Effects of the hypoxic radiosensitizer misonidazole on normal and irradiated epidermis.

Abstract:

:Misonidazole, a hypoxic cell radiation-sensitizer, has been used in vivo to analyze its effect on normal and x-irradiated epidermis. The drug action was evaluated 3 days after being implanted subcutaneously. The response of the epidermis and especially of the basal cells to the drug alone and in combination with x-radiation was studied. The ultramorphological analysis as well as quantitative data on epidermal thickness and keratinocyte volume showed that high doses of misonidazole impair the usual post-irradiation epidermal reaction, thus enhancing the involutional effects of radiation and inhibiting radiation-damage repair, even under conditions or normal oxygenation.

journal_name

J Cutan Pathol

authors

de Rey BM,Lanfranchi HE,Klein-Szanto AJ,Itoiz ME

doi

10.1111/j.1600-0560.1981.tb00991.x

subject

Has Abstract

pub_date

1981-04-01 00:00:00

pages

89-95

issue

2

eissn

0303-6987

issn

1600-0560

journal_volume

8

pub_type

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