A fresh morphological and functional look at dermal dendritic cells.


:During the past decade, a group of cells located in the dermis and possessing a dendritic morphology have emerged from obscurity and become recognized as important members of the "dermal immune system". This group of cells is characterized by a considerable degree of immunophenotypic and functional heterogeneity. In this review, the salient features of these dermal dendritic cells are put into a dermatopathology perspective, with particular emphasis on a broad group of inflammatory and neoplastic skin diseases. There appear to be multiple subsets of dermal dendritic cells, and 17 different conditions linked to active participation of these newly recognized cells. Exactly how these different subsets of dermal dendritic cells interact amongst each other, as well as with adjacent cells such as T-lymphocytes, endothelial cells, fibroblasts, and keratinocytes in these different diseases is unclear at this time. However, isolation techniques and monoclonal antibodies capable of distinguishing these subsets, as well as functional assays, are currently available and will permit definitive conclusions to be drawn regarding their pathophysiological significance. It is highly likely that, as more data is gathered, dermal dendritic cells will be the focus of further investigative activity by dermatopathologists for the next decade, and well past the year 2000.


J Cutan Pathol


Nestle FO,Nickoloff BJ




Has Abstract


1995-10-01 00:00:00












  • Sinonasal non-keratinizing squamous cell carcinoma with nasal skin extension as the initial presentation.

    abstract::Sinonasal non-keratinizing squamous cell carcinoma (SCC), previously designated as transitional cell carcinoma or cylindrical cell carcinoma, is an uncommon malignant neoplasm with distinct histopathological features, considered to be a low-grade malignancy that usually occurs in elderly patients. Extensive local inva...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Guo R,Metcalf S,Crowson AN

    更新日期:2012-08-01 00:00:00

  • Elastic fiber pattern in scleroderma/morphea.

    abstract:BACKGROUND:Scleroderma/morphea is characterized by expansion of the dermis with thickened collagen bundles and loss of CD34(+) dermal dendrocytes. Variable elastic fiber changes have been described, but to our knowledge, no systematic study of the elastic fiber pattern correlated with CD34 expression has been reported....

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Walters R,Pulitzer M,Kamino H

    更新日期:2009-09-01 00:00:00

  • When to suspect tinea; a histopathologic study of 103 cases of PAS-positive tinea.

    abstract:BACKGROUND:The histopathologic features of tinea vary widely and its diagnosis could be easily missed if the index of suspicion is not high. We aimed in this study to detect histopathologic features that could be a clue for diagnosis METHODS:We retrospectively reviewed 103 cases of tinea, confirmed by Periodic acid-Sc...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Elbendary A,Valdebran M,Gad A,Elston DM

    更新日期:2016-10-01 00:00:00

  • Sweet's syndrome with subcutaneous involvement associated with pegfilgrastim treatment: first reported case.

    abstract::Neutrophilic panniculitis is an infrequent entity, considered by most authors as part of the 'neutrophilic dermatosis' spectrum. Few cases have been reported to be related with granulocyte colony-stimulating factor (G-CSF); we report a case of neutrophilic panniculitis and Sweet's syndrome lesions related with pegfilg...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Llamas-Velasco M,García-Martín P,Sánchez-Pérez J,Fraga J,García-Diez A

    更新日期:2013-01-01 00:00:00

  • Alteration of the β-catenin pathway in spiradenoma.

    abstract:BACKGROUND:Although skin carcinogenesis has been widely investigated, only limited information is available for epidermal tumors, while even less is known about other skin structures. Alterations in the β-catenin pathway have been reported in several epidermal tumors, while little is known about in adnexal tumors. This...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Im M,Kim DH,Park JS,Chung H,Lee Y,Kim CD,Seo YJ,Lee JH

    更新日期:2011-08-01 00:00:00

  • PD-1 and PD-L1 in neoplastic cells and the tumor microenvironment of Merkel cell carcinoma.

    abstract:BACKGROUND:Merkel cell carcinoma (MCC) is an aggressive neoplasm, which is often associated with Merkel cell polyomavirus (MCPyV). Programmed death-1 (PD-1) and its ligand PD-L1 are key players of the tumor microenvironment (TME). METHODS:Fourteen paraffin-embedded tissue samples of MCC were stratified by their MCPyV ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Mitteldorf C,Berisha A,Tronnier M,Pfaltz MC,Kempf W

    更新日期:2017-09-01 00:00:00

  • CD44 expression in alopecia areata and androgenetic alopecia.

    abstract::CD44 is a widely distributed cell surface protein thought to be involved in multiple steps of normal immune cell function, including T-cell activation, and in cellular adhesion where it mediates cell attachment to hyaluronate. In normal skin, CD44 is found by immunohistochemical means to be primarily in eccrine coil c...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Sawaya ME,Bakshandeh H,Hordinsky MK,Penneys NS

    更新日期:1994-06-01 00:00:00

  • Nature of cell kinetics in psoriatic epidermis.

    abstract:BACKGROUND:Psoriasis vulgaris is a common chronic inflammatory dermatosis. Disorders in keratinocyte proliferation, differentiation, inflammation and immune dysregulation are the major factors implicated in the pathogenesis of psoriasis vulgaris. METHODS:The study was performed in skin specimens of 25 patients with ps...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Doger FK,Dikicioglu E,Ergin F,Unal E,Sendur N,Uslu M

    更新日期:2007-03-01 00:00:00

  • High-pressure paint-gun injury of the finger simulating giant cell tumor of tendon sheath.

    abstract::High-pressure paint guns deliver paint at approximately 3000 pounds per square inch. At this pressure, paint will penetrate the skin and spread quickly through fascial planes and tendon sheaths. The present case is that of a lesion from the finger of a 35-year-old white male in whom a history was initially unavailable...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Stefanato CM,Turner MS,Bhawan J

    更新日期:2005-02-01 00:00:00

  • Matrical carcinoma of the skin.

    abstract::Two elderly patients with unusual hair-follicle tumors of the face are reported. The lesions showed some histologic resemblance to pilomatrixomas but differed by the presence at the advancing edge of cytologically-atypical cells without the usual shadow cell transformation and maturation of pilomatrixomas. The term ma...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Weedon D,Bell J,Mayze J

    更新日期:1980-02-01 00:00:00

  • Differential expression of factor XIIIa and CD34 in cutaneous mesenchymal tumors.

    abstract::The histogenetic relationship amongst various dendritic cells of the dermis which may express markers including factor XIIIa (FXIIIa) or CD34 remains unclear. In this study we utilized a sensitive indirect immunoperoxidase staining technique to identify CD34 and FXIIIa, as well the monocyte/macrophage markers KP-1 and...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Altman DA,Nickoloff BJ,Fivenson DP

    更新日期:1993-04-01 00:00:00

  • Erythema elevatum diutinum: an ultrastructural case study.

    abstract::An electron microscopic study was made of a patient with erythema elevatum diutinum, a rare variant of cutaneous leukocytoclastic vasculitis. Biopsies were obtained from early evolving and late fibroproliferative lesions. Early lesions showed vasculitis and a massive dermal infiltrate composed mainly of neutrophils, h...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Lee AY,Nakagawa H,Nogita T,Ishibashi Y

    更新日期:1989-08-01 00:00:00

  • Transepithelial elimination in sarcoidosis: a frequent finding.

    abstract:BACKGROUND:Transepithelial elimination is a process by which dermal materials are expelled through an active epithelial-dermal connective tissue interaction. It has been described as a regular or sporadic occurrence in a variety of dermatologic conditions, including sarcoidosis. OBSERVATION:Our patient demonstrated a ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Ismail A,Beckum K,McKay K

    更新日期:2014-01-01 00:00:00

  • Pleiotrophin expression correlates with melanocytic tumor progression and metastatic potential.

    abstract:BACKGROUND:Gene expression profiling of melanoma and nevic tissue has demonstrated that pleiotrophin (PTN) is significantly overexpressed in human melanomas. METHODS:To further evaluate PTN expression in melanocytic lesions, protein immunohistochemistry was performed on the spectrum of melanocytic lesions. RESULTS:Me...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Wu H,Barusevicius A,Babb J,Klein-Szanto A,Godwin A,Elenitsas R,Gelfand JM,Lessin S,Seykora JT

    更新日期:2005-02-01 00:00:00

  • Orthokeratotic Bowen disease: a histopathologic, immunohistochemical and molecular study.

    abstract:BACKGROUND:Some examples of Bowen disease lack the characteristic broad parakeratosis making their histopathologic diagnosis particularly difficult in small and incomplete biopsies. MATERIALS AND METHODS:The archives of our dermatopathology laboratory were searched for cases of Bowen disease with >75% orthokeratosis (...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Idriss MH,Misri R,Böer-Auer A

    更新日期:2016-01-01 00:00:00

  • Choriocarcinoma presenting as a cutaneous metastasis.

    abstract::The rare presentation of choriocarcinoma as a cutaneous metastasis in a 23-year-old male is reported. Histological and immunohistochemical analysis of the biopsy material demonstrated two distinct cell populations, syncytiotrophoblasts and cytotrophoblasts, with syncytiotrophoblasts strongly positive for human chorion...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Chhieng DC,Jennings TA,Slominski A,Mihm MC Jr

    更新日期:1995-08-01 00:00:00

  • Surgical management of melanoma.

    abstract::Traditionally, melanoma has been considered by surgeons to be a highly lethal malignancy, always requiring a radical surgical approach for optimal chance of cure. Yet melanoma patients who are now being referred for treatment frequently have small early lesions, and surgeons should develop a flexible attitude about ma...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Patterson WB

    更新日期:1979-06-01 00:00:00

  • Pigmented basal cell carcinoma: increased melanin or increased melanocytes?

    abstract:BACKGROUND:Studies on the precise cause of increased melanization in pigmented basal cell carcinomas (BCC) are limited. We aimed to determine whether the cause of melanization is from increased number of melanocytes or increased melanin pigment, and if there is a difference in the number of melanocytes on different sun...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Brankov N,Prodanovic EM,Hurley MY

    更新日期:2016-12-01 00:00:00

  • Glomus-like bodies within a neurofibroma: a novel neoplasm arising in neurofibromatosis type 1 or a coincidence?

    abstract::Neurofibromatosis type 1 is a relatively common genetic disorder with variable phenotypes. Tumors with features of both glomus tumors and neurofibromas are exceedingly rare in literature. Herein, we report a not yet described neoplasm with features of both a glomangioma/glomus tumor and a neurofibroma arising in a pat...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Thareja S,Honigbaum A,Jukic D

    更新日期:2015-04-01 00:00:00

  • Influence of variability in assessment of Breslow thickness, mitotic rate and ulceration among US pathologists interpreting invasive melanoma, for the purpose of AJCC staging.

    abstract:BACKGROUND:Melanoma staging has depended on depth of invasion (Breslow thickness, BT), mitotic rate (MR) and ulceration. In anticipation of the AJCC's eighth edition, variability in pathologists' assessment of these factors and consequently in tumor staging was assessed. METHODS:One-hundred and fifteen cases of invasi...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Taylor L,Hood K,Reisch L,Elmore J,Piepkorn M,Barnhill R,Knezevich S,Radick A,Elder D

    更新日期:2018-08-01 00:00:00

  • Cytokeratin 20 expression in basaloid follicular hamartoma and infundibulocystic basal cell carcinoma.

    abstract:BACKGROUND:Tumors with similar or identical histopathologic features have been termed basaloid follicular hamartoma (BFH) or infundibulocystic basal cell carcinoma (BCC). BCC typically lacks immunoreactivity with cytokeratin 20 (CK20) and pleckstrin homology-like domain, family A, member 1 protein (PHLDA1). AIM:A seri...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Honarpisheh H,Glusac EJ,Ko CJ

    更新日期:2014-12-01 00:00:00

  • A comparison of clinical, morphological and immunohistochemical features of lymphomatoid papulosis and primary cutaneous CD30(Ki-1)-positive anaplastic large cell lymphoma.

    abstract::The advent of immunoperoxidase technique on paraffin embedded tissue has identified a number of shared immunologic markers present in various lymphoproliferative cutaneous disorders. Two such disorders are the recently described primary cutaneous CD30-positive anaplastic large cell lymphoma (ALCL) and lymphomatoid pap...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Tomaszewski MM,Lupton GP,Krishnan J,May DL

    更新日期:1995-08-01 00:00:00

  • Eosinophilic panniculitis: a clinicopathologic study.

    abstract::Study of 18 patients with biopsy diagnoses of eosinophilic panniculitis revealed diverse patterns of systemic disease, including Wells' syndrome, vasculitis, atopy, and erythema nodosum as well as localized panniculitis. Significant associated diseases included psychiatric illness, 6 (drug dependency, 4); atopy, 5 (as...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Winkelmann RK,Frigas E

    更新日期:1986-02-01 00:00:00

  • A diagnostically-challenging case of melanoma ex blue nevus with comprehensive molecular analysis, including the 23-gene expression signature (myPath melanoma).

    abstract::Melanoma ex blue nevus (MEBN) is a rare, aggressive, and potentially lethal neoplasm. Distinguishing MEBN from an atypical cellular blue nevus can be very challenging. We report a diagnostically difficult case of MEBN with lymph node metastases, in which single nucleotide polymorphism array and fluorescence in situ hy...

    journal_title:Journal of cutaneous pathology



    authors: Castillo SA,Pham AK,Barton DT,Lefferts JA,Yan S,Bridge JA,Linos K

    更新日期:2019-03-01 00:00:00

  • Immunohistochemistry in ocular carcinomas.

    abstract:BACKGROUND:The distinction between ocular sebaceous carcinoma, poorly differentiated ocular squamous cell carcinoma and ocular basal cell carcinoma can be challenging. An appropriate immunohistochemical panel may help to differentiate these lesions. METHODS:To determine the distribution and use of several immunostains...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Sramek B,Lisle A,Loy T

    更新日期:2008-07-01 00:00:00

  • Verruciform xanthoma in the setting of cutaneous trauma and chronic inflammation: report of a patient and a brief review of the literature.

    abstract::We report a rare case of multiple, co-exisitng verruciform xanthomas (VXs) of the anogenital region in the setting of cutaneous trauma. VX is a rare benign mucocutaneous neoplasm that typically presents as a solitary lesion with a predilection for the oral cavity, although extra-oral lesions have been reported involvi...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Cumberland L,Dana A,Resh B,Fitzpatrick J,Goldenberg G

    更新日期:2010-08-01 00:00:00

  • Churg-Strauss syndrome with coexistence of eosinophilic vasculitis, granulomatous phlebitis and granulomatous dermatitis in bullous pemphigoid-like blisters.

    abstract::The main histopathological features in the cutaneous lesions of Churg-Strauss syndrome (CSS) are dermal leukocytoclastic vasculitis with a variable eosinophilic infiltrate and non-vasculitic tissue eosinophilia with granuloma formation. This wide histopathological spectrum may account for the various skin manifestatio...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Ishibashi M,Kudo S,Yamamoto K,Shimai N,Chen KR

    更新日期:2011-03-01 00:00:00

  • Comparative performance of insulinoma-associated protein 1 (INSM1) and routine immunohistochemical markers of neuroendocrine differentiation in the diagnosis of endocrine mucin-producing sweat gland carcinoma.

    abstract::Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare cutaneous adnexal malignancy with predilection for the eyelids of older adults. It must be distinguished from metastatic adenocarcinomas of extracutaneous origin and from benign adnexal proliferations on partial samples when a solid growth component an...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Parra O,Linos K,Yan S,Lilo M,LeBlanc RE

    更新日期:2021-01-01 00:00:00

  • The T1796A mutation of the BRAF gene is absent in Spitz nevi.

    abstract:BACKGROUND:BRAF, a serine/threonine kinase, is a component of the retrovirus-associated sequence (RAS)-RAF-extracellular-regulated protein kinase (ERK)-MAP kinase signal transduction pathway mediating signals from RAS to ERK. The T1796A single point mutation in exon 15 of the BRAF gene has recently been reported in a h...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Palmedo G,Hantschke M,Rütten A,Mentzel T,Hügel H,Flaig MJ,Yazdi AS,Sander CA,Kutzner H

    更新日期:2004-03-01 00:00:00

  • Broad range of adverse cutaneous eruptions in patients on TNF-alpha antagonists.

    abstract::Biologic therapies targeting tumor necrosis factor (TNF)-alpha have become a mainstay in the management of a number of autoimmune diseases. We report a series of adverse skin eruptions in six patients (four females, two males, age: 21-58 years, mean: 39) receiving 4 months to 10 years (mean 3.1 years) of anti-TNF-alph...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Hawryluk EB,Linskey KR,Duncan LM,Nazarian RM

    更新日期:2012-05-01 00:00:00