Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy.

Abstract:

:The microbiome of the female reproductive tract has implications for women's reproductive health. We examined the vaginal microbiome in two cohorts of women who experienced normal term births: a cross-sectionally sampled cohort of 613 pregnant and 1,969 non-pregnant women, focusing on 300 pregnant and 300 non-pregnant women of African, Hispanic or European ancestry case-matched for race, gestational age and household income; and a longitudinally sampled cohort of 90 pregnant women of African or non-African ancestry. In these women, the vaginal microbiome shifted during pregnancy toward Lactobacillus-dominated profiles at the expense of taxa often associated with vaginal dysbiosis. The shifts occurred early in pregnancy, followed predictable patterns, were associated with simplification of the metabolic capacity of the microbiome and were significant only in women of African or Hispanic ancestry. Both genomic and environmental factors are likely contributors to these trends, with socioeconomic status as a likely environmental influence.

journal_name

Nat Med

journal_title

Nature medicine

authors

Serrano MG,Parikh HI,Brooks JP,Edwards DJ,Arodz TJ,Edupuganti L,Huang B,Girerd PH,Bokhari YA,Bradley SP,Brooks JL,Dickinson MR,Drake JI,Duckworth RA 3rd,Fong SS,Glascock AL,Jean S,Jimenez NR,Khoury J,Koparde VN,La

doi

10.1038/s41591-019-0465-8

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

1001-1011

issue

6

eissn

1078-8956

issn

1546-170X

pii

10.1038/s41591-019-0465-8

journal_volume

25

pub_type

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