当前位置： SCI文献检索 > JOURNAL OF CUTANEOUS PATHOLOGY期刊下所有文献 > Analysis of the signal transduction pathway of nickel-induced matrix metalloproteinase-2 expression in the human keratinocytes in vitro: preliminary findings.

Analysis of the signal transduction pathway of nickel-induced matrix metalloproteinase-2 expression in the human keratinocytes in vitro: preliminary findings.

Abstract：

BACKGROUND:Nickel can induce cellular and nuclear damages responsible for chronic diseases, like allergic contact dermatitis (ACD). We previously showed that matrix metalloproteinase-2 (MMP-2) gene expression was induced by nickel in nontumorigenic human keratinocytes cell line (HaCat). OBJECTIVE:To investigate the signal transduction pathways involved in gelatinolytic activity induced in HaCat under nickel stimulation. METHODS:We analyzed the involvement of protein kinase A (PKA), protein kinase C (PKC), tyrosine kinase (PTK), nuclear factor-kB (NF-kB) and activator protein-1 (AP-1) using specific inhibitors (H89, calphostin C, genistein, carpain and curcumin) by electrophoretic mobility shift assay, reverse transcription-polymerase chain reaction and gelatin zymography. RESULTS:Our results indicate that nickel-induced MMP-2 production was inhibited with PTK, PKC and AP-1 specific inhibitors. Moreover, both PKA and NF-kB were not involved in nickel pathway. CONCLUSIONS:Using HaCat, we showed that curcumin and genistein can revert nickel-induced MMP-2 upregulation. Whether the use of PTK and AP-1 inhibitors has therapeutic ramifications in the management of ACD remains to be investigated.

journal_name

J Cutan Pathol

journal_title

Journal of cutaneous pathology

authors

Perfetto B,Lamberti M,Giuliano MT,Canozo N,Cammarota M,Baroni A

doi

10.1111/j.1600-0560.2006.00647.x

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

441-7

issue

6

eissn

0303-6987

issn

1600-0560

pii

CUP647

journal_volume

34

pub_type

杂志文章

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