Abstract:
:Rapid and accurate measurement of biomarkers in tissue and fluid samples is a major challenge in medicine. Here we report the development of a new, miniaturized diagnostic magnetic resonance (DMR) system for multiplexed, quantitative and rapid analysis. By using magnetic particles as a proximity sensor to amplify molecular interactions, the handheld DMR system can perform measurements on unprocessed biological samples. We show the capability of the DMR system by using it to detect bacteria with high sensitivity, identify small numbers of cells and analyze them on a molecular level in real time, and measure a series of protein biomarkers in parallel. The DMR technology shows promise as a robust and portable diagnostic device.
journal_name
Nat Medjournal_title
Nature medicineauthors
Lee H,Sun E,Ham D,Weissleder Rdoi
10.1038/nm.1711subject
Has Abstractpub_date
2008-08-01 00:00:00pages
869-74issue
8eissn
1078-8956issn
1546-170Xpii
nm.1711journal_volume
14pub_type
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