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Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses.

Abstract：

:The occurrence of multiple tumors in an organ heralds a rapidly fatal course. Although intravascular administration may deliver oncolytic viruses/vectors to each of these tumors, its efficiency is impeded by an antiviral activity present in complement-depleted plasma of rodents and humans. Here, this activity was shown to interact with complement in a calcium-dependent fashion, and antibody neutralization studies indicated preimmune IgM has a contributing role. Short-term exposure to cyclophosphamide (CPA) partially suppressed this activity in rodents and humans. At longer time points, cyclophosphamide also abrogated neutralizing antibody responses. Cyclophosphamide treatment of rats with large single or multiple intracerebral tumors substantially increased viral survival and propagation, leading to neoplastic regression.

journal_name

Nat Med

journal_title

Nature medicine

authors

Ikeda K,Ichikawa T,Wakimoto H,Silver JS,Deisboeck TS,Finkelstein D,Harsh GR 4th,Louis DN,Bartus RT,Hochberg FH,Chiocca EA

doi

10.1038/11320

keywords:

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

881-7

issue

8

eissn

1078-8956

issn

1546-170X

journal_volume

5

pub_type

杂志文章

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