Sudoriferous acrosyringeal acantholytic disease. A subset of Grover's disease.

Abstract:

:Three selected cases of transient acantholytic dermatosis were studied because of their definitive correlation with sweating due to fever and/ or bed-ridden situations. Biopsy specimens were serially sectioned and acantholysis was found in the acrosyringium or traced to connect to the acrosyringium in all biopsy specimens. Carcinoembryonic antigen (CEA) and eccrine gland-specific monoclonal antibody, IKH-4, were positive in acantholytic cells. Electron microscopy revealed electron dense material filling the lumen of intraepidermal eccrine ducts. This material leaked into lateral intercellular spaces of the luminal cells, passing tight junctions. Marked edema and numerous lysosomes were reminiscent of those found when eccrine acrosyringium is formed in the embryo; this suggested that an occluded and damaged eccrine intraepidermal duct was being rebuilt via lysosomal digestion.

journal_name

J Cutan Pathol

authors

Hashimoto K,Moiin A,Chang MW,Tada J

doi

10.1111/j.1600-0560.1996.tb01289.x

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

151-64

issue

2

eissn

0303-6987

issn

1600-0560

journal_volume

23

pub_type

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