当前位置： SCI文献检索 > FORENSIC SCIENCE INTERNATIONAL期刊下所有文献 > Determination of the R- and S-enantiomers of methylone and ethylone in seized drugs by enantioselective liquid chromatography tandem mass spectrometry analysis.

Determination of the R- and S-enantiomers of methylone and ethylone in seized drugs by enantioselective liquid chromatography tandem mass spectrometry analysis.

Abstract：

:Synthetic cathinones constitute a major class of the new psychoactive substances (NPS) that have come to dominate recreational drug abuse in recent years. As synthetic cathinones are all chiral molecules, the use of chiral analysis to determine their enantiomeric ratios (ER) in seized drug samples can assist in the identification of the precursor chemicals and manufacturing processes used in production, thereby contributing to drug intelligence. In addition, as different enantiomers of synthetic cathinones vary in biological activity and toxicology, chiral analysis can support research into the physiological properties and side effects of seized drugs, thus enabling better treatment for overdose or addiction. Therefore, suitable methods for chiral separation and quantitative analysis of synthetic cathinones in forensic laboratories are needed. This study describes the separation of R- and S-enantiomers of methylone and ethylone, two of the most commonly abused synthetic cathinones, by liquid chromatography (LC) using a Lux AMP polysaccharide-based chiral column, followed by tandem mass spectrometry analysis. Enantiomeric separation was achieved in 13.4min, and the precision, accuracy, carryover, detection limit, and quantification limit of this method were determined. A total of 39 seized drug samples were analyzed in this study, and the results yielded ER of 0.97-1.09 for methylone and 0.87-1.17 for ethylone. The purity of methylone or ethylone was lower in instant coffee bags than in other package types. The ER and purity profiles can be useful for forensic science and drug intelligence.

journal_name

Forensic Sci Int

journal_title

Forensic science international

authors

Lin HR,Kuo FW

doi

10.1016/j.forsciint.2020.110528

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

110528

eissn

0379-0738

issn

1872-6283

pii

S0379-0738(20)30390-X

journal_volume

317

pub_type

杂志文章

相关文献

FORENSIC SCIENCE INTERNATIONAL文献大全
  • Ivory vs. osseous ivory substitutes-Non-invasive diffractometric discrimination.

    abstract：:A new discrimination method for the bioapatite materials bone, antler and ivory was developed using X-ray diffractometry and comprises non-invasive measurements in order to take valuable objects into account. Our approach deals with the analysis of peak intensity ratios resulting from several measurements on each obje...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2020.110159

    authors： Hoelzig H,Muenster T,Blanke S,Kloess G,Garmasukis R,Koenig A

    更新日期：2020-03-01 00:00:00

  • The detection of THC, CBD and CBN in the oral fluid of Sativex® patients using two on-site screening tests and LC-MS/MS.

    abstract：:Sativex(®) is an oromucosal spray used to treat spasticity in multiple sclerosis sufferers in some European countries, the United Kingdom, Canada and New Zealand. The drug has also recently been registered by the Therapeutic Goods Administration (TGA) in Australia for treatment of multiple sclerosis. Sativex(®) contai...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2014.03.004

    authors： Molnar A,Fu S,Lewis J,Allsop DJ,Copeland J

    更新日期：2014-05-01 00:00:00

  • Gastrointestinal hypomotility: an under-recognised life-threatening adverse effect of clozapine.

    abstract：AIM:To highlight some problems that may occur when investigating clozapine-associated deaths including (i) that death may be related to gastrointestinal hypomotility and (ii) that post-mortem blood clozapine and norclozapine concentrations may not reflect ante-mortem concentrations. CASE REPORTS:A 41-year-old male die...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2010.07.021

    authors： Flanagan RJ,Ball RY

    更新日期：2011-03-20 00:00:00

  • Preservation of dental evidence following exposure to high temperatures.

    abstract：:The success of the Disaster Victim Identification (DVI) process relies upon sufficient post-mortem data being recovered to allow for a meaningful comparison with ante-mortem records of the missing person. Human bodies subjected to prolonged high temperatures, as experienced during the Black Saturday bushfires in Victo...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2010.08.011

    authors： Hill AJ,Lain R,Hewson I

    更新日期：2011-02-25 00:00:00

  • Nonlinear methods of vehicle velocity determination based on inverse systems and tensor products of Legendre polynomials in compact car class.

    abstract：:The article presents research on the methods of crash velocity determination based on the Compact car class. The database used in the research is provided by the NHTSA (National Highway Traffic Safety Administration) and includes numerous frontal crash tests, which allowed the determination of the mathematical model p...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2018.11.023

    authors： Kubiak P,Mierzejewska P,Krukowski M

    更新日期：2019-02-01 00:00:00

  • Identification of deceased based on sternal bone computed tomography features.

    abstract：:Identification of deceased with unclear identity is a common problem in forensic science, whereby radiologic comparison can be applied as method for identification. As this comparison is mostly made on a visual basis, it is highly dependent on the examiner and often lacks standardized procedures and statistical suppor...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2018.03.018

    authors： Weiss G,Wittig H,Scheurer E,Ruprecht R,Lenz C

    更新日期：2018-05-01 00:00:00

  • Validation of an ELISA-based screening assay for the detection of amphetamine, MDMA and MDA in blood and oral fluid.

    abstract：:The use of amphetamine and 'ecstasy' (MDMA) has increased exponentially in many European countries since the late nineties, leading to a rapid growth in the number of clinical and forensic analyses. Therefore, a rapid screening procedure for these substances in biological specimens has become an important part of rout...

    journal_title：Forensic science international

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.forsciint.2005.04.019

    authors： Laloup M,Tilman G,Maes V,De Boeck G,Wallemacq P,Ramaekers J,Samyn N

    更新日期：2005-10-04 00:00:00

  • The effect of starvation on the larval behavior of two forensically important species of blow flies (Diptera: Calliphoridae).

    abstract：:The postfeeding larval stage in blow flies is generally an irreversible condition when the fully grown third instar larvae stop feeding and give no response towards food. The larvae of most species then disperse away from their feeding medium and pupariate. There are several cases reported about the use of postfeeding...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2009.09.022

    authors： Singh D,Bala M

    更新日期：2009-12-15 00:00:00

  • Experimental fragmentation of pipe bombs with varying case thickness.

    abstract：:Among all the improvised explosive devices (IEDs) known, pipe bombs are one of the most popular devices used by terrorists. They are simple to use, easy to construct and materials are readily available. For this IED, fragmentation is the primary injury mechanism, which makes them a desirable weapon for terrorists aimi...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2019.110034

    authors： da Silva LA,Johnson S,Critchley R,Clements J,Norris K,Stennett C

    更新日期：2020-01-01 00:00:00

  • On the interpretation of likelihood ratios in forensic science evidence: Presentation formats and the weak evidence effect.

    abstract：:Likelihood ratios are increasingly being adopted to convey expert evaluative opinions to courts. In the absence of appropriate databases, many of these likelihood ratios will include verbal rather than numerical estimates of the support offered by the analysis. However evidence suggests that verbal formulations of unc...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2014.04.005

    authors： Martire KA,Kemp RI,Sayle M,Newell BR

    更新日期：2014-07-01 00:00:00

  • Sex determination using discriminant analysis of the medial and lateral condyles of the femur in Koreans.

    abstract：:The proximal and distal parts of the femur show the differences between the sexes. Head diameter and the breadth of the epicondyle of the femur are known to distinguish males from females. The proximal end of the femur is studied to determine sex using discriminant analysis but; its distal end is not done. This study ...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2013.08.028

    authors： Kim DI,Kwak DS,Han SH

    更新日期：2013-12-10 00:00:00

  • Visualization of the air ejected from the temporary cavity in brain and tissue simulants during gunshot wounding.

    abstract：:One hypothesis for the physical mechanism responsible for backspatter during cranial gunshot wounding is that air is ejected by the collapse of the temporary cavity formed around the bullet path. Using bovine and ovine heads and simulant materials, evidence of this ejection was sought by measuring the velocity of the ...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2014.11.005

    authors： Lazarjan MS,Geoghegan PH,Taylor MC,Jermy MC

    更新日期：2015-01-01 00:00:00

  • A dedicated internal standard in fragment length analysis of hyperpolymorphic short tandem repeats.

    abstract：:Some of the most polymorphic short tandem repeats (STRs) have alleles differing in size by as little as one basepair. Since sizing precision with commercially available internal standards ordinarily does not allow safe discrimination at this level, typing is accomplished through comparisons with allelic ladders run on...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/s0379-0738(97)02137-3

    authors： Dupuy BM,Olaisen B

    更新日期：1997-05-05 00:00:00

  • Differentiation of the 1-(methylenedioxyphenyl)-2-piperazinopropanes and 1-(methoxyphenyl)-2-piperazinopropanones by GC-IRD and GC-MS.

    abstract：:Two amphetamine-like piperazine-containing compounds, 1-(3,4-methylenedioxyphenyl)-2-piperazinopropane (3,4-MDPPP), its positional isomer 1-(2,3-methylenedioxyphenyl)-2-piperazinopropane (2,3-MDPPP) and three methcathinone-like piperazine-containing regioisomeric ring substituted 1-(methoxyphenyl)-2-piperazinopropanon...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2013.11.015

    authors： Abdel-Hay KM,DeRuiter J,Clark CR

    更新日期：2014-02-01 00:00:00

  • The effect of mismatched recording conditions on human and automatic speaker recognition in forensic applications.

    abstract：:In this paper, we analyse mismatched technical conditions in training and testing phases of speaker recognition and their effect on forensic human and automatic speaker recognition. We use perceptual tests performed by non-experts and compare their performance with that of a baseline automatic speaker recognition syst...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2004.09.078

    authors： Alexander A,Botti F,Dessimoz D,Drygajlo A

    更新日期：2004-12-02 00:00:00

  • An insertion/deletion polymorphism within 3'UTR of RYR2 modulates sudden unexplained death risk in Chinese populations.

    abstract：:Sudden unexplained death (SUD) constitutes a part of the overall sudden death that can not be underestimated. Over the last years, genetic testing on SUD has revealed that inherited channelopathies might play important roles in the pathophysiology of this disease. Ryanodine receptor type-2 (RYR2) is a kind of ion chan...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2016.12.005

    authors： Wang S,Zhang Z,Yang Y,Wang C,Tao R,Hu S,Yin Z,Zhang Q,Li L,He Y,Zhu S,Li C,Zhang S,Zhang J,Sheng L,Wu F,Luo B,Gao Y

    更新日期：2017-01-01 00:00:00

  • Three-dimensional analysis of bitemarks: A validation study using an intraoral scanner.

    abstract：:Conservation of the three-dimensional aspect of bitemarks optimizes their analysis. Although bitemarks could be recorded with a surface scanner, in clinical dentistry, intraoral scanners are used as an alternative to conventional dental impressions. Here we assess the reproducibility and the reliability of a three-dim...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2020.110198

    authors： Fournier G,Savall F,Galibourg A,Gély L,Telmon N,Maret D

    更新日期：2020-04-01 00:00:00

  • A non-fatal intoxication and seven deaths involving the dissociative drug 3-MeO-PCP.

    abstract：INTRODUCTION:3-methoxyphencyclidine (3-MeO-PCP) appeared on the illicit drug market in 2011 and is an analogue of phencyclidine, which exhibits anesthetic, analgesic and hallucinogenic properties. In this paper, we report data from a non-fatal intoxication and seven deaths involving 3-MeO-PCP in Sweden during the perio...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2017.02.034

    authors： Johansson A,Lindstedt D,Roman M,Thelander G,Nielsen EI,Lennborn U,Sandler H,Rubertsson S,Ahlner J,Kronstrand R,Kugelberg FC

    更新日期：2017-06-01 00:00:00

  • Toxicological analysis after asphyxial suicide with helium and a plastic bag.

    abstract：:A 23-year-old man was found on a raised hide in lying position, the head wrapped in a plastic bag connected with a helium gas cylinder by a polypropylene tube. The autopsy did not show any specific findings nor did the routine toxicological analysis reveal significant information regarding the cause of death (BAC 0.9 ...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2007.03.027

    authors： Auwaerter V,Perdekamp MG,Kempf J,Schmidt U,Weinmann W,Pollak S

    更新日期：2007-08-06 00:00:00

  • Molecularly imprinted photonic hydrogels for fast screening of atropine in biological samples with high sensitivity.

    abstract：:Based on molecularly imprinted photonic hydrogels (MIPHs) that combined the colloidal-crystal with molecular imprinting technique, a novel label-free colorimetric chemosensor for convenient and fast efficient detection of atropine with high sensitivity and specificity was developed. Due to the special inverse opal arr...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2013.04.008

    authors： Meng L,Meng P,Tang B,Zhang Q,Wang Y

    更新日期：2013-09-10 00:00:00

  • Experimental study of the expansion dynamic of 9 mm Parabellum hollow point projectiles in ballistic gelatin.

    abstract：:We study in this paper the expanding behaviour of hollow point 9 mm Parabellum projectiles (Hornady XTP(®) and Speer Gold Dot(®)). We defined a deformation rate that takes into account both the diameter increase and the length reduction. We plotted the behaviour of this parameter versus impact velocity (we refer to th...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2011.12.007

    authors： Bresson F,Ducouret J,Peyré J,Maréchal C,Delille R,Colard T,Demondion X

    更新日期：2012-06-10 00:00:00

  • A transnasal intracranial stab wound by a plastic-covered umbrella tip.

    abstract：:A 48-year-old man died from a transnasal intracranial stab wound caused by an umbrella. The track of the stab passed from the right nostril, through the sphenoid sinus, the left side of the sella turcica and anterior clinoid process, and finally reached the surface of the brain. The stab wound crossed the left interna...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2011.07.004

    authors： Ihama Y,Nagai T,Ninomiya K,Fukasawa M,Fuke C,Miyazaki T

    更新日期：2012-01-10 00:00:00

  • Concentrations of trace element in human dentin by sex and age.

    abstract：:Teeth are recently drawing attention for their potential as biological modeling investigation samples due to their ability to be collected and their slow substance metabolism. There is no active metabolism of elements after the completion of dentin. Dentin is surrounded by enamel and cementum, and is not affected by t...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2011.11.012

    authors： Kumagai A,Fujita Y,Endo S,Itai K

    更新日期：2012-06-10 00:00:00

  • Ethical and medico-legal problems concerning so-called hunger strikers.

    abstract：:In the Middle European medico-legal climate, the moral rule 'salus aegroti suprema lex' has been accepted for a long time. In the last few years, under the pressure of fear of accusation of a paternalistic attitude, this postulate has been changed to 'voluntas aegroti suprema lex'. The question stands: Is this valid i...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/0379-0738(94)90399-9

    authors： Neoral L

    更新日期：1994-12-16 00:00:00

  • The anatomical mummies of Mombello: detection of cocaine, nicotine, and caffeine in the hair of psychiatric patients of the early 20th century.

    abstract：:The Mombello Psychiatric Hospital in Limbiate, near Milan, replaced the old Senavra Hospital as the Psychiatric Hospital for the Province of Milan in the 19th century. During the early 20th century, bodies of several Mombello patients were dissected and preserved by Giuseppe Paravicini, an anatomist who operated withi...

    journal_title：Forensic science international

    pub_type： 历史文章,杂志文章

    doi：10.1016/j.forsciint.2016.11.011

    authors： Musshoff F,Fels H,Carli A,Piombino-Mascali D

    更新日期：2017-01-01 00:00:00

  • Synthesis of 4-methyl-5-arylpyrimidines and 4-arylpyrimidines: route specific markers for the Leuckardt preparation of amphetamine, 4-methoxyamphetamine, and 4-methylthioamphetamine.

    abstract：:General synthetic routes to 4-methyl-5-arylpyrimidines and 5-arylpyrimidines are described. 4-Benzylpyrimidine, 4-methyl-5-phenylpyrimidine, 4-(4-methoxybenzyl)pyrimidine, and 4-methyl-5-(4-methoxyphenyl)pyrimidine have been positively identified as route-specific by-products in the Leuckardt preparations of amphetami...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/s0379-0738(00)00311-x

    authors： Kirkbride KP,Ward AD,Jenkins NF,Klass G,Coumbaros JC

    更新日期：2001-01-01 00:00:00

  • Chemical profile of counterfeit buprenorphine vials seized in Tehran, Iran.

    abstract：:Buprenorphine, commonly known by the trademark Temgesic, is one of the most popular drugs of abuse among the opioid-addicted young individuals in Iran. Temgesic, Bungesic, etc. are the most popular and important illicit opioid drugs in Tehran's illicit drugs black market, and are now among the most widely abused by op...

    journal_title：Forensic science international

    pub_type： 信件

    doi：10.1016/j.forsciint.2007.06.016

    authors： Soltaninejad K,Faryadi M,Akhgari M,Bahmanabadi L

    更新日期：2007-10-25 00:00:00

  • Child sexual abuse--Medical statement conclusions in criminal legal process.

    abstract：OBJECTIVES:To evaluate medical statement conclusions in the criminal-legal process in suspected cases of child sexual abuse (CSA). STUDY DESIGN:An observational study of a random sample of 130 medically examined, police reported CSA suspected cases during 2001-2009. Medical statements were evaluated and their conclusi...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2014.03.006

    authors： Joki-Erkkilä M,Niemi J,Ellonen N

    更新日期：2014-06-01 00:00:00

  • Bitemarks: distortion and covariation of the maxillary and mandibular dentition as impressed in human skin.

    abstract：:In bitemark analysis the extent of distortion of both maxillary and mandibular arches and how one affects the other has not been studied. A single dentition was used to create 49 bites on unembalmed cadavers. Landmarks were placed on digital images of the bitemarks and scanned images of the biting dentition. A sample ...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2012.08.044

    authors： Sheets HD,Bush PJ,Bush MA

    更新日期：2012-11-30 00:00:00

  • Identification of fatty acid methyl esters (FAMEs) in postmortem tissue. A new marker of alcohol abuse?

    abstract：:Based on a method that combines thin layer chromatography and gas chromatography, it proved possible to detect postmortem fatty acid methyl esters (FAMEs) in human tissues (pancreas, liver, heart and adipose tissue). The highest concentrations were found in the pancreas, medium concentrations in the liver and adipose ...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/s0379-0738(96)02078-6

    authors： Emrich J,Sprung R,Sammler J,Remberg G

    更新日期：1997-02-07 00:00:00