Angiosarcomatous transdifferentiation of metastatic melanoma.


:Melanoma is known to show considerable variation in its histopathological presentation. In exceptional cases, heterologous or divergent differentiation (metaplastic melanoma) can be observed. We report a case of a 69-year-old man who was diagnosed with nodular melanoma on the right upper leg. One year later, the patient presented with an inguinal lymph node metastasis and a lymph node dissection was carried out. In two out of five positive lymph nodes, an angiosarcomatous component was found next to a conventional melanoma component. Shortly after, the patient developed two in-transit metastases in which again an angiosarcomatous component was seen. The vascular component stained positive for ERG and CD31 and negative for melanocytic markers (Mart-1, S100, SOX-10), while the conventional melanoma had an opposite staining pattern. Molecular analysis on both components showed an identical mutation in the NRAS gene, which in our opinion proves the divergent differentiation. To the best of our knowledge, this is the first case report describing angiosarcomatous transdifferentiation of melanoma.


J Cutan Pathol


Kilsdonk MJ,Romeijn TR,Kelder W,van Kempen LC,Diercks GF




Has Abstract


2020-12-01 00:00:00












  • When to suspect tinea; a histopathologic study of 103 cases of PAS-positive tinea.

    abstract:BACKGROUND:The histopathologic features of tinea vary widely and its diagnosis could be easily missed if the index of suspicion is not high. We aimed in this study to detect histopathologic features that could be a clue for diagnosis METHODS:We retrospectively reviewed 103 cases of tinea, confirmed by Periodic acid-Sc...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Elbendary A,Valdebran M,Gad A,Elston DM

    更新日期:2016-10-01 00:00:00

  • Follicular mycosis fungoides: a case report and review of the literature.

    abstract:BACKGROUND:Follicular mycosis fungoides is an unusual variant of mycosis fungoides (MF). Unlike classic MF where atypical lymphocytes show a predilection for the epidermis (epidermotropism), follicular MF displays a malignant lymphocytic infiltrate tropic for hair follicles (folliculotropism). This malignant lymphocyti...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章,评审


    authors: DeBloom J 2nd,Severson J,Gaspari A,Scott G

    更新日期:2001-07-01 00:00:00

  • Immunohistochemical expression of p16 in desmoplastic melanoma.

    abstract::Desmoplastic melanoma can be difficult to distinguish from desmoplastic melanocytic nevi both clinically and histopathologically. Several attempts have been made to explore the use of ancillary studies to facilitate this distinction. Prior work has suggested that immunohistochemical expression of p16 could help distin...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章,随机对照试验


    authors: Blokhin E,Pulitzer M,Busam KJ

    更新日期:2013-09-01 00:00:00

  • Spiky follicular mycosis fungoides: a clinicopathologic study of 8 cases.

    abstract:BACKGROUND:The early stages of follicular mycosis fungoides (FMF) have not been described previously in the literature. OBJECTIVE:Our goal was to better categorize the clinicopathologic features of early stages of FMF. METHODS:The clinical notes of patients with a diagnosis of FMF seen during the previous 5 years wer...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Tomasini C,Kempf W,Novelli M,Fava P,Annessi G,Rongioletti F,Fierro MT,Quaglino P

    更新日期:2015-03-01 00:00:00

  • Adenoma sebaceum of Pringle: a clinicopathologic review, with a discussion of related pathologic entities.

    abstract::"Adenoma sebaceum of Pringle" (ASP) is a misnomer. The tumor is not an adenoma and is not derived from sebaceous glands. The lesion is characterized by dermal fibrosis and associated vascular proliferation and dilatation. Changes in contiguous sebaceous glands and other adnexal structures are merely secondary. Thus, "...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章,评审


    authors: Sanchez NP,Wick MR,Perry HO

    更新日期:1981-12-01 00:00:00

  • Basal cell carcinoma with tricholemmal (at the lower portion) differentiation within seborrheic keratosis.

    abstract:BACKGROUND:Recent genetic investigations support the idea that basal cell carcinoma (BCC) is trichoblastic carcinoma. However, it is generally thought that clear cell basal cell carcinoma is a result of degeneration rather than tricholemmal differentiation. METHODS:We report a case of BCC, with clear cell components, ...

    journal_title:Journal of cutaneous pathology

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    authors: Misago N,Satoh T,Narisawa Y

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  • Dermatofibroma is a clonal proliferative disease.

    abstract::Benign fibrous histiocytoma of the skin or dermatofibroma (DF) has been regarded as a fibrohistiocytic tumor. Whether DF is a neoplastic growth or a reactive process has not been settled. Since a neoplastic process is clonal in nature, clonal analysis of DF was conducted to see if DF is a clonal disease. Fresh specime...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Chen TC,Kuo T,Chan HL

    更新日期:2000-01-01 00:00:00

  • Transient acantholytic dermatosis with involvement of oral mucosa.

    abstract::Histologic, immunologic and electron microscopic studies were performed in a patient with transient acantholytic dermatosis which involved oral mucosa. Hitologic and electron microscopic findings were almost identical in both cutaneous and mucous membrane lesions, and these were similar to pemphigus vulgaris; suprabas...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Kanzaki T,Hashimoto K

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  • The T1796A mutation of the BRAF gene is absent in Spitz nevi.

    abstract:BACKGROUND:BRAF, a serine/threonine kinase, is a component of the retrovirus-associated sequence (RAS)-RAF-extracellular-regulated protein kinase (ERK)-MAP kinase signal transduction pathway mediating signals from RAS to ERK. The T1796A single point mutation in exon 15 of the BRAF gene has recently been reported in a h...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


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    更新日期:2004-03-01 00:00:00

  • The keratinization disorder in collodion babies evolving into lamellar ichthyosis. Its possible relevance for determining the primary defect in lamellar ichthyosis.

    abstract::Two collodion baby girls with disorder evolving into lamellar ichthyosis were followed by light and electron microscopy. Light microscopically, the neonatal colloidion skin was characterized by a thick compact stratum corneum which was PAS positive in its upper two thirds, by a thin stratum granulosum and by a non-aca...

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    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Liu YA,Finn AJ,Subtil A

    更新日期:2021-01-07 00:00:00

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    abstract::Bullous pemphigoid (BP) antigen and alpha 6 integrin are hemidesmosome-associated glycoproteins of basal keratinocytes. In this work, the immunoreactivity of antibodies to BP and to alpha 6 in salt- or dispase-split human skin, and in 46 biopsy specimens of various genetic and autoimmune bullous dermatoses taken from ...

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    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


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  • Congenital agminated Spitz nevi: immunoreactivity with a melanoma-associated monoclonal antibody.

    abstract::Agminated, or grouped Spitz nevi are a curious expression of nevomelanocytic growth; and represent an uncommon manifestation of these nevi. We encountered an example of agminated Spitz nevi present at birth, which showed progression and rapid growth over months. All showed histologic Spitz nevus features. Avidin-bioti...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Palazzo JP,Duray PH

    更新日期:1988-06-01 00:00:00

  • Pigmented hidrocystoma of the eccrine secretory coil in the vulva: clinicopathologic, immunohistochemical and ultrastructural studies.

    abstract::A case of pigmented hidrocystoma of eccrine secretory coil is presented. A 47-year-old woman had developed a bluish black small nodule in the anterior portion of the labium minor a few years before entry. Microscopically, the cyst was lined by eosinophilic columnar epithelium with abundant brownish granules. There was...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Kamishima T,Igarashi S,Takeuchi Y,Ito M,Fukuda T

    更新日期:1999-03-01 00:00:00

  • De novo intraepidermal epithelioid melanocytic dysplasia as a marker of the atypical mole phenotype -- a clinical and pathological study of 75 patients.

    abstract:BACKGROUND:We encountered a distinctive pattern of dysplastic intraepidermal melanocytic proliferation, which defies classification as a dysplastic melanocytic nevus, but in which the morphologic features fall short of a diagnosis of melanoma in situ. We designate such lesions as de novo intraepidermal epithelioid mela...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Sachdeva M,Frambach GE,Crowson AN,Deng AC,Mihm MC Jr,Magro CM

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  • Eosinophilic panniculitis: a clinicopathologic study.

    abstract::Study of 18 patients with biopsy diagnoses of eosinophilic panniculitis revealed diverse patterns of systemic disease, including Wells' syndrome, vasculitis, atopy, and erythema nodosum as well as localized panniculitis. Significant associated diseases included psychiatric illness, 6 (drug dependency, 4); atopy, 5 (as...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Winkelmann RK,Frigas E

    更新日期:1986-02-01 00:00:00

  • Clumped perinuclear BAP1 expression is a frequent finding in sporadic epithelioid Spitz tumors.

    abstract:BACKGROUND:BRCA1-associated protein 1 (BAP1) represents a recently identified tumor suppressor protein. Loss of BAP1 has been observed in cutaneous epithelioid Spitz tumors. These cutaneous melanocytic tumors show a distinct histopathologic phenotype characterized by an intradermal sheet-like proliferation of epithelio...

    journal_title:Journal of cutaneous pathology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Gammon B,Traczyk TN,Gerami P

    更新日期:2013-06-01 00:00:00

  • Epithelioid sarcoma arising on the nose of a child: a case report and review of the literature.

    abstract::A 4-year-old boy presented with a 6-month history of a red papule on the nasal septum. Physical examination was otherwise unremarkable. A biopsy specimen showed an epithelioid sarcoma characterized by nodular collections of epithelioid tumor cells with central, tumor cell necrosis. By immunohistochemistry the tumor ce...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章,评审


    authors: Billings SD,Hood AF

    更新日期:2000-04-01 00:00:00

  • Revisiting histopathologic findings in Goltz syndrome.

    abstract::Goltz syndrome (focal dermal hypoplasia) is an X-linked dominant disorder that is classically associated with yellowish papules representing fat herniation (superficial adipocytes). We report a series of three cases, with clinicopathologic correlation of biopsies from Blaschkoid streaks. A range of histopathologic fea...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Ko CJ,Antaya RJ,Zubek A,Craiglow B,Damsky W,Galan A,McNiff JM

    更新日期:2016-05-01 00:00:00

  • Sclerosing nevus with pseudomelanomatous features.

    abstract:BACKGROUND:Among the pigmented lesions with a central area of scar, we found a group of cases histologically characterized by striking architectural alteration of the melanocytic component, but with no cytological atypia and mitotically quiescent. The aim of the current study was to assess the biological nature of such...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Fabrizi G,Pennacchia I,Pagliarello C,Massi G

    更新日期:2008-11-01 00:00:00

  • Fli-1 expression in mycosis fungoides.

    abstract:BACKGROUND:The Fli-1 transcription factor functions in cellular proliferation and tumorigenesis. Its role in various neoplasms and its presence in lymphocytes suggest a link between Fli-1 dysregulation and the pathogenesis of mycosis fungoides (MF). In this study, we further elucidate this possible link. METHODS:Secti...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Quick CM,Smoller BR,Hiatt KM

    更新日期:2006-09-01 00:00:00

  • Cutaneous intestinal metaplasia: An unusual cause of peristomal complication with malignant potential.

    abstract::Peristomal ulcer with cutaneous intestinal metaplasia, defined by scattered colonic crypts within variably intact epidermis, is an exceedingly rare pathologic diagnosis, which possesses the potential to progress to primary adenocarcinoma. Herein, we report the third case of cutaneous intestinal metaplasia in a peristo...

    journal_title:Journal of cutaneous pathology



    authors: Tinker DG,Roberts S,Hurley MY,Missall TA

    更新日期:2020-05-01 00:00:00

  • Pagetoid reticulosis (Woringer-Kolopp disease).

    abstract::Two patients with solitary lesions of pagetoid reticulosis are presented. A third case with disseminated lesions and similar microscopic detail is also reported. Lighg microscopic findings include an abnornal cell infiltrate confined to the epidermis and distributed diffusely in a pagetoid pattern. In ultrathin sectio...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Wood WS,Killby VA,Stewart WD

    更新日期:1979-04-01 00:00:00

  • Langerhans cell histiocytosis and multiple reticulohistiocytomas in a patient with TAR syndrome: An association not previously described.

    abstract::We describe a patient with thrombocytopenia-absent radius (TAR) syndrome, multisystemic Langerhans cell histiocytosis and multiple reticulohistiocytomas. A mutational study by massive sequencing identified the Val600Glu (V600E) BRAF mutation in the Langerhans cell histiocytosis lesions, but no molecular alterations we...

    journal_title:Journal of cutaneous pathology



    authors: Hipólito LN,Mendoza-Cembranos MD,Villaescusa MT,Jo-Velasco M,Requena L,Alegría-Landa V

    更新日期:2019-08-01 00:00:00

  • Immunohistochemistry in ocular carcinomas.

    abstract:BACKGROUND:The distinction between ocular sebaceous carcinoma, poorly differentiated ocular squamous cell carcinoma and ocular basal cell carcinoma can be challenging. An appropriate immunohistochemical panel may help to differentiate these lesions. METHODS:To determine the distribution and use of several immunostains...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Sramek B,Lisle A,Loy T

    更新日期:2008-07-01 00:00:00

  • A case of extramedullary hematopoiesis presenting as hemorrhagic panniculitis and evolving in acute myeloid leukemia.

    abstract::Extramedullary hematopoiesis (EMH) in adults is a rare event, usually associated with myeloid disorders, and can be the first sign of chronic myelomonocytic leukemia. We report a case of EMH presenting as a hemorrhagic panniculitis in a patient who did not apparently present any myeloid disorders. The patient received...

    journal_title:Journal of cutaneous pathology



    authors: Gallo G,Bigliardi S,Cesinaro AM

    更新日期:2019-10-01 00:00:00

  • Cornified cell envelope proteins and keratins are normally distributed in harlequin ichthyosis.

    abstract::Long-term survivors of harlequin ichthyosis (HI) have raised a controversy over the differences between HI and lamellar ichthyosis (LI). Abnormal lamellar granules and the failure of conversion from profilaggrin to filaggrin have been reported in HI. On the other hand, malformation of the cornified cell envelope as a ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Akiyama M,Yoneda K,Kim SY,Koyama H,Shimizu H

    更新日期:1996-12-01 00:00:00

  • Dermatomyositis with universal calcinosis. A histopathological and electron optic study.

    abstract::Biopsies from a 5-year-old girl with dermatomyositis and universal calcinosis were studied histopathologically and by means of electron optical techniques. The dermis was infiltrated by fibroblasts, lymphocytes and plasma cells. In the lower part of the dermis, dense basophilic areas were present. In the vicinity of t...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Nielsen AO,Johnson E,Hentzer B,Kobayasi T

    更新日期:1979-12-01 00:00:00

  • Broad histopathologic patterns of non-glabrous skin and glabrous skin from patients with a new variant of endemic pemphigus foliaceus-part 1.

    abstract::A prospective, controlled epidemiologic survey performed in El Bagre, Colombia revealed a new variant of endemic pemphigus disease, occurring in a gold mining region. The disease resembled Senear-Usher syndrome, and occurred in an endemic fashion. The aim of this study is to describe the most frequent histopathologic ...

    journal_title:Journal of cutaneous pathology

    pub_type: 杂志文章


    authors: Howard MS,Yepes MM,Maldonado-Estrada JG,Villa-Robles E,Jaramillo A,Botero JH,Patiño PJ,Hashimoto T,Abreu-Velez AM

    更新日期:2010-02-01 00:00:00