A fresh morphological and functional look at dermal dendritic cells.


:During the past decade, a group of cells located in the dermis and possessing a dendritic morphology have emerged from obscurity and become recognized as important members of the "dermal immune system". This group of cells is characterized by a considerable degree of immunophenotypic and functional heterogeneity. In this review, the salient features of these dermal dendritic cells are put into a dermatopathology perspective, with particular emphasis on a broad group of inflammatory and neoplastic skin diseases. There appear to be multiple subsets of dermal dendritic cells, and 17 different conditions linked to active participation of these newly recognized cells. Exactly how these different subsets of dermal dendritic cells interact amongst each other, as well as with adjacent cells such as T-lymphocytes, endothelial cells, fibroblasts, and keratinocytes in these different diseases is unclear at this time. However, isolation techniques and monoclonal antibodies capable of distinguishing these subsets, as well as functional assays, are currently available and will permit definitive conclusions to be drawn regarding their pathophysiological significance. It is highly likely that, as more data is gathered, dermal dendritic cells will be the focus of further investigative activity by dermatopathologists for the next decade, and well past the year 2000.


J Cutan Pathol


Nestle FO,Nickoloff BJ




Has Abstract


1995-10-01 00:00:00












  • Cutaneous extraskeletal Ewing's sarcoma.

    abstract::Extraskeletal Ewing's sarcoma has been recognized as being histologically indistinguishable from Ewing's sarcoma of bone. Although the occurrence of extraosseous Ewing's sarcoma in deep soft tissues has been well described, such cutaneous lesions are rare. We report the clinical history, histopathologic findings, and ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Peters MS,Reiman HM,Muller SA

    更新日期:1985-12-01 00:00:00

  • Low-fat and fat-free spindle cell lipomas in the oral cavity: Immunohistochemical analysis and review of the literature.

    abstract::The low-fat and fat-free spindle cell lipomas (SCLs) are rare and often mistaken for other benign and malignant morphological mimics, because of the fact that the diagnosis relies on its non-lipogenic component analysis. Here, we report the clinicopathological features of two oral SCLs (low-fat and fat-free variants)....

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章,评审


    authors: Rocha AFL,Miotto LN,Ferrisse TM,Silveira HA,Almeida LY,Bufalino A,Navarro CM,León JE

    更新日期:2019-10-01 00:00:00

  • Multiple cutaneous fibromyxomas: a light and electron microscopic study.

    abstract::A 27-year-old woman developed many nodular lesions, ranging in diameter from 3 mm to 15 mm and clinically indistinguishable from dermatofibromas. Light microscopic examination showed large amounts of mucin, fibroblasts and histiocytes throughout the dermis. Electron microscopic study revealed wide electron lucent area...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Zina AM,Bundino S

    更新日期:1980-12-01 00:00:00

  • Lymphoma- and leukemia-associated cutaneous atypical CD30+ T-cell reactions.

    abstract::Cutaneous CD30+ lymphoid infiltrates appear cytologically atypical and occasionally may be misinterpreted as recurrent disease when they occur in patients treated for other primary hematologic malignancies. We recently encountered two such cases and present our findings. One patient with B-cell lymphoma and another wi...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Su LD,Duncan LM

    更新日期:2000-05-01 00:00:00

  • Broad range of adverse cutaneous eruptions in patients on TNF-alpha antagonists.

    abstract::Biologic therapies targeting tumor necrosis factor (TNF)-alpha have become a mainstay in the management of a number of autoimmune diseases. We report a series of adverse skin eruptions in six patients (four females, two males, age: 21-58 years, mean: 39) receiving 4 months to 10 years (mean 3.1 years) of anti-TNF-alph...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Hawryluk EB,Linskey KR,Duncan LM,Nazarian RM

    更新日期:2012-05-01 00:00:00

  • Metastatic laryngeal large cell neuroendocrine carcinoma: A rare case of presentation and extreme tumor burden.

    abstract::Large cell neuroendocrine carcinoma (LCNEC) of the larynx is an aggressive form of neuroendocrine carcinoma that affects smokers at an average age of 60 years. LCNEC is characterized by large cells with round to ovoid nuclei distributed in a trabecular or nested growth pattern. Previously, laryngeal LCNEC and atypical...

    journal_title:Journal of cutaneous pathology



    authors: Dunn A,Broadfoot BG,Hunt J,Kaley JR,Atiq O,Gutta NB,Wang X,Gardner JM,Shalin SC

    更新日期:2018-03-01 00:00:00

  • Molluscum contagiosum: immunomorphological aspects of keratinocytes markers of differentiation and adhesion.

    abstract:BACKGROUND:Molluscum contagiosum (MC) is a Molluscipox virus infection of keratinocytes with hyperplasia and intracytoplasmic inclusions - the molluscum bodies (MBs). Few papers address cytokeratins (K) profile in MC, mainly focusing terminal keratinization process. METHODS:Forty-one MC lesions were subjected to immun...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Callegaro CF,Sotto MN

    更新日期:2009-12-01 00:00:00

  • C3d immunohistochemistry on formalin-fixed tissue is a valuable tool in the diagnosis of bullous pemphigoid of the skin.

    abstract:BACKGROUND:Direct immunofluorescence (DIF) testing is an important procedure in the diagnosis of autoimmune bullous dermatoses. We investigated the expression of C3d in formalin-fixed, paraffin-embedded tissue of autoimmune bullous dermatoses. METHODS:The immunohistochemical expression of C3d in bullous pemphigoid (BP...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Pfaltz K,Mertz K,Rose C,Scheidegger P,Pfaltz M,Kempf W

    更新日期:2010-06-01 00:00:00

  • Distant metastasis due to heavily pigmented epithelioid melanoma with underlying BRAF V600E, NOTCH1, ERBB3, and PTEN mutations.

    abstract::Pigment-synthesizing melanoma (PSM) describes a morphologically and genetically diverse group of melanomas. In contrast, pigmented epithelioid melanocytoma (PEM) encompasses a spectrum of indolent tumors now classified as borderline/intermediate melanocytic tumors. Herein, we report a case of widely metastatic heavily...

    journal_title:Journal of cutaneous pathology



    authors: Motaparthi K,George EV,Guo R

    更新日期:2019-08-01 00:00:00

  • A clinical mimicker of melanoma with distinctive histopathology: Topical silver nitrate exposure.

    abstract::Exposure to silver-containing compounds can result in reversible discoloration of the skin, presenting as an irregular brown or black macule, which can have a clinical appearance similar to melanoma. Both the clinical scenario and the histopathology are unique. Silver nitrate darkens with exposure to light, and the ar...

    journal_title:Journal of cutaneous pathology



    authors: Ondrasik RM,Jordan P,Sriharan A

    更新日期:2020-12-01 00:00:00

  • A unique case of concurrent chronic lymphocytic leukemia/small lymphocytic lymphoma and lymphomatoid papulosis in the same biopsy.

    abstract::Chronic lymphocytic leukemia (CLL/SLL) is the most common leukemia in the western world and its cutaneous dissemination a very uncommon phenomenon. Lymphomatoid papulosis (LyP) is a CD30+ lymphoproliferative disorder characterized by chronic, recurrent and self healing skin lesions. Up to 20% of patients with LyP have...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Hibler J,Salavaggione AL,Martin A,Gru AA

    更新日期:2015-04-01 00:00:00

  • Male genital leiomyomas showing androgen receptor expression.

    abstract::Genital leiomyoma in men include those superficial leiomyomas arising in the scrotum and the areola. They are unusual neoplasms: few cases have been reported in the literature and they usually escape clinical diagnosis. Three cases of male genital leiomyomas are reported: two in the scrotum and one in the areola. They...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Suárez-Peñaranda JM,Vieites B,Evgenyeva E,Vázquez-Veiga H,Forteza J

    更新日期:2007-12-01 00:00:00

  • Erythema nodosum-like panniculitis mimicking disease recurrence: A novel toxicity from immune checkpoint blockade therapy-Report of 2 patients.

    abstract::Immunotherapies targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and the programmed cell death 1 (PD-1) receptor and its ligand (PD-L1) have showed substantial therapeutic benefit in patients with clinically advanced solid malignancies. However, autoimmune toxicities are common and often significant adve...

    journal_title:Journal of cutaneous pathology



    authors: Tetzlaff MT,Jazaeri AA,Torres-Cabala CA,Korivi BR,Landon GA,Nagarajan P,Choksi A,Chen L,Uemura M,Aung PP,Diab A,Sharma P,Davies MA,Amaria R,Prieto VG,Curry JL

    更新日期:2017-12-01 00:00:00

  • Primary cutaneous marginal zone lymphoma with subclinical cutaneous involvement and biclonality.

    abstract::Primary cutaneous extranodal marginal zone lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT) represents a monoclonal B-cell neoplasm that typically presents with papules, plaques or nodules. We describe a patient with a primary cutaneous MALT lymphoma with unusual clinical features and an unusual immunophenot...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Edinger JT,Lorenzo CR,Breneman DL,Swerdlow SH

    更新日期:2011-09-01 00:00:00

  • DNA determination of human hair bulbs in normal and androgenetic alopecia.

    abstract::We carried out a cytophotometric study of the DNA content of matrix cells from normal hair follicles and those affected by androgenetic alopecia (early and established baldness), using the Feulgen technique. We thereby obtained a 2C reference value from lymphocyte nuclei from normal skin, from which we established a 2...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Villena A,Alcaraz MV,Pérez de Vargas I

    更新日期:1994-08-01 00:00:00

  • Aberrant bcl-2 protein expression provides a possible mechanism of neoplastic cell growth in cutaneous basal-cell carcinoma.

    abstract::The bcl-2 proto-oncogene encodes a protein that protects cells from programmed cell death (apoptosis). High levels of this protein confer a growth advantage to neoplastic cells even in the absence of a high mitotic rate. This gene is involved in the interchromosomal 14;18 translocation, an abnormality present in more ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Cerroni L,Kerl H

    更新日期:1994-10-01 00:00:00

  • Pseudoxanthoma elasticum-like changes in nonuremic calciphylaxis: Case series and brief review of a helpful diagnostic clue.

    abstract::Calciphylaxis is a rare syndrome of vascular calcification with thrombosis that occurs most often in patients with end-stage renal disease, and it frequently portends a guarded prognosis. Rarely, nonuremic calciphylaxis (NUC) may occur; in this context, a strongly supportive histology is crucial in establishing the di...

    journal_title:Journal of cutaneous pathology



    authors: Nathoo RK,Harb JN,Auerbach J,Guo R,Vincek V,Motaparthi K

    更新日期:2017-12-01 00:00:00

  • Malignant transformation of eccrine tumors.

    abstract::Malignant transformation occurred in pre-existing sweat gland tumors in 7 patients. Three lesions showed an histologic pattern of eccrine spiradenoma, 2 eccrine poroma, one cylindroma and one papillary eccrine adenoma. Malignant transformation was histologically characterized by the presence of solid tumor areas popul...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Galadari E,Mehregan AH,Lee KC

    更新日期:1987-02-01 00:00:00

  • Epidermal apoptosis: cell deletion by phagocytosis.

    abstract::Apoptosis is a process found in many tissues by which devitalized cells are eliminated in an orderly manner. In skin, apoptosis occurs following sunburn, in Bowen's disease and in basal cell carcinoma. Scattered cells are observed in which the cytoplasm has become condensed and dyskeratotic. These dyskeratotic cells a...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Olson RL,Everett MA

    更新日期:1975-01-01 00:00:00

  • Cytokeratin 20 expression in basaloid follicular hamartoma and infundibulocystic basal cell carcinoma.

    abstract:BACKGROUND:Tumors with similar or identical histopathologic features have been termed basaloid follicular hamartoma (BFH) or infundibulocystic basal cell carcinoma (BCC). BCC typically lacks immunoreactivity with cytokeratin 20 (CK20) and pleckstrin homology-like domain, family A, member 1 protein (PHLDA1). AIM:A seri...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Honarpisheh H,Glusac EJ,Ko CJ

    更新日期:2014-12-01 00:00:00

  • Pleomorphic fibroma and dermal atypical lipomatous tumor: are they related?

    abstract::Pleomorphic fibromas represent dome-shaped or polypoid cutaneous lesions characterized by a paucicellular and densely fibrotic background punctuated by scattered atypical to pleomorphic spindle and multinucleated giant cells. Some of these tumors will have incorporated adipose tissue, although these adipocytic areas l...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Al-Zaid T,Wang WL,Lopez-Terrada D,Lev D,Hornick JL,Hafeez Diwan A,Fletcher CD,Lazar AJ

    更新日期:2013-04-01 00:00:00

  • GATA3 staining in primary cutaneous apocrine cribriform carcinoma: Usefulness to differentiate it from breast cancer metastasis.

    abstract:BACKGROUND:Primary cutaneous apocrine cribriform carcinoma (PCACC) is a rare tumor, clinically appearing as a solitary nodule, mostly involving extremities of females and this lesion usually raises a differential diagnosis with metastatic cribriform carcinomas, especially breast cancer. OBJECTIVE:To study GATA3 expres...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Llamas-Velasco M,Pérez-Gónzalez YC,Daudén E,Rütten A

    更新日期:2018-05-01 00:00:00

  • Sebaceous carcinoma within rippled/carcinoid pattern sebaceoma.

    abstract::Although the histogenesis of sebaceous carcinomas remains unclear, the occurrence of intraepidermal or intraepithelial sebaceous carcinoma in the epidermis or conjunctiva may suggest de novo histogenesis. This report describes a case of sebaceous carcinoma within preexisting rippled/carcinoid pattern sebaceoma. This l...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Misago N,Toda S

    更新日期:2016-01-01 00:00:00

  • Analysis of the signal transduction pathway of nickel-induced matrix metalloproteinase-2 expression in the human keratinocytes in vitro: preliminary findings.

    abstract:BACKGROUND:Nickel can induce cellular and nuclear damages responsible for chronic diseases, like allergic contact dermatitis (ACD). We previously showed that matrix metalloproteinase-2 (MMP-2) gene expression was induced by nickel in nontumorigenic human keratinocytes cell line (HaCat). OBJECTIVE:To investigate the si...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Perfetto B,Lamberti M,Giuliano MT,Canozo N,Cammarota M,Baroni A

    更新日期:2007-06-01 00:00:00

  • Centrofacial Balamuthiasis: case report of a rare cutaneous amebic infection.

    abstract::Free-living amebae are ubiquitous in our environment, but rarely cause cutaneous infection. Balamuthia mandrillaris has a predilection for infecting skin of the central face. Infection may be restricted to the skin or associated with life-threatening central nervous system (CNS) involvement. We report a case of a 91-y...

    journal_title:Journal of cutaneous pathology



    authors: Chang OH,Liu F,Knopp E,Muehlenbachs A,Cope JR,Ali I,Thompson R,George E

    更新日期:2016-10-01 00:00:00

  • Epithelioid malignant mesothelioma metastatic to the skin: A case report and review of the literature.

    abstract::Malignant mesothelioma (MM) is an aggressive and invasive neoplasm primarily affecting the pleura, peritoneum and pericardium. While mesothelioma commonly metastasizes to visceral organs, it has rarely been documented to involve the skin and subcutaneous tissue. There is a paucity of reports of cutaneous metastatic me...

    journal_title:Journal of cutaneous pathology



    authors: Ward RE,Ali SA,Kuhar M

    更新日期:2017-12-01 00:00:00

  • Comparison of macromelanosomes and autophagic giant melanosome complexes in nevocellular nevi, lentigo simplex and malignant melanoma.

    abstract::This study compared the fine structure of macromelanosomes with that of giant melanosome complexes formed through melanosomal autophagocytosis in nevocytes and melanocytes of nevocellular nevi, lentigo simplex and malignant melanoma. While macromelanosomes were found only on rare occasions in these pigmentary disorder...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Horikoshi T,Jimbow K,Sugiyama S

    更新日期:1982-10-01 00:00:00

  • Tumor-stage mycosis fungoides in palmoplantar localization with large-cell transformation and partial CD30 expression shows complete response to brentuximab vedotin.

    abstract::Mycosis fungoides in palmoplantar localization (MFPP) is a rare variant of MF that is confined to the hands and feet. Patients commonly receive treatment over many years for suspected palmoplantar dermatitis before the diagnosis is made. Most MFPP patients remain at patch or plaque stage, and often respond to treatmen...

    journal_title:Journal of cutaneous pathology



    authors: Pham AK,Carter JB,Ratcliffe NR,Fuld AD,Lansigan F,Burnside NJ,Guill MA 3rd,Zug KA,Jarvis LA,LeBlanc RE

    更新日期:2018-06-01 00:00:00

  • Multiple perifollicular fibromas: report of a case and analysis of the literature.

    abstract::Perifollicular fibroma is a cutaneous hamartomatous proliferation of the pilar connective tissue sheath. We describe a patient with multiple perifollicular fibromas and analyze the literature on this topic. Histologically, perifollicular fibroma is characterized by a concentric arrangement of collagen fibers surroundi...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章,评审


    authors: Junkins-Hopkins JM,Cooper PH

    更新日期:1994-10-01 00:00:00

  • Dermatofibroma is a clonal proliferative disease.

    abstract::Benign fibrous histiocytoma of the skin or dermatofibroma (DF) has been regarded as a fibrohistiocytic tumor. Whether DF is a neoplastic growth or a reactive process has not been settled. Since a neoplastic process is clonal in nature, clonal analysis of DF was conducted to see if DF is a clonal disease. Fresh specime...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Chen TC,Kuo T,Chan HL

    更新日期:2000-01-01 00:00:00