Metastatic follicular carcinoma of the thyroid to the skin: a case confirmed by immunohistochemistry.

abstract：INTRODUCTION:Granulomatous mycosis fungoides (MF) is a rare variant in which granulomas are associated with other typical signs of MF. Its prognosis is worse than that of classical MF. Plasmacytoid dendritic cells (PDCs) are a subset of interferon-producing dendritic cells that link the innate and the adaptative immune...

journal_title：Journal of cutaneous pathology

authors： Fernandez-Flores A,Cassarino DS

更新日期：2019-05-01 00:00:00

abstract：:Dermal non-neural granular cell tumor (NNGCT) was first described in 1991 as an S100-negative polypoid non-melanocytic tumor. Although originally introduced in the literature as a primary cutaneous tumor, it was later emphasized that such qualification could not be held until the line of differentiation was clarified....

journal_title：Journal of cutaneous pathology

authors： Fernandez-Flores A,Cassarino DS,Riveiro-Falkenbach E,Rodriguez-Peralto JL,Fernandez-Figueras MT,Monteagudo C

更新日期：2017-06-01 00:00:00

abstract：:Many patients who present with patch and early plaque stage mycosis fungoides follow an indolent course and survive for many years following diagnosis. A certain subset of patients, however, have rapidly progressive disease leading to accelerated demise. We examined 21 histologic sections from initial biopsies taken f...

journal_title：Journal of cutaneous pathology

authors： Smoller BR,Detwiler SP,Kohler S,Hoppe RT,Kim YH

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:BRAF, a serine/threonine kinase, is a component of the retrovirus-associated sequence (RAS)-RAF-extracellular-regulated protein kinase (ERK)-MAP kinase signal transduction pathway mediating signals from RAS to ERK. The T1796A single point mutation in exon 15 of the BRAF gene has recently been reported in a h...

journal_title：Journal of cutaneous pathology

authors： Palmedo G,Hantschke M,Rütten A,Mentzel T,Hügel H,Flaig MJ,Yazdi AS,Sander CA,Kutzner H

更新日期：2004-03-01 00:00:00

abstract：:Sinonasal non-keratinizing squamous cell carcinoma (SCC), previously designated as transitional cell carcinoma or cylindrical cell carcinoma, is an uncommon malignant neoplasm with distinct histopathological features, considered to be a low-grade malignancy that usually occurs in elderly patients. Extensive local inva...

journal_title：Journal of cutaneous pathology

authors： Guo R,Metcalf S,Crowson AN

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Diagnosis of autoantibody- and immune complex-induced skin diseases is primarily based on direct immunofluorescence (DIF) microscopy. DIF staining is usually performed manually and, therefore, is labor intensive. The quality of immunohistochemical results considerably depends on the experience of the person ...

journal_title：Journal of cutaneous pathology

authors： Lemcke S,Sokolowski S,Rieckhoff N,Buschtez M,Kaffka C,Winter-Keil A,Schaller C,Rottmann N,Sadik CD,Stöcker W,Zillikens D,Schmidt E

更新日期：2016-03-01 00:00:00

abstract：:We report a first case of ossifying fibromyxoid tumor of soft parts of the back, a 10 x 9.5 x 6 cm well-circumscribed elevated subcutaneous tumor demarcated by an incomplete fibrous capsule with bone formation at its base. The tumor was composed of both myxomatous areas with spindle tumor cells and pseudoalveolar stru...

journal_title：Journal of cutaneous pathology

authors： Nakayama F,Kuwahara T

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:BRCA1-associated protein 1 (BAP1) represents a recently identified tumor suppressor protein. Loss of BAP1 has been observed in cutaneous epithelioid Spitz tumors. These cutaneous melanocytic tumors show a distinct histopathologic phenotype characterized by an intradermal sheet-like proliferation of epithelio...

journal_title：Journal of cutaneous pathology

authors： Gammon B,Traczyk TN,Gerami P

更新日期：2013-06-01 00:00:00

abstract：:Apoptosis is a process found in many tissues by which devitalized cells are eliminated in an orderly manner. In skin, apoptosis occurs following sunburn, in Bowen's disease and in basal cell carcinoma. Scattered cells are observed in which the cytoplasm has become condensed and dyskeratotic. These dyskeratotic cells a...

journal_title：Journal of cutaneous pathology

authors： Olson RL,Everett MA

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:Cicatricial forms of alopecia, including lichen planopilaris (LPP) and discoid lupus erythematosus (DLE), may present with overlapping clinical features. In such cases, histopathological examination may provide key information for resolving the differential diagnosis. Optimally, microscopical analysis for al...

journal_title：Journal of cutaneous pathology

authors： Nguyen JV,Hudacek K,Whitten JA,Rubin AI,Seykora JT

更新日期：2011-05-01 00:00:00

abstract：:Perifollicular fibroma is a cutaneous hamartomatous proliferation of the pilar connective tissue sheath. We describe a patient with multiple perifollicular fibromas and analyze the literature on this topic. Histologically, perifollicular fibroma is characterized by a concentric arrangement of collagen fibers surroundi...

journal_title：Journal of cutaneous pathology

authors： Junkins-Hopkins JM,Cooper PH

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Some examples of Bowen disease lack the characteristic broad parakeratosis making their histopathologic diagnosis particularly difficult in small and incomplete biopsies. MATERIALS AND METHODS:The archives of our dermatopathology laboratory were searched for cases of Bowen disease with >75% orthokeratosis (...

journal_title：Journal of cutaneous pathology

authors： Idriss MH,Misri R,Böer-Auer A

更新日期：2016-01-01 00:00:00

abstract：:Another histological variant of basal cell carcinoma (BCC) is described. This clear-cell variant appeared as a recurrent lesion on the back of an elderly man. Histological examination revealed that part of the tumor was composed of clear cells with faintly eosinophilic cytoplasm. Degenerative changes were present, alo...

journal_title：Journal of cutaneous pathology

authors： Oliver GF,Winkelmann RK

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:Hereditary hypotrichosis simplex (MIM 146520, HHS) is a rare form of nonsyndromic alopecia. The locus for autosomal dominant HHS was mapped to 18p11.32-p11.23 and 6p21.3, respectively, suggestive of genetic heterogeneity. AIM:To identify the disease-causing gene for a four-generation Chinese family with dom...

journal_title：Journal of cutaneous pathology

authors： Xu C,Zhang L,Chen N,Su B,Pan CM,Li JY,Zhang GW,Liu Z,Sheng Y,Song HD

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Cardiac angiosarcoma is a rare tumor that has a predilection for middle-aged males and a marked predominance in the right atrium. The tumor may present abruptly with a fulminant clinical course. Initial presentation with metastatic disease is rare. Only one case has been reported of a patient who presented w...

journal_title：Journal of cutaneous pathology

authors： Val-Bernal JF,Figols J,Arce FP,Sanz-Ortiz J

更新日期：2001-05-01 00:00:00

abstract：:The rare presentation of choriocarcinoma as a cutaneous metastasis in a 23-year-old male is reported. Histological and immunohistochemical analysis of the biopsy material demonstrated two distinct cell populations, syncytiotrophoblasts and cytotrophoblasts, with syncytiotrophoblasts strongly positive for human chorion...

journal_title：Journal of cutaneous pathology

authors： Chhieng DC,Jennings TA,Slominski A,Mihm MC Jr

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:The Fli-1 transcription factor functions in cellular proliferation and tumorigenesis. Its role in various neoplasms and its presence in lymphocytes suggest a link between Fli-1 dysregulation and the pathogenesis of mycosis fungoides (MF). In this study, we further elucidate this possible link. METHODS:Secti...

journal_title：Journal of cutaneous pathology

authors： Quick CM,Smoller BR,Hiatt KM

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:BRAF inhibition has improved overall survival in patients with BRAF mutant melanoma, but this is associated with a range of known and predictable cutaneous side effects, including squamous cell carcinomas associated with RAS mutations. METHODS:We identified three severely dysplastic nevi, one atypical intra...

journal_title：Journal of cutaneous pathology

authors： Parekh V,Sobanko J,Miller CJ,Karakousis G,Xu W,Letrero R,Elenitsas R,Xu X,Elder DE,Amaravadi R,Schuchter LM,Nathanson KL,Wilson MA,Chu EY

更新日期：2019-03-01 00:00:00

abstract：:The diagnosis of a CD30+ cutaneous infiltrate is often difficult and requires clinicopathologic correlation. To further evaluate this challenge, initial clinical and histopathologic diagnoses were correlated with final clinicopathologic diagnosis in 44 cases with CD30 immunopositivity. Dermatopathologic evaluation con...

journal_title：Journal of cutaneous pathology

authors： De Souza A,Carter JB,Harris NL,Ferry JA,Duncan LM

更新日期：2015-07-01 00:00:00

abstract：:Study of 18 patients with biopsy diagnoses of eosinophilic panniculitis revealed diverse patterns of systemic disease, including Wells' syndrome, vasculitis, atopy, and erythema nodosum as well as localized panniculitis. Significant associated diseases included psychiatric illness, 6 (drug dependency, 4); atopy, 5 (as...

journal_title：Journal of cutaneous pathology

authors： Winkelmann RK,Frigas E

更新日期：1986-02-01 00:00:00

abstract：:Syndecan-1 is a cell surface proteoglycan predominantly expressed on the surface of adult epithelial cells, and is normally present in all epidermal layers except for the most superficial terminally differentiated cells. Syndecan-1 mediates cell-cell and cell-extracellular matrix adhesion, thereby influencing cell mor...

journal_title：Journal of cutaneous pathology

authors： Bayer-Garner IB,Sanderson RD,Smoller BR

更新日期：1999-09-01 00:00:00

abstract：:Palisaded encapsulated neuroma (PEN; solitary circumscribed neuroma) is a benign, morphologically characteristic cutaneous or mucosal neuroma. Most are solitary lesions on the face, neck or oral mucosa. Histologically, the majority appears as dermal nodules of Schwann cell-rich fascicles, with or without distinctive e...

journal_title：Journal of cutaneous pathology

authors： Jokinen CH,Ragsdale BD,Argenyi ZB

更新日期：2010-01-01 00:00:00

abstract：:Perivascular epithelioid cell tumors (PEComas) are a group of lesions sharing the common features of co-expression of melanocytic and myogenic markers, with focal association of the cells with vascular walls. The PEComa group exhibits a wide range of morphologies. A "fibroma-like" variant of PEComa has been recently d...

journal_title：Journal of cutaneous pathology

authors： Odoño EIG,Tan KB,Tay SY,Lee VKM

更新日期：2020-06-01 00:00:00

abstract：:The nuclei of spindle and epithelioid cell nevus (SECN) cells often contain inclusions. To determine the origin and pathogenesis of the nuclear inclusions, 12 cases of SECN were electron microscopically examined. True inclusions, pseudoinclusions, and electron-lucent areas were frequently found in the nuclei of SECN c...

journal_title：Journal of cutaneous pathology

authors： Sakamoto F,Ito M,Sato Y

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND:BMI-1 is involved in the maintenance of stem cells and functions as an oncogene in both lymphomas and solid carcinomas, acting by downregulation of p16ink4a. We have investigated the expression profile of BMI-1 in normal and inflamed skin as well as in basal cell carcinomas (BCCs) and squamous cell carcinoma...

journal_title：Journal of cutaneous pathology

authors： Reinisch CM,Uthman A,Erovic BM,Pammer J

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Myxoid liposarcoma typically presents as a deep-seated mass in the lower extremity of adults. Presentation as a primary subcutaneous tumor is rare. Here we discuss clinicopathologic characteristics of three such cases and their differential diagnosis to alert dermatopathologists to this unusual clinical pres...

journal_title：Journal of cutaneous pathology

authors： Buehler D,Marburger TB,Billings SD

更新日期：2014-12-01 00:00:00

abstract：:During the past decade, a group of cells located in the dermis and possessing a dendritic morphology have emerged from obscurity and become recognized as important members of the "dermal immune system". This group of cells is characterized by a considerable degree of immunophenotypic and functional heterogeneity. In t...

journal_title：Journal of cutaneous pathology

authors： Nestle FO,Nickoloff BJ

更新日期：1995-10-01 00:00:00

abstract：:Cutaneous syncytial myoepithelioma (CSM) is a recently recognized, histopathological variant of myoepithelial (ME) tumors of the skin. It is characterized by a syncytial arrangement of spindled, ovoid, and/or epithelioid cells forming a well-circumscribed, unencapsulated dermal nodule. There is a paucity of intervenin...

journal_title：Journal of cutaneous pathology

authors： MacKinnon WF,Carter MD,Bridge JA,Tremaine RD,Walsh NMG

更新日期：2019-06-01 00:00:00

abstract：:This report documents the case of a 64-year-old African-American female with new end-stage renal disease (ESRD), diagnosed with systemic lupus erythematosus (SLE) on renal biopsy and serologies including a positive ANA (>1:2560), positive anti-Sm antibodies, low titer anti-RNP antibodies, high titer anti-Ro antibodies...

journal_title：Journal of cutaneous pathology

authors： Goyal A,Jain M,Rehberg K,Goodman W,Gertner E

更新日期：2019-09-01 00:00:00

abstract：:Epidermal Langerhans cells (LC) from skin of clinically normal appearance in psoriatics were studied electron microscopically and compared with LC from the skin of healthy volunteers and from those with other dermatoses. Results show that LC from psoriatics display partly distinct cytoplasmic alterations. Moreover, ab...

journal_title：Journal of cutaneous pathology

authors： Klug H,Sönnichsen N

更新日期：1988-12-01 00:00:00