Angiosarcomatous transdifferentiation of metastatic melanoma.

Abstract:

:Melanoma is known to show considerable variation in its histopathological presentation. In exceptional cases, heterologous or divergent differentiation (metaplastic melanoma) can be observed. We report a case of a 69-year-old man who was diagnosed with nodular melanoma on the right upper leg. One year later, the patient presented with an inguinal lymph node metastasis and a lymph node dissection was carried out. In two out of five positive lymph nodes, an angiosarcomatous component was found next to a conventional melanoma component. Shortly after, the patient developed two in-transit metastases in which again an angiosarcomatous component was seen. The vascular component stained positive for ERG and CD31 and negative for melanocytic markers (Mart-1, S100, SOX-10), while the conventional melanoma had an opposite staining pattern. Molecular analysis on both components showed an identical mutation in the NRAS gene, which in our opinion proves the divergent differentiation. To the best of our knowledge, this is the first case report describing angiosarcomatous transdifferentiation of melanoma.

journal_name

J Cutan Pathol

authors

Kilsdonk MJ,Romeijn TR,Kelder W,van Kempen LC,Diercks GF

doi

10.1111/cup.13857

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

1211-1214

issue

12

eissn

0303-6987

issn

1600-0560

journal_volume

47

pub_type

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