Plasmacytoid dendritic cells in granulomatous variant of mycosis fungoides.

abstract：BACKGROUND:Gene expression profiling of melanoma and nevic tissue has demonstrated that pleiotrophin (PTN) is significantly overexpressed in human melanomas. METHODS:To further evaluate PTN expression in melanocytic lesions, protein immunohistochemistry was performed on the spectrum of melanocytic lesions. RESULTS:Me...

journal_title：Journal of cutaneous pathology

authors： Wu H,Barusevicius A,Babb J,Klein-Szanto A,Godwin A,Elenitsas R,Gelfand JM,Lessin S,Seykora JT

更新日期：2005-02-01 00:00:00

abstract：:Goltz syndrome (focal dermal hypoplasia) is an X-linked dominant disorder that is classically associated with yellowish papules representing fat herniation (superficial adipocytes). We report a series of three cases, with clinicopathologic correlation of biopsies from Blaschkoid streaks. A range of histopathologic fea...

journal_title：Journal of cutaneous pathology

authors： Ko CJ,Antaya RJ,Zubek A,Craiglow B,Damsky W,Galan A,McNiff JM

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Ornithine decarboxylase (ODC) plays an important role in the biosynthesis of polyamines. Induction of ODC and polyamine synthesis has been demonstrated in neoplastic tumors and is thought to be related to the degree of malignancy. METHODS:In this study, we investigated a series of basal cell epitheliomas (B...

journal_title：Journal of cutaneous pathology

authors： Kagoura M,Toyoda M,Matsui C,Morohashi M

更新日期：2000-08-01 00:00:00

abstract：:Extraskeletal Ewing's sarcoma has been recognized as being histologically indistinguishable from Ewing's sarcoma of bone. Although the occurrence of extraosseous Ewing's sarcoma in deep soft tissues has been well described, such cutaneous lesions are rare. We report the clinical history, histopathologic findings, and ...

journal_title：Journal of cutaneous pathology

authors： Peters MS,Reiman HM,Muller SA

更新日期：1985-12-01 00:00:00

abstract：:Although CD1a+ dendritic cells (DC) in cutaneous T-cell lymphomas (CTCL) have been well documented, the presence of large numbers of DC within lymphoid infiltrates can pose a diagnostic difficulty. We present a case of a 70-year-old man with a 3-year history of recurrent red papules and plaques on the extremities and ...

journal_title：Journal of cutaneous pathology

authors： Jokinen CH,Wolgamot GM,Wood BL,Olerud J,Argenyi ZB

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:The migration of circulating monocytes into the dermis is considered to be essential for both the initiation and the progression of xanthoma. The contribution of vascular endothelial cells to the migration process is unclear. METHODS:Twenty cases of xanthelasma and six cases of tuberous xanthoma lesions wer...

journal_title：Journal of cutaneous pathology

authors： Matsumoto M,Kunimitsu S,Wada K,Ikeda M,Yokogawa M,Keyama A,Kodama H

更新日期：2007-10-01 00:00:00

abstract：:Acral pseudolymphomatous angiokeratoma of children (APACHE) is a disease comprised by a dense dermal infiltrate of B-lymphocytes and T-lymphocytes in which prominent blood vessels with plump endothelium are found. In the past, the lesion was interpreted as a variant of angiokeratoma, a vascular malformation, or a nevu...

journal_title：Journal of cutaneous pathology

authors： Fernandez-Flores A,Fierro S,Larralde M

更新日期：2015-01-01 00:00:00

abstract：:A 4-year-old boy presented with a 6-month history of a red papule on the nasal septum. Physical examination was otherwise unremarkable. A biopsy specimen showed an epithelioid sarcoma characterized by nodular collections of epithelioid tumor cells with central, tumor cell necrosis. By immunohistochemistry the tumor ce...

journal_title：Journal of cutaneous pathology

authors： Billings SD,Hood AF

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:BMI-1 is involved in the maintenance of stem cells and functions as an oncogene in both lymphomas and solid carcinomas, acting by downregulation of p16ink4a. We have investigated the expression profile of BMI-1 in normal and inflamed skin as well as in basal cell carcinomas (BCCs) and squamous cell carcinoma...

journal_title：Journal of cutaneous pathology

authors： Reinisch CM,Uthman A,Erovic BM,Pammer J

更新日期：2007-02-01 00:00:00

abstract：:In past years, association of primary cutaneous B-cell lymphoma (CBCL) with infection by Borrelia burgdorferi has been reported in a few patients. The evidence for a pathogenetic role was based on clinical grounds or raised titre of antibodies in serum. Both methods, however, do not prove the association between the m...

journal_title：Journal of cutaneous pathology

authors： Cerroni L,Zöchling N,Pütz B,Kerl H

更新日期：1997-09-01 00:00:00

abstract：:Dermatomyositis, a connective tissue disease syndrome where antibodies to the endothelium of the microvasculature of the skin, muscle and lung are implicated in lesional propagation, is characterized by photodistributed erythema, heliotrope rash, Gottron's papules, muscle weakness and interstitial pulmonary fibrosis. ...

journal_title：Journal of cutaneous pathology

authors： Magro CM,Schaefer JT,Waldman J,Knight D,Seilstad K,Hearne D

更新日期：2008-01-01 00:00:00

abstract：:The plasma membrane ultrastructure of the extramammary Paget cells was characterized by freeze-fracture electron microscopy, which was first employed for the study of Paget cells. The Paget cell plasma membrane revealed a flat fractured plane with much fewer and smaller desmosome-particle aggregations than those of th...

journal_title：Journal of cutaneous pathology

authors： Kitajima Y,Mori S

更新日期：1980-12-01 00:00:00

abstract：:As many as 40% of all primary cutaneous melanomas can have histologic remnants of nevomelanocytic nevi adjacent to the tumor. There is increasing evidence that dysplastic nevi are at least a clinical marker for melanoma risk. Spitz nevi are not known for such an association, but are noteworthy because of their histolo...

journal_title：Journal of cutaneous pathology

authors： Winokur TS,Palazzo JP,Johnson WC,Duray PH

更新日期：1990-12-01 00:00:00

abstract：:Glomus tumors are rare, soft-tissue neoplasms arising from the thermoregulatory neuromyoarterial glomus bodies. They are commonly observed in the extremities and typically present with symptoms of cold hypersensitivity, pain and localized tenderness. Intraneural glomus tumors (INGTs) are even rarer. Here we review the...

journal_title：Journal of cutaneous pathology

authors： Muthiah S,Hussain R,Stefanos N,Husain A

更新日期：2018-04-01 00:00:00

abstract：:A 1-month-old female infant was seen in consultation because of a congenital subcutaneous nodule, 2 x 3 cm in diameter, in the right retroauricular area. The nodule was surgically excised. Histologically, a large subcutaneous nodular mass was well delimited but not encapsulated. It consisted of a monomorphous sheet of...

journal_title：Journal of cutaneous pathology

authors： Sánchez Yus E,Requena L,Villegas C,Valle P

更新日期：1995-10-01 00:00:00

abstract：:Psoriasis is characterized by immune activation, increased proliferation and abnormal differentiation of keratinocytes. The reported anti-psoriatic mechanisms of action in vivo of vitamin D analogues include reduction of keratinocyte proliferation and induction of keratinocyte terminal differentiation. We investigated...

journal_title：Journal of cutaneous pathology

authors： Lu I,Gilleaudeau P,McLane JA,Heftler N,Kamber M,Gottlieb S,Krueger JG,Gottlieb AB

更新日期：1996-10-01 00:00:00

abstract：:We report the case of a 51-year-old man with an asymptomatic indurated plaque on the chest wall that was surgically excised and submitted for histopathological examination. Microscopically, the dermis was occupied by a neoplastic process with spindle-shaped cells arranged in longitudinal fascicles with cytologic atypi...

journal_title：Journal of cutaneous pathology

authors： Berzal-Cantalejo F,Sabater-Marco V,Pérez-Vallés A,Martorell-Cebollada M

更新日期：2006-09-01 00:00:00

abstract：:Carcinoembryonic antigen (CEA) is a well-established marker for sweat gland differentiation in adnexal neoplasms. In contrast to previous assumptions, CEA does not represent a single oncofetal antigen but comprises a family of homologous glycoproteins, i.e. the classical CEA-180, biliary glycoprotein (BGP), and non-sp...

journal_title：Journal of cutaneous pathology

authors： Metze D,Grunert F,Neumaier M,Bhardwaj R,Amann U,Wagener C,Luger TA

更新日期：1996-02-01 00:00:00

abstract：:We present the case of a 28-year-old male with a history of human immunodeficiency virus (HIV) with a 1-month history of a steadily enlarging, firm painful lesion on the right posterior shoulder. The patient was initially treated for cellulitis given his clinical picture. Histopathologic examination revealed an angioc...

journal_title：Journal of cutaneous pathology

authors： Malviya N,Rainwater YB,Vandergriff T,Mauskar MM

更新日期：2017-03-01 00:00:00

abstract：:Subungual melanoma commonly presents with solitary longitudinal melanonychia. Herein, we report the case of a patient with subungual melanoma who developed involvement of three digits by three independent primary melanomas. A 98-year-old male patient presented with a two-year history of longitudinal melanonychia on th...

journal_title：Journal of cutaneous pathology

authors： Liu Y,Wang L

更新日期：2012-02-01 00:00:00

abstract：:Immunotherapies targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and the programmed cell death 1 (PD-1) receptor and its ligand (PD-L1) have showed significant therapeutic benefit in patients with clinically advanced solid malignancies, including melanoma. However, immune-related adverse events (irAE) ar...

journal_title：Journal of cutaneous pathology

authors： Trinidad C,Nelson KC,Glitza Oliva IC,Torres-Cabala CA,Nagarajan P,Tetzlaff MT,Ivan D,Hwu WJ,Prieto VG,Curry JL,Aung PP

更新日期：2018-07-01 00:00:00

abstract：:A patient with chronic myelocytic leukemia (CML) in blast transformation with extensive involvement of the skin is reported. The leukemic infiltrates consisted of blasts with lymphoblastoid morphology which were positive for terminal deoxynucleotidyl transferase (TdT) by fluorescent assay. The infiltrates rapidly reso...

journal_title：Journal of cutaneous pathology

authors： Ansell JE,Bhawan J,Pechet L

更新日期：1980-10-01 00:00:00

abstract：:This report documents the case of a 64-year-old African-American female with new end-stage renal disease (ESRD), diagnosed with systemic lupus erythematosus (SLE) on renal biopsy and serologies including a positive ANA (>1:2560), positive anti-Sm antibodies, low titer anti-RNP antibodies, high titer anti-Ro antibodies...

journal_title：Journal of cutaneous pathology

authors： Goyal A,Jain M,Rehberg K,Goodman W,Gertner E

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Direct immunofluorescence (DIF) is a valuable tool in the diagnosis of cutaneous lupus erythematosus (LE). Our goal was to characterize the most frequent immune reactants in the skin biopsies of cutaneous LE and identify the most common immunofluorescence staining patterns. METHODS:DIF results of immunoglob...

journal_title：Journal of cutaneous pathology

authors： Kontos AP,Jirsari M,Jacobsen G,Fivenson DP

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:It is not clear why melanocyte disappearance occurs without fibrotic evolution in halo nevus and with fibrotic evolution in regressing melanoma. METHODS:Six halo nevi, seven regressing primary melanomas, and seven primary melanoma (PM) without regression were studied using immunohistochemistry for the pheno...

journal_title：Journal of cutaneous pathology

authors： Moretti S,Spallanzani A,Pinzi C,Prignano F,Fabbri P

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Ulceration and osteoclast-like giant cells are two pathological features uncommonly seen in dermatofibromas. To our knowledge, the presence of these features has not been previously described within the same lesion. METHODS:We report the clinical, histopathological and immunohistochemical findings of a 38-y...

journal_title：Journal of cutaneous pathology

authors： González-Vilas D,García-Gavín J,Ginarte M,Rodríguez-Blanco I,Toribio J

更新日期：2009-10-01 00:00:00

abstract：:Cutaneous lesions of lupus erythematosus (LE) show a broad spectrum of clinicopathologic features. Histopathologically, besides typical patterns such as interface dermatitis, perivascular lymphocytic infiltrate and dermal mucin deposits, an involvement of the eccrine structures, especially the acrosyringium, may be ob...

journal_title：Journal of cutaneous pathology

authors： Fried I,Wiesner T,Cerroni L

更新日期：2010-01-01 00:00:00

abstract：:Dirofilaria repens (formerly Dirofilaria conjunctiva) is a natural parasite of the subcutaneous tissues of dogs, cats and wild carnivores in Europe, Africa and Asia. Microfilariae are transmitted to humans by various species of mosquito. An autochthonous case of subcutaneous dirofilariasis is reported in a Greek patie...

journal_title：Journal of cutaneous pathology

authors： Tzanetou K,Gasteratos S,Pantazopoulou A,Gogou C,Konidaris D,Fragia K

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:The diagnosis of 'cellular dermal nodule in melanocytic nevi' is challenging, as it can simulate invasive and tumorigenic melanoma. Because cellular nodules are presumed benign, it is essential to differentiate them from true malignant melanoma arising within a nevus, which portends a poor prognosis. Althoug...

journal_title：Journal of cutaneous pathology

authors： Xu X,Bellucci KS,Elenitsas R,Elder DE

更新日期：2004-02-01 00:00:00

abstract：:Long-term survivors of harlequin ichthyosis (HI) have raised a controversy over the differences between HI and lamellar ichthyosis (LI). Abnormal lamellar granules and the failure of conversion from profilaggrin to filaggrin have been reported in HI. On the other hand, malformation of the cornified cell envelope as a ...

journal_title：Journal of cutaneous pathology

authors： Akiyama M,Yoneda K,Kim SY,Koyama H,Shimizu H

更新日期：1996-12-01 00:00:00