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Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis.

Abstract：

:Peroxisome proliferator-activated receptor-delta (PPAR-delta; also known as PPAR-beta) is expressed at high levels in colon tumors, but its contribution to colon cancer is unclear. We examined the role of PPAR-delta in colon carcinogenesis using PPAR-delta-deficient (Ppard(-/-)) mice. In both the Min mutant and chemically induced mouse models, colon polyp formation was significantly greater in mice nullizygous for PPAR-delta. In contrast to previous reports suggesting that activation of PPAR-delta potentiates colon polyp formation, here we show that PPAR-delta attenuates colon carcinogenesis.

journal_name

Nat Med

journal_title

Nature medicine

authors

Harman FS,Nicol CJ,Marin HE,Ward JM,Gonzalez FJ,Peters JM

doi

10.1038/nm1026

keywords:

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

481-3

issue

5

eissn

1078-8956

issn

1546-170X

pii

nm1026

journal_volume

10

pub_type

杂志文章

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