Time to 'walk the walk' about industry ties to enhance health.

abstract：:The inwardly rectifying K(+) channel Kir6.1 forms K(+) channels by coupling with a sulfonylurea receptor in reconstituted systems, but the physiological roles of Kir6.1-containing K(+) channels have not been determined. We report here that mice lacking the gene encoding Kir6.1 (known as Kcnj8) have a high rate of sudd...

journal_title：Nature medicine

authors： Miki T,Suzuki M,Shibasaki T,Uemura H,Sato T,Yamaguchi K,Koseki H,Iwanaga T,Nakaya H,Seino S

更新日期：2002-05-01 00:00:00

abstract：:Treating KRAS-mutant lung adenocarcinoma (LUAD) remains a major challenge in cancer treatment given the difficulties associated with directly inhibiting the KRAS oncoprotein. One approach to addressing this challenge is to define mutations that frequently co-occur with those in KRAS, which themselves may lead to thera...

journal_title：Nature medicine

authors： Romero R,Sayin VI,Davidson SM,Bauer MR,Singh SX,LeBoeuf SE,Karakousi TR,Ellis DC,Bhutkar A,Sánchez-Rivera FJ,Subbaraj L,Martinez B,Bronson RT,Prigge JR,Schmidt EE,Thomas CJ,Goparaju C,Davies A,Dolgalev I,Heguy A,A

更新日期：2017-11-01 00:00:00

abstract：:The optimism of the early period of antimicrobial discovery has been tempered by the emergence of bacterial strains with resistance to these therapeutics. Today, clinically important bacteria are characterized not only by single drug resistance but also by multiple antibiotic resistance--the legacy of past decades of ...

journal_title：Nature medicine

authors： Levy SB,Marshall B

更新日期：2004-12-01 00:00:00

abstract：:Some individuals remain uninfected with human immunodeficiency virus type-1 (HIV-1) despite multiple high-risk sexual exposures. We studied a cohort of 25 subjects with histories of multiple high-risk sexual exposures to HIV-1 and found that their CD8+ lymphocytes had greater anti-HIV-1 activity than did CD8+ lymphocy...

journal_title：Nature medicine

authors： Paxton WA,Martin SR,Tse D,O'Brien TR,Skurnick J,VanDevanter NL,Padian N,Braun JF,Kotler DP,Wolinsky SM,Koup RA

更新日期：1996-04-01 00:00:00

abstract：:TRK fusions are found in a variety of cancer types, lead to oncogenic addiction, and strongly predict tumor-agnostic efficacy of TRK inhibition1-8. With the recent approval of the first selective TRK inhibitor, larotrectinib, for patients with any TRK-fusion-positive adult or pediatric solid tumor, to identify mechani...

journal_title：Nature medicine

authors： Cocco E,Schram AM,Kulick A,Misale S,Won HH,Yaeger R,Razavi P,Ptashkin R,Hechtman JF,Toska E,Cownie J,Somwar R,Shifman S,Mattar M,Selçuklu SD,Samoila A,Guzman S,Tuch BB,Ebata K,de Stanchina E,Nagy RJ,Lanman RB,

更新日期：2019-09-01 00:00:00

abstract：:The lifetime prevalence (∼16%) and the economic burden ($100 billion annually) associated with major depressive disorder (MDD) make it one of the most common and debilitating neurobiological illnesses. To date, the exact cellular and molecular mechanisms underlying the pathophysiology of MDD have not been identified. ...

journal_title：Nature medicine

authors： Duric V,Banasr M,Licznerski P,Schmidt HD,Stockmeier CA,Simen AA,Newton SS,Duman RS

更新日期：2010-11-01 00:00:00

abstract：:Chondrocyte hypertrophy followed by cartilage matrix degradation and vascular invasion, characterized by expression of type X collagen (COL10A1), matrix metalloproteinase-13 (MMP-13) and vascular endothelial growth factor (VEGF), respectively, are central steps of endochondral ossification during normal skeletal growt...

journal_title：Nature medicine

authors： Saito T,Fukai A,Mabuchi A,Ikeda T,Yano F,Ohba S,Nishida N,Akune T,Yoshimura N,Nakagawa T,Nakamura K,Tokunaga K,Chung UI,Kawaguchi H

更新日期：2010-06-01 00:00:00

abstract：:Immune-checkpoint blockade (ICB) has demonstrated efficacy in many tumor types, but predictors of responsiveness to anti-PD1 ICB are incompletely characterized. In this study, we analyzed a clinically annotated cohort of patients with melanoma (n = 144) treated with anti-PD1 ICB, with whole-exome and whole-transcripto...

journal_title：Nature medicine

authors： Liu D,Schilling B,Liu D,Sucker A,Livingstone E,Jerby-Arnon L,Zimmer L,Gutzmer R,Satzger I,Loquai C,Grabbe S,Vokes N,Margolis CA,Conway J,He MX,Elmarakeby H,Dietlein F,Miao D,Tracy A,Gogas H,Goldinger SM,Utikal J

更新日期：2019-12-01 00:00:00

abstract：:We studied the effects of Lyn ablation on the survival of drug-resistant chronic myelogenous leukemia (CML) blast crisis cells using siRNA. Lyn siRNA reduced Lyn protein in both normal hematopoietic cells and BCR-ABL1-expressing (BCR-ABL1(+)) blasts by 80-95%. Within 48 h, siRNA-treated BCR-ABL1(+) blasts underwent ap...

journal_title：Nature medicine

authors： Ptasznik A,Nakata Y,Kalota A,Emerson SG,Gewirtz AM

更新日期：2004-11-01 00:00:00

abstract：:Azoospermia or oligozoospermia due to disruption of spermatogenesis are common causes of human male infertility. We used the technique of spermatogonial transplantation in two infertile mouse strains, Steel (Sl) and dominant white spotting (W), to determine if stem cells from an infertile male were capable of generati...

journal_title：Nature medicine

authors： Ogawa T,Dobrinski I,Avarbock MR,Brinster RL

更新日期：2000-01-01 00:00:00

abstract：:Bypass of stenotic coronary arteries with autologous saphenous vein is an established treatment for ischemic heart disease. However, its long-term clinical success is limited. Late vein graft failure is the result of medial and intimal thickening consequent upon medial vascular smooth muscle cell migration, proliferat...

journal_title：Nature medicine

authors： Mehta D,George SJ,Jeremy JY,Izzat MB,Southgate KM,Bryan AJ,Newby AC,Angelini GD

更新日期：1998-02-01 00:00:00

abstract：:Although prognostic gene expression signatures for survival in early-stage lung cancer have been proposed, for clinical application, it is critical to establish their performance across different subject populations and in different laboratories. Here we report a large, training-testing, multi-site, blinded validation...

journal_title：Nature medicine

authors： Director's Challenge Consortium for the Molecular Classification of Lung Adenocarcinoma.,Shedden K,Taylor JM,Enkemann SA,Tsao MS,Yeatman TJ,Gerald WL,Eschrich S,Jurisica I,Giordano TJ,Misek DE,Chang AC,Zhu CQ,Strumpf D,Hanash

更新日期：2008-08-01 00:00:00

abstract：:Platelet-activating factor (PAF) induces pulmonary edema and has a key role in acute lung injury (ALI). Here we show that PAF induces pulmonary edema through two mechanisms: acid sphingomyelinase (ASM)-dependent production of ceramide, and activation of the cyclooxygenase pathway. Agents that interfere with PAF-induce...

journal_title：Nature medicine

authors： Göggel R,Winoto-Morbach S,Vielhaber G,Imai Y,Lindner K,Brade L,Brade H,Ehlers S,Slutsky AS,Schütze S,Gulbins E,Uhlig S

更新日期：2004-02-01 00:00:00

abstract：:Endothelial dysfunction is a critical factor in many cardiovascular diseases, including hypertension. Although lipid signaling has been implicated in endothelial dysfunction and cardiovascular disease, specific molecular mechanisms are poorly understood. Here we report that Nogo-B, a membrane protein of the endoplasmi...

journal_title：Nature medicine

authors： Cantalupo A,Zhang Y,Kothiya M,Galvani S,Obinata H,Bucci M,Giordano FJ,Jiang XC,Hla T,Di Lorenzo A

更新日期：2015-09-01 00:00:00

abstract：:An effective acquired immune response to infectious agents mediated by HLA-restricted T-cell recognition can target different stages of disease pathogenesis. We show here that three distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct intervals after HIV-1 infection. The discret...

journal_title：Nature medicine

authors： Gao X,Bashirova A,Iversen AK,Phair J,Goedert JJ,Buchbinder S,Hoots K,Vlahov D,Altfeld M,O'Brien SJ,Carrington M

更新日期：2005-12-01 00:00:00

abstract：:Telomerase is a ribonucleoprotein enzyme that maintains the protective structures at the ends of eukaryotic chromosomes, called telomeres. In most human somatic cells, telomerase expression is repressed, and telomeres shorten progressively with each cell division. In contrast, most human tumors express telomerase, res...

journal_title：Nature medicine

authors： Hahn WC,Stewart SA,Brooks MW,York SG,Eaton E,Kurachi A,Beijersbergen RL,Knoll JH,Meyerson M,Weinberg RA

更新日期：1999-10-01 00:00:00

abstract：:CD23 is a low-affinity receptor for immunoglobulin E (IgE) expressed by a variety of haematopoietic cells. Proteolytic cleavage of the transmembrane receptor generates soluble forms, which can be detected in biological fluids. CD23 regulates many functional aspects of immune cells, both in its cell-associated and solu...

journal_title：Nature medicine

authors： Plater-Zyberk C,Bonnefoy JY

更新日期：1995-08-01 00:00:00

abstract：:Because of their abundance, resistance to proteolysis, rapid aggregation and neurotoxicity, N-terminally truncated and, in particular, pyroglutamate (pE)-modified Abeta peptides have been suggested as being important in the initiation of pathological cascades resulting in the development of Alzheimer's disease. We fou...

journal_title：Nature medicine

authors： Schilling S,Zeitschel U,Hoffmann T,Heiser U,Francke M,Kehlen A,Holzer M,Hutter-Paier B,Prokesch M,Windisch M,Jagla W,Schlenzig D,Lindner C,Rudolph T,Reuter G,Cynis H,Montag D,Demuth HU,Rossner S

更新日期：2008-10-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA) is an important neurotransmitter that, through the subtype A GABA receptor (GABAAR), induces inhibition in the adult brain. Here we show that an excitatory, rather than inhibitory, GABAergic system exists in airway epithelial cells. Both GABAARs and the GABA synthetic enzyme glutamic aci...

journal_title：Nature medicine

authors： Xiang YY,Wang S,Liu M,Hirota JA,Li J,Ju W,Fan Y,Kelly MM,Ye B,Orser B,O'Byrne PM,Inman MD,Yang X,Lu WY

更新日期：2007-07-01 00:00:00

abstract：: ...

journal_title：Nature medicine

authors： Stower H

更新日期：2019-02-01 00:00:00

abstract：:Spinal sensorimotor networks that are functionally disconnected from the brain because of spinal cord injury (SCI) can be facilitated via epidural electrical stimulation (EES) to restore robust, coordinated motor activity in humans with paralysis1-3. Previously, we reported a clinical case of complete sensorimotor par...

journal_title：Nature medicine

authors： Gill ML,Grahn PJ,Calvert JS,Linde MB,Lavrov IA,Strommen JA,Beck LA,Sayenko DG,Van Straaten MG,Drubach DI,Veith DD,Thoreson AR,Lopez C,Gerasimenko YP,Edgerton VR,Lee KH,Zhao KD

更新日期：2018-11-01 00:00:00

abstract：:The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) is of global concern: the virus has caused severe respiratory illness, with 111 confirmed cases and 52 deaths at the time of this article's publication. Therapeutic interventions have not been evaluated in vivo; thus, patient management relies ex...

journal_title：Nature medicine

authors： Falzarano D,de Wit E,Rasmussen AL,Feldmann F,Okumura A,Scott DP,Brining D,Bushmaker T,Martellaro C,Baseler L,Benecke AG,Katze MG,Munster VJ,Feldmann H

更新日期：2013-10-01 00:00:00

abstract：:How should clinical trials be improved? Ken Getz, a senior fellow at the Tufts Center for the Study of Drug Development, has been thinking up answers to this question for two decades. In 2003, Getz took on a new challenge when he launched the Center for Information & Study on Clinical Research, a nonprofit focused on ...

journal_title：Nature medicine

authors： Getz K

更新日期：2010-02-01 00:00:00

abstract：:The Dunning rat prostatic carcinoma is a model system where cell motility closely correlates with the metastatic phenotype. We have identified a novel gene, upregulated in the highly motile and metastatic Dunning cancer cell lines, that represents a new member of the thymosin-beta family, thymosin beta 15. Transfectio...

journal_title：Nature medicine

authors： Bao L,Loda M,Janmey PA,Stewart R,Anand-Apte B,Zetter BR

更新日期：1996-12-01 00:00:00

abstract：:Modest clinical outcomes of dendritic-cell (DC) vaccine trials call for the refinement of DC vaccine design. Although many potential antigens have been identified, development of methods to enhance antigen presentation by DCs has lagged. We have engineered a potent, drug-inducible CD40 (iCD40) receptor that permits te...

journal_title：Nature medicine

authors： Hanks BA,Jiang J,Singh RA,Song W,Barry M,Huls MH,Slawin KM,Spencer DM

更新日期：2005-02-01 00:00:00

abstract：:Natalizumab (NZM), a humanized monoclonal IgG4 antibody to α4 integrins, is used to treat patients with relapsing-remitting multiple sclerosis (MS)1,2, but in about 6% of the cases persistent neutralizing anti-drug antibodies (ADAs) are induced leading to therapy discontinuation3,4. To understand the basis of the ADA ...

journal_title：Nature medicine

authors： Cassotta A,Mikol V,Bertrand T,Pouzieux S,Le Parc J,Ferrari P,Dumas J,Auer M,Deisenhammer F,Gastaldi M,Franciotta D,Silacci-Fregni C,Fernandez Rodriguez B,Giacchetto-Sasselli I,Foglierini M,Jarrossay D,Geiger R,Sallusto

更新日期：2019-09-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature medicine

authors： Qi X,Yun C,Sun L,Xia J,Wu Q,Wang Y,Wang L,Zhang Y,Liang X,Wang L,Gonzalez FJ,Patterson AD,Liu H,Mu L,Zhou Z,Zhao Y,Li R,Liu P,Zhong C,Pang Y,Jiang C,Qiao J

更新日期：2019-09-01 00:00:00

abstract：:Members of the suppressor of cytokine signaling (SOCS) family are involved in the pathogenesis of many inflammatory diseases. SOCS-3 is predominantly expressed in T-helper type 2 (T(H)2) cells, but its role in T(H)2-related allergic diseases remains to be investigated. In this study we provide a strong correlation bet...

journal_title：Nature medicine

authors： Seki Y,Inoue H,Nagata N,Hayashi K,Fukuyama S,Matsumoto K,Komine O,Hamano S,Himeno K,Inagaki-Ohara K,Cacalano N,O'Garra A,Oshida T,Saito H,Johnston JA,Yoshimura A,Kubo M

更新日期：2003-08-01 00:00:00

abstract：:Chlamydia trachomatis is the leading cause worldwide of preventable infectious blindness (trachoma) and sexually transmitted disease, including nongonoccocal urethritis and pelvic inflammatory disease. To date, no effective vaccine against C. trachomatis infection has been identified. A monoclonal anti-idiotypic antib...

journal_title：Nature medicine

authors： Whittum-Hudson JA,An LL,Saltzman WM,Prendergast RA,MacDonald AB

更新日期：1996-10-01 00:00:00

abstract：:Genetic variants of human and simian immunodeficiency virus (HIV and SIV) that evolve during the course of infection and progression to AIDS are phenotypically and antigenically distinct from their progenitor viruses present at early stages of infection. However, it has been unclear how these late variants, which are ...

journal_title：Nature medicine

authors： Kimata JT,Kuller L,Anderson DB,Dailey P,Overbaugh J

更新日期：1999-05-01 00:00:00