically; presentations range from mild and self-limited to fulminant and fatal. The molecular mechanisms underlying irAE...

journal_title：Nature medicine

authors： Johnson DB,McDonnell WJ,Gonzalez-Ericsson PI,Al-Rohil RN,Mobley BC,Salem JE,Wang DY,Sanchez V,Wang Y,Chastain CA,Barker K,Liang Y,Warren S,Beechem JM,Menzies AM,Tio M,Long GV,Cohen JV,Guidon AC,O'Hare M,Chandra S

更新日期：2019-08-01 00:00:00

abstract：:Hepatic insulin resistance is a driving force in the pathogenesis of type 2 diabetes mellitus (T2DM) and is tightly coupled with excessive storage of fat and the ensuing inflammation within the liver. There is compelling evidence that activation of the transcription factor nuclear factor-κB (NF-κB) and downstream infl...

journal_title：Nature medicine

authors： Kiechl S,Wittmann J,Giaccari A,Knoflach M,Willeit P,Bozec A,Moschen AR,Muscogiuri G,Sorice GP,Kireva T,Summerer M,Wirtz S,Luther J,Mielenz D,Billmeier U,Egger G,Mayr A,Oberhollenzer F,Kronenberg F,Orthofer M,Penni

更新日期：2013-03-01 00:00:00

abstract：:Huntington's disease is caused by an expanded polyglutamine repeat in the huntingtin protein (HTT), but the pathophysiological sequence of events that trigger synaptic failure and neuronal loss are not fully understood. Alterations in N-methyl-D-aspartate (NMDA)-type glutamate receptors (NMDARs) have been implicated. ...

journal_title：Nature medicine

authors： Marco S,Giralt A,Petrovic MM,Pouladi MA,Martínez-Turrillas R,Martínez-Hernández J,Kaltenbach LS,Torres-Peraza J,Graham RK,Watanabe M,Luján R,Nakanishi N,Lipton SA,Lo DC,Hayden MR,Alberch J,Wesseling JF,Pérez-Otaño I

更新日期：2013-08-01 00:00:00

abstract：:Exercise has numerous health-promoting effects in humans; however, individual responsiveness to exercise with regard to endurance or metabolic health differs markedly. This 'exercise resistance' is considered to be congenital, with no evident acquired causative factors. Here we show that the anti-oxidative hepatokine ...

journal_title：Nature medicine

authors： Misu H,Takayama H,Saito Y,Mita Y,Kikuchi A,Ishii KA,Chikamoto K,Kanamori T,Tajima N,Lan F,Takeshita Y,Honda M,Tanaka M,Kato S,Matsuyama N,Yoshioka Y,Iwayama K,Tokuyama K,Akazawa N,Maeda S,Takekoshi K,Matsugo S,

更新日期：2017-04-01 00:00:00

abstract：:Owing to recent medical and technological advances in neonatal care, infants born extremely premature have increased survival rates1,2. After birth, these infants are at high risk of hypoxic episodes because of lung immaturity, hypotension and lack of cerebral-flow regulation, and can develop a severe condition called...

journal_title：Nature medicine

authors： Pașca AM,Park JY,Shin HW,Qi Q,Revah O,Krasnoff R,O'Hara R,Willsey AJ,Palmer TD,Pașca SP

更新日期：2019-05-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA) is an important neurotransmitter that, through the subtype A GABA receptor (GABAAR), induces inhibition in the adult brain. Here we show that an excitatory, rather than inhibitory, GABAergic system exists in airway epithelial cells. Both GABAARs and the GABA synthetic enzyme glutamic aci...

journal_title：Nature medicine

authors： Xiang YY,Wang S,Liu M,Hirota JA,Li J,Ju W,Fan Y,Kelly MM,Ye B,Orser B,O'Byrne PM,Inman MD,Yang X,Lu WY

更新日期：2007-07-01 00:00:00

abstract：:CD4(+) T cells that express the forkhead box P3 (FOXP3) transcription factor function as regulatory T (Treg) cells and hinder effective immune responses against cancer cells. Abundant Treg cell infiltration into tumors is associated with poor clinical outcomes in various types of cancers. However, the role of Treg cel...

journal_title：Nature medicine

authors： Saito T,Nishikawa H,Wada H,Nagano Y,Sugiyama D,Atarashi K,Maeda Y,Hamaguchi M,Ohkura N,Sato E,Nagase H,Nishimura J,Yamamoto H,Takiguchi S,Tanoue T,Suda W,Morita H,Hattori M,Honda K,Mori M,Doki Y,Sakaguchi S

更新日期：2016-06-01 00:00:00

abstract：:Copy number variants are a recently discovered source of large-scale genomic diversity present in all individuals. We capitalize on these inherent genomic differences, focusing on deletion polymorphisms, to develop informative fluorescence in situ hybridization probes with the ability to unequivocally distinguish betw...

journal_title：Nature medicine

authors： Wu D,Vu Q,Nguyen A,Stone JR,Stubbs H,Kuhlmann G,Sholl LM,Iafrate AJ

更新日期：2009-02-01 00:00:00

abstract：:Neurofibrillary tangles (NFTs), composed of truncated and hyperphosphorylated tau, are a common feature of numerous aging-related neurodegenerative diseases, including Alzheimer's disease (AD). However, the molecular mechanisms mediating tau truncation and aggregation during aging remain elusive. Here we show that asp...

journal_title：Nature medicine

authors： Zhang Z,Song M,Liu X,Kang SS,Kwon IS,Duong DM,Seyfried NT,Hu WT,Liu Z,Wang JZ,Cheng L,Sun YE,Yu SP,Levey AI,Ye K

更新日期：2014-11-01 00:00:00

abstract：:Endogenous mechanisms leading to host protection and resolution of infections without immunosuppression are of wide interest. Here we elucidate the structures of four new host-protective molecules produced in neutrophil-endothelial cocultures and present in human and mouse tissues after sterile inflammation or infecti...

journal_title：Nature medicine

authors： Dalli J,Chiang N,Serhan CN

更新日期：2015-09-01 00:00:00

abstract：:The ability to patent human genes has been costly to researchers and patients, and has restricted competition in the biotech marketplace. The recent US Supreme Court decision making isolated human genes unpatentable will bring freedom of choice to the patient, and level the playing field for research and development. ...

journal_title：Nature medicine

authors：

更新日期：2013-07-01 00:00:00

abstract：:The skin-associated chemokine CCL27 (also called CTACK, ALP and ESkine) and its receptor CCR10 (GPR-2) mediate chemotactic responses of skin-homing T cells in vitro. Here we report that most skin-infiltrating lymphocytes in patients suffering from psoriasis, atopic or allergic-contact dermatitis express CCR10. Epiderm...

journal_title：Nature medicine

authors： Homey B,Alenius H,Müller A,Soto H,Bowman EP,Yuan W,McEvoy L,Lauerma AI,Assmann T,Bünemann E,Lehto M,Wolff H,Yen D,Marxhausen H,To W,Sedgwick J,Ruzicka T,Lehmann P,Zlotnik A

更新日期：2002-02-01 00:00:00

abstract：:Targeted gene transduction to specific tissues and organs through intravenous injection would be the ultimate preferred method of gene delivery. Here, we report successful targeting in a living animal through intravenous injection of a lentiviral vector pseudotyped with a modified chimeric Sindbis virus envelope (term...

journal_title：Nature medicine

authors： Morizono K,Xie Y,Ringpis GE,Johnson M,Nassanian H,Lee B,Wu L,Chen IS

更新日期：2005-03-01 00:00:00

abstract：:Cells from the telomerase knockout mouse immortalize with an approximately ten million-fold greater frequency than human cells. In this commentary, Wright and Shay discuss the implications of this difference between mice and men and its relationship to cancer. ...

journal_title：Nature medicine

authors： Wright WE,Shay JW

更新日期：2000-08-01 00:00:00

abstract：:Relapse is the leading cause of mortality in children with acute lymphoblastic leukemia (ALL). Among chemotherapeutics, thiopurines are key drugs in ALL combination therapy. Using whole-exome sequencing, we identified relapse-specific mutations in the phosphoribosyl pyrophosphate synthetase 1 gene (PRPS1), which encod...

journal_title：Nature medicine

authors： Li B,Li H,Bai Y,Kirschner-Schwabe R,Yang JJ,Chen Y,Lu G,Tzoneva G,Ma X,Wu T,Li W,Lu H,Ding L,Liang H,Huang X,Yang M,Jin L,Kang H,Chen S,Du A,Shen S,Ding J,Chen H,Chen J,von Stackelberg A,Gu L,Zhang J,

更新日期：2015-06-01 00:00:00

abstract：:Computerized electrocardiogram (ECG) interpretation plays a critical role in the clinical ECG workflow1. Widely available digital ECG data and the algorithmic paradigm of deep learning2 present an opportunity to substantially improve the accuracy and scalability of automated ECG analysis. However, a comprehensive eval...

journal_title：Nature medicine

authors： Hannun AY,Rajpurkar P,Haghpanahi M,Tison GH,Bourn C,Turakhia MP,Ng AY

更新日期：2019-01-01 00:00:00

abstract：:Insulin receptor substrate (IRS)-1 and IRS-2 have dominant roles in the action of insulin, but other substrates of the insulin receptor kinase, such as Gab1, c-Cbl, SH2-B and APS, are also of physiological relevance. Although the protein downstream of tyrosine kinases-1 (Dok1) is known to function as a multisite adapt...

journal_title：Nature medicine

authors： Hosooka T,Noguchi T,Kotani K,Nakamura T,Sakaue H,Inoue H,Ogawa W,Tobimatsu K,Takazawa K,Sakai M,Matsuki Y,Hiramatsu R,Yasuda T,Lazar MA,Yamanashi Y,Kasuga M

更新日期：2008-02-01 00:00:00

abstract：:Modest clinical outcomes of dendritic-cell (DC) vaccine trials call for the refinement of DC vaccine design. Although many potential antigens have been identified, development of methods to enhance antigen presentation by DCs has lagged. We have engineered a potent, drug-inducible CD40 (iCD40) receptor that permits te...

journal_title：Nature medicine

authors： Hanks BA,Jiang J,Singh RA,Song W,Barry M,Huls MH,Slawin KM,Spencer DM

更新日期：2005-02-01 00:00:00

abstract：:Diabetes in non-obese diabetic (NOD) mice is mediated by pathogenic T-helper type 1 (Th1) cells that arise because of a deficiency in regulatory or suppressor T cells. V alpha 14-J alpha 15 natural killer T (NKT) cells recognize lipid antigens presented by the major histocompatibility complex class I-like protein CD1d...

journal_title：Nature medicine

authors： Hong S,Wilson MT,Serizawa I,Wu L,Singh N,Naidenko OV,Miura T,Haba T,Scherer DC,Wei J,Kronenberg M,Koezuka Y,Van Kaer L

更新日期：2001-09-01 00:00:00

abstract：:The balance between detrimental, pro-aging, often stochastic processes and counteracting homeostatic mechanisms largely determines the progression of aging. There is substantial evidence suggesting that the endocannabinoid system (ECS) is part of the latter system because it modulates the physiological processes under...

journal_title：Nature medicine

authors： Bilkei-Gorzo A,Albayram O,Draffehn A,Michel K,Piyanova A,Oppenheimer H,Dvir-Ginzberg M,Rácz I,Ulas T,Imbeault S,Bab I,Schultze JL,Zimmer A

更新日期：2017-06-01 00:00:00

abstract：:Improved techniques to noninvasively image protein-protein interactions (PPIs) are essential. We molecularly engineered a positron emission tomography (PET)-based split reporter (herpes simplex virus type 1 thymidine kinase), cleaved between Thr265 and Ala266, and used this in a protein-fragment complementation assay ...

journal_title：Nature medicine

authors： Massoud TF,Paulmurugan R,Gambhir SS

更新日期：2010-08-01 00:00:00

abstract：:In chronic kidney disease (CKD), loss of functional nephrons results in metabolic and mechanical stress in the remaining ones, resulting in further nephron loss. Here we show that Akt2 activation has an essential role in podocyte protection after nephron reduction. Glomerulosclerosis and albuminuria were substantially...

journal_title：Nature medicine

authors： Canaud G,Bienaimé F,Viau A,Treins C,Baron W,Nguyen C,Burtin M,Berissi S,Giannakakis K,Muda AO,Zschiedrich S,Huber TB,Friedlander G,Legendre C,Pontoglio M,Pende M,Terzi F

更新日期：2013-10-01 00:00:00

abstract：:A new study provides mechanistic insights into how live attenuated simian immunodeficiency virus (SIV) vaccines (LAVs) can protect monkeys from infection with pathogenic SIV. The authors show that replicating LAVs stimulate a protective immune response from a safe haven in the germinal centers of lymph nodes (pages 16...

journal_title：Nature medicine

authors： Robinson HL,Amara RR

更新日期：2012-11-01 00:00:00

abstract：:Retinal neovascularization is a major cause of blindness in such disorders as retinopathy of prematurity, proliferative diabetic retinopathy and senile macular degeneration. Because ligation of vitronectin receptor-type integrins appears to be required for the survival and maturation of newly formed but not quiescent ...

journal_title：Nature medicine

authors： Hammes HP,Brownlee M,Jonczyk A,Sutter A,Preissner KT

更新日期：1996-05-01 00:00:00

abstract：:How well antibodies can protect against disease due to HIV-1 infection remains a pivotal but unresolved issue with important implications for vaccine design and the use of prophylactic antibody to prevent infection after accidental exposure to the virus and to interrupt transmission of virus from mother to child. Stro...

journal_title：Nature medicine

authors： Gauduin MC,Parren PW,Weir R,Barbas CF,Burton DR,Koup RA

更新日期：1997-12-01 00:00:00

abstract：:Oral administration of protein can induce antigen-specific immune hyporesponsiveness. However, the utility of oral tolerance to autoantigens in the treatment of autoimmune diseases may be limited when candidate autoantigens cannot be produced by conventional systems in quantities sufficient for clinical studies. Plant...

journal_title：Nature medicine

authors： Ma SW,Zhao DL,Yin ZQ,Mukherjee R,Singh B,Qin HY,Stiller CR,Jevnikar AM

更新日期：1997-07-01 00:00:00

abstract：:The structure and function of blood vessels adapt to environmental changes such as physical development and exercise. This phenomenon is based on the ability of the endothelial cells to sense and respond to blood flow; however, the underlying mechanisms remain unclear. Here we show that the ATP-gated P2X4 ion channel,...

journal_title：Nature medicine

authors： Yamamoto K,Sokabe T,Matsumoto T,Yoshimura K,Shibata M,Ohura N,Fukuda T,Sato T,Sekine K,Kato S,Isshiki M,Fujita T,Kobayashi M,Kawamura K,Masuda H,Kamiya A,Ando J

更新日期：2006-01-01 00:00:00

abstract：:Advances in imaging are transforming our understanding of angiogenesis and the evaluation of drugs that stimulate or inhibit angiogenesis in preclinical models and human disease. Vascular imaging makes it possible to quantify the number and spacing of blood vessels, measure blood flow and vascular permeability, and an...

journal_title：Nature medicine

authors： McDonald DM,Choyke PL

更新日期：2003-06-01 00:00:00

abstract：: ...

journal_title：Nature medicine

authors： Stower H

更新日期：2018-12-01 00:00:00