Abstract:
:This study was conducted to test the hypothesis that physiological changes which occur during aging increase the biological impact of fluoride and reduce the threshold of safe fluoride exposure. Four groups of rats were fed a low-fluoride diet (< 1.2 ppm) ad libitum and received 0, 5, 15, or 50 ppm fluoride in their drinking water. Animals were killed after three, six, 12, or 18 months of treatment. Blood and urine were monitored for biochemical markers of tissue function, and plasma, urine, feces, and representative tissues were analyzed for fluoride. In addition, bone marrow cells from animals killed after 18 months of treatment were examined for frequency of sister chromatid exchange (SCE), a marker of genetic damage. Study results indicated that, within treatment groups, fluoride intake, excretion, and retention did not change significantly between three and 18 months. Fluoride concentration in soft tissues did not change with treatment duration in the fluoride-treated animals. Mineralized tissue fluoride concentration and the total fluoride in the carcasses increased continually as the animals aged. In spite of significant, dose-related differences in tissue fluoride levels which occurred in all age groups in this study, there were no indications that increased fluoride in the tissues caused any adverse physiological or genotoxic effects. None of the monitored clinical "wellness" markers of tissue integrity and function was altered by fluoride in a clinically significant manner. Therefore, there was no evidence from this study that aging reduces the threshold of safe chronic fluoride exposure.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Dunipace AJ,Brizendine EJ,Zhang W,Wilson ME,Miller LL,Katz BP,Warrick JM,Stookey GKdoi
10.1177/00220345950740011201subject
Has Abstractpub_date
1995-01-01 00:00:00pages
358-68issue
1eissn
0022-0345issn
1544-0591journal_volume
74pub_type
杂志文章abstract::Caries increment is affected by sugar-sweetened beverage (SSB) consumption. Taxing SSBs could reduce sugar consumption and caries increment. The authors aimed to estimate the impact of a 20% SSB sales tax on caries increment and associated treatment costs (as well as the resulting tax revenue) in the context of German...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034516660278
更新日期:2016-11-01 00:00:00
abstract::Dimensional alterations of the facial bone wall following tooth extractions in the esthetic zone have a profound effect on treatment outcomes. This prospective study in 39 patients is the first to investigate three-dimensional (3D) alterations of facial bone in the esthetic zone during the initial 8 wks following flap...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章
doi:10.1177/0022034513506713
更新日期:2013-12-01 00:00:00
abstract::A model system consisting of vacuum-deposited aluminum on glass was developed to demonstrate the effectiveness of cavitational activity (occurring within the cooling water supply of a dental ultrasonic scaler) in the removal of particulate material from solid surfaces. The amount of solid material removed from the mod...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630091401
更新日期:1984-09-01 00:00:00
abstract::Thermal diffusivity, a property related to the thermal insulative efficiency of a material, was measured in nine glass-ionomer cements and compared with results from a silicate and a polycarboxylate cement. Each cement was mixed at various powder-liquid ratios (P/L) and moulded into a rectangular prism of approximate ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345870660051001
更新日期:1987-05-01 00:00:00
abstract::Extracellular matrix (ECM) mineralization is regulated by mineral ion availability, proteins, and other molecular determinants. To investigate protein regulation of mineralization in tooth dentin and cementum, and in alveolar bone, we expressed matrix Gla protein (MGP) ectopically in bones and teeth in mice, using an ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910808700907
更新日期:2008-09-01 00:00:00
abstract::Cardiovascular disease is a common cause of morbidity and premature mortality. Cardiovascular disease can be prevented when risk factors are identified early. Calcified carotid artery atheromas (CCAAs), detected in panoramic radiographs, and periodontitis have both been associated with increased risk of cardiovascular...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034519885362
更新日期:2020-01-01 00:00:00
abstract::Enamel fluorosis can occur following either an acute or chronic exposure to fluoride during tooth formation. Fluorosed enamel is characterized by a retention of amelogenins in the early-maturation stage, and by the formation of a more porous enamel with a subsurface hypomineralization. The mechanisms by which fluoride...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/00220345920710051701
更新日期:1992-05-01 00:00:00
abstract::Symphyseal secondary cartilage is important for mandibular development, but the molecular mechanisms underlying its formation remain largely unknown. Here we asked whether Indian hedgehog (Ihh) regulates symphyseal cartilage development and growth. By embryonic days 16.5 to 18.5, Sox9-expressing chondrocytes formed wi...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034510397836
更新日期:2011-05-01 00:00:00
abstract::The dental pulp in human primary teeth is densely innervated by a plethora of nerve endings at the coronal pulp-dentin interface. This study analyzed how the physiological root resorption (PRR) process affects dental pulp innervation before exfoliation of primary teeth. Forty-four primary canine teeth, classified into...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034515593055
更新日期:2015-10-01 00:00:00
abstract::Fibroblast cultures derived from uninjured and reparative rabbit buccal mucosa were compared in terms of extracellular glycosaminoglycan (GAG) content and cellular response to interleukin-1 (IL-1). Under identical growth conditions, proliferation of both cell lines was the same. Both lines incorporated [3H]-glucosamin...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345890680010801
更新日期:1989-01-01 00:00:00
abstract::Samples of dental plaque obtained from the interproximal tooth surfaces of seven young men showed considerable variation in the prevalence and anatomic site distribution of the potentially cariogenic microorganism S mutans. Multiple application of 10% SnF2 topical solution and saline solution delivered to interproxima...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560010301
更新日期:1977-01-01 00:00:00
abstract::Sense of coherence (SOC) has been related to oral health behaviors and oral-health-related quality of life (OHRQoL) in observational studies. This cluster-randomized trial aimed to test the effect of an intervention to enhance SOC on OHRQoL in children. Twelve primary schools were randomly allocated to intervention an...
journal_title:Journal of dental research
pub_type: 杂志文章,随机对照试验
doi:10.1177/0022034512459757
更新日期:2013-01-01 00:00:00
abstract::Pieces of fresh rat incisor enamel were extracted with various buffer solutions and prepared for electron microscopy. I observed partial or complete removal of organic constituents, shrinkage of rods and interrods, separation of stippled material from the enamel, and partial decalcification. The results modify the con...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:
更新日期:1982-12-01 00:00:00
abstract::The effects of Escherichia coli endotoxin upon mouse L929 cell proliferation, DNA synthesis, protein synthesis, and proline incorporation were determined. It was found that a level of endotoxin which inhibited cell proliferation prompted a similar inhibition of DNA synthesis and overall cell protein synthesis. In cont...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345790580061301
更新日期:1979-06-01 00:00:00
abstract::The remodeling of gingival tissue was measured by determining the incorporation of tritiated proline and the disappearance of tritium activity from proline and hydroxyproline for 18 days after administration of label. There was a rapid decrease in the tritium activity from gingiva which was paralleled by a decrease in...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345780570023101
更新日期:1978-02-01 00:00:00
abstract::The recording of multiple interval-censored failure times is common in dental research. Modeling multilevel data has been a difficult task. This paper aims to use the Bayesian approach to analyze a set of multilevel clustered interval-censored data from a clinical study to investigate the effectiveness of silver diami...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/154405910508400907
更新日期:2005-09-01 00:00:00
abstract::Adenosine has various biological effects on human gingival fibroblasts (HGF) and epithelial cells closely associated with inflammation, such as cytokine production and cell adhesion. However, the mechanism of adenosine formation in periodontal tissues is not yet defined. In this study, we examined the involvement of C...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308201108
更新日期:2003-11-01 00:00:00
abstract::The aim of this study was to test the potential of liposomes as drug carriers to the ulcerated oral mucosa. Radioactive triamcinolone acetonide palmitate (3H-TRMAp) was encapsulated in large multilamellar lipid vesicles and served as the test lotion. 3H-TRMAp in solution served as control. Forty-six hamsters were divi...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650090501
更新日期:1986-09-01 00:00:00
abstract::A quantitative microprobe analysis was conducted on three commercial amalgams to determine the nature of the phases present. The presence of tin in the Ag-Hg phase (gamma1) was confirmed and Cu-3Sn was found in the original alloy particles. In the dispersant amalgam studied, little Sn-Hg phase (gamma-2) was found and ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:
更新日期:1975-03-01 00:00:00
abstract::The kinetics of growth of calcium phosphates on synthetic hydroxyapatite (HAP), human enamel, whole dentin, and human calculus has been studied at 37 C at pH values from 4.97 to 5.10 held constant by the pH-stat addition of base. Following an initial induction period, dicalcium phosphate dihydrate (DCPD) crystallizati...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345780570010901
更新日期:1978-01-01 00:00:00
abstract::The solubilities of extracellular polysaccharide fractions produced by 14 oral streptococcal strains were compared in water, aqueous lithium and guanidine salt solutions, dimethyl sulfoxide (DMSO), and a 9:1 DMSO-water mixture. The best results for solubilizing the fractions were obtained with the DMSO-water mixture p...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345750540042601
更新日期:1975-07-01 00:00:00
abstract::The aim of this study was to test effects of preventive regimes using fluoride and chlorhexidine to prevent caries and periodontal diseases in 34 patients with overdentures. The patients, who were treated with immediate overdentures, were distributed at random into three experimental groups. In these groups, different...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/00220345870660101301
更新日期:1987-10-01 00:00:00
abstract::The goal of the present investigation was to study whether periodic use of fluoride-gel treatments resulted in an increased prevalence of dental fluorosis. 269 children, from 14 to 16 years of age, who had received semi-annual or quarterly fluoride-gel treatments were examined for possible fluoride-induced enamel chan...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345850640081101
更新日期:1985-08-01 00:00:00
abstract::Periodontitis is characterized by periodontal tissue destruction. Since interleukin-17 (IL-17) has been reported to up-regulate IL-1beta and tumor necrosis factor-alpha (TNF-alpha), it was hypothesized that it is increased in periodontitis and up-regulates these cytokines and tissue-destructive matrix metalloproteinas...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910708600409
更新日期:2007-04-01 00:00:00
abstract::Although the tripeptides Glu-O-Phosphoserine-Tyr and Glu-O-Phosphoserine-Leu have been identified in embryonic bovine enamel proteins, 1, 2 the issue of whether both sequences occur in each of the phosphopeptides, or whether certain sequences occur in specific peptides only, has recently been resolved by isolating hom...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345790580023101
更新日期:1979-03-01 00:00:00
abstract::The color of an unshaded body porcelain was determined at three thicknesses on white, gray, and three chromatic backings. Spectral absorption and scattering coefficients of the porcelain were determined from the diffuse reflectance at one thickness on the white and gray backings. These optical coefficients, when utili...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345850640061801
更新日期:1985-06-01 00:00:00
abstract::Patients with restorations cemented with a reinforced zinc oxide-eugenol cement and a zinc phosphate cement were recalled after a four- to seven-year interval. No significant differences in clinical success were observed between restoration luted with the two cements. No significant difference in the incidence of cari...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550022201
更新日期:1976-03-01 00:00:00
abstract::Selected area reflection electron diffraction has been used to determine the phases present in the reaction zones surrounding the Ag-Cu eutectic dispersant in Dispersalloy amalgam. The experiments were carried out on two kinds of specimens, (1) Dispersalloy amalgam and (2) Dispersalloy amalgam using 30, 50, 75, and 10...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560090101
更新日期:1977-09-01 00:00:00
abstract::Minimizing patient exposure while maintaining a diagnostically acceptable radiograph is a major goal in diagnostic radiography. Rare-earth filters may be the means to achieve this goal due to their "band-pass effect". The purpose of this study was to examine the image contrast effects and exposure reductions for vario...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345870660080701
更新日期:1987-08-01 00:00:00
abstract::Known antimalarial compunds from several chemical classes were tested for their ability to inhibit in vitro growth of microorganisms causing dental plaque and to prevent the development of plaque in a hamster model. Approximately a third of the compounds tested inhibited in vitro growth; however, none prevented develo...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345750540030901
更新日期:1975-05-01 00:00:00