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Capillary electrophoresis: a new tool in forensic toxicology. Applications and prospects in hair analysis for illicit drugs.

Abstract：

:Capillary electrophoresis, the modern approach to instrumental electrophoresis, is probably the most rapidly expanding analytical technique that has appeared in recent years. In the hands of forensic toxicologists, capillary electrophoresis (CE) represents a powerful new analytical tool, which has proved suitable for the investigation of illicit drugs in seized preparations and also in complex biological matrices, among which is hair. CE can be applied according to different separation mechanisms, and among those that are toxicologically relevant are capillary zone electrophoresis and micellar electrokinetic capillary chromatography, which display different selectivities. For the investigation of hair for drugs of abuse, capillary electrophoresis proved effective, providing simultaneous determinations of different drugs without derivatization, with acceptable sensitivity (typically better than 1 ng of drug per mg of hair). The possibility of carrying out determinations of the same analytes, based on different separation mechanisms (capillary zone electrophoresis and micellar electrokinetic chromatography) with the same instrumentation, simply changing the buffer composition, provides an interesting possibility of 'internal' confirmation of the results.

journal_name

Forensic Sci Int

journal_title

Forensic science international

authors

Tagliaro F,Smyth WF,Turrina S,Deyl Z,Marigo M

doi

10.1016/0379-0738(94)01612-9

subject

Has Abstract

pub_date

1995-01-05 00:00:00

pages

93-104

issue

1-3

eissn

0379-0738

issn

1872-6283

pii

0379-0738(94)01612-9

journal_volume

70

pub_type

杂志文章

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