Abstract:
:The C2 domain of synaptotagmin I, which binds to anionic phospholipids in cell membranes, was shown to bind to the plasma membrane of apoptotic cells by both flow cytometry and confocal microscopy. Conjugation of the protein to superparamagnetic iron oxide nanoparticles allowed detection of this binding using magnetic resonance imaging. Detection of apoptotic cells, using this novel contrast agent, was demonstrated both in vitro, with isolated apoptotic tumor cells, and in vivo, in a tumor treated with chemotherapeutic drugs.
journal_name
Nat Medjournal_title
Nature medicineauthors
Zhao M,Beauregard DA,Loizou L,Davletov B,Brindle KMdoi
10.1038/nm1101-1241keywords:
subject
Has Abstractpub_date
2001-11-01 00:00:00pages
1241-4issue
11eissn
1078-8956issn
1546-170Xpii
nm1101-1241journal_volume
7pub_type
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