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Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand.

Abstract：

:Myelin-specific T lymphocytes are considered essential in the pathogenesis of multiple sclerosis. The myelin basic protein peptide (a.a. 83-99) represents one candidate antigen; therefore, it was chosen to design an altered peptide ligand, CGP77116, for specific immunotherapy of multiple sclerosis. A magnetic resonance imaging-controlled phase II clinical trial with this altered peptide ligand documented that it was poorly tolerated at the dose tested, and the trial had therefore to be halted. Improvement or worsening of clinical or magnetic resonance imaging parameters could not be demonstrated in this small group of individuals because of the short treatment duration. Three patients developed exacerbations of multiple sclerosis, and in two this could be linked to altered peptide ligand treatment by immunological studies demonstrating the encephalitogenic potential of the myelin basic protein peptide (a.a. 83-99) in a subgroup of patients. These data raise important considerations for the use of specific immunotherapies in general.

journal_name

Nat Med

journal_title

Nature medicine

authors

Bielekova B,Goodwin B,Richert N,Cortese I,Kondo T,Afshar G,Gran B,Eaton J,Antel J,Frank JA,McFarland HF,Martin R

doi

10.1038/80516

keywords:

subject

Has Abstract

pub_date

2000-10-01 00:00:00

pages

1167-75

issue

10

eissn

1078-8956

issn

1546-170X

journal_volume

6

pub_type

临床试验,杂志文章

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