Abstract：
:Atherosclerosis is a systemic disease of the large arteries, and activation of inflammatory pathways is important in its pathogenesis. Increasing evidence supports the importance of CD40-CD154 interactions in atherosclerosis, interactions originally known to be essential in major immune reactions and autoimmune diseases. CD40 is present on atheroma-derived cells in vitro and in human atheromata in situ. Ligation of CD40 on atheroma-associated cells in vitro activates the production of chemokines, cytokines, matrix metalloproteinases, adhesion molecules and tissue factor, substances responsible for lesion progression and plaque destabilization. Administration of antibody against CD154 to low-density lipoprotein receptor-deficient mice has been shown to reduce atherosclerosis and decrease T-lymphocyte and macrophage content; however, only initial lesions were studied. Here, we determined the effect of genetic disruption of CD154 in ApoE-/- mice in both initial and advanced atherosclerotic lesions. Plaque area was reduced 550%. In contrast to previous reports, initial lesion development was not affected. Advanced plaques in CD154-/-ApoE-/- mice had a less-lipid-containing, collagen-rich, stable plaque phenotype, with a reduced T-lymphocyte/macrophage content. These data indicate that CD40-CD154 signaling is important in late atherosclerotic changes, such as lipid core formation and plaque destabilization.
journal_name
Nat Medjournal_title
Nature medicineauthors
Lutgens E,Gorelik L,Daemen MJ,de Muinck ED,Grewal IS,Koteliansky VE,Flavell RAdoi
10.1038/15271keywords:
subject
Has Abstractpub_date
1999-11-01 00:00:00pages
1313-6issue
11eissn
1078-8956issn
1546-170Xjournal_volume
5pub_type
杂志文章相关文献
NATURE MEDICINE文献大全abstract：:Immunodeficiency is a barrier to successful vaccination in individuals with cancer and chronic infection. We performed a randomized phase 1/2 study in lymphopenic individuals after high-dose chemotherapy and autologous hematopoietic stem cell transplantation for myeloma. Combination immunotherapy consisting of a singl...
journal_title：Nature medicine
pub_type： 杂志文章,随机对照试验
doi：10.1038/nm1310
更新日期：2005-11-01 00:00:00
abstract：:Despite a more than 20-year experience of therapeutic benefit, the relevant molecular and cellular targets of intravenous immunoglobulin (IVIg) in autoimmune disease remain unclear. Contrary to the prevailing theories of IVIg action in autoimmunity, we show that IVIg drives signaling through activating Fc gamma recept...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm1416
更新日期：2006-06-01 00:00:00
abstract：:The recent development of tissue microarrays-composed of hundreds of tissue sections from different tumors arrayed on a single glass slide-facilitates rapid evaluation of large-scale outcome studies. Realization of this potential depends on the ability to rapidly and precisely quantify the protein expression within ea...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm791
更新日期：2002-11-01 00:00:00
abstract：:Overwhelming evidence that relationships between universities, physicians and the medical products industry benefit patients explains the ubiquitous calls to encourage such relationships. Yet accumulating 'conflict of interest' regulations in academic health centers, government and industry have had the opposite effec...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm0411-437
更新日期：2011-04-01 00:00:00
abstract：:Improved techniques to noninvasively image protein-protein interactions (PPIs) are essential. We molecularly engineered a positron emission tomography (PET)-based split reporter (herpes simplex virus type 1 thymidine kinase), cleaved between Thr265 and Ala266, and used this in a protein-fragment complementation assay ...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.2185
更新日期：2010-08-01 00:00:00
abstract：:Noninvasive methods are needed to study the kinetic properties of viruses in living organisms. Oncolytic viruses are used increasingly for cancer therapy but there is currently no satisfactory way to measure efficiency of tumor transduction, changing levels of viral gene expression or the timing of virus elimination. ...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm0502-527
更新日期：2002-05-01 00:00:00
abstract：:Preoperative immunotherapy with anti-PD1 plus anti-CTLA4 antibodies has shown remarkable pathological responses in melanoma1 and colorectal cancer2. In NABUCCO (ClinicalTrials.gov: NCT03387761 ), a single-arm feasibility trial, 24 patients with stage III urothelial cancer (UC) received two doses of ipilimumab and two ...
journal_title：Nature medicine
pub_type： 杂志文章,多中心研究
doi：10.1038/s41591-020-1085-z
更新日期：2020-12-01 00:00:00
abstract：:Together with recent advances in the processing and culture of human tissue, bioengineering, xenotransplantation and genome editing, Induced pluripotent stem cells (iPSCs) present a range of new opportunities for the study of human cancer. Here we discuss the main advantages and limitations of iPSC modeling, and how t...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.4238
更新日期：2016-12-06 00:00:00
abstract：:Brown adipose tissue (BAT) promotes a lean and healthy phenotype and improves insulin sensitivity. In response to cold or exercise, brown fat cells also emerge in the white adipose tissue (WAT; also known as beige cells), a process known as browning. Here we show that the development of functional beige fat in the ing...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.3994
更新日期：2015-12-01 00:00:00
abstract：:Alzheimer's disease is a progressive and incurable disease whose prevalence increases dramatically with age. A biochemical marker for monitoring the onset and progression of the disease would be a valuable tool for disease management. In addition, such a marker might be used as an end point in clinical intervention pr...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm1196-1230
更新日期：1996-11-01 00:00:00
abstract：:Metastasis of breast cancer occurs primarily through the lymphatic system, and the extent of lymph node involvement is a key prognostic factor for the disease. Whereas the significance of angiogenesis for tumor progression has been well documented, the ability of tumor cells to induce the growth of lymphatic vessels (...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/84643
更新日期：2001-02-01 00:00:00
abstract：:Recent studies of subjects infected with human immunodeficiency virus (HIV-1) have produced conflicting results about the extent of reconstitution possible in the CD4+ lymphocyte repertoire after highly active antiretroviral therapy (HAART). The effect of HAART on the incidence of opportunistic infections will probabl...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm0898-953
更新日期：1998-08-01 00:00:00
abstract：:Molecular targeted therapy has the potential to dramatically improve survival in patients with cancer. However, complete and durable responses to targeted therapy are rare in individuals with advanced-stage solid cancers. Even the most effective targeted therapies generally do not induce a complete tumor response, res...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.4091
更新日期：2016-05-05 00:00:00
abstract：:Angiogenesis, the formation of new blood vessels, is a requirement for malignant tumor growth and metastasis. In the absence of angiogenesis, local tumor expansion is suppressed at a few millimeters and cells lack routes for distant hematogenous spread. Clinical studies have demonstrated that the degree of angiogenesi...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm0598-623
更新日期：1998-05-01 00:00:00
abstract：:Delayed T cell recovery and restricted T cell receptor (TCR) diversity after allogeneic hematopoietic stem cell transplantation (allo-HSCT) are associated with increased risks of infection and cancer relapse. Technical challenges have limited faithful measurement of TCR diversity after allo-HSCT. Here we combined 5' r...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.3100
更新日期：2013-03-01 00:00:00
abstract：:De novo mutations arising on the paternal chromosome make the largest known contribution to autism risk, and correlate with paternal age at the time of conception. The recurrence risk for autism spectrum disorders is substantial, leading many families to decline future pregnancies, but the potential impact of assessin...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/s41591-019-0711-0
更新日期：2020-01-01 00:00:00
abstract：:Peripheral nerve injuries represent a significant problem in public health, constituting 2-5% of all trauma cases1. For severe nerve injuries, even advanced forms of clinical intervention often lead to incomplete and unsatisfactory motor and/or sensory function2. Numerous studies report the potential of pharmacologica...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/s41591-018-0196-2
更新日期：2018-12-01 00:00:00
abstract：:Bypass of stenotic coronary arteries with autologous saphenous vein is an established treatment for ischemic heart disease. However, its long-term clinical success is limited. Late vein graft failure is the result of medial and intimal thickening consequent upon medial vascular smooth muscle cell migration, proliferat...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm0298-235
更新日期：1998-02-01 00:00:00
abstract：:Major depressive disorder is a devastating psychiatric disease that afflicts up to 17% of the world's population. Postmortem brain analyses and imaging studies of patients with depression have implicated basal lateral amygdala (BLA) dysfunction in the pathophysiology of depression. However, the circuit and molecular m...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/s41591-018-0299-9
更新日期：2019-02-01 00:00:00
abstract：:Despite the central role of the liver in the regulation of glucose and lipid metabolism, there are currently no methods to directly assess hepatic oxidative metabolism in humans in vivo. By using a new (13)C-labeling strategy in combination with (13)C magnetic resonance spectroscopy, we show that rates of mitochondria...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.3415
更新日期：2014-01-01 00:00:00
abstract：:Post-ischemic inflammation is an essential step in the progression of brain ischemia-reperfusion injury. However, the mechanism that activates infiltrating macrophages in the ischemic brain remains to be clarified. Here we demonstrate that peroxiredoxin (Prx) family proteins released extracellularly from necrotic brai...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.2749
更新日期：2012-06-01 00:00:00
abstract：:Diabetes in non-obese diabetic (NOD) mice is mediated by pathogenic T-helper type 1 (Th1) cells that arise because of a deficiency in regulatory or suppressor T cells. V alpha 14-J alpha 15 natural killer T (NKT) cells recognize lipid antigens presented by the major histocompatibility complex class I-like protein CD1d...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm0901-1052
更新日期：2001-09-01 00:00:00
abstract：:The gene encoding the lysine-specific histone methyltransferase KMT2D has emerged as one of the most frequently mutated genes in follicular lymphoma and diffuse large B cell lymphoma; however, the biological consequences of KMT2D mutations on lymphoma development are not known. Here we show that KMT2D functions as a b...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.3943
更新日期：2015-10-01 00:00:00
abstract：:HIV infection can cause extensive neuronal loss and clinically a severe dementia. The cause of the neurotoxicity remains unclear as neurons are not infected, but disturbance of glutamate-linked calcium entry has been implicated. In this study, we have shown a decrease in HIV-infected brain of the expression of mRNA an...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm1195-1174
更新日期：1995-11-01 00:00:00
abstract：:Mesenchymal stem cells can give rise to several cell types, but varying results depending on isolation methods and tissue source have led to controversies about their usefulness in clinical medicine. Here we show that vascular endothelial cells can transform into multipotent stem-like cells by an activin-like kinase-2...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm.2252
更新日期：2010-12-01 00:00:00
abstract：:While searching for alternative reading-frame peptides encoded by influenza A virus that are recognized by CD8+ T cells, we found an abundant immunogenic peptide encoded by the +1 reading frame of PB1. This peptide derives from a novel conserved 87-residue protein, PB1-F2, which has several unusual features compared w...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm1201-1306
更新日期：2001-12-01 00:00:00
abstract：:A new investigation into Duchenne muscular dystrophy (DMD) pathogenesis suggests that at least part of the muscle degeneration observed in DMD patients may result from the reduced production of muscle membrane-associated neuronal nitric oxide synthase. This reduction may lead to impaired regulation of the vasoconstric...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/83309
更新日期：2001-01-01 00:00:00
abstract：:Sympathetic innervation is critical for effective cardiac function. However, the developmental and regulatory mechanisms determining the density and patterning of cardiac sympathetic innervation remain unclear, as does the role of this innervation in arrhythmogenesis. Here we show that a neural chemorepellent, Sema3a,...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm1570
更新日期：2007-05-01 00:00:00
abstract：:Reactive oxygen species (ROS) induce chemokines responsible for the recruitment of inflammatory cells to sites of injury or infection. Here we show that the plasma membrane Ca(2+)-permeable channel TRPM2 controls ROS-induced chemokine production in monocytes. In human U937 monocytes, hydrogen peroxide (H(2)O(2)) evoke...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm1758
更新日期：2008-07-01 00:00:00
abstract：:Surgery or radiation therapy of metastatic cancer often damages lymph nodes, leading to secondary lymphedema. Here we show, using a newly established mouse model, that collecting lymphatic vessels can be regenerated and fused to lymph node transplants after lymph node removal. Treatment of lymph node-excised mice with...
journal_title：Nature medicine
pub_type： 杂志文章
doi：10.1038/nm1689
更新日期：2007-12-01 00:00:00
