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Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis.

Abstract：

:Accumulation of fibrils composed of amyloid A in tissues resulting in displacement of normal structures and cellular dysfunction is the characteristic feature of systemic amyloidoses. Here we show that RAGE, a multiligand immunoglobulin superfamily cell surface molecule, is a receptor for the amyloidogenic form of serum amyloid A. Interactions between RAGE and amyloid A induced cellular perturbation. In a mouse model, amyloid A accumulation, evidence of cell stress and expression of RAGE were closely linked. Antagonizing RAGE suppressed cell stress and amyloid deposition in mouse spleens. These data indicate that RAGE is a potential target for inhibiting accumulation of amyloid A and for limiting cellular dysfunction induced by amyloid A.

journal_name

Nat Med

journal_title

Nature medicine

authors

Yan SD,Zhu H,Zhu A,Golabek A,Du H,Roher A,Yu J,Soto C,Schmidt AM,Stern D,Kindy M

doi

10.1038/76216

keywords:

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

643-51

issue

6

eissn

1078-8956

issn

1546-170X

journal_volume

6

pub_type

杂志文章

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