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The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease.

Abstract：

:Infections are thought to be important in the pathogenesis of many heart diseases. Coxsackievirus B3 (CVB3) has been linked to chronic dilated cardiomyopathy, a common cause of progressive heart disease, heart failure and sudden death. We show here that the sarcoma (Src) family kinase Lck (p56lck) is required for efficient CVB3 replication in T-cell lines and for viral replication and persistence in vivo. Whereas infection of wild-type mice with human pathogenic CVB3 caused acute and very severe myocarditis, meningitis, hepatitis, pancreatitis and dilated cardiomyopathy, mice lacking the p56lck gene were completely protected from CVB3-induced acute pathogenicity and chronic heart disease. These data identify a previously unknown function of Src family kinases and indicate that p56lck is the essential host factor that controls the replication and pathogenicity of CVB3.

journal_name

Nat Med

journal_title

Nature medicine

authors

Liu P,Aitken K,Kong YY,Opavsky MA,Martino T,Dawood F,Wen WH,Kozieradzki I,Bachmaier K,Straus D,Mak TW,Penninger JM

doi

10.1038/74689

keywords:

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

429-34

issue

4

eissn

1078-8956

issn

1546-170X

journal_volume

6

pub_type

杂志文章

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