Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity.

Abstract:

:A variable region gene of the T-cell receptor, V beta 8.2, is rearranged, and its product is expressed on pathogenic T cells that induce experimental autoimmune encephalomyelitis (EAE) in H-2u mice after immunization with myelin basic protein (MBP). Vaccination of these mice with naked DNA encoding V beta 8.2 protected mice from EAE. Analysis of T cells reacting to the pathogenic portion of the MBP molecule indicated that in the vaccinated mice there was a reduction in the Th1 cytokines interleukin-2 (IL-2) and interferon-gama. In parallel, there was an elevation in the production of IL-4, a Th2 cytokine associated with suppression of disease. A novel feature of DNA immunization for autoimmune disease, reversal of the autoimmune response from Th1 to Th2, may make this approach attractive for treatment of Th1-mediated diseases like multiple sclerosis, juvenile diabetes and rheumatoid arthritis.

journal_name

Nat Med

journal_title

Nature medicine

authors

Waisman A,Ruiz PJ,Hirschberg DL,Gelman A,Oksenberg JR,Brocke S,Mor F,Cohen IR,Steinman L

doi

10.1038/nm0896-899

subject

Has Abstract

pub_date

1996-08-01 00:00:00

pages

899-905

issue

8

eissn

1078-8956

issn

1546-170X

journal_volume

2

pub_type

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