Expression of WT-1 by the vascular component of acral pseudolymphomatous angiokeratoma of children.

Abstract:

:Acral pseudolymphomatous angiokeratoma of children (APACHE) is a disease comprised by a dense dermal infiltrate of B-lymphocytes and T-lymphocytes in which prominent blood vessels with plump endothelium are found. In the past, the lesion was interpreted as a variant of angiokeratoma, a vascular malformation, or a nevus. Currently, most authors consider it to be a type of pseudolymphoma with prominent blood vessels. The latter express CD34 and D2-40, while they lack the expression of Glut-1. The expression of Wilms tumor-1 (WT-1) by APACHE has not yet been studied. In this report, we present a case of APACHE on the right foot of a 4-year-old boy and demonstrate immunoexpression of WT-1 by the blood vessels of the lesion. We also performed serial sections and demonstrated that the WT-1+ vessels with prominent endothelium were D2-40-.

journal_name

J Cutan Pathol

authors

Fernandez-Flores A,Fierro S,Larralde M

doi

10.1111/cup.12429

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

50-5

issue

1

eissn

0303-6987

issn

1600-0560

journal_volume

42

pub_type

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